4.3 Article

Beam modeling and VMAT performance with the Agility 160-leaf multileaf collimator

Journal

JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
Volume 14, Issue 2, Pages 172-185

Publisher

MULTIMED INC
DOI: 10.1120/jacmp.v14i2.4136

Keywords

multileaf collimator; dose calculation; volumetric-modulated arc therapy; treatment planning system

Ask authors/readers for more resources

The Agility multileaf collimator (Elekta AB, Stockholm, Sweden) has 160 leaves of projected width 0.5 cm at the isocenter, with maximum leaf speed 3.5 cms(-1). These characteristics promise to facilitate fast and accurate delivery of radiotherapy, particularly volumetric-modulated arc therapy (VMAT). The aim of this study is therefore to create a beam model for the Pinnacle(3) treatment planning system (Philips Radiation Oncology Systems, Fitchburg, WI), and to use this beam model to explore the performance of the Agility MLC in delivery of VMAT. A 6 MV beam model was created and verified by measuring doses under irregularly shaped fields. VMAT treatment plans for five typical head-and-neck patients were created using the beam model and delivered using both binned and continuously variable dose rate (CVDR). Results were compared with those for an MLCi unit without CVDR. The beam model has similar parameters to those of an MLCi model, with interleaf leakage of only 0.2%. The verification of irregular fields shows a mean agreement between measured and planned dose of 1.3% (planned dose higher). The Agility VMAT head-and-neck plans show equivalent plan quality and delivery accuracy to those for an MLCi unit, with 95% of verification measurements within 3% and 3 mm of planned dose. Mean delivery time is 133 s with the Agility head and CVDR, 171 s without CVDR, and 282 s with an MLCi unit. Pinnacle(3) has therefore been shown to model the Agility MLC accurately, and to provide accurate VMAT treatment plans which can be delivered significantly faster with Agility than with an MLCi.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.3
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Cell Biology

Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling

Caleb A. Dawson, Bhupinder Pal, Francois Vaillant, Luke C. Gandolfo, Zhaoyuan Liu, Camille Bleriot, Florent Ginhoux, Gordon K. Smyth, Geoffrey J. Lindeman, Scott N. Mueller, Anne C. Rios, Jane E. Visvader

NATURE CELL BIOLOGY (2020)

Article Rheumatology

Circulating Small Noncoding RNA Biomarkers of Response to Triple Disease-modifying Antirheumatic Drug Therapy in White Women With Early Rheumatoid Arthritis

Andrew D. Foers, Alexandra L. Garnham, Gordon K. Smyth, Susanna M. Proudman, Lesley Cheng, Andrew F. Hill, Ken C. Pang, Ian P. Wicks

JOURNAL OF RHEUMATOLOGY (2020)

Article Multidisciplinary Sciences

Pre-mitotic genome re-organisation bookends the B cell differentiation process

Wing Fuk Chan, Hannah D. Coughlan, Jie H. S. Zhou, Christine R. Keenan, Naiara G. Bediaga, Philip D. Hodgkin, Gordon K. Smyth, Timothy M. Johanson, Rhys S. Allan

Summary: The study elucidated the chromosome conformational changes in B lymphocytes as they differentiate into plasma cells, indicating that these changes occur prior to cell division and may guide the gene expression necessary for differentiation.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Extracellular Vesicles in Synovial Fluid from Rheumatoid Arthritis Patients Contain miRNAs with Capacity to Modulate Inflammation

Andrew D. Foers, Alexandra L. Garnham, Simon Chatfield, Gordon K. Smyth, Lesley Cheng, Andrew F. Hill, Ian P. Wicks, Ken C. Pang

Summary: In rheumatoid arthritis, extracellular vesicles are associated with joint inflammation and destruction. Through sequencing EV miRNAs in synovial fluid from RA patients, differences between joints with high- and low-grade inflammation were identified, suggesting a role in regulating inflammation-related genes. EV miRNAs have the potential to modulate inflammation and contribute to RA pathophysiology.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Oncology

Determining the incidence of interstitial pneumonitis and chronic kidney disease following full intensity haemopoetic stem cell transplant conditioned using a forward-planned intensity modulated total body irradiation technique

Emily Durie, Emma Nicholson, Chloe Anthias, Emma M. Dunne, Mike Potter, Mark Ethell, Christina Messiou, Joy Brennan, Sally Eagle, James Talbot, Gregory Smyth, Westley Ingram, Frank Saran, Henry C. Mandeville

Summary: The retrospective study evaluated 74 adult patients treated with forward-planned intensity modulated radiotherapy technique for total body irradiation (TBI), showing that this treatment method has lower rates of idiopathic interstitial pneumonitis and chronic kidney disease compared to the literature.

RADIOTHERAPY AND ONCOLOGY (2021)

Article Developmental Biology

The histone acetyltransferase HBO1 promotes efficient tip cell sprouting during angiogenesis

Zoe L. Grant, Peter F. Hickey, Waruni Abeysekera, Lachlan Whitehead, Sabrina M. Lewis, Robert C. A. Symons, Tracey M. Baldwin, Daniela Amann-Zalcenstein, Alexandra L. Garnham, Gordon K. Smyth, Tim Thomas, Anne K. Voss, Leigh Coultas

Summary: The histone acetyltransferase HBO1 plays a crucial role in blood vessel development, with its impairment leading to defects in developmental sprouting angiogenesis and pathological EC overgrowth in the retinal endothelium. Loss of HBO1 results in an increased abundance of tip cells, hindering efficient tip cell migration and causing EC overcrowding in the retinal sprouting front.

DEVELOPMENT (2021)

Article Oncology

Clinical Implementation of Robust Multi-isocentric Volumetric Modulated Arc Radiotherapy for Craniospinal Irradiation

G. Smyth, S. Mowat, K. Chia, K. Robinson, K. Warren-Oseni, L. C. Welsh, I Blasiak-Wal, H. C. Mandeville

Summary: This study aimed to evaluate the safety and accuracy of using CSI-VMAT in a commercially available treatment planning system. The initial clinical experience showed that the technique is feasible for patients undergoing craniospinal irradiation, with the limitation being the available beam overlap length in the neck.

CLINICAL ONCOLOGY (2022)

Article Multidisciplinary Sciences

The concerted change in the distribution of cell cycle phases and zone composition in germinal centers is regulated by IL-21

Dimitra Zotos, Isaak Quast, Connie S. N. Li-Wai-Suen, Craig I. McKenzie, Marcus J. Robinson, Andrey Kan, Gordon K. Smyth, Philip D. Hodgkin, David M. Tarlinton

Summary: IL-21 plays a crucial role in promoting cell cycle progression within the germinal centre (GC) light zone, facilitating release from the G1 cell cycle stage. This cytokine is essential for establishing normal zone representation and preventing cell accumulation in the G1 cell cycle stage in the GC LZ, highlighting its importance in antibody affinity maturation.

NATURE COMMUNICATIONS (2021)

Article Oncology

SEAFARER - A new concept for validating radiotherapy patient specific QA for clinical trials and clinical practice

Joerg Lehmann, Mohammad Hussein, Miriam A. Barry, Shankar Siva, Alisha Moore, Michael Chu, Patricia Diez, David J. Eaton, Jeffrey Harwood, Peta Lonski, Elizabeth Claridge Mackonis, Carole Meehan, Rushil Patel, Xenia Ray, Maddison Shaw, Justin Shepherd, Gregory Smyth, Therese S. Standen, Brindha Subramanian, Peter B. Greer, Catharine H. Clark

Summary: This study aims to improve the quality of radiation therapy and patient outcomes by assessing institutions' ability to detect errors through routine Patient Specific Quality Assurance (PSQA). A new audit concept is needed as existing dosimetry audits may not catch all errors. The study evaluates institutions' ability to detect errors by embedding deliberately introduced edits into radiation treatment plans.

RADIOTHERAPY AND ONCOLOGY (2022)

Article Multidisciplinary Sciences

R code and downstream analysis objects for the scRNA-seq atlas of normal and tumorigenic human breast tissue

Yunshun Chen, Bhupinder Pal, Geoffrey J. Lindeman, Jane E. Visvader, Gordon K. Smyth

Summary: This article extends our understanding of the development mechanism of breast cancer by providing quality control thresholds, processed data objects, complete cell annotation, and R code for analysis of a large-scale single-cell RNA expression atlas.

SCIENTIFIC DATA (2022)

Article Cell Biology

Loss of TIP60 (KAT5) abolishes H2AZ lysine 7 acetylation and causes p53, INK4A, and ARF-independent cell cycle arrest

Johannes Wichmann, Catherine Pitt, Samantha Eccles, Alexandra L. Garnham, Connie S. N. Li-Wai-Suen, Rose May, Elizabeth Allan, Stephen Wilcox, Marco J. Herold, Gordon K. Smyth, Brendon J. Monahan, Tim Thomas, Anne K. Voss

Summary: Histone acetylation is crucial for chromatin conformation and gene transcription, and TIP60 is a key enzyme involved in this process. Loss of TIP60 leads to cell growth arrest and abnormal chromosome alignment during mitosis. However, cell survival is not affected. TIP60 is essential for the acetylation of H2AZ at lysine 7 and plays a role in the activation of transcription for thousands of genes, including those involved in metabolism.

CELL DEATH & DISEASE (2022)

Article Multidisciplinary Sciences

Activation of stably silenced genes by recruitment of a synthetic de-methylating module

Wing Fuk Chan, Hannah D. Coughlan, Yunshun Chen, Christine R. Keenan, Gordon K. Smyth, Andrew C. Perkins, Timothy M. Johanson, Rhys S. Allan

Summary: By coupling the catalytic domain of DNA demethylating enzyme TET1 with transcriptional activators (TETact), the authors have developed an improved activation system that can induce transcription of stably silenced genes. The TETact system is applicable in various cell types and has the ability to reactivate embryonic haemoglobin genes in non-erythroid cells. It is expected that TETact will have significant implications in functional studies, genetic screens, and potential therapeutics.

NATURE COMMUNICATIONS (2022)

Article Immunology

Overexpression of Lmo2 initiates T-lymphoblastic leukemia via impaired thymocyte competition

Hesham D. D. Abdulla, Raed Alserihi, Christoffer Flensburg, Waruni Abeysekera, Meng-Xiao Luo, Daniel H. D. Gray, Xiaodong Liu, Gordon K. K. Smyth, Warren S. S. Alexander, Ian J. J. Majewski, Matthew P. P. McCormack

Summary: Abdulla et al. demonstrate that the LMO2 transcription factor promotes the development of T-lymphoblastic leukemia by inhibiting thymocyte competition in a transgenic mouse model.

JOURNAL OF EXPERIMENTAL MEDICINE (2023)

Article Biochemical Research Methods

Neither random nor censored: estimating intensity-dependent probabilities for missing values in label-free proteomics

Mengbo Li, Gordon K. Smyth

Summary: Mass spectrometry proteomics in biomedical research suffers from the problem of missing values in peptides. Many analysis strategies have been proposed to distinguish different types of missing values and estimate detection probabilities. A logit-linear function is used to accurately model the detection probability, showing that missing values are related to peptide intensity. A probability model is developed to infer the distribution of unobserved intensities from observed values.

BIOINFORMATICS (2023)

Article Biochemistry & Molecular Biology

Dividing out quantification uncertainty allows efficient assessment of differential transcript expression with edgeR

Pedro L. Baldoni, Yunshun Chen, Soroor Hediyeh-zadeh, Yang Liao, Xueyi Dong, Matthew E. Ritchie, Wei Shi, Gordon K. Smyth

Summary: Differential expression analysis of RNA-seq is commonly used in bioinformatics. However, transcript-level quantifications are more uncertain due to the ambiguity of sequence reads. To address this issue, a new method is proposed to estimate the overdispersion caused by read-to-transcript ambiguity and generate scaled transcript counts, which improves the efficiency and accuracy of differential analysis.

NUCLEIC ACIDS RESEARCH (2023)

No Data Available