Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics

Specificity of the Ester Bond Forming Condensation Enzyme SgcC5 in C-1027 Biosynthesis

(2012) Shuangjun Lin et al.   ORGANIC LETTERS

Influence of apoproteins for enediyne production

(2011) Vu Thi Thu Hang et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Fijiolides A and B, Inhibitors of TNF-α-Induced NFκB Activation, from a Marine-Derived Sediment Bacterium of the GenusNocardiopsis

(2010) Sang-Jip Nam et al.   JOURNAL OF NATURAL PRODUCTS

Enediyne Antitumor Antibiotic Maduropeptin Biosynthesis Featuring aC-Methyltransferase That Acts on a CoA-Tethered Aromatic Substrate

(2010) Jianya Ling et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Complexity and simplicity in the biosynthesis of enediyne natural products

(2010) Zhao-Xun Liang   NATURAL PRODUCT REPORTS

Characterization of the Epoxide Hydrolase NcsF2 from the Neocarzinostatin Biosynthetic Gene Cluster

(2010) Shuangjun Lin et al.   ORGANIC LETTERS

Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes

(2010) G. P. Horsman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Total Synthesis of a Protected Aglycon of the Kedarcidin Chromophore

(2009) Kouki Ogawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Polyketide-Chain Branching by an Enzymatic Michael Addition

(2009) Björn Kusebauch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular Basis of Substrate Promiscuity for the SAM-DependentO-Methyltransferase NcsB1, Involved in the Biosynthesis of the Enediyne Antitumor Antibiotic Neocarzinostatin

(2009) Heather A. Cooke et al.   BIOCHEMISTRY

C-1027, A Radiomimetic Enediyne Anticancer Drug, Preferentially Targets Hypoxic Cells

(2009) T. A. Beerman et al.   CANCER RESEARCH

Unusual Chemistry in the Biosynthesis of the Antibiotic Chondrochlorens

(2009) Shwan Rachid et al.   CHEMISTRY & BIOLOGY

Characterization of SgcE6, the flavin reductase component supporting FAD-dependent halogenation and hydroxylation in the biosynthesis of the enediyne antitumor antibiotic C-1027

(2009) Steven G. Van Lanen et al.   FEMS MICROBIOLOGY LETTERS

Characterization of the SgcF Epoxide Hydrolase Supporting an (R)-Vicinal Diol Intermediate for Enediyne Antitumor Antibiotic C-1027 Biosynthesis

(2009) Shuangjun Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A free-standing condensation enzyme catalyzing ester bond formation in C-1027 biosynthesis

(2009) S. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural-Product Sugar Biosynthesis and Enzymatic Glycodiversification

(2008) Christopher J. Thibodeaux et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biosynthesis of Enediyne Antitumor Antibiotics

(2008) Steven Van Lanen et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The biosynthetic genes encoding for the production of the dynemicin enediyne core inMicromonospora chersinaATCC53710

(2008) Qunjie Gao et al.   FEMS MICROBIOLOGY LETTERS

RegiospecificO-Methylation of Naphthoic Acids Catalyzed by NcsB1, anO-Methyltransferase Involved in the Biosynthesis of the Enediyne Antitumor Antibiotic Neocarzinostatin

(2008) Yinggang Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of the Two-Component, FAD-Dependent Monooxygenase SgcC That Requires Carrier Protein-Tethered Substrates for the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027

(2008) Shuangjun Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unraveling the Biosynthesis of the Sporolide Cyclohexenone Building Block

(2008) Ryan P. McGlinchey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

InterPro: the integrative protein signature database

(2008) S. Hunter et al.   NUCLEIC ACIDS RESEARCH

A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis

(2008) J. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism

(2008) S. G. Van Lanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM

(2007) Timothy J. Montavon et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS