Polyketide synthase chimeras reveal key role of ketosynthase domain in chain branching

Twofold polyketide branching by a stereoselective enzymatic Michael addition

(2015) Daniel Heine et al.   CHEMICAL COMMUNICATIONS

Enzymatic Polyketide Chain Branching To Give Substituted Lactone, Lactam, and Glutarimide Heterocycles

(2014) Daniel Heine et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biosynthetic Code for Divergolide Assembly in a Bacterial Mangrove Endophyte

(2014) Zhongli Xu et al.   CHEMBIOCHEM

Cycloheximide and Actiphenol Production in Streptomyces sp. YIM56141 Governed by Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase

(2014) Min Yin et al.   ORGANIC LETTERS

Formation of 1,3-Cyclohexanediones and Resorcinols Catalyzed by a Widely Occuring Ketosynthase

(2013) Sebastian W. Fuchs et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Vinylogous chain branching catalysed by a dedicated polyketide synthase module

(2013) Tom Bretschneider et al.   NATURE

Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation

(2013) Bo Wang et al.   ORGANIC LETTERS

Symbiotic Cooperation in the Biosynthesis of a Phytotoxin

(2012) Kirstin Scherlach et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antiproliferative Effects of Ester- and Amide-Functionalized Rhizoxin Derivatives

(2011) Björn Kusebauch et al.   ChemMedChem

A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis

(2011) Tom Bretschneider et al.   Nature Chemical Biology

Multifaceted Modes of Action for the Glutarimide-Containing Polyketides Revealed

(2010) Scott R. Rajski et al.   CHEMBIOCHEM

Synthesis and Antiviral Activities of Synthetic Glutarimide Derivatives

(2010) Xing-yue Ji et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin

(2010) Tilman Schneider-Poetsch et al.   Nature Chemical Biology

Polyketide-Chain Branching by an Enzymatic Michael Addition

(2009) Björn Kusebauch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Biosynthetic Logic of Polyketide Diversity

(2009) Christian Hertweck   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

iso-Migrastatin, Migrastatin, and Dorrigocin Production in Streptomyces platensis NRRL 18993 Is Governed by a Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase

(2009) Si-Kyu Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein structure prediction on the Web: a case study using the Phyre server

(2009) Lawrence A Kelley et al.   Nature Protocols

Endofungal bacteria as producers of mycotoxins

(2009) Gerald Lackner et al.   TRENDS IN MICROBIOLOGY

Evolution of host resistance in a toxin-producing bacterial–fungal alliance

(2008) Imke Schmitt et al.   ISME Journal

Isoprenoid-like alkylations in polyketide biosynthesis

(2008) Christopher T. Calderone   NATURAL PRODUCT REPORTS

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

(2008) TuAnh Nguyen et al.   NATURE BIOTECHNOLOGY