Article
Biochemistry & Molecular Biology
Kosar Hooshmand, Glenda M. Halliday, Sandy S. Pineda, Greg T. Sutherland, Boris Guennewig
Summary: Genetic factors and pathological mechanisms play crucial roles in the early detection and treatment of neurodegenerative disorders. This study discovered that there is little overlap between AD and PD, with AD mainly characterized by changes related to nervous system development in the brain, and PD involving abnormalities in exocytosis and genes related to the SNARE complex. These findings contribute to a better understanding of the specific pathomechanisms of these two diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Cato Romero, Josefin Werme, Philip R. Jansen, Joel Gelernter, Murray B. Stein, Daniel Levey, Renato Polimanti, Christiaan de Leeuw, Danielle Posthuma, Mats Nagel, Sophie Van der Sluis
Summary: The comorbidity among psychiatric disorders is supported by genetic correlations, but finding shared biological mechanisms remains challenging due to variation in power and genetic architecture between disorders.
Article
Geriatrics & Gerontology
Douglas P. Wightman, Jeanne E. Savage, Elleke Tissink, Cato Romero, Iris E. Jansen, Danielle Posthuma
Summary: Neurodegenerative diseases are a group of disorders characterized by neuronal cell death, causing various physical and mental problems. This study identified genetic overlap between three or more neurodegenerative disorders, including shared genetic loci, important genes, and tissues. These findings are important for understanding and treating neurodegenerative diseases.
NEUROBIOLOGY OF AGING
(2023)
Article
Neurosciences
Jennifer Monereo-Sanchez, Miranda T. Schram, Oleksandr Frei, Kevin O'Connell, Alexey A. Shadrin, Olav B. Smeland, Lars T. Westlye, Ole A. Andreassen, Tobias Kaufmann, David E. J. Linden, Dennis van der Meer
Summary: This study identified substantial genetic overlap, with mixed directions of effects, between Alzheimer's disease and depression. The use of biostatistical tools provided valuable insight into the genetic architectures of these disorders, highlighting the complexity of their underlying pathophysiology.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Montse Guardiola, Gerard Muntane, Iris Martinez, Lourdes Martorell, Josefa Girona, Daiana Ibarretxe, Nuria Plana, Maria J. Bullido, Elisabet Vilella, Josep Ribalta
Summary: This study identified three variants in PVRL2 that predispose individuals to Alzheimer's disease (AD) while also influencing the lipid profile, increasing cardiovascular risk in patients with type 2 diabetes mellitus (T2DM).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Parasitology
Sukanya Narasimhan, Andrea Swei, Selma Abouneameh, Utpal Pal, Joao H. F. Pedra, Erol Fikrig
Summary: Ixodes scapularis and Ixodes pacificus are the main vectors of various human pathogens, including Borrelia burgdorferi. Despite advances in sequencing technologies, understanding of the tick microbiome is limited by technical difficulties and biological variables. Researchers are working to overcome these challenges and explore the significance of the tick microbiome in tick biology.
TRENDS IN PARASITOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alessio Martucci, Francesca Di Giuliano, Silvia Minosse, Giulio Pocobelli, Carlo Nucci, Francesco Garaci
Summary: This article summarizes the current research status of the use of advanced neuroimaging techniques in glaucoma and Alzheimer's disease, and explores the shared biomarkers between the two diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Robert J. van der Linden, Lianne M. Reus, Ward De Witte, Betty M. Tijms, Marcel Olde Rikkert, Pieter Jelle Visser, Geert Poelmans
Summary: The study revealed genetic sharing between late-onset Alzheimer's disease (AD) and the blood levels of 31 lipid metabolites, with a positive genetic concordance found for 16 of these metabolites. This suggests that genetic risk factors for AD may influence lipid levels, which could be utilized to develop novel treatment strategies for AD.
NEUROBIOLOGY OF AGING
(2021)
Review
Multidisciplinary Sciences
Gustavo G. Nascimento, Fabio R. M. Leite, Caio Melo Mesquita, Maria Tereza Campos Vidigal, Guilherme Henrique Borges, Luiz Renato Paranhos
Summary: This study systematically reviewed the association between periodontitis and Alzheimer's disease (AD) and assessed the impact of confounding factors on this association. The study found a positive relationship between periodontitis and AD, but highlighted the importance of considering confounding factors.
Article
Immunology
Xiaolei Shi, Tao Wei, Yachun Hu, Meng Wang, Yi Tang
Summary: This study found a suggestive association between plasma sTrem1 and AD, indicating that sTrem1 may play a vital role in the causal pathway of this disease. Additionally, higher plasma sTrem1 was associated with an increased risk of epilepsy.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Cell Biology
Taha Alqahtani, Sharada L. Deore, Anjali A. Kide, Bhavana A. Shende, Ritika Sharma, Rita Dadarao Chakole, Lalita S. Nemade, Nikita Kishor Kale, Sudarshana Borah, Savita Shrikant Deokar, Ashok Behera, Divya Dhawal Bhandari, Nikita Gaikwad, Abul Kalam Azad, Arabinda Ghosh
Summary: Misfolded proteins in the central nervous system can induce oxidative damage, impacting mitochondrial function and leading to neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's and Amyotrophic Lateral Sclerosis. Mitochondrial dynamics play a crucial role in cellular apoptosis and are affected by these diseases. The dysfunction of mitochondria contributes to the selective neurodegeneration seen in these disorders. Novel techniques are being explored to treat mitochondrial malfunction and oxidative stress in these neurodegenerative diseases.
Article
Environmental Sciences
Weeberb J. Requia, Ana Maria Vicedo-Cabrera, Evan de Schrijver, Heresh Amini, Antonio Gasparrini
Summary: Further research on the impact of temperature on health in Brazil is needed. This study examines the relationship between high ambient temperature and hospital admissions for circulatory and respiratory diseases in Brazilian municipalities. The findings indicate that respiratory diseases are more strongly associated with high temperature.
ENVIRONMENTAL POLLUTION
(2023)
Review
Immunology
Ana Marquez, Javier Martin
Summary: Type 1 diabetes (T1D) is a chronic disease caused by the destruction of pancreatic beta cells by autoreactive T lymphocytes. Genetic studies have identified common susceptibility loci between T1D and other autoimmune diseases, which can help in the development of new therapeutic approaches. Identifying common pathogenic mechanisms is crucial for understanding the shared genetic component and improving treatment strategies.
SEMINARS IN IMMUNOPATHOLOGY
(2022)
Review
Geriatrics & Gerontology
Jiaqi Zeng, Xinchan Wang, Fei Pan, Zhiqi Mao
Summary: An increasing number of studies suggest that Parkinson's disease may originate from the gut, with Lewy pathology being transported to the central nervous system via the vagal nerve, an imbalance in gut microbiota causing alterations in microbial metabolites, and activated inflammation affecting the CNS.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Geriatrics & Gerontology
Ranran Lu, Lijie Zhang, Xinling Yang
Summary: Autophagy is crucial for maintaining cellular homeostasis by degrading damaged organelles, misfolded proteins, and pathogens. Autophagy has a complex interaction with neuroinflammation. Strengthening autophagy can reduce neuroinflammation and protect neurons. Clearance of protein aggregates through autophagy activation can delay the progression of neurodegenerative diseases.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
