Review
Biochemistry & Molecular Biology
Aikaterini Berdiaki, Monica Neagu, Ioanna Spyridaki, Andrey Kuskov, Serge Perez, Dragana Nikitovic
Summary: Hyaluronan (HA) is a natural compound that is found on the cell surface and tissue extracellular matrix. It is synthesized by enzymes and degraded by other substances. HA has different effects on the body depending on its molecular weight, with high molecular weight HA being anti-inflammatory and low molecular weight HA being pro-inflammatory. Reactive oxygen species (ROS) can degrade HA and affect vascular integrity, while HA can also play a role in wound healing. Understanding the interactions between ROS and HA is an important research topic.
Review
Biochemistry & Molecular Biology
Valentine Suteau, Mathilde Munier, Claire Briet, Patrice Rodien
Summary: Differentiated thyroid cancers are more common in women, possibly due to differences in patient behavior and thyroid investigations, as well as the potential impact of sex hormones. The reasons behind the poorer prognosis of thyroid cancer in male patients remain poorly explained.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jiaqi Zhu, Peter Langer, Claas Ulrich, Juergen Eberle
Summary: This study investigated the efficacy of three indirubin derivatives in four cSCC cell lines, showing significant effects on cell proliferation, viability, and apoptosis. The mechanisms of action involved induction of reactive oxygen species and activation of various apoptotic pathways, highlighting the importance of ROS in antitumor effects of indirubins.
Review
Plant Sciences
Su Yin Phua, Barbara De Smet, Claire Remacle, Kai Xun Chan, Frank Van Breusegem
Summary: The evolution of photosynthesis in plants has been crucial but has also led to challenges in the form of reactive oxygen species (ROS) production. Multiple forms of ROS are generated in various plant cell compartments, requiring a sophisticated network of ROS detoxification and signaling tailored to individual organelles to safeguard the cell as a whole.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Review
Biochemistry & Molecular Biology
Gaetana Napolitano, Gianluca Fasciolo, Paola Venditti
Summary: Mitochondria in aerobic eukaryotic cells not only produce energy but also harmful substances such as ROS, and possess an efficient antioxidant system to detoxify these substances. As ROS production increases, mitochondria are damaged and release more harmful substances, but their antioxidant system can detoxify exogenous ROS at the expense of reducing the equivalents generated in mitochondria.
Article
Fisheries
Lunjian Chen, Gen Kaneko, Yichao Li, Jun Xie, Guangjun Wang, Zhifei Li, Jingjing Tian, Kai Zhang, Wangbao Gong, Yun Xia, Ermeng Yu
Summary: The study found that natural oxidant faba beans can improve the muscle textural quality of grass carp, but dietary antioxidants supplementation almost completely abolishes this effect. However, the addition of oxidant (vitamin K3) to commercial feed can effectively improve the muscle textural quality of grass carp. There is a positive feedback relationship between ROS accumulation and production mainly in the mitochondria, which plays a role in improving muscle texture.
Review
Biochemistry & Molecular Biology
Silvia Piccirillo, Simona Magi, Alessandra Preziuso, Tiziano Serfilippi, Giorgia Cerqueni, Monia Orciani, Salvatore Amoroso, Vincenzo Lariccia
Summary: ROS have dual roles, acting as signaling molecules shaping physiological cell functions and as detrimental end products of unbalanced redox reactions. The brain is particularly vulnerable to ROS-mediated toxicity, which may influence the onset and progression of neurodegenerative diseases.
Review
Oncology
Osama Hussein Bekhet, Mohamed Elsayed Eid
Summary: This study focused on the roles of reactive oxygen species (ROS) and antioxidants in cancer progression and therapy. Cancer is a diverse disease at the cellular level with different causes. High levels of ROS have protumorigenic activities, while antioxidants play a role in maintaining cellular redox balance.
TRANSLATIONAL CANCER RESEARCH
(2021)
Review
Chemistry, Multidisciplinary
Chenyang Zhang, Xin Wang, Jiangfeng Du, Zhanjun Gu, Yuliang Zhao
Summary: ROS play a vital role in physiological and pathological processes, and research on regulating ROS for disease treatments has gained wide attention. Advances in nanotechnology have led to the development of numerous nanomaterials with the ability to regulate ROS, aiming to find new and effective ROS-related nanotherapeutic modalities. Despite significant progress in ROS-based nanomedicines, there is a need to address fundamental principles for designing ROS-associated nanomedicines to minimize gaps in biomedical applications. This review summarizes current progress in ROS-associated nanomedicines in disease treatments and presents key principles for their design. Future perspectives in the development of ROS-associated nanomedicines are also discussed.
Review
Chemistry, Inorganic & Nuclear
Nahyun Kwon, Dayeh Kim, K. M. K. Swamy, Juyoung Yoon
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play crucial roles in human life, but overproduction can lead to cell damage and diseases. Researchers have developed fluorescent and luminescent probes based on metal-coordinated systems to detect and image these active species, providing valuable tools for studying their roles in signaling and pathology.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Biotechnology & Applied Microbiology
Jiaxue Liu, Boyan Jia, Zhibo Li, Wenliang Li
Summary: Applying reactive polymer materials sensitive to biological stimuli has attracted extensive research interest. The application of reactive oxygen species (ROS)-responsive polymers as drug-delivery systems in organisms has received much attention due to the special physiological effects of ROS on tumors or inflammation. The research progress of ROS-responsive polymers and their application in recent years were summarized and analyzed in this paper. From the perspective of nanoparticle drug delivery systems, multi-responsive delivery systems, and ROS-responsive hydrogels, the future development trends in this field were discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Immunology
Juan Li, Yu Liang, Xiaochen Zhao, Chihua Wu
Summary: In this study, a reliable ROS signature (ROSig) model was developed to assess ROS levels in TNBC patients, and the heterogeneity of different ROSig levels was successfully resolved. Furthermore, ROSig was found to be a good predictor of risk for TNBC and was associated with factors such as cell replication activity, tumor heterogeneity, and the immune suppressive microenvironment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Shivkanya Fuloria, Vetriselvan Subramaniyan, Sundram Karupiah, Usha Kumari, Kathiresan Sathasivam, Dhanalekshmi Unnikrishnan Meenakshi, Yuan Seng Wu, Mahendran Sekar, Nitin Chitranshi, Rishabha Malviya, Kalvatala Sudhakar, Sakshi Bajaj, Neeraj Kumar Fuloria
Summary: Evidence suggests that reactive oxygen species (ROS) play complex roles in cancer, with both beneficial and harmful effects, depending on concentration. Further research is needed to understand the relationship between ROS, antioxidants, and cancer, and to develop more accurate methods for ROS detection.
Article
Medicine, Research & Experimental
Fabiola Lili Sarmiento-Salinas, Andrea Perez-Gonzalez, Adilene Acosta-Casique, Adrian Ix-Ballote, Alfonso Diaz, Samuel Trevino, Nora Hilda Rosas-Murrieta, Lourdes Millan-Perez-Pena, Paola Maycotte
Summary: Cancer is a major global cause of death, with the role of reactive oxygen species (ROS) in cancer development and progression being extensively studied. However, conflicting evidence exists regarding the specific impact of ROS on cancer, which may vary depending on the type of cancer and stage of tumorigenesis. Recent research has focused on exploring the diverse aspects of ROS interaction with cancer at different stages of cancer progression.
Article
Biotechnology & Applied Microbiology
Changcheng Wang, Jia Guo, Zeng'An Wu
Summary: Traditional Chinese medicine Curcuma zedoary, specifically Curdione, combined with docetaxel (DTX) may enhance the chemotherapeutic efficacy on triple negative breast cancer cells by inducing ROS-mediated cell apoptosis through MAPKs and PI3K/Akt signaling pathways. This combination therapy shows potential as a therapeutic strategy for TNBC.
Article
Biochemistry & Molecular Biology
Sukhdeep Kumar, Tapan K. Mukherjee, Purnananda Guptasarma
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2016)
Review
Oncology
Dharambir Kashyap, Rajkumar Mondal, Hardeep Singh Tuli, Gaurav Kumar, Anil K. Sharma
Article
Biotechnology & Applied Microbiology
Shadab Alam, Jiban Jyoti Panda, Tapan Kumar Mukherjee, Virander Singh Chauhan
JOURNAL OF NANOBIOTECHNOLOGY
(2016)
Review
Medicine, Research & Experimental
Dharambir Kashyap, Gaurav Kumar, Ajay Sharma, Katrin Sak, Hardeep Singh Tuli, Tapan K. Mukherjee
Review
Food Science & Technology
Dharambir Kashyap, Ajay Sharma, Hardeep Singh Tuli, Katrin Sak, Sandeep Punia, Tapan K. Mukherjee
JOURNAL OF FUNCTIONAL FOODS
(2017)
Review
Oncology
Rohit Sharma, Rohini Sharma, Tejinder Pal Khaket, Chanchala Dutta, Bornisha Chakraborty, Tapan Kumar Mukherjee
Review
Oncology
Dharambir Kashyap, Ajay Sharma, Hardeep Singh Tuli, Katrin Sak, Tapan Mukherjee, Anupam Bishayee
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Meenu Narwal, Deepak Kumar, Tapan Kumar Mukherjee, Rajasri Bhattacharyya, Dibyajyoti Banerjee
MOLECULAR BIOLOGY REPORTS
(2018)
Review
Pharmacology & Pharmacy
Tejinder Pal Khaket, Sun Chul Kang, Tapan Kumar Mukherjee
CURRENT DRUG TARGETS
(2019)
Review
Pharmacology & Pharmacy
Parth Malik, Tapan K. Mukherjee
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2018)
Article
Chemistry, Physical
Parth Malik, Gajender Kumar Inwati, Tapan Kumar Mukherjee, Sunita Singh, Man Singh
JOURNAL OF MOLECULAR LIQUIDS
(2019)
Article
Chemistry, Multidisciplinary
Parth Malik, Shrikant S. Maktedar, Gopal Avashthi, Tapan K. Mukherjee, Man Singh
ARABIAN JOURNAL OF CHEMISTRY
(2020)
Review
Respiratory System
Parth Malik, John R. Hoidal, Tapan Kumar Mukherjee
Summary: COPD is a slowly progressive and irreversible airway obstruction disease caused by factors such as genetic susceptibility, environmental factors, and tobacco exposure. Current treatments, including anti-inflammatory drugs, are not able to completely halt disease progression and mortality. RAGE and its polymorphic variants play a significant role in COPD complications, suggesting a potential avenue for therapeutic intervention.
COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Article
Mathematical & Computational Biology
Sachin Nagra, Deepak Kumar, Rajasri Bhattacharyya, Dibyajyoti Banerjee, Tapan Mukherjee