Identification of the incednine biosynthetic gene cluster: characterization of novel β-glutamate-β-decarboxylase IdnL3

Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics

(2013) Jeremy R. Lohman et al.   Molecular BioSystems

Structural Studies of the Spinosyn Rhamnosyltransferase, SpnG

(2012) Eta A. Isiorho et al.   BIOCHEMISTRY

Crystal structure of the glycosyltransferase SnogD from the biosynthetic pathway of nogalamycin inStreptomyces nogalater

(2012) Magnus Claesson et al.   FEBS Journal

Silvalactam, a 24-membered macrolactam antibiotic produced by Streptomyces sp. Tü 6392

(2012) Dirk Schulz et al.   JOURNAL OF ANTIBIOTICS

A Unique Pathway for the 3-Aminobutyrate Starter Unit from l-Glutamate through β-Glutamate during Biosynthesis of the 24-Membered Macrolactam Antibiotic, Incednine

(2012) Makoto Takaishi et al.   ORGANIC LETTERS

Controlling reaction specificity in pyridoxal phosphate enzymes

(2011) Michael D. Toney   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Function of MbtH homologs in nonribosomal peptide biosynthesis and applications in secondary metabolite discovery

(2011) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

A Natural Protecting Group Strategy To Carry an Amino Acid Starter Unit in the Biosynthesis of Macrolactam Polyketide Antibiotics

(2011) Yuji Shinohara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cloning and Elucidation of the FR901464 Gene Cluster Revealing a Complex Acyltransferase-less Polyketide Synthase Using Glycerate as Starter Units

(2011) Feng Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

(2011) L. Laureti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of Glycosyltransferase DesVII and Its Auxiliary Partner Protein DesVIII in the Methymycin/Pikromycin Biosynthetic Pathway

(2010) Svetlana A. Borisova et al.   BIOCHEMISTRY

Activation of the Pacidamycin PacL Adenylation Domain by MbtH-like Proteins

(2010) Wenjun Zhang et al.   BIOCHEMISTRY

The methoxymalonyl-acyl carrier protein biosynthesis locus and the nearby gene with the β-ketoacyl synthase domain are involved in the biosynthesis of galbonolides in Streptomyces galbus, but these loci are separate from the modular polyketide synthase ge

(2010) Suman Karki et al.   FEMS MICROBIOLOGY LETTERS

Biosynthesis of a New UDP-sugar, UDP-2-acetamido-2-deoxyxylose, in the Human PathogenBacillus cereusSubspeciescytotoxisNVH 391-98

(2010) Xiaogang Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into the Evolution of Macrolactam Biosynthesis through Cloning and Comparative Analysis of the Biosynthetic Gene Cluster for a Novel Macrocyclic Lactam, ML-449

(2009) H. Jorgensen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Biosynthesis of Macrolactam BE-14106 Involves Two Distinct PKS Systems and Amino Acid Processing Enzymes for Generation of the Aminoacyl Starter Unit

(2009) Hanne Jørgensen et al.   CHEMISTRY & BIOLOGY

The Crystal Structure of the Pseudomonas dacunhae Aspartate-β-Decarboxylase Dodecamer Reveals an Unknown Oligomeric Assembly for a Pyridoxal-5′-Phosphate-Dependent Enzyme

(2009) Santiago Lima et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and Functional Analysis of RifR, the Type II Thioesterase from the Rifamycin Biosynthetic Pathway

(2008) Heather B. Claxton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase

(2008) Adrian Keatinge-Clay   JOURNAL OF MOLECULAR BIOLOGY

In VitroCharacterization of the Enzymes Involved in TDP-d-Forosamine Biosynthesis in the Spinosyn Pathway ofSaccharopolysporaspinosa

(2008) Lin Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of Incednine as a Potent Modulator of the Anti-apoptotic Function of Bcl-xL from Microbial Origin

(2008) Yushi Futamura et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of TmcN as a pathway-specific positive regulator of tautomycetin biosynthesis in Streptomyces sp. CK4412

(2008) Y.-A. Hur et al.   MICROBIOLOGY-SGM

Biosynthesis of polyketide synthase extender units

(2008) Yolande A. Chan et al.   NATURAL PRODUCT REPORTS

Structural basis for the selectivity of the external thioesterase of the surfactin synthetase

(2008) Alexander Koglin et al.   NATURE

Biosynthetic pathway of 24-membered macrolactam glycoside incednine

(2008) Makoto Takaishi et al.   TETRAHEDRON