Article
Microbiology
Chunru Liu, Stoffel Matjeke Radebe, Hang Zhang, Junpeng Jia, Shuang Xie, Miaolei Shi, Qinghua Yu
Summary: This study found that Bacillus coagulans can maintain the intestinal mucosal barrier by improving the intestinal flora, enhancing innate immunity, and promoting intestinal epithelial proliferation.
VETERINARY MICROBIOLOGY
(2022)
Article
Nutrition & Dietetics
Jiqing Yang, Pu Xiong, Ling Bai, Zunyue Zhang, Yong Zhou, Cheng Chen, Zhenrong Xie, Yu Xu, Minghui Chen, Huawei Wang, Mei Zhu, Juehua Yu, Kunhua Wang
Summary: Heroin dependence significantly alters gut microbiota diversity and composition, leading to impaired intestinal mucosal barrier integrity and decreased body weight in mice.
FRONTIERS IN NUTRITION
(2021)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Teng Teng, Gerard Clarke, Michael Maes, Yuanliang Jiang, Jun Wang, Xuemei Li, Bangmin Yin, Yajie Xiang, Li Fan, Xueer Liu, Jie Wang, Shouhuan Liu, Yunqing Huang, Julio Licinio, Xinyu Zhou, Peng Xie
Summary: The study found that chronic unpredictable mild stress (CUMS) led to significantly more depressive-like behaviors in male cynomolgus macaques, and revealed differences in mucosal and luminal microbial composition between the CUMS and control groups, as well as alterations in microbiome community functions and metabolites related to carbohydrate and energy metabolism.
MOLECULAR PSYCHIATRY
(2022)
Article
Biotechnology & Applied Microbiology
Jihua Shi, Yiran Wang, Dan Chen, Xue Xu, Wenbin Li, Kai Li, Jing He, Wen Su, Qingfeng Luo
Summary: The expression of intestinal mucosal alpha-synuclein in Parkinson's disease patients is related to mucosal microbiota and may have diagnostic value.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Immunology
Shuai Li, Xiaolu Wen, Xuefen Yang, Li Wang, Kaiguo Gao, Xingwei Liang, Hao Xiao
Summary: This study investigated the effects of glutamine supplementation on the intestinal microbiota and microbial metabolites. The results showed no significant changes in the microbiota, but differences were observed in the metabolites. Metabolomics analysis revealed alterations in various metabolic pathways and differential metabolites, which are beneficial for intestinal development and immunity. Overall, glutamine supplementation may maintain intestinal homeostasis and improve intestinal immunity through the modulation of intestinal microbial metabolites.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Microbiology
Huan Liu, Jihao Xu, Chiuwing Yeung, Qikui Chen, Jieyao Li
Summary: This study found that supplementation of 10% or 20% hemicellulose improved glycemic control, gut barrier integrity, and reduced systemic inflammation in db/db mice with type 2 diabetes mellitus (T2DM). Additionally, hemicellulose supplementation had significant effects on the gut microbiota and metabolome composition. Therefore, hemicellulose may serve as a potential therapeutic intervention for T2DM.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Immunology
Felipe Melo-Gonzalez, Javiera Sepulveda-Alfaro, Barbara M. Schultz, Isidora D. Suazo, David L. Boone, Alexis M. Kalergis, Susan M. Bueno
Summary: Infectious diseases are a major cause of illness and death worldwide, with pathogens causing local immune and inflammatory responses that can lead to changes in microbiota, metabolites, and cytokines. Recent studies suggest a link between diseases in distal mucosal barriers such as the lung and intestine. The bidirectional interaction between these barriers through the gut-lung axis is not fully understood.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Meng Yan, Li Hou, Yaoyao Cai, Hanfei Wang, Yujun Ma, Qiming Geng, Weiwei Jiang, Weibing Tang
Summary: This study revealed that activation of the FXR signaling pathway by OCA significantly improved liver fibrosis and intestinal inflammation in cholestatic liver disease rats, while also positively influencing the composition of intestinal microbiota and protecting intestinal mucosa.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Yu He, Zhuan Song, Yun Ji, Patrick Tso, Zhenlong Wu
Summary: The study found that L-glutamine can improve lipid metabolic abnormality caused by a high-fat diet via the gut-liver axis. It works by regulating lipid metabolism, inhibiting inflammation, reducing bile acid synthesis, and improving intestinal barrier function. Additionally, it also alters the composition of the gut microbiota.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Food Science & Technology
Weizhe Chen, Jie Wang, Liyu Du, Junjie Chen, Qikai Zheng, Pan Li, Bing Du, Xiang Fang, Zhenlin Liao
Summary: Kefir, a fermented food with probiotics, can regulate intestinal microbiota balance and enhance immune response to shape mucosal immunity. Its metabolites and microbial antigens can shape the mucosal immunity and regulate antibody levels to maintain intestinal homeostasis, affecting the occurrence of intestinal inflammation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Microbiology
Xiaodan Shi, Wei Xu, Xinghua Che, Jiawen Cui, Xinchi Shang, Xiaohua Teng, Zhiying Jia
Summary: The research found that aquatic organisms such as fish can accumulate high concentrations of arsenic (As), which has toxic effects on fish. However, whether the intestinal flora are involved in As damage to fish intestinal tissues and the underlying process are unclear.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Immunology
Han Zheng, Chi Zhang, Qianqian Wang, Shuyan Feng, Yi Fang, Shuo Zhang
Summary: The dysfunctional immune system in the intestinal mucosa with age promotes the occurrence of age-associated diseases. While there have been numerous studies on the impact of aging on systemic immunity, the research on the impact of aging on the intestinal mucosal immune system is relatively limited. This review briefly introduces the effects of aging on the intestinal mucosal barrier, immune cells, immune molecules, and the interaction between intestinal mucosal immunity and gut microbiota during aging. Additionally, potential strategies to slow down intestinal aging in the elderly are discussed.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Pawel Serek, Monika Oleksy-Wawrzyniak
Summary: The intestinal barrier, composed of cells, mucus, and microbiota, plays a crucial role in maintaining immune homeostasis. Disturbances in its tightness can lead to a range of issues, including systemic infections and autoimmune diseases. Zonulin, a protein found in epithelial cells, plays a key regulatory role.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Pawel Liskiewicz, Mariusz Kaczmarczyk, Blazej Misiak, Michal Wronski, Agata Baba-Kubis, Karolina Skonieczna-Zydecka, Wojciech Marlicz, Przemyslaw Bienkowski, Agata Misera, Justyna Pelka-Wysiecka, Jolanta Kucharska-Mazur, Anna Konopka, Igor Loniewski, Jerzy Samochowiec
Summary: The study found a significant correlation between gut microbiota and the severity of depressive symptoms, but they do not serve as predictors of symptomatic improvement during antidepressant treatment. Intestinal integrity and inflammation markers were associated with the response to treatment and symptom severity in patients with MDD. Additional studies are needed to confirm and expand on these findings.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Agriculture, Dairy & Animal Science
D. Menoyo, G. Kuehn, N. Ruiz-Lopez, K. Pallauf, I Stubhaug, J. J. Pastor, I. R. Ipharraguerre, G. Rimbach
Article
Agriculture, Dairy & Animal Science
M. Nardoia, C. Romero, A. Brenes, I Arija, A. Viveros, C. Ruiz-Capillas, S. Chamorro
Article
Agriculture, Dairy & Animal Science
Carlos Farias-Kovac, Nuria Nicodemus, Rebeca Delgado, Cesar Ocasio-Vega, Tamia Noboa, Ramadan Allam-Sayed Abdelrasoul, Rosa Carabano, Javier Garcia
Article
Chemistry, Applied
Susana Chamorro, Ruben Cueva-Mestanza, Sonia de Pascual-Teresa
Summary: The impact of spray drying on various polyphenolic compounds in the root of purple-fleshed sweet potatoes native to Peru was investigated using HPLC-QTOF-MSMS. The study identified nine anthocyanins and twenty-nine cinnamoylquinic acids, with significant losses of polyphenols observed during the spray drying process. Among the compounds, mono-CiQAs with feruloyl moieties and mono acylated peonidin derivatives with p-hydroxybenzoic acid were the least affected.
Article
Biochemistry & Molecular Biology
Carlos Romero, Maria Nardoia, Ignacio Arija, Agustin Viveros, Ana I. Rey, Marin Prodanov, Susana Chamorro
Summary: Feeding broiler chickens diets containing grape skins negatively impacts growth performance and digestibility, but the inclusion of grape polyphenol sources increases alpha- and gamma-tocopherol concentrations in plasma and meat.
Article
Biochemistry & Molecular Biology
Noelia Carballeda-Sangiao, Susana Chamorro, Sonia de Pascual-Teresa
Summary: The study found that a freeze-dried fruit mixture rich in anthocyanins has the potential for nutraceutical use in preventing neurodegeneration associated with age or environmental factors.
Article
Biochemistry & Molecular Biology
Noelia Carballeda Sangiao, Susana Chamorro, Sonia de Pascual-Teresa, Luis Goya
Summary: The study confirms the significant protective effect of phenolic compounds and epicatechin in aqueous extract of cocoa powder against oxidative stress on neuronal-like cells under physiological conditions.
Article
Agriculture, Dairy & Animal Science
E. Llaurado-Calero, I Badiola, A. Delpino-Rius, R. Lizardo, D. Torrallardona, E. Esteve-Garcia, N. Tous
Summary: The study shows that replacing animal fat in sow diets with fish oil can increase the levels of n-3 fatty acids and their oxygenated derivatives in colostrum and milk, leading to a reduction of inflammatory factors in milk.
Article
Agriculture, Dairy & Animal Science
Carlos Romero, Maria Nardoia, Agustin Brenes, Ignacio Arija, Agustin Viveros, Susana Chamorro
Summary: The combination of grape seeds and skins in chicken diets improved plasma and meat a-tocopherol content and mitigated meat lipid oxidation. Combinations with at least 50% grape skins provided optimal results of meat oxidative stability during 7-day storage.
Article
Agriculture, Dairy & Animal Science
Carlos Romero, Ignacio Arija, Agustin Viveros, Susana Chamorro
Summary: Grape products can improve egg quality but reduce feed intake and egg weight. Grape pomace has a higher antioxidant potential compared to grape extract.
Article
Agriculture, Dairy & Animal Science
E. Llaurado-Calero, I Badiola, I Samarra, R. Lizardo, D. Torrallardona, E. Esteve-Garcia, N. Tous
Summary: The addition of fish oil rich in EPA and DHA to the diets of sows and piglets was found to increase the concentrations of anti-inflammatory molecules in their blood, enhancing the viability of piglets.
Article
Agriculture, Dairy & Animal Science
Carlos Fernandez, Tamara Romero, Ignacio Badiola, Jesus Diaz-Cano, Gregorio Sanzol, Juan J. Loor
Summary: This research evaluated the effects of incorporating a postbiotic yeast fermentation product in diets of lactating goats on energy partitioning, carbon and nitrogen balance, and performance. The results showed that the postbiotic led to greater ruminal propionate concentration and fiber digestibility, and decreased energy partitioning to methane, ultimately increasing milk production. The study suggested that postbiotics can enhance efficiency of nutrient use for milk production.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Microbiology
Eudald Llaurado-Calero, Eric Climent, Empar Chenoll, Maria Ballester, Ignacio Badiola, Rosil Lizardo, David Torrallardona, Enric Esteve-Garcia, Nuria Tous
Summary: This study evaluates the impact of n-3 long-chain fatty acids (n-3 LCFAs) in sow diets on the microbiota composition of sows' feces, colostrum, milk, and piglets' feces. The results show that dietary n-3 LCFA increases microbiota diversity and beneficial bacteria populations in suckling piglets' feces, with minor modifications in milk and gestating sows' feces. However, no changes were observed in lactating sows' feces or colostrum. This study provides crucial information on the early-stage microbiota status of sows, colostrum, milk, and suckling piglets during the lactation period.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Javier Herrero-Encinas, Almudena Huerta, Marta Blanch, Jose Javier Pastor, Sofia Morais, David Menoyo
Summary: This study explored the mechanism of action of a mixture of extracts containing capsaicin, black pepper, and ginger, which showed positive effects on broiler chicken growth performance. The results showed an enhancement of growth parameters, improved nutrient digestibility, and effects on antioxidant enzyme activity. In conclusion, the inclusion of this mixture in broiler diets improved growth performance and positively affected nutrient digestibility and antioxidant response.
Article
Biochemistry & Molecular Biology
Javier Herrero-Encinas, Nereida L. Corrales, Fernando Sevillano, Robert Ringseis, Klaus Eder, David Menoyo
Summary: This study examines the effects of replacing vitamin E with a liquid obtained from alpeorujo, an olive oil by-product rich in hydroxytyrosol, as an antioxidant in broiler chicken feeds. The results show that the olive oil by-product can be used as an antioxidant in broiler diets without affecting liver lipid and TBARS concentrations. The differential gene expression analysis suggests a potential role of olive polyphenols in enhancing the chicken immune response.