Article
Multidisciplinary Sciences
Luis Rios, Suman Pokhrel, Sin-Jin Li, Gwangbeom Heo, Bereketeab Haileselassie, Daria Mochly-Rosen
Summary: The researchers have identified a small molecule that can mimic the effects of a peptide inhibitor and reduce the burden of protein-related diseases. This study is important for understanding and potentially treating various pathologies associated with protein dysregulation.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Yvette C. Wong, Soojin Kim, Jasmine Cisneros, Catherine G. Molakal, Pingping Song, Steven J. Lubbe, Dimitri Krainc
Summary: This study reveals that inter-lysosomal untethering events are driven by mitochondria-lysosome contact sites, which are regulated by a Mid51/Fis1 oligomerization complex. The complex mediates the hydrolysis of Rab7 GTP, leading to reorganization of the lysosomal network. These findings have significant implications for understanding cellular homeostasis and human diseases.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Paola Lenzi, Francesca Biagioni, Carla L. Busceti, Gloria Lazzeri, Maico Polzella, Alessandro Frati, Michela Ferrucci, Francesco Fornai
Summary: Recent evidence suggests that methamphetamine (METH) causes mitochondrial alterations, leading to neurotoxicity. However, most studies have focused on mitochondrial activity rather than morphology. In this study, researchers used light and transmission electron microscopy to analyze dose-dependent mitochondrial structural changes during METH exposure. The findings indicate that METH-induced neurodegeneration is closely associated with specific mitochondrial damage, and a scoring system for mitochondrial integrity was established. Furthermore, the study revealed changes in mitochondrial proteins related to fission/mitophagy and mitochondrial dynamics. These results provide structural evidence that mitochondria are direct and indirect targets of METH-induced toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Paola Lenzi, Carla L. L. Busceti, Gloria Lazzeri, Rosangela Ferese, Francesca Biagioni, Alessandra Salvetti, Elena Pompili, Valerio De Franchis, Stefano Puglisi-Allegra, Alessandro Frati, Michela Ferrucci, Francesco Fornai
Summary: Cells from glioblastoma multiforme (GBM) show increased levels of the mechanistic Target of Rapamycin (mTOR), which adversely affects malignancy and disease progression. The up-regulation of mTOR inhibits autophagy, which is important for the neurobiology of GBM. This study investigates the relationship between abnormal levels of cellular prion protein (PrPc), mitochondrial alterations, and mTOR inhibition in GBM cells.
Article
Biochemistry & Molecular Biology
Yan Yu, Xiao-Dan Peng, Xiao-Jun Qian, Kai-Ming Zhang, Xiang Huang, Yu-Hong Chen, Yun-Tian Li, Gong-Kan Feng, Hai-Liang Zhang, Xue-Lian Xu, Shun Li, Xuan Li, Jia Mai, Zhi-Ling Li, Yun Huang, Dong Yang, Li-Huan Zhou, Zhuo-Yan Zhong, Jun-Dong Li, Rong Deng, Xiao-Feng Zhu
Summary: MET receptor tyrosine kinase plays a critical role in tumor growth by regulating mitochondrial activities to promote cancer metastasis. The study revealed a direct phosphorylation of outer mitochondrial membrane protein Fis1 by MET, which facilitated mitochondrial fission and cell migration in hepatocellular carcinoma. This novel pathway provides a potential therapeutic target for metastatic HCC.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Neurosciences
Wenjia Shi, Cheng Tan, Can Liu, Dan Chen
Summary: This review highlights the importance of mitochondrial dynamics in neurodegenerative diseases, particularly abnormal mitochondrial divisions under pathological conditions. It provides a detailed description of the relationship between mitochondrial dynamics and neurodegenerative diseases, and summarizes the detection indicators in basic experiments, aiming to provide references for further mechanism exploration and therapeutic targets.
REVIEWS IN THE NEUROSCIENCES
(2023)
Article
Multidisciplinary Sciences
Lisa Tilokani, Fiona M. Russell, Stevie Hamilton, Daniel M. Virga, Mayuko Segawa, Vincent Paupe, Anja V. Gruszczyk, Margherita Protasoni, Luis -Carlos Tabara, Mark Johnson, Hanish Anand, Michael P. Murphy, D. Grahame Hardie, Franck Polleux, Julien Prudent
Summary: This study identifies MTFR1L as a critical mitochondrial protein that transduces AMPK-dependent metabolic changes through regulation of mitochondrial dynamics. The phosphorylation of MTFR1L by AMPK controls its function in regulating mitochondrial morphology and stress-induced AMPK-dependent mitochondrial fragmentation.
Article
Cell Biology
Philipp Portz, Michael K. Lee
Summary: The study found that pathological changes in alpha-synuclein (α S) in a mouse model were associated with decreased localization and activity of Drp1 in mitochondria, leading to enlarged neuronal mitochondria. These findings suggest that altered mitochondrial dynamics play a significant neuropathological role in alpha-synucleinopathies.
Article
Biochemistry & Molecular Biology
Bojjibabu Chidipi, Mariana Burgos Angulo, Syed Islamuddin Shah, Michelle Rieser, Ganim Ullah, Thomas McDonald, Sami F. Noujaim
Summary: Friedreich ataxia is a congenital neurodegenerative disease caused by a deficiency in the frataxin protein, leading to left ventricular hypertrophic cardiomyopathy. However, the mitochondrial anatomy in Friedreich ataxia hypertrophic cardiomyopathy is poorly understood. In this study, we investigated mitochondrial fission, fusion, and function in cardiomyocytes derived from a patient with Friedreich ataxia hypertrophic cardiomyopathy and a healthy individual. Our results showed a decrease in mitochondrial fission, an increase in reactive oxygen species, and a decrease in mitochondrial membrane potential in Friedreich ataxia cardiomyocytes.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jennifer Lising Roxas, Shylaja Ramamurthy, Katie Cocchi, Ilga Rutins, Anusha Harishankar, Al Agellon, John Scott Wilbur, Gresa Sylejmani, Gayatri Vedantam, V. K. Viswanathan
Summary: Bacterial pathogens manipulate host cell structures and functions, contributing to disease symptoms. Enteropathogenic Escherichia coli (EPEC) secretes proteins that alter host cell behavior. Two secreted proteins, EspZ and EspH, have contrasting effects on host mitochondria. EspZ interacts with FIS1 and protects the host mitochondrial network, enhancing host cell viability. In contrast, EspH increases FIS1 and leads to significant mitochondrial fragmentation and host cell death, facilitating pathogen dispersal.
Article
Cell Biology
Kai Cao, Joel S. Riley, Rosalie Heilig, Alfredo E. Montes-Gomez, Esmee Vringer, Kevin Berthenet, Catherine Cloix, Yassmin Elmasry, David G. Spiller, Gabriel Ichim, Kirsteen J. Campbell, Andrew P. Gilmore, Stephen W. G. Tait
Summary: This study reveals that mitochondrial dysfunction can promote cancer through the regulation of mitochondrial dynamics and caspase-dependent DNA damage, deepening our understanding of the association between mitochondria and cancer.
DEVELOPMENTAL CELL
(2022)
Review
Biochemistry & Molecular Biology
Shuheng Wen, Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, Koichi Uemura
Summary: This review discusses the neurotoxic effects of cocaine and the role of mitochondrial dynamics in cellular physiology. It highlights how cocaine can disrupt neuronal mitochondrial dynamics and impair cellular function. Understanding and studying the relationship between mitochondrial dynamics and cocaine exposure is crucial for exploring the mechanisms of cocaine neurotoxicity and potential therapeutic interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Shuheng Wen, Kana Unuma, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura
Summary: Long-term cocaine abuse is associated with cardiovascular and pulmonary vascular complications. The vascular toxicity of cocaine can lead to vascular remodeling characterized by excessive proliferation of vascular smooth muscle cells. In this study, the effect of cocaine on the proliferation of vascular smooth muscle cells was explored, and it was found that the cocaine-induced vascular smooth muscle cell hyperproliferation is achieved by enhancing DRP1-mediated mitochondrial fission and activating PI3K/HIF-1a signaling.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Cell Biology
Christina G. Towers, Darya K. Wodetzki, Jacqueline Thorburn, Katharine R. Smith, M. Cecilia Caino, Andrew Thorburn
Summary: This study investigated alternative forms of mitochondrial quality control beyond mitophagy to compensate for inactive autophagy. Rare surviving autophagy-deficient clones were found to adapt to maintain mitochondrial homeostasis through regulating mitochondrial dynamics and mitochondrial-derived vesicles. The research indicates unique dependencies of autophagy-dependent cells on these mechanisms to maintain mitochondrial health.
DEVELOPMENTAL CELL
(2021)
Article
Biochemistry & Molecular Biology
William T. King, Christopher L. Axelrod, Elizabeth R. M. Zunica, Robert C. Noland, Gangarao Davuluri, Hisashi Fujioka, Bernard Tandler, Kathryn Pergola, Gerlinda E. Hermann, Richard C. Rogers, Sandra Lopez-Domenech, Wagner S. Dantas, Krisztian Stadler, Charles L. Hoppel, John P. Kirwan
Summary: The study reveals that DRP1 regulates substrate oxidation by altering whole-cell and mitochondrial calcium dynamics.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Margarita C. Dinamarca, Monica Di Luca, Juan A. Godoy, Nibaldo C. Inestrosa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Clinical Neurology
Nibaldo C. Inestrosa, Juvenal A. Rios, Pedro Cisternas, Cheril Tapia-Rojas, Daniela S. Rivera, Nady Braidy, Juan M. Zolezzi, Juan A. Godoy, Francisco J. Carvajal, Alvaro O. Ardiles, Francisco Bozinovic, Adrian G. Palacios, Perminder S. Sachdev
Article
Neurosciences
Jorge s Parodi, Carla Montecinos-Oliva, Rodrigo Varas, Ivan E. Alfaro, Felipe G. Serrano, Manuel Varas-Godoy, Francisco J. Munoz, Waldo Cerpa, Juan A. Godoy, Nibaldo C. Inestrosa
MOLECULAR AND CELLULAR NEUROSCIENCE
(2015)
Article
Neurosciences
Juan F. Codocedo, Juvenal A. Rios, Juan A. Godoy, Nibaldo C. Inestrosa
MOLECULAR NEUROBIOLOGY
(2016)
Article
Neurosciences
Biuse Guivernau, Jaume Bonet, Victoria Valls-Comamala, Monica Bosch-Morato, Juan A. Godoy, Nibaldo C. Inestrosa, Alex Peralvarez-Marin, Xavier Fernandez-Busquets, David Andreu, Baldomero Oliva, Francisco J. Munoz
JOURNAL OF NEUROSCIENCE
(2016)
Article
Neurosciences
Juan A. Godoy, Carolina B. Lindsay, Rodrigo A. Quintanilla, Francisco J. Carvajal, Waldo Cerpa, Nibaldo C. Inestrosa
MOLECULAR NEUROBIOLOGY
(2017)
Article
Cell Biology
Juvenal A. Rios, Juan A. Godoy, Nibaldo C. Inestrosa
CELL COMMUNICATION AND SIGNALING
(2018)
Article
Neurosciences
Juan A. Godoy, Angel G. Valdivieso, Nibaldo C. Inestrosa
MOLECULAR NEUROBIOLOGY
(2018)
Article
Neurosciences
Matias Lira, Duxan Arancibia, Patricio R. Orrego, Carolina Montenegro-Venegas, Yocelin Cruz, Jonathan Garcia, Sergio Leal-Ortiz, Juan A. Godoy, Eckart D. Gundelfinger, Nibaldo C. Inestrosa, Craig C. Garner, Pedro Zamorano, Viviana I. Torres
MOLECULAR NEUROBIOLOGY
(2019)
Review
Pharmacology & Pharmacy
Viviana I. Torres, Juan A. Godoy, Nibaldo C. Inestrosa
PHARMACOLOGY & THERAPEUTICS
(2019)
Article
Neurosciences
Evelyn Pardo, Francisca Barake, Juan A. Godoy, Claudia Oyanadel, Sofia Espinoza, Claudia Metz, Claudio Retamal, Loreto Massardo, Cheril Tapia-Rojas, Nibaldo C. Inestrosa, Andrea Soza, Alfonso Gonzalez
MOLECULAR NEUROBIOLOGY
(2019)
Article
Cell Biology
Duxan Arancibia, Matias Lira, Yocelin Cruz, Daniela P. Barrera, Carolina Montenegro-Venegas, Juan A. Godoy, Craig C. Garner, Nibaldo C. Inestrosa, Eckart D. Gundelfinger, Pedro Zamorano, Viviana Torres
Review
Biology
Juan M. Zolezzi, Manuel J. Santos, Sussy Bastias-Candia, Claudio Pinto, Juan A. Godoy, Nibaldo C. Inestrosa
BIOLOGICAL REVIEWS
(2017)
Article
Biochemistry & Molecular Biology
Juan A. Godoy, Juan M. Zolezzi, Nibaldo C. Inestrosa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Medicine, General & Internal
Juan A. Godoy, Carola L. Rios, Pia A. Venegas, Carolina R. Lopez, Jose Luis Alvarez, Tomas P. Labb, Camila M. Ramirez, Juvenal A. Rios
REVISTA MEDICA DE CHILE
(2020)