Review
Emergency Medicine
Nathan Balzer, Shelley L. McLeod, Chris Walsh, Keerat Grewal
Summary: Low-dose ketamine (LDK) and morphine showed similar analgesic effectiveness within the first 60 minutes of administration in emergency department for acute pain management, and had comparable safety profiles.
ACADEMIC EMERGENCY MEDICINE
(2021)
Article
Neurosciences
Ming Zhang, Ziyan Yang, Jiahui Zhong, Yuqi Zhang, Xiaomin Lin, Huajian Cai, Yazhuo Kong
Summary: Nostalgia, as a positive emotion, has an analgesic effect and may modulate brain activity to reduce pain perception.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Kazuyoshi Hirota, David G. Lambert
Summary: Ketamine, in addition to its use as an anesthetic, has various beneficial effects such as analgesia, anti-inflammatory, anti-tumor, and even anti-depressive actions.
Article
Medicine, General & Internal
Zijian Zhao, Qiqi Xu, Yao Chen, Chen Liu, Fangfang Zhang, Yuan Han, Junli Cao
Summary: Intraoperative low-dose ketamine infusion did not improve the overall quality of recovery on postoperative day 1 in breast cancer patients, but may increase pain levels.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Anesthesiology
Maria Zamfir, Behrang Sharif, Samantha Locke, Aliza T. Ehrlich, Nicole E. Ochandarena, Gregory Scherrer, Alfredo Ribeiro-da-Silva, Brigitte L. Kieffer, Philippe Seguela
Summary: The anterior cingulate cortex (ACC) processes the affective component of pain, whereas the primary somatosensory cortex (S1) is involved in its sensory-discriminative component. Injection of morphine in the ACC has been reported to be analgesic, and endogenous opioids in this area are required for pain relief.
Article
Multidisciplinary Sciences
Dominique Abrahams, Arig Ibrahim-Hashim, Robert S. Ackerman, Joel S. Brown, Christopher J. Whelan, Megan B. Garfinkel, Robert A. Gatenby, Aaron R. Muncey
Summary: The study suggests that isoflurane and ketamine may promote lung tumor growth and metastasis through suppression of immune function, specifically decreased T lymphocytes and monocytes.
Article
Medicine, General & Internal
Nadir Sharawi, Matthew Williams, Waseem Athar, Caroline Martinello, Kyle Stoner, Cameron Taylor, Nan Guo, Pervez Sultan, Jill M. Mhyre
Summary: This study aimed to compare the anesthesia effect of dural-puncture epidural (DPE) and standard epidural in cesarean delivery. The results showed that DPE technique resulted in a faster onset and better quality of anesthesia compared to the standard epidural technique. Therefore, in scheduled cesarean delivery, the DPE technique can provide better anesthesia effect.
Review
Pharmacology & Pharmacy
Krzysztof Nosek, Wojciech Leppert, Lukasz Puchala, Krzysztof Lon
Summary: Topical morphine may be effective in treating ulcers, erosions of inflammatory etiology, and painful skin lesions including post-mastectomy pain. However, its recommended use in everyday medical practice is limited.
Article
Emergency Medicine
Daniel Dove, Catsim Fassassi, Ashley Davis, Jefferson Drapkin, Mahlaqa Butt, Rukhsana Hossain, Sarah Kabariti, Antonios Likourezos, Ankit Gohel, Patrizia Favale, Michael Silver, John Marshall, Sergey Motov
Summary: This study compared the analgesic efficacies and adverse effects of three different doses of ketamine administered through a breath-actuated nebulizer for emergency department patients. The results showed no significant difference in pain relief among the three doses for short-term treatment of moderate to severe pain in the emergency department.
ANNALS OF EMERGENCY MEDICINE
(2021)
Article
Emergency Medicine
Louis Gerges, Catsim Fassassi, Carla Barberan, Sophia Correa Bravo, Ashley Davis, Jefferson Drapkin, Antonios Likourezos, Michael Silver, Rukhsana Hossain, Patrizia Niceforo, Ankit Gohel, Sergey Motov
Summary: This study aims to compare the analgesic effect of orally administered aspirin and ketamine combination versus ketamine alone in adult patients with acute musculoskeletal pain in the emergency department. The results show that the combination of aspirin and ketamine provides less analgesia compared to ketamine alone.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Karolina Fraczek, Agnieszka Kowalczyk, Martyna Pekala, Kaja Kasarello, Grazyna Sygitowicz, Dorota Sulejczak, Malgorzata Zaremba, Marek Konop, Malgorzata Frankowska, Malgorzata Filip, Magdalena Bujalska-Zadrozny, Patrycja Kleczkowska
Summary: The study showed that in rats, disulfiram (DSF) can enhance the analgesic effect of morphine (MRF) and reduce MRF-induced tolerance and aggressive behavior, but at the same time can cause severe liver damage.
Article
Neurosciences
Mattias Savallampi, Anne M. S. Maallo, Sumaiya Shaikh, Francis McGlone, Frederique J. Bariguian-Revel, Hakan Olausson, Rebecca Boehme
Summary: Unmyelinated low-threshold mechanoreceptors (C-tactile, CT) in the human skin play a crucial role in transmitting hedonic aspects of touch. Our previous research demonstrated that CT-targeted brush stroking by a robot can reduce experimental mechanical pain. In order to enhance the ecological validity of the stimulation, we developed standardized human-human touch gestures for signaling attention and calming, where the attention gesture is perceived as neutral and the calming gesture is perceived as pleasant. The fMRI study conducted in this research showed that the calming touch gesture led to stronger activation in the periaqueductal gray matter and reduced pain compared to the tapping touch gesture.
Article
Emergency Medicine
F. Michelet, M. Smyth, R. Lall, H. Noordali, K. Starr, L. Berridge, J. Yeung, G. Fuller, S. Petrou, A. Walker, J. Mark, A. Canaway, K. Khan, G. D. Perkins
Summary: The PACKMAN study is the first UK clinical trial to evaluate the clinical and cost-effectiveness of ketamine and morphine for the treatment of acute severe pain following traumatic injury. The findings of this study will guide future clinical practice and provide insights into the effectiveness of ketamine as a prehospital analgesia.
SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE
(2023)
Article
Psychiatry
Jun Zhong, Huawang Wu, Fengchun Wu, Hongbo He, Zhaohua Zhang, Jiaxin Huang, Penghui Cao, Ni Fan
Summary: This study found that chronic ketamine users have reduced cortical thickness in multiple brain areas, especially in the prefrontal cortex. The dose, frequency, and duration of ketamine use were negatively correlated with cortical thickness in some brain areas. Chronic ketamine users also showed significantly poorer cognitive performance in working memory, visual learning, processing speed, and overall cognition, but there was no correlation between reduced cortical thickness and decreased cognitive performance.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Critical Care Medicine
Andrew J. Casamento, Ary Serpa Neto, Marcus Young, Mervin Lawrence, Christina Taplin, Glenn M. Eastwood, Angajendra Ghosh, Rinaldo Bellomo
Summary: The study compared the effects of fentanyl and morphine on ventilated patients and found that fentanyl infusion significantly increased ventilator-free days at Day 28 compared to morphine. ICU-free days were also greater and length of ICU stay shorter in the fentanyl group. Further investigation is needed to understand the clinical implications of choosing between different opioid infusion agents.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Neurosciences
Machiko Matsumoto, Hiroki Shikanai, Hiroko Togashi, Takeshi Izumi, Takeya Kitta, Riki Hirata, Taku Yamaguchi, Mitsuhiro Yoshioka
Article
Neurosciences
Hiroki Shikanai, Takayuki Yoshida, Kohtarou Konno, Miwako Yamasaki, Takeshi Izumi, Yu Ohmura, Masahiko Watanabe, Mitsuhiro Yoshioka
JOURNAL OF NEUROSCIENCE
(2012)
Article
Pharmacology & Pharmacy
Hiroki Shikanai, Takeshi Izumi, Machiko Matsumoto, Hiroko Togashi, Taku Yamaguchi, Takayuki Yoshida, Mitsuhiro Yoshioka
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2010)
Article
Pharmacology & Pharmacy
Sumitaka Inoue, Hiroki Shikanai, Machiko Matsumoto, Sachiko Hiraide, Yasuhiro Saito, Yoshiki Yanagawa, Mitsuhiro Yoshioka, Kei-ichi Shimamura, Hiroko Togashi
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2014)
Article
Pharmacology & Pharmacy
Tsugumi Shindo, Hiroki Shikanai, Akane Watarai, Sachiko Hiraide, Kenji Iizuka, Takeshi Izumi
Summary: This study found that the dysfunction of D-serine metabolism associated with AD/HD leads to NMDA receptor dysfunction. Inhibiting DAAO enzyme can increase D-serine levels and improve AD/HD-like behaviors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Hiroki Shikanai, Kazuko Ikimura, Momoko Miura, Tsugumi Shindo, Akane Watarai, Takeshi Izumi
Summary: D-serine functions as an endogenous allosteric agonist of N-methyl-D-aspartate (NMDA) receptor in the mammalian brain. This study presents a detailed description of a method using conventional high performance liquid chromatography (HPLC) to measure D-/L-serine. The method involves the reaction of D-serine and L-serine with ortho-phthalaldehyde (OPA) and N-acetyl-L-cysteine (NAC) to form diastereomeric isoindole derivatives, followed by separation and detection using conventional reversed phase HPLC with electrochemical detector (ECD). The measurement data obtained from rat brain homogenate serves as an example of a convenient and suitable method for determining brain concentrations of D-serine. Confirmation of the originating peaks from serine is achieved by decomposing D-serine using D-amino oxidase and catalase, resulting in the disappearance of one peak.
Article
Pharmacology & Pharmacy
Hiroki Shikanai, Shinichi Kimura, Hiroko Togashi
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2013)