Review
Biochemistry & Molecular Biology
Anna Orzel, Katarzyna Unrug-Bielawska, Dagmara Filipecka-Tyczka, Krzysztof Berbeka, Natalia Zeber-Lubecka, Malgorzata Zielinska, Anna Kajdy
Summary: This review summarizes the current knowledge on the effects of perinatal hypoxia on brain development, including the causes, symptoms, and methods of predicting brain damage. It also discusses the unique aspects of brain development in growth-restricted fetuses and how it is studied in animal models. The review aims to identify the least understood molecular pathways of abnormal brain development and potential treatment interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Daniela Costa, Simon Levesque, Nitin Kumar, Pablo Fresia, Ignacio Ferres, Trevor D. Lawley, Gregorio Iraola
Summary: The subspecies of Campylobacter hyointestinalis, hyointestinalis and lawsonii, show distinct phylogenetic lineages and apparent genetic isolation, with hyointestinalis having a more diverse accessory genome likely due to its colonization of different mammalian hosts. The higher incidence of genome-wide recombination events in hyointestinalis may be the driving force behind its diversification, with distinct patterns of gene families involved in genome plasticity and DNA repair compared to lawsonii.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Brooke Zanco, Christen K. Mirth, Carla M. Sgro, Matthew D. W. Piper
Summary: Research on fruit flies shows that the influence of protein and carbohydrates on lifespan is indirect, affecting the distribution of dietary sterols. Supplementing with cholesterol can rescue the shortened lifespan caused by high protein: carbohydrate diets. This highlights the complex and indirect effects of nutrient-dependent trade-offs on life histories.
Review
Nutrition & Dietetics
Ligia M. Watanabe, Anderson M. Navarro, Lucia A. Seale
Summary: Obesity is a major health concern in developing countries like Brazil, where approximately one quarter of the population is obese. The combination of obesity, selenium deficiency, and statin treatment poses significant challenges to public health in Brazil.
Article
Nutrition & Dietetics
Mitchell T. Ringuet, Billie Hunne, Markus Lenz, David M. Bravo, John B. Furness
Summary: The study found that inorganic, organic, and nanoelemental selenium can all be effectively incorporated into tissues, significantly increasing the antioxidant capability of GPx in the intestine and liver. Despite being 11 to 25 times less concentrated than the high selenium diet, lower selenium diets also produced similarly high levels of selenium in the liver, ileum, and plasma, independent of the selenium source.
Article
Biology
Zahida Sultanova, Edward R. Ivimey-Cook, Tracey Chapman, Alexei A. Maklakov
Summary: Research on fruit flies showed that individuals subjected to dietary restriction did not experience reduced survival upon subsequent re-feeding, and even had increased reproduction and mating success, indicating that the dietary restriction response is adaptive and increases fitness when temporary food shortages cease.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Review
Nutrition & Dietetics
Xin Huang, Yu-Lan Dong, Tong Li, Wei Xiong, Xu Zhang, Peng-Jie Wang, Jia-Qiang Huang
Summary: Selenium is essential for maintaining a healthy physiological state, but deficiencies or excesses can lead to various diseases related to cognitive decline, immune disorders, and metabolic risks. MiRNAs play crucial roles in regulating interactions between the environment and genes, but the mechanisms of selenium metabolism and miRNA regulation remain unclear.
Article
Biochemistry & Molecular Biology
Milica Manojlovic-Stojanoski, Slavica Borkovic-Mitic, Natasa Nestorovic, Natasa Ristic, Svetlana Trifunovic, Magdalena Stevanovic, Nenad Filipovic, Aleksandar Stojsavljevic, Sladan Pavlovic
Summary: Selenium is an essential element for normal cellular functioning, but low status and high concentrations can both increase oxidative stress. This study compared the effects of selenium nanoparticles and inorganic sodium selenite supplementation on pregnant rats. The results showed that selenium nanoparticles increased fetal lethality and changed antioxidant defense parameters in the placenta.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Zhen-Ling Liu, Huan-Huan Chen, Li-Li Zheng, Li-Ping Sun, Lei Shi
Summary: Angiogenesis is a complex process regulated by various molecules and plays a crucial role in tumor growth and metastasis. Targeted therapeutic research based on these molecules has led to the emergence of promising anti-angiogenic strategies in cancer therapy.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Vita Maria Marino, Teresa Rapisarda, Margherita Caccamo, Bernardo Valenti, Alessandro Priolo, Giuseppe Luciano, Antonio Natalello, Adriana Campione, Mariano Pauselli
Summary: Compared to the C group, HNP cheese had more than twice as many tocopherols and mono-unsaturated FA, and respectively 38% and 24% less cholesterol and saturated FA. Tocopherols and cholesterol levels remained rather stable up to 14 days of storage regardless of the experimental group, suggesting no cholesterol oxidation. Therefore, the inclusion of HNP in ewe diets could be a valid resource to produce cheese with a healthier lipid profile and higher tocopherols content.
Article
Nutrition & Dietetics
Rosa M. Garcia-Garcia, Maria Arias-Alvarez, Pilar Millan, Maria Rodriguez, Ana Sanchez-Rodriguez, Pedro L. Lorenzo, Pilar G. Rebollar
Summary: The study found that maternal food restriction followed by re-feeding in early and mid-pregnancy in a rabbit model can establish a compensatory energy status in dams and alleviate potential long-term consequences in growth and metabolism in offspring, even if fetal metabolism was altered. Although fetal metabolism was affected, offspring in the juvenile period showed a similar pattern of growth and serum metabolic parameters, except for slightly increased serum aminotransferases levels associated with higher liver fibrosis.
Article
Biochemistry & Molecular Biology
Weicheng Zhao, Amy C. Kelly, Rosa I. Luna-Ramirez, Christopher A. Bidwell, Miranda J. Anderson, Sean W. Limesand
Summary: This study found that skeletal muscle of fetuses with intrauterine growth restriction (FGR) has lower mitochondrial respiration rate and altered transcriptomic profiles associated with energy metabolism. FGR skeletal muscle showed attenuated pyruvate oxidation, possibly due to the inability of pyruvate to enter the TCA cycle, and fatty acid oxidation might compensate for the attenuated energy metabolism. The findings provide phenotypic and molecular evidence for adaptive deficiencies in FGR skeletal muscle.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Zabihollah Nemati, Kazem Alirezalu, Maghsoud Besharati, Benjamin W. B. Holman, Mohammadreza Hajipour, Benjamin M. Bohrer
Summary: This study found that additional selenium supplementation in the diet can improve the nutritional quality and shelf life of goose meat and liver samples, and both inorganic and organic selenium forms are beneficial for this effect.
Review
Endocrinology & Metabolism
Han Fang, Kirsten P. Stone, Laura A. Forney, Desiree Wanders, Thomas W. Gettys
Summary: FGF21 is a potent metabolic regulator that is influenced by dietary protein, specifically methionine restriction, leading to effects on energy balance, adipose tissue remodeling, and insulin sensitivity. Liver functions as a sentinel to detect changes in dietary amino acid composition and mobilizes FGF21 as a key element of the homeostatic response. Therapeutic diets could be developed to increase FGF21 levels through nutritional modulation for sustained biological effects.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Erik M. Anderson, Jared M. Rozowsky, Brian J. Fazzone, Emilie A. Schmidt, Bruce R. Stevens, Kerri A. O'Malley, Salvatore T. Scali, Scott A. Berceli
Summary: Short-term dietary restriction can modulate the gut microbiome, causing relative dysbiosis, which is quickly restored after resuming a normal diet. This study highlights the importance of understanding the impact of nutritional interventions on the microbiome in order to improve surgical outcomes.
Article
Microbiology
Samat Amat, Devin B. Holman, Kaycie Schmidt, Kacie L. McCarthy, Sheri T. Dorsam, Alison K. Ward, Pawel P. Borowicz, Lawrence P. Reynolds, Joel S. Caton, Kevin K. Sedivec, Carl R. Dahlen
Summary: This study found that a diverse microbiota is present in early-stage bovine fetuses, with different microbial community structures in different fetal compartments. The microbial diversity in the intestinal and placental samples was lower compared to fetal fluid microbiota, and the maternal nutritional regime may influence the early fetal microbiota.
FRONTIERS IN MICROBIOLOGY
(2022)
Letter
Obstetrics & Gynecology
Lawrence P. Reynolds
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Wellison J. S. P. Diniz, Lawrence P. K. Reynolds, Alison K. P. Ward, Pawel P. K. Borowicz, Kevin K. L. Sedivec, Kacie L. J. McCarthy, Cierrah J. Kassetas, Friederike D. Baumgaertner, James D. T. Kirsch, Sheri T. L. Dorsam, Tammi L. R. Neville, J. Chris S. Forcherio, Ronald R. R. Scott, Joel S. Caton, Carl R. Dahlen
Summary: This study investigates the expression profile of cotyledon and caruncle in nulliparous beef heifers carrying female fetuses to identify changes contributing to placental function and tissue-specific roles. Differentially expressed genes, including nutrient transporters and paternally imprinted genes, were identified. Key regulators of tissue function and differentiation were rewired between the tissues. Over-represented pathways related to immune tolerance, tissue differentiation, and remodeling were also identified. These findings highlight the intricate cross-talk between fetal-maternal tissues and provide evidence of a fine-tuned gene regulatory network underlying pregnancy and tissue-specific function in the bovine placenta.
Review
Microbiology
Samat Amat, Carl R. Dahlen, Kendall C. Swanson, Alison K. Ward, Lawrence P. Reynolds, Joel S. Caton
Summary: Recent developments require further research on the timing and mechanisms of initial colonization of the fetal/infant gut by the maternal microbiome and its role in Developmental Origins of Health and Disease (DOHaD). Ethical and legal constraints hinder research progress in embryo/fetal-related research and the understanding of the developmental and mechanistic roles of the maternal microbiome in fetal microbial imprinting and early-life microbiome development. Rodent models are effective for studying the role of the maternal microbiome in fetal programming, but limitations exist for studying perinatal microbial colonization from a biomedical perspective. This review discusses the potential use of bovine animals as a biomedical model to study the maternal microbiome, in utero microbial colonization of the fetal gut, and their impact on offspring development and DOHaD.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Genetics & Heredity
Matthew S. Crouse, Joel S. Caton, Kate J. Claycombe-Larson, Wellison J. S. Diniz, Amanda K. Lindholm-Perry, Lawrence P. Reynolds, Carl R. Dahlen, Pawel P. Borowicz, Alison K. Ward
Summary: Epigenetic modifiers are crucial for early embryonic development, with roles as methyl donors and cofactors in methylation reactions. Supplementation of multiple epigenetic modifiers in ruminants can enhance cell growth, mitochondrial function, and DNA methylation, potentially improving growth parameters beyond control treated cells.
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Wellison J. S. Diniz, Matthew S. Crouse, Joel S. Caton, Kate J. Claycombe-Larson, Amanda K. Lindholm-Perry, Lawrence P. Reynolds, Carl R. Dahlen, Pawel P. Borowicz, Alison K. Ward
Summary: Fetal programming, established early in life through epigenetic mechanisms, can be influenced by micronutrients acting as epigenetic modifiers (EM). This study provides a genome-wide DNA methylation dataset of bovine embryonic fibroblast cells exposed to different supplementation levels of glucose and EM. The findings offer valuable information on putative candidate genes responsive to DNA methylation due to EM supplementation.
Article
Agriculture, Dairy & Animal Science
Ana Clara B. Menezes, Kacie L. McCarthy, Cierrah J. Kassetas, Friederike Baumgaertner, James D. Kirsch, Sheri T. Dorsam, Tammi L. Neville, Alison K. Ward, Pawel P. Borowicz, Lawrence P. Reynolds, Kevin K. Sedivec, J. Chris Forcherio, Ronald Scott, Joel S. Caton, Carl R. Dahlen
Summary: This study investigates the effects of vitamin/mineral and protein/energy supplements on dam performance and fetal outcomes in pregnant replacement heifers. The results show that moderate rates of gain via protein/energy supplementation can result in fetuses with heavier femurs and reduced liver mass. Vitamin and mineral supplementation can increase fetal liver mass, and when combined with moderate gain treatments, it can result in greater fetal intestinal weights. These findings suggest that replacement heifer nutrition during early gestation can alter the development of organs relevant for future offspring performance.
Article
Agriculture, Dairy & Animal Science
Kacie L. McCarthy, Ana Clara B. Menezes, Cierrah J. Kassetas, Friederike Baumgaertner, James D. Kirsch, Sheri T. Dorsam, Tammi L. Neville, Alison K. Ward, Pawel P. Borowicz, Lawrence P. Reynolds, Kevin K. Sedivec, J. Chris Forcherio, Ronald Scott, Joel S. Caton, Carl R. Dahlen
Summary: Maternal vitamin and mineral supplementation during pre-breeding and the first trimester of gestation resulted in higher concentrations of selenium, copper, and cobalt in beef heifers and their fetuses. These trace minerals are essential components of the antioxidant system and may have positive impacts on the immune system of the future offspring. Additionally, low rates of gain during gestation resulted in higher concentrations of molybdenum and cobalt in fetal liver.
Article
Biochemistry & Molecular Biology
Matthew S. Crouse, Kacie L. McCarthy, Ana Clara B. Menezes, Cierrah J. Kassetas, Friederike Baumgaertner, James D. Kirsch, Sheri Dorsam, Tammi L. Neville, Alison K. Ward, Pawel P. Borowicz, Lawrence P. Reynolds, Kevin K. Sedivec, J. Chris Forcherio, Ronald Scott, Joel S. Caton, Carl R. Dahlen
Summary: The objective of this study was to evaluate the effects of feeding heifers a vitamin and mineral supplement and targeting divergent rates of weight gain during early gestation on the fetal liver amino acid, carbohydrate, and energy profile at d 83 of gestation. The results showed that both rate of weight gain and vitamin/mineral supplementation significantly affected the metabolites in the fetal liver. In addition, the study found that vitamin and mineral supplementation had different effects on the TCA cycle and Oxidative Phosphorylation pathways within the Energy Metabolism superpathway.
Article
Agriculture, Dairy & Animal Science
Matthew S. Crouse, Harvey C. Freetly, Amanda K. Lindholm-Perry, Bryan W. Neville, William T. Oliver, Robert T. Lee, Jessica G. Syring, Layla E. King, Lawrence P. Reynolds, Carl R. Dahlen, Joel S. Caton, Alison K. Ward, Robert A. Cushman
Summary: The study aimed to determine the optimal doses of vitamins B-12 and folate for beef heifers to maintain increased levels of these nutrients in circulation. Results showed that weekly injections of 20 mg of B-12 and 320 mg of folate were effective in sustaining elevated concentrations of these nutrients in serum.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
A. R. Tanner, M. L. Bauer, K. C. Swanson, V. C. Kennedy, J. D. Kirsch, J. Gaspers, N. Negrin-Pereira, A. B. P. Fontoura, G. A. Perry, G. Stokka, A. Rodas-Gonzalez, A. Ward, C. R. Dahlen, B. Neville, P. P. Borowicz, L. P. Reynolds, K. H. Ominski, K. A. Vonnahme
Summary: The purpose of this study was to evaluate the effects of supplementing corn to gestating beef cows fed low-quality forage on uterine and mammary hemodynamics and neonatal performance. The results showed that corn supplementation enhanced uterine and mammary hemodynamics and increased placental microvascularity. Corn can be a good substitute for hay when cost and availability are economically advantageous to the producer.
Review
Developmental Biology
Lawrence P. Reynolds, Wellison J. S. Diniz, Matthew S. Crouse, Joel S. Caton, Carl R. Dahlen, Pawel P. Borowicz, Alison K. Ward
Summary: Developmental programming refers to the long-term changes in gene expression caused by stressors during development, which can affect organ structure and function. Maternal nutrition plays a crucial role in the developmental program. Future research should focus on the effects of developmental programming on the offspring's life course and subsequent generations, as well as utilizing the positive aspects of developmental programming.
REPRODUCTION FERTILITY AND DEVELOPMENT
(2023)
Article
Biochemistry & Molecular Biology
Ana Clara B. Menezes, Carl R. Dahlen, Kacie L. McCarthy, Cierrah J. Kassetas, Friederike Baumgaertner, James D. Kirsch, Sheri T. Dorsam, Tammi L. Neville, Alison K. Ward, Pawel P. Borowicz, Lawrence P. Reynolds, Kevin K. Sedivec, J. Chris Forcherio, Ronald Scott, Joel S. Caton, Matthew S. Crouse
Summary: In this study, the hepatic lipid metabolic profiles of bovine fetuses were evaluated in response to maternal vitamin and mineral supplementation and different rates of gain. The results showed that maternal body weight gain had a greater influence on fetal lipid profiles than vitamin and mineral supplementation, with lower rates of gain resulting in increased lipid composition.
Article
Agriculture, Dairy & Animal Science
Wellison J. S. Diniz, Alison K. Ward, Kacie L. McCarthy, Cierrah J. Kassetas, Friederike Baumgaertner, Lawrence P. Reynolds, Pawel P. Borowicz, Kevin K. Sedivec, James D. Kirsch, Sheri T. Dorsam, Tammi L. Neville, J. Chris Forcherio, Ronald Scott, Joel S. Caton, Carl R. Dahlen
Summary: Maternal nutrient supply during the periconceptual period has long-term effects on fetal development and tissue function. Our study investigated the impacts of maternal vitamin and mineral supplementation and rate of body-weight gain during early pregnancy on fetal liver development and gene expression profiles. We found that maternal nutrition during the periconceptual period affects fetal hepatic function through altered expression of energy- and lipid-related genes.
Review
Biochemistry & Molecular Biology
Muhammad Anas, Wellison J. S. Diniz, Ana Clara B. Menezes, Lawrence P. Reynolds, Joel S. Caton, Carl R. Dahlen, Alison K. Ward
Summary: Maternal mineral nutrition during critical phases of fetal development can have lifelong impacts on individual productivity. Research has focused on the role of macronutrients in genome function and fetal programming, but little is known about the role of micronutrients and minerals in livestock species. This review will address the effects of maternal dietary mineral supply on fetal development in cattle and draw parallels with research in other animals and cell lines.