Article
Biochemistry & Molecular Biology
Muhammad Faheem, Napoleao Fonseca Valadares, Jose Brandao-Neto, Dom Bellini, Patrick Collins, Nicholas M. Pearce, Louise Bird, Juliana Roberta Torini, Raymond Owens, Humberto DMuniz Pereira, Frank Von Delft, Joao Alexandre Ribeiro Goncalves Barbosa
Summary: Schistosomiasis is an endemic disease in 78 countries, ranking second among parasitic diseases in terms of its socioeconomic impact and human health importance. The drug of choice for treatment, praziquantel, has limitations such as unclear mechanism, high cost, efficacy only against adult parasites, and reports of resistance. The lack of a de novo purine pathway in the parasites makes the purine salvage pathway an attractive target for the development of necessary and selective drugs.
BIOCHEMICAL JOURNAL
(2021)
Review
Biotechnology & Applied Microbiology
Vagish Dwibedi, Sahil Jain, Divya Singhal, Anuradha Mittal, Santosh Kumar Rath, Sanjai Saxena
Summary: This review summarizes the inhibitory activities of grape polyphenols on various key human-related enzymes associated with different diseases, as well as their potential as therapeutic and drug development candidates.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Chungen Li, Xirong Tian, Zongkai Huang, Xupeng Gou, Buhari Yusuf, Cong Li, Yamin Gao, Song Liu, Yanmei Wang, Tao Yang, Zhiyong Liu, Qingxiang Sun, Tianyu Zhang, Youfu Luo
Summary: This study identifies 5a as a novel lead compound with potent activity against drug-resistant tuberculosis. The structure-activity relationship analysis reveals the crucial role of the central pyrimidine ring moiety and the tolerance of hydrophobic substitutes. In vitro and in vivo experiments demonstrate the safety and oral bioavailability of 5a, while molecular assays indicate PknB as a potential target.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Bayi Lang, Yanqiang Zhao, Rong Yang, Aizhong Liu, Sailesh Ranjitkar, Lixin Yang
Summary: The traditional fermented Rosa (TFR) is a popular food and medicinal product among the Dali Bai people, with studies revealing its medicinal benefits, traditional processing procedures, and functional food properties. Through field sample collection and lab synthesis, the dominant microbial strain TFR-1 in TFR was identified to enhance antioxidant and tyrosinase inhibitory activities. TFR exhibited strong antioxidant and free-radical scavenging properties, suggesting its potential use in skincare and nutrition as a cosmetic or nutraceutical product.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Raul Lopez-Fernandez-Sobrino, Jorge R. Soliz-Rueda, Maria Margalef, Anna Arola-Arnal, Manuel Suarez, Francisca Bravo, Begona Muguerza
Summary: This study investigated the ACEi activity and BP lowering effects of wine lees from different grape varieties, with Cabernet wine lees showing significant antihypertensive effects related to high levels of anthocyanins and flavanols. The potential of Cabernet wine lees for controlling arterial BP was confirmed, suggesting a promising commercial use in the wine industry.
Article
Chemistry, Medicinal
Kazuyoshi Ikeda, Yuichiro Kezuka, Takamasa Nonaka, Tomoki Yonezawa, Masanori Osawa, Etsuko Katoh
Summary: Fragment-based screening using F-19 NMR is shown to be efficient in exploring seed and lead compounds for drug discovery, providing useful information on the binding between hit fragments and target proteins. While F-19-FS and enzymatic assays show weak correlation, they both indicate the presence of inhibitory compounds in hit fragments, and in silico calculations can partially explain differences in activity levels.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Food Science & Technology
Chaowanee Chupeerach, Amornrat Aursalung, Thareerat Watcharachaisoponsiri, Kanyawee Whanmek, Parunya Thiyajai, Kachakot Yosphan, Varittha Sritalahareuthai, Yuraporn Sahasakul, Chalat Santivarangkna, Uthaiwan Suttisansanee
Summary: The study found that the energy, carbohydrate, and vitamin B1 content of tea leaves increased after steaming, while most nutrients decreased. After fermentation, energy, fat, sodium, potassium, and iron content increased, while calcium and certain vitamins decreased compared to steamed tea leaves. Total phenolic content and antioxidant activities significantly increased after steaming and fermentation, indicating structural changes in bioactive compounds.
Review
Food Science & Technology
Christian A. Pensamiento-Nino, Araceli Castaneda-Ovando, Javier Anorve-Morga, Alma D. Hernandez-Fuentes, Karina Aguilar-Arteaga, Deyanira Ojeda-Ramirez
Summary: Traditionally, edible flowers have been used in alternative medicine, but recently they have become popular in worldwide gastronomy due to their organoleptic properties and health benefits. Edible flowers are rich in macronutrients, vitamins, and antioxidant compounds, which can prevent illnesses associated with oxidative stress, cardiovascular issues, and cancers. Current studies focus on the nutritional, functional, and biological properties of edible flowers, as well as their acceptance and safety risks. It is important to incorporate edible flowers into human nutrition due to their positive health effects.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Haifa A. A. Omer, Giovanni Caprioli, Doaa Abouelenein, Ahmed M. Mustafa, Abdullahi Ibrahim Uba, Gunes Ak, Refiye Beyza Ozturk, Gokhan Zengin, Sakina Yagi
Summary: This study evaluated the phenolic content, antioxidant, and enzyme inhibition activities of leaf methanolic extracts from several species within the genera Cassia or Senna. The results showed that these plants are rich in phenolic compounds and exhibit high antioxidant and enzyme inhibition activities, making them a promising source of natural bioactive agents.
Review
Chemistry, Inorganic & Nuclear
Nathan Davison, Erli Lu
Summary: Organo-alkali metal reagents are important tools in synthetic chemistry, and their aggregation behavior and structure-reactivity relationship have been extensively studied. This Perspective focuses on the strategies employed to isolate low aggregates and monomeric complexes of common alkali metal alkyls. The relationship between aggregation level, structure, and reactivity is also discussed.
DALTON TRANSACTIONS
(2023)
Article
Food Science & Technology
Steve Djiazet, Laurette Blandine Mezajoug Kenfack, Palanisamy Bruntha Devi, Maria Sheeba Nazareth, Clerge Tchiegang, Prathapkumar Halady Shetty
Summary: This study evaluated the phytochemical profile, antioxidant, and enzyme inhibitory activity of underutilized Cameroon spices such as Xylopia africana, Aframomum sulcatum, and Hypodaphnis zenkeri. The results showed high antioxidant and enzyme inhibitory activity in these spices, suggesting their potential use in managing oxidative stress, lipid, and carbohydrate metabolism related diseases.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2021)
Article
Food Science & Technology
Yu Xiao, Xing Wu, Xinshuo Yao, Yulian Chen, Chi-Tang Ho, Cheng He, Zongjun Li, Yuanliang Wang
Summary: Processing buckwheat with solid-state fermentation using Eurotium cristatum YL-1 can significantly enhance its phytochemical components, leading to improved antioxidant and alpha-glucosidase inhibitory activities. This innovative method shows promise for enhancing the health benefits of buckwheat.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Food Science & Technology
Yiling Fan, Xueying Li, Lan Ding, Weiying Zhou, Guangzhi Xu, Yan Wang, Youzuo Zhang, Qinxue Ni
Summary: This study optimized ASE parameters for extracting antioxidants from Gardeniae fructus and compared it with other extraction methods. The results showed that ASE yielded higher levels of antioxidants and neuroprotective abilities, indicating its great potential for treating Alzheimer's disease.
Article
Chemistry, Multidisciplinary
M. Ihsan Han, Miyase Gozde Gunduz, Gokce Alci, Simone Giovannuzzi, Donay Yuvali, Claudiu T. Supuran, Sengul Dilem Dogan
Summary: Novel carbonic anhydrase (CA, EC 4.2.1.1) inhibitors were synthesized by linking sulfonate esters to a benzenesulfonamide fragment via hydrazone functionality. These inhibitors showed inhibitory activity against tumor-associated human (h) isoforms hCA IX and XII, and the dominant hCA I and II isoforms. Substituents of methyl, methoxy or chlorine in the para position of the terminal phenyl ring enhanced the inhibitory activity against hCA IX and/or hCA XII with K-i values < 10 nM. Computational techniques were used to predict drug-likeness and pharmacokinetic profiles of the selected compounds. Molecular docking studies were conducted to rationalize the inhibition data of the most effective inhibitor, 4-((2-(4-sulfamoylbenzoyl)hydrazono)methyl)phenyl 4-methoxybenzenesulfonate (SH3), against tumor-associated hCA isoforms IX (K-i = 9.4 nM) and XII (K-i = 5.9 nM).
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Urszula Kielczewska, Radek Jorda, Gabriel Gonzalez, Jacek W. Morzycki, Haresh Ajani, Katarina Svrckova, Sarka Stepankova, Agnieszka Wojtkielewicz
Summary: The newly synthesized solasodine analogues act as non-competitive inhibitors of acetyl- and butyryl-cholinesterases, showing potential neuroprotective effects without neurotoxicity. They are able to inhibit and bind cholinesterases, exhibiting the ability to increase cell viability in neuroprotective assays compared to standard drugs.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Masayuki Okuyama, Kana Matsunaga, Ken-ichi Watanabe, Keitaro Yamashita, Takayoshi Tagami, Asako Kikuchi, Min Ma, Patcharapa Klahan, Haruhide Mori, Min Yao, Atsuo Kimura
Article
Virology
Keisuke Komoda, Masanori Narita, Keitaro Yamashita, Isao Tanaka, Min Yao
JOURNAL OF VIROLOGY
(2017)
Article
Multidisciplinary Sciences
Minghao Chen, Shin-ichi Asai, Shun Narai, Shusuke Nambu, Naoki Omura, Yuriko Sakaguchi, Tsutomu Suzuki, Masao Ikeda-Saito, Kimitsuna Watanabe, Min Yao, Naoki Shigi, Yoshikazu Tanaka
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Multidisciplinary Sciences
Meirong Chen, Koji Kato, Yume Kubo, Yoshikazu Tanaka, Yuchen Liu, Feng Long, William B. Whitman, Pascal Lill, Christos Gatsogiannis, Stefan Raunser, Nobutaka Shimizu, Akira Shinoda, Akiyoshi Nakamura, Isao Tanaka, Min Yao
NATURE COMMUNICATIONS
(2017)
Article
Biochemistry & Molecular Biology
Wataru Saburi, Nongluck Jaito, Koji Kato, Yuka Tanaka, Min Yao, Haruhide Mori
Article
Cell Biology
Hiroshi Oyama, Koji Takahashi, Yoshikazu Tanaka, Hiroshi Takemoto, Hisashi Haga
CELL STRUCTURE AND FUNCTION
(2018)
Article
Biochemistry & Molecular Biology
Takehito Tanzawa, Koji Kato, Dylan Girodat, Toyoyuki Ose, Yuki Kumakura, Hans-Joachim Wieden, Toshio Uchiumi, Isao Tanaka, Min Yao
NUCLEIC ACIDS RESEARCH
(2018)
Letter
Hematology
Masatoshi Sakurai, Hiroshi Takemoto, Takehiko Mori, Shinichiro Okamoto, Satoshi Yamazaki
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2020)
Article
Genetics & Heredity
Takafumi Yumoto, Misaki Kimura, Ryota Nagatomo, Tsukika Sato, Shun Utsunomiya, Natsue Aoki, Motoji Kitaura, Koji Takahashi, Hiroshi Takemoto, Hirotaka Watanabe, Hideyuki Okano, Fumiaki Yoshida, Yosuke Nao, Taisuke Tomita
Article
Multidisciplinary Sciences
Masatoshi Sakurai, Kantaro Ishitsuka, Ryoji Ito, Adam C. Wilkinson, Takaharu Kimura, Eiji Mizutani, Hidekazu Nishikii, Kazuhiro Sudo, Hans Jiro Becker, Hiroshi Takemoto, Tsubasa Sano, Keisuke Kataoka, Satoshi Takahashi, Yukio Nakamura, David G. Kent, Atsushi Iwama, Shigeru Chiba, Shinichiro Okamoto, Hiromitsu Nakauchi, Satoshi Yamazaki
Summary: Haematopoietic stem cells (HSCs) can reconstitute the entire blood and immune systems after transplantation and have the potential to be used as a curative cell therapy for various haematological diseases. However, the low number of HSCs and the limited ex vivo expansion ability of human HSCs pose challenges for biological analysis and clinical application. In this study, a culture system was established using chemical agonists and a caprolactam-based polymer, which successfully promoted long-term ex vivo expansion of human HSCs. The chemically defined expansion culture system will contribute to the advancement of clinical HSC therapies.
Article
Pharmacology & Pharmacy
Shun Utsunomiya, Yusuke Kishi, Masafumi Tsuboi, Daichi Kawaguchi, Yukiko Gotoh, Manabu Abe, Kenji Sakimura, Kazuma Maeda, Hiroshi Takemoto
Summary: The study shows that elevated expression of Ezh1 plays a role in the maturation of cortical neurons, with its conditional knockout leading to downregulation of genes related to neuronal maturation. Additionally, Ezh1 directly targets the gene encoding Cpg15/Neuritin, which is involved in stabilization and maturation of excitatory synapses.
DRUG DISCOVERIES AND THERAPEUTICS
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Minghao Chen, Shin-ichi Asai, Shun Narai, Shusuke Nambu, Naoki Omura, Yuriko Sakaguchi, Tsutomu Suzuki, Masao Ikeda-Saito, Kimitsuna Watanabe, Min Yao, Naoki Shigi, Yoshikazu Tanaka
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Asako Kikuchi, Masayuki Okuyama, Koji Kato, Shohei Osaki, Min Ma, Yuya Kumagai, Kana Matsunaga, Patcharapa Kiahan, Takayoshi Tagami, Min Yao, Atsuo Kimura
Article
Biochemistry & Molecular Biology
Thittaya Kunthic, Hirokazu Watanabe, Ryuji Kawano, Yoshikazu Tanaka, Boonhiang Promdonkoy, Min Yao, Panadda Boonserm
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2017)
Article
Biochemistry & Molecular Biology
Hideaki Sakamoto, Tetsuya Yoshida, Takao Sanaki, Shuhei Shigaki, Hirotoshi Morita, Miki Oyama, Masaru Mitsui, Yoshikazu Tanaka, Toru Nakano, Susumu Mitsutake, Yasuyuki Igarashi, Hiroshi Takemoto
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)