Review
Endocrinology & Metabolism
Julia S. Brunner, Lydia W. S. Finley
Summary: This review emphasizes the important role of metabolic pathways in influencing the early stages of tumor development, highlighting the metabolic alterations present in cancer cells compared to normal cells. It discusses how these metabolic changes can support the growth and survival of tumors, as well as their potential impact on gene expression programs that promote malignant progression. The review also explores the factors, both intrinsic and extrinsic, that contribute to tumor initiation and underscores the significance of understanding how metabolic pathways control this process in the design of interventions to limit tumor incidence.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Yang Li, Shuaibing Wang, Wenbo Yang, Hong Liu
Summary: The study found that the survival of breast cancer patients is associated with molecular subtypes, metastatic sites, and primary tumor surgery. Patients with hormone receptor positive/HER2 positive subtype showed the best survival time, while triple negative patients showed the worst survival time.
Article
Medicine, Research & Experimental
Federica Zilli, Pedro Marques Ramos, Priska Auf Der Maur, Charly Jehanno, Atul Sethi, Marie-May Coissieux, Tobias Eichlisberger, Loic Sauteur, Adelin Rouchon, Laura Bonapace, Joana Pinto Couto, Roland Rad, Michael Rugaard Jensen, Andrea Banfi, Michael B. Stadler, Mohamed Bentires-Alj
Summary: NFIB is a transcription factor that plays a crucial role in promoting primary mammary tumor growth and lung metastatic colonization by increasing the expression of ERO1A. Its high expression is associated with poor prognosis in basal-like breast cancer patients.
EMBO MOLECULAR MEDICINE
(2021)
Editorial Material
Medicine, Research & Experimental
Mara De Martino, Claire Vanpouille-Box, Lorenzo Galluzzi
Summary: Research indicates that radiation therapy can enhance the sensitivity of mouse mammary carcinomas to immune checkpoint inhibitors, but clinical trials in breast cancer patients have shown little efficacy. These observations highlight potential immunological barriers that may prevent radiation therapy from unlocking the therapeutic potential of ICIs in patients with breast cancer.
EMBO MOLECULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Andrew A. Davis, Lorenzo Gerratana, Katherine Clifton, Arielle J. Medford, Marko Velimirovic, Whitney L. Hensing, Leslie Bucheit, Ami N. Shah, Paolo D'Amico, Carolina Reduzzi, Qiang Zhang, Charles S. Dai, Elyssa N. Denault, Nusayba A. Bagegni, Mateusz Opyrchal, Foluso O. Ademuyiwa, Ron Bose, William J. Gradishar, Amir Behdad, Cynthia X. Ma, Aditya Bardia, Massimo Cristofanilli
Summary: This study analyzed genomic differences in circulating tumor DNA (ctDNA) among patients with invasive lobular carcinoma (ILC), invasive ductal carcinoma (IDC), and mixed histology. The results showed that ILC was associated with specific HR+ HER2 negative and HER2 low characteristics. Higher levels of single nucleotide variations (SNVs) were observed in ILC patients compared to IDC or mixed histology patients. Mutations in CDFII, ERBB2, and PTEN genes were significantly associated with HR+ HER2 negative ILC. Additionally, mutations in the PI3K pathway genes were more common in ILC patients. These findings have implications for histologic classification and precision medicine treatment.
Article
Oncology
Soojin Cha, Esak Lee, Hong-Hee Won
Summary: Metastasis is the major cause of death in breast cancer patients and identifying genetic alterations specific to metastatic breast cancer (MBC) is crucial. This study integrated clinical and mutation data of 261 genes from MBC and PBC patients to identify MBC-enriched genetic alterations across various metastatic sites. Several novel genes were found to be frequently altered in MBC samples, with specific mutations associated with different metastatic sites.
Article
Oncology
Mya L. Roberson, Anna Henricks, Joshua Woods, Lesley Glenn, Julia Maues, Deltra James, Sonya Reid
Summary: There are substantial gaps in providing patient-centered supportive care for metastatic breast cancer. This study aims to assess how patients with metastatic breast cancer would re-imagine cancer care delivery.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Multidisciplinary Sciences
Axel Muendlein, Kathrin Geiger, Stella Gaenger, Tobias Dechow, Christoph Nonnenbroich, Andreas Leiherer, Heinz Drexel, Andreas Gaumann, Wolfgang Jagla, Thomas Winder, Frank Mayer, Thomas Decker
Summary: Mutational analysis of circulating tumor DNA shows promise in predicting the prognosis of metastatic breast cancer, with the number of mutations correlating with progression free survival and overall survival. Mutational status of ESR1 and TP53 can serve as predictive markers for patient outcomes in advanced breast cancer management.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Zhe Jiang, YoungJun Ju, Amjad Ali, Philip E. D. Chung, Patryk Skowron, Dong-Yu Wang, Mariusz Shrestha, Huiqin Li, Jeff C. Liu, Ioulia Vorobieva, Ronak Ghanbari-Azarnier, Ethel Mwewa, Marianne Koritzinsky, Yaacov Ben-David, James R. Woodgett, Charles M. Perou, Adam Dupuy, Gary D. Bader, Sean E. Egan, Michael D. Taylor, Eldad Zacksenhaus
Summary: Metastatic breast cancer is a major cause of death in women worldwide, and there is still controversy over the relationship between oncogenic drivers for metastasis and primary cancer. Through transposon-mutagenesis screens and loss-of-function Rb experiments in mice, the authors identified gene-centric common insertion sites (gCIS) that are enriched in primary tumors, metastases, or shared by both. Analysis of clinical cohorts revealed similar patterns in human breast cancer, with subtype-specific shared-drivers, primary-enriched, and metastasis-enriched oncogenic signaling. Targeting shared- and metastasis-enriched drivers could be a rational strategy to prevent metastatic breast cancer.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Annasofia Anemone, Lorena Consolino, Laura Conti, Pietro Irrera, Myriam Y. Hsu, Daisy Villano, Walter Dastru, Paolo E. Porporato, Federica Cavallo, Dario Livio Longo
Summary: This study found that extracellular acidification is associated with metastatic potential, with tumors of higher metastatic potential showing more acidic pH. The marker of CD44(+)CD24(-) is indicative of highly invasive tumors.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Marcia A. Inda, Paul van Swinderen, Anne van Brussel, Cathy B. Moelans, Wim Verhaegh, Hans van Zon, Eveline den Biezen, Jan Willem Bikker, Paul J. van Diest, Anja van de Stolpe
Summary: Personalized breast cancer treatment with targeted therapy requires identification of responder patients. Phenotypical heterogeneity within the primary tumor and between primary tumor and metastases may affect therapy response, suggesting analysis of metastatic samples for late stage patients is important. Targeted therapy based on analysis of one primary tumor biopsy may not fully represent the heterogeneity within and between tumors, highlighting the need for further analysis of metastatic biopsies.
Article
Biochemistry & Molecular Biology
Dominik Hadzega, Gabriel Minarik, Marian Karaba, Katarina Kalavska, Juraj Benca, Sona Ciernikova, Tatiana Sedlackova, Petra Nemcova, Martin Bohac, Daniel Pindak, Lubos Klucar, Michal Mego
Summary: Recent research shows that breast tissues are not sterile and can harbor various species of microorganisms. Analysis of microbial composition in tumor tissue and normal breast tissue revealed differences between different breast cancer phenotypes. RNA sequencing highlighted variation in microbial composition between samples from Slovakia and China.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Surgery
A. Kanani, T. Veen, K. Soreide
Summary: Immunotherapy has shown promising results in both early-stage and advanced colorectal cancer, with potential for changing treatment strategies and further trials.
BRITISH JOURNAL OF SURGERY
(2021)
Review
Biochemistry & Molecular Biology
Marina Ibragimova, Matvey Tsyganov, Nikolai Litviakov
Summary: This review discusses the main mechanisms of CSCs in breast cancer, including markers and signaling pathways, heterogeneity, plasticity, and ecological behavior. The study also considers the significance of dynamic heterogeneity of CSCs and dynamic transitions between CSCs and non-CSCs for metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Lucia Borriello, John Condeelis, David Entenberg, Maja H. Oktay
Summary: The research found that breast cancer cells can disseminate not only from primary tumors and metastatic nodules in the lymph nodes to distant organs, but also from lung metastases. Re-dissemination of cancer cells could be a crucial mechanism leading to overt metastases and patient demise.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pathology
Ying-Ting Chen, Karina Nikulina, Stanislav Lazarev, Ahmad F. Bahrami, Lisa B. Noble, Marianne Gallup, Nancy A. McNamara
AMERICAN JOURNAL OF PATHOLOGY
(2010)
Article
Pathology
Delu Zhou, Ying-Ting Chen, Feeling Chen, Marianne Gallup, Trinka Vijmasi, Ahmad F. Bahrami, Lisa B. Noble, Nico van Rooijen, Nancy A. McNamara
AMERICAN JOURNAL OF PATHOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Nora Pencheva, Hien Tran, Colin Buss, Doowon Huh, Marija Drobnjak, Klaus Busam, Sohail F. Tavazoie
Article
Biochemistry & Molecular Biology
Michael V. Airola, Doowon Huh, Nattakan Sukomon, Joanne Widom, Ria Sircar, Peter P. Borbat, Jack H. Freed, Kylie J. Watts, Brian R. Crane
JOURNAL OF MOLECULAR BIOLOGY
(2013)
Article
Ophthalmology
Doowon Huh, Khoa D. Tran, Megan M. W. Straiko, Matthew W. McCarthy, Angela S. Loo, Thomas J. Walsh, Christopher S. Sales
Article
Biochemistry & Molecular Biology
Doowon Huh, Maria C. Passarelli, Jenny Gao, Shahnoza N. Dusmatova, Clara Goin, Lisa Fish, Alexandra M. Pinzaru, Henrik Molina, Zhiji Ren, Elizabeth A. McMillan, Hosseinali Asgharian, Hani Goodarzi, Sohail F. Tavazoie
Summary: Eukaryotic transfer RNAs can be selectively fragmented under stress conditions, impacting translation of genes enriched in specific codons and leading to inhibition of cell growth and metabolism. This tRNA fragmentation is triggered by oxidative stress, revealing a novel regulatory pathway in response to cellular stress.
Article
Otorhinolaryngology
Lisa B. Earnest-Noble, Rachel S. Lipsky, William Kuhel, David Kutler
Summary: This study demonstrates that LSG-ND is effective in the treatment of N0 oral squamous cell carcinoma, reducing the rate of regional recurrence significantly.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)