Article
Medicine, Research & Experimental
Evelyn Lopez Soares, Fabio Andre dos Santos, Tayline Mroczek, Debora Cristina de Lima, Hemily Victoria Bardini Josefino, Luise Adrieli Bochenek da Silva, Leomar Emanuel Almeida Mecca, Gilson Cesar Nobre Franco
Summary: The study found that caloric restriction reduced alveolar bone loss, improved the glycemic profile, and alleviated gingival inflammation in rats with experimental periodontitis.
Article
Biochemistry & Molecular Biology
Anna Damanaki, Svenja Memmert, Marjan Nokhbehsaim, Ali Abedi, Birgit Rath-Deschner, Andressa Nogueira, James Deschner
Summary: The study found that obesity can negatively influence bone healing after periodontal treatment, and the application of regeneration-promoting molecules can partially compensate for this effect but not fully. Obesity may also inhibit the stimulatory effects of regeneration-promoting molecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Evelyn Lopez Soares, Fabio Andre dos Santos, Tayline Mroczek, Debora Cristina de Lima, Hemily Victoria Bardini Josefino, Bruna Carolina Mehret Scorsin, Dionizia Xavier Scomparin, Gilson Cesar Nobre Franco
Summary: The study suggests that caloric restriction can reduce alveolar bone loss in obese rats with experimental periodontitis, while also benefiting glycemic profile and clinical periodontal measures.
Article
Biochemistry & Molecular Biology
Yuwei Zhang, Yifei Zhang, Yutian Tan, Xiao Luo, Ru Jia
Summary: There is a significant relationship between obesity and periodontitis, and adipokines play a role in this relationship. In obese rats with periodontitis, there is increased bone absorption, inflammation, and expression of pro-inflammatory cytokines. The expression of adipokines is also altered, contributing to a more severe periodontal inflammatory state.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Vinicius Ruan Neves dos Santos, Deborah Ribeiro Frazao, Railson de Oliveira Ferreira, Paulo Fernando Santos Mendes, Daiane Claydes Baia-da-Silva, Deiweson Souza-Monteiro, Leonardo Oliveira Bittencourt, Joao Daniel Mendonca de Moura, Jose Messias Perdigao, Bruno Jose Brito Teixeira, Everton Luiz Pompeu Varela, Gabriela de Souza Balbinot, Sandro Percario, Herve Rogez, Cassiano Kuchenbecker Rosing, Fabricio Mezzomo Collares, Rafael Rodrigues Lima
Summary: The study found that supplementation with acai could increase blood antioxidant capacity, reduce lipid peroxidation, and decrease alveolar bone loss caused by experimental periodontitis. Furthermore, acai could modulate oxidative biochemistry and bone microstructure.
Article
Medicine, Research & Experimental
Xiaoke Xu, Zhenshan Jia, Ningrong Chen, Subodh M. Lele, Richard A. Reinhardt, Amy C. Killeen, Dong Wang
Summary: Periodontitis is a common and severe oral disease with limited treatment options. This study developed a new treatment method by converting simvastatin into a gel form, which effectively treated periodontitis in an experimental animal model and achieved good therapeutic effects.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Anna Damanaki, Svenja Beisel-Memmert, Marjan Nokhbehsaim, Ali Abedi, Birgit Rath-Deschner, Andressa V. B. Nogueira, James Deschner
Summary: The aim of this study was to investigate the effect of occlusal hypofunction on alveolar bone healing and the potential of enamel matrix derivative (EMD) for healing. A standardized fenestration defect was created in the mandibular first molar of Wistar rats, and occlusal hypofunction was induced. Regenerative therapy using EMD was applied to the defect. Three groups were established: normal occlusion without EMD treatment, occlusal hypofunction without EMD treatment, and occlusal hypofunction with EMD treatment. The results show that normal occlusal loading is beneficial for alveolar bone healing, while occlusal hypofunction delays bone regeneration. EMD partially compensates for the inhibitory effects of occlusal hypofunction on bone healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Renan Dal-Fabbro, Leopoldo Cosme-Silva, Leticia Cabrera Capalbo, Antonio Hernandes Chaves-Neto, Edilson Ervolino, Luciano Tavares Angelo Cintra, Joao Eduardo Gomes-Filho
Summary: The study found that excessive caffeine exposure through gavage in rats may exacerbate periapical bone destruction and inflammation caused by periapical periodontitis, leading to increased expression levels of RANKL, IL-1 beta, and TRAP.
INTERNATIONAL ENDODONTIC JOURNAL
(2021)
Article
Immunology
Nannan Wang, Lichun Zheng, Jun Qian, Min Wang, Lili Li, Yuezhen Huang, Qian Zhang, Yanfen Li, Fuhua Yan
Summary: This study investigated the effects of periodontitis on osteoporosis. The results showed that the salivary microbiota of patients with periodontitis aggravated femoral bone resorption in rats with ovariectomy-induced osteoporosis. Additionally, intestinal inflammation was exacerbated after the administration of periodontitis salivary microbiota in these rats. The correlation analysis of microbiota and metabolomics revealed potential involvement of lipolysis and tryptophan metabolism in bone loss induced by periodontitis salivary microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Cynthia Mireya Jara, Karina Kiimiko Yamashina Pereira, Fabio Luiz Dal Moro Maito, Carlos Gabriel Adorno, Maximiliano Schunke Gomes
Summary: The presence and treatment of periodontal disease and apical periodontitis had an impact on the aorta and liver of both obese and non-obese rats. The combination of these conditions increased aorta thickness in obese rats, while treatments reduced vascular endothelial lesions. Obseity was a predictor variable for liver steatosis.
INTERNATIONAL ENDODONTIC JOURNAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Youn Soo Lee, Ae Ri Kim, Yeong-Eui Jeon, Eun-Jung Bak, Yun-Jung Yoo
Summary: The objective of this study was to examine the effect of periodontitis on renal function and morphology in rats with or without nephrectomy-induced chronic kidney disease. The results showed that periodontitis increased renal fibrosis and inflammation, but did not affect renal function. In the presence of chronic kidney disease, periodontitis also increased TNFa expression in the kidneys.
Article
Biochemistry & Molecular Biology
Ye jin Yang, Jun-Ho Song, Ju-Hye Yang, Min Jung Kim, Kwang Youn Kim, Jin-Kyoung Kim, Yeung Bea Jin, Woo Hyun Kim, Suk Kim, Ki-Rim Kim, Kwang Il Park, Hu-Jang Lee
Summary: In this study, the potential of Dendropanax morbiferus H.Lev leaf hot-water extracts (DMWE) as a treatment for periodontitis was evaluated. The results showed that DMWE exhibited anti-inflammatory effects, reduced cytokine concentration, and improved periodontal tissue damage and tooth loss caused by the inflammatory response.
Article
Engineering, Biomedical
Lu Wang, Yuzhou Li, Mingxing Ren, Xu Wang, Lingjie Li, Fengyi Liu, Yiqing Lan, Sheng Yang, Jinlin Song
Summary: This study designed a novel dual responsive and dual drug-loading nanocarrier system for precise and controlled drug delivery to treat periodontitis in patients with diabetes. In vitro and in vivo studies confirmed the effectiveness of this nanocarrier, which can inhibit the formation of subgingival microbial colonies and promote osteogenic differentiation of cells, ameliorating periodontal bone resorption.
BIOACTIVE MATERIALS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Andre L. G. Moreira, Pedro H. F. Silva, Sergio L. Salvador, Karin H. Ishikawa, Graziele C. Ferreira, Jose E. Tanus-Santos, Marcia P. A. Mayer, Sergio L. S. de Souza, Flavia A. C. Furlaneto, Michel R. Messora
Summary: This study evaluated the systemic and local impact of probiotic therapy on rats with metabolic syndrome and periodontitis. The results showed that probiotics can reduce the severity of periodontitis, and modulate lipogenic genes and intestinal morphological and microbiological parameters in rats with metabolic syndrome.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yiyun Yue, Xinchan Liu, Yan Li, Boyuan Xia, Weixian Yu
Summary: This study aimed to clarify the immune mechanism of hepatic injury induced by periodontitis using a rat model. The results showed higher levels of inflammatory response and bone retraction in the periodontitis group, along with elevated levels of immune markers. The study concluded that the TLR4/MyD88/NF-kappa B pathway may play a role in periodontitis-induced liver inflammation in rats.
Article
Dentistry, Oral Surgery & Medicine
H. B. Abdalla, M. H. Napimoga, C. A. Trindade-da-Silva, M. Guimaraes, M. Lopes, P. C. Dos Santos, W. A. Buarque E. Silva, F. Andrade E. Silva, J. T. Clemente-Napimoga
Summary: Occlusal trauma may induce an increase in inflammatory mediators in the periarticular TMJ tissue, affect the trigeminal ganglia, enhance neuronal excitation, and ultimately lead to a neuroinflammatory state.
JOURNAL OF DENTAL RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Carlos Antonio Trindade da Silva, Juliana Trindade Clemente-Napimoga, Henrique Ballassini Abdalla, Rosanna Tarkany Basting, Solely Marcelo Henrique Napimoga
Summary: Pain is a multidimensional experience involving the biological, psychological, and social dimensions of each individual. Peroxisome proliferator-activated receptor-gamma (PPAR gamma) is an important regulatory factor that plays a crucial role in pain control.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2022)
Article
Immunology
Henrique Ballassini Abdalla, Marcelo Henrique Napimoga, Juliana Maia Teixeira, Carlos Antonio Trindade-da-Silva, Victor Luis Pieroni, Fernanda Souto Maior dos Santos Araujo, Bruce D. Hammock, Juliana Trindade Clemente-Napimoga
Summary: This study demonstrates that pre-treatment with a local soluble epoxide hydrolase (sEH) inhibitor can prevent inflammatory hyperalgesia in the temporomandibular joint (TMJ) of rats, and has both analgesic and anti-inflammatory effects.
INFLAMMOPHARMACOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Monique Maria Melo Mouchrek, Mayra Moura Franco, Leslie Alves da Silva, Kerry Alynne Campos Martins, Sueli Ismael Oliveira da Conceicao, Vandilson Pinheiro Rodrigues, Bruno Braga Benatti
Summary: This study found that the severity and extent of periodontitis in patients with Down syndrome may be related to certain metabolic parameters, such as mean corpuscular hemoglobin and volume values, as well as arm circumference measurements.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Genetics & Heredity
Alessandro Rozim Zorzi, Patricia R. Delai, Henrique L. C. Rosa, Wander E. Brito, Victor A. M. Montalli, Juliana C. Napimoga, Marcelo H. Napimoga, Francisco H. Nociti
Summary: This article summarizes the current status of FOP in Brazil and describes strategies proposed to approach this challenge in the country.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Pharmacology & Pharmacy
Henrique B. Abdalla, Carla Alvarez, Yu-Chiao Wu, Paola Rojas, Bruce D. Hammock, Krishna R. Maddipati, Carlos Antonio Trindade-da-Silva, Mariana Q. S. Soares, Juliana T. Clemente-Napimoga, Alpdogan Kantarci, Marcelo H. Napimoga, Thomas E. Van Dyke
Summary: This study found that pharmacological sEH inhibition can promote SPM synthesis and alter the plasticity of gingival macrophages, which may help control osteolytic inflammatory disorders.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Marcelo Franchin, Thaise Mayumi Taira, Douglas da Silva Prado, Cesar Augusto Speck Hernandez, Fabio Bonifacio de Andrade, Henrique Ballassini Abdalla, Marcelo Henrique Napimoga, Thiago Mattar Cunha, Sandra Yasuyo Fukada, Pedro Luiz Rosalen
Summary: In this study, we investigated the modulatory effects of PI3K gamma on IL-17A expression and the progression of experimental periodontitis in vivo. Our results showed that PI3K gamma inhibitor can attenuate alveolar bone loss and downregulate IL-17A and Rankl gene expression.
INFLAMMATION RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Sangwook Oh, Xuming Mao, Silvio Manfredo-Vieira, Jinmin Lee, Darshil Patel, Eun Jung Choi, Andrea Alvarado, Ebony Cottman-Thomas, Damian Maseda, Patricia Y. Y. Tsao, Christoph T. T. Ellebrecht, Sami L. L. Khella, David P. P. Richman, Kevin C. C. O'Connor, Uri Herzberg, Gwendolyn K. K. Binder, Michael C. C. Milone, Samik Basu, Aimee S. S. Payne
Summary: Engineered T cells expressing MuSK-CAART effectively target B cells expressing anti-MuSK autoantibodies, reducing muscle weakness caused by autoimmune disease.
NATURE BIOTECHNOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Leslie A. da Silva, Consuelo P. C. Marques, Izabel C. V. de Oliveira, Mayra M. Franco, Vandilson P. Rodrigues, Bruno B. Benatti
Summary: This study investigated the influence of periodontal status, clinical data, and serum markers on salivary leptin levels in patients with systemic lupus erythematosus (SLE). The results showed that SLE patients had lower salivary leptin levels, and the level of salivary leptin did not appear to be related to periodontal status.
SAUDI DENTAL JOURNAL
(2022)
Article
Education & Educational Research
Concepta McManus, Abilio Afonso Baeta Neves, Antonio Gomes Souza Filho, Arthur Antonio Silva Rosa, Carlos Henrique Carvalho, Denise Maria Guimaraes Freire, Maria Clorinda Soares Fioravanti, Sonia Nair Bao, Isac Almeida de Medeiros, Jose Alexandre Diniz-Filho, Bruno Lourenco Diaz, Ernani Rodrigues de Carvalho, Jorge Luis Nicolas Audy, Marcio C. Silva-Filho, Juliano Gimenez, Margarida Carvalho, Roberio Rodrigues da Silva, Marcelo Henrique Napimoga
Summary: This study provides an overview of the Brazilian post-graduate evaluation system using evaluation data from various sources. The system is highly standardized and lacks flexibility, causing a disconnect with international graduate studies. The evaluation focuses on process rather than results, impact, and social relevance.
FRONTIERS IN EDUCATION
(2022)
Article
Education & Educational Research
Conce McManus, Abilio Afonso Baeta Neves, Carlos Henrique Carvalho, Antonio Gomes Souza Filho, Denise Maria Guimaraes Freire, Maria Clorinda Soares Fioravanti, Sonia Nair Bao, Isac Almeida de Medeiros, Jose Alexandre Diniz Filho, Bruno Lourenco Diaz, Ernani Rodrigues de Carvalho, Jorge Luis Nicolas Audy, Marcio de Castro Silva Filho, Juliano Rodrigues Gimenez, Margarida Carvalho, Roberio Rodrigues da Silva, Marcelo Henrique Napimoga
Summary: The number of programs and students in the Brazilian postgraduate system has doubled in the last 10 years. This study investigates the reasons and limitations for this expansion. Data from various sources were analyzed, and opinions from different types of institutions in different regions were considered. Factors such as demand, regionalization, program quality, funding, and student vacancies need to be taken into account for the continued expansion of the Brazilian postgraduate system.
FRONTIERS IN EDUCATION
(2023)
Article
Immunology
Rosanna Tarkany Basting, Marcelo Henrique Napimoga, Carlos Antoonio Trindade Silva, Henrique Ballassini Abdalla, Braz Campos Durso, Leopoldo Henrique Barboza Martins, Herbert de Abreu Cavalcanti, Bruce D. Hammock, Juliana Trindade Clemente-Napimoga
Summary: Rheumatoid arthritis (RA) is a chronic condition characterized by joint pain and immune cell infiltration. Inhibition of soluble epoxide hydrolase (sEH) can enhance the therapeutic effect of endogenous epoxy-eicosatrienoic acids (EETs) and alleviate inflammation and pain in RA patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Meeting Abstract
Cell & Tissue Engineering
Ana Luiza Millas, Karen Elizabeth Galvao, Geovany Candido, Marcelo Napimoga, Hector Barone, Pedro X. R. Massaguer
TISSUE ENGINEERING PART A
(2022)
Article
Dentistry, Oral Surgery & Medicine
Poliana Mendes Duarte, Tamires Szeremeske Miranda, Leticia Macedo Marins, Joao Ricardo Batistao da Silva, Fernando de Souza Malta, Bruno Cesar de Vasconcelos Gurgel, Marcelo Henrique Napimoga
Summary: This study demonstrates that LiCl can enhance extraction socket repair, stimulate bone formation, and restrict TRAP levels in rats.
ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG
(2022)
Article
Engineering, Biomedical
Laercio Uemura, Rossana Baggio Simeoni, Paulo Andre Bispo Machado Junior, Gustavo Gavazzoni Blume, Luize Kremer Gamba, Murilo Sgarbossa Tonial, Paulo Ricardo Baggio Simeoni, Victoria Stadler Tasca Ribeiro, Rodrigo Silvestre, Katherine Athayde Teixeira de Carvalho, Marcelo Henrique Napimoga, Julio Cesar Francisco, Luiz Cesar Guarita-Souza
Summary: This study investigates the effects of transplantation of bone marrow mononuclear cells (BMMC) associated with 15d-PGJ2-loaded nanoparticles in a rat model of chronic myocardial infarction (MI). The results show that this method can promote angiogenesis and improve electrical and mechanical integration of the myocardium.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
