Article
Chemistry, Inorganic & Nuclear
Christophe Nguyen, Isabelle Toubia, Stephane Diring, Kamel Hadj-Kaddour, Magali Gary-Bobo, Marwan Kobeissi, Fabrice Odobel
Summary: The study demonstrates that the combination of a gold porphyrin and organotin complexes results in new compounds with enhanced anticancer activity against human breast cancer cells, showing significant cytotoxicity and selectivity towards cancer cells.
DALTON TRANSACTIONS
(2021)
Review
Chemistry, Multidisciplinary
Kun Li, Mei Lu, Xinhua Xia, Yuanyu Huang
Summary: Photothermal therapy (PTT) is a new treatment technique that has attracted worldwide attention in cancer treatment due to its excellent absorption ability, easy regulation, and biodegradability. The synergistic therapy of photothermal and RNA interfering (RNAi) has recently become a hot research topic, showing potential in enhancing the therapeutic effect against tumors.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Physical
Nurul'Ain Azman, Thanh Xuan Nguyen, James Chen Yong Kah
Summary: The study found that the conformational changes of HSA molecules around gold nanorods are influenced by surface ligands, with PDADMAC showing the largest impact. The involvement of neighboring HSA molecules in the simulation of corona formation makes the results more representative.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Biochemistry & Molecular Biology
Tatyana V. Popova, Inna A. Pyshnaya, Olga D. Zakharova, Andrey E. Akulov, Oleg B. Shevelev, Julia Poletaeva, Evgenii L. Zavjalov, Vladimir N. Silnikov, Elena I. Ryabchikova, Tatyana S. Godovikova
Summary: This study demonstrates the development of a theranostic system by conjugating anticancer nucleotides or boron-neutron capture therapy drugs to human serum albumin and reacting with gold nanoparticles. Despite a long circulation time, the accumulation of the therapeutic conjugates in the tumor was not significant.
Article
Pharmacology & Pharmacy
Karen Bolanos, Macarena Sanchez-Navarro, Andreas Tapia-Arellano, Ernest Giralt, Marcelo J. Kogan, Eyleen Araya
Summary: Gold nanoparticles functionalized with albumin and the r(8) peptide show potential as biomedical tools, enhancing cell penetration and internalization. The coating of nanoparticles with BSA-r(8) improves their internalization into cells, with low impact on cell viability. This novel nanoconstruct presents a promising approach for optimizing drug delivery and biomedical applications.
Article
Chemistry, Multidisciplinary
Evgeniya D. Novikova, Yuri A. Vorotnikov, Nazar A. Nikolaev, Alphiya R. Tsygankova, Michael A. Shestopalov, Olga A. Efremova
Summary: Photodynamic and photothermal therapies are promising candidates for multimodal anticancer therapies, and combining octahedral molybdenum clusters with plasmonic spherical gold nanoparticles can enhance their photophysical properties synergistically. By careful selection of spacing between the cluster and the gold nanoparticle, significant improvements in luminescence and photosensitizing properties of the cluster were achieved compared to similar gold-free particles. The cluster complex also facilitated energy conversion to heat by gold particles, increasing the heating rate under laser irradiation.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Biophysics
Xing Huang, Zhao-Huan Zhang, Jie Chen, Zhihui Mao, Han Zhu, Yawen Liu, Zhongzheng Zhu, Hongxia Chen
Summary: A highly specific surface plasmon resonance biosensor was designed for the detection of PD-L1 using magneto-optical nanocomplexes, which provided dual selective recognition of PD-L1 and showed good linear range for PD-L1 detection. The practical performance of this immunosensing platform was successfully verified by clinical samples, offering a new strategy for point-of-care detection of PD-L1.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Inorganic & Nuclear
Mickael Marloye, Haider Inam, Connor J. Moore, Tyler R. Mertens, Aude Ingels, Marilin Koch, Michal O. Nowicki, Veronique Mathieu, Justin R. Pritchard, Samuel G. Awuah, Sean E. Lawler, Franck Meyer, Francois Dufrasne, Gilles Berger
Summary: We disclose novel amphiphilic ruthenium and osmium complexes that self-assemble into nanomedicines with potent antiproliferative activity by inhibiting mitochondrial respiration. These complexes show high cellular activity, nano-assembling and mitochondrial targeting due to the appended C-16 fatty chain. They block cell proliferation in the sub-micromolar range and are particularly effective against glioblastoma neurospheres made from patient-derived cancer stem cells. In an in vivo mouse model, one of our C-16 Os-II nanomedicines showed high success. Mechanistically, they act as metabolic poisons, strongly impairing mitochondrial respiration, and potentially involving microtubules in cell death induction.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Jiahui Dai, Chao Chen, Man Yin, Huixing Li, Wenbo Li, Zhaowei Zhang, Qian Wang, Zhongyu Du, Xiangyu Xu, Yunfei Wang
Summary: Three different shapes of gold nanoparticles were synthesized and studied for their interactions with human serum albumin (HSA). The results showed that the three types of gold nanoparticles have different binding abilities and abilities to induce conformational changes in HSA.
FRONTIERS IN CHEMISTRY
(2023)
Article
Engineering, Biomedical
Xiang Liu, Qi Su, Huijuan Song, Xiaoguang Shi, Yuming Zhang, Chuangnian Zhang, Pingsheng Huang, Anjie Dong, Deling Kong, Weiwei Wang
Summary: The study demonstrates that PTT-induced in situ vaccination cancer therapy can effectively combat disseminated and metastatic tumors, showing promising anti-tumor immunity in mice. The use of gold nanorods covalently coupled with polyTLR7/8a and MMP-2-sensitive R9-PEG resulted in the formation of nanovaccines directly in vivo, activating dendritic cells and enhancing antitumor T-cell responses. Peritumoral administration of low-dose multifunctional AuNRs followed by noninvasive NIR laser irradiation inhibits local and distant metastatic tumors in mice, suggesting a potent therapeutic strategy for advanced cancers.
Article
Pharmacology & Pharmacy
Man Zhang, Jinti Lin, Jiakang Jin, Wei Yu, Yiying Qi, Huimin Tao
Summary: In this study, GNR multifunctional nanoplatforms were designed and synthesized to target autophagy in OS, improving treatment efficacy and inhibiting metastasis. This research provides a new approach to enhance clinical outcomes for OS.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mi Wang, Mo Zhang, Xiaoxiao Hu, Wenli Wang, Yao Zhang, Lina Zhang, Jing Wang
Summary: This study presents a lipid-functionalized gold nanorods-based mitochondrial targeting photothermal-chemotherapy all-in-one nanoplatform, which can effectively improve the therapeutic effects of cancer. The constructed nanoplatform achieves mitochondrial targeting, photothermal therapy, and dual drug loading, efficiently generating reactive oxygen species in mitochondria and exhibiting excellent anti-tumor efficacy. This promising strategy provides a feasible approach for organelle-targeted combination photothermal-chemotherapy to enhance therapeutic effects.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Nanoscience & Nanotechnology
Adedamola S. Arojojoye, Breyanna Walker, James C. Dawahare, Maame Abena O. Afrifa, Sean Parkin, Samuel G. Awuah
Summary: Optimizing the bioavailability of metal-derived chemotherapeutic agents is crucial for successful drug development. Nanoparticle delivery strategies can improve bioavailability, pharmacokinetics, efficacy, and minimize toxicity. Using biodegradable albumin nanoconstructs to deliver gold(III) complexes improved solubility, intracellular accumulation, and anticancer activity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Adedamola S. Arojojoye, Breyanna Walker, James C. Dawahare, Maame Abena O. Afrifa, Sean Parkin, Samuel G. Awuah
Summary: Optimizing the bioavailability of metal-derived chemotherapeutic agents is crucial for successful drug development. Nanoparticle delivery strategies can improve solubility and anticancer activity of metal drugs, with potential translational benefits in the clinic.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Lin Wang, Penghe Qiu, Tao Yang, Ningyun Zhou, Mengmeng Zhai, Yan Li, Yadong Zhou, Shengli Zou, Mingying Yang, Chuanbin Mao
Summary: Linear light-absorbing nanomaterials with 3D structured nanochains of plasmonic nanoparticles show enhanced optical broadening effect for efficient solar thermal power generation.
MATERIALS HORIZONS
(2021)
Article
Chemistry, Multidisciplinary
Laetitia Bardet, Herve Roussel, Stefano Saroglia, Masoud Akbari, David Munoz-Rojas, Carmen Jimenez, Aurore Denneulin, Daniel Bellet
Summary: The thermal instability of silver nanowires leads to increased electrical resistance in AgNW networks. Understanding the relationship between structural and electrical properties of AgNW networks is crucial for their integration as transparent electrodes in flexible optoelectronics. In situ X-ray diffraction measurements were used to study the crystallographic evolution of Ag-specific Bragg peaks during thermal ramping, revealing differences in thermal and structural transitions between bare and SnO2-coated AgNW networks.
Article
Chemistry, Multidisciplinary
Nathalia Cancino-Fuentes, Arnau Manasanch, Joana Covelo, Alex Suarez-Perez, Enrique Fernandez, Stratis Matsoukis, Christoph Guger, Xavi Illa, Anton Guimera-Brunet, Maria V. Sanchez-Vives
Summary: This study provides a comprehensive characterization of graphene-based solution-gated field-effect transistors (gSGFETs) for brain recordings, highlighting their potential clinical applications.
Article
Chemistry, Multidisciplinary
Sikandar Aftab, Hailiang Liu, Dhanasekaran Vikraman, Sajjad Hussain, Jungwon Kang, Abdullah A. Al-Kahtani
Summary: This study examines the effects of hybrid nanoparticles made of NiO@rGO and NiO@CNT on the active layers of polymer solar cells and X-ray photodetectors. The findings show that these hybrid nanoparticles can enhance the charge carrier capacities and exciton dissociation properties of the active layers. Among the tested configurations, the NiO@CNT device demonstrates superior performance in converting sunlight into electricity, and achieves the best sensitivity for X-ray detection.
Article
Chemistry, Multidisciplinary
Hyo Jung Shin, Seung Gyu Choi, Fengrui Qu, Min-Hee Yi, Choong-Hyun Lee, Sang Ryong Kim, Hyeong-Geug Kim, Jaewon Beom, Yoonyoung Yi, Do Kyung Kim, Eun-Hye Joe, Hee-Jung Song, Yonghyun Kim, Dong Woon Kim
Summary: This study investigates the role of SOX9 in reactive astrocytes following ischemic brain damage using a PLGA nanoparticle plasmid delivery system. The results demonstrate that PLGA nanoparticles can reduce ischemia-induced neurological deficits and infarct volume, providing a potential opportunity for stroke treatment.
Article
Chemistry, Multidisciplinary
Anurag Chaudhury, Koushik Debnath, Nikhil R. Jana, Jaydeep K. Basu
Summary: The study investigates the interaction between nanoparticles and cell membranes, and identifies key parameters, including charge, crowding, and membrane fluidity, that determine the adsorbed concentration and unbinding transition of nanoparticles.
Article
Chemistry, Multidisciplinary
Sina Sadeghi, Fazel Bateni, Taekhoon Kim, Dae Yong Son, Jeffrey A. Bennett, Negin Orouji, Venkat S. Punati, Christine Stark, Teagan D. Cerra, Rami Awad, Fernando Delgado-Licona, Jinge Xu, Nikolai Mukhin, Hannah Dickerson, Kristofer G. Reyes, Milad Abolhasani
Summary: In this study, an autonomous approach for the development of lead-free metal halide perovskite nanocrystals is presented, which integrates a modular microfluidic platform with machine learning-assisted synthesis modeling. This approach enables rapid and optimized synthesis of copper-based lead-free nanocrystals.
Article
Chemistry, Multidisciplinary
Zahir Abbas, Nissar Hussain, Surender Kumar, Shaikh M. Mobin
Summary: The rational construction of free-standing and flexible electrodes for electrochemical energy storage devices is an emerging research focus. In this study, a redox-active metal-organic framework (MOF) was prepared on carbon nanofibers using an in situ approach, resulting in a flexible electrode with high redox-active behavior and unique properties such as high flexibility and lightweight. The prepared electrode showed excellent cyclic retention and rate capability in supercapacitor applications. Additionally, it could be used as a freestanding electrode in flexible devices at different bending angles.
Article
Chemistry, Multidisciplinary
Lishan Zhang, Xiaoting Zhang, Hui Ran, Ze Chen, Yicheng Ye, Jiamiao Jiang, Ziwei Hu, Miral Azechi, Fei Peng, Hao Tian, Zhili Xu, Yingfeng Tu
Summary: Photodynamic therapy (PDT) is a promising local treatment modality in cancer therapy, but its therapeutic efficacy is restricted by ineffective delivery of photosensitizers and tumor hypoxia. In this study, a phototactic Chlorella-based near-infrared (NIR) driven green affording-oxygen microrobot system was developed for enhanced PDT. The system exhibited desirable phototaxis and continuous oxygen generation, leading to the inhibition of tumor growth in mice. This study demonstrates the potential of using a light-driven green affording-oxygen microrobot to enhance photodynamic therapy.
Article
Chemistry, Multidisciplinary
Yujin Li, Jing Xu, Xinqi Luo, Futing Wang, Zhong Dong, Ke-Jing Huang, Chengjie Hu, Mengyi Hou, Ren Cai
Summary: In this study, hollow heterostructured materials were constructed using an innovative template-engaged method as cathodes for zinc-ion batteries. The materials exhibited fast Zn2+ transport channels, improved electrical conductivity, and controlled volume expansion during cycling. The designed structure allowed for an admirable reversible capacity and high coulombic efficiency.
Article
Chemistry, Multidisciplinary
Paritosh Mahato, Shashi Shekhar, Rahul Yadav, Saptarshi Mukherjee
Summary: This study comprehensively elucidates the role of the core and electrostatic surface of metal nanoclusters in catalytic reduction reactions. The electrostatic surface dramatically modulates the reactivity of metal nanoclusters.
Article
Chemistry, Multidisciplinary
Pei Liu, Mengdi Liang, Zhengwei Liu, Haiyu Long, Han Cheng, Jiahe Su, Zhongbiao Tan, Xuewen He, Min Sun, Xiangqian Li, Shuai He
Summary: This study demonstrates a simple and environmentally-friendly method for the synthesis of zinc oxide nanozymes (ZnO NZs) using wasted hop extract (WHE). The WHE-ZnO NZs exhibit exceptional peroxidase-like activity and serve as effective catalysts for the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2). In addition, a straightforward colorimetric technique for detecting both H2O2 and glucose was developed using the WHE-ZnO NZs as peroxidase-like catalysts.
Article
Chemistry, Multidisciplinary
Hyunkyu Oh, Young Jun Lee, Eun Ji Kim, Jinseok Park, Hee-Eun Kim, Hyunsoo Lee, Hyunjoo Lee, Bumjoon J. Kim
Summary: Mesoporous carbon particles have unique structural properties that make them suitable as support materials for catalytic applications. This study investigates the impact of channel nanostructures on the catalytic activity of porous carbon particles (PCPs) by fabricating PCPs with controlled channel exposure on the carbon surface. The results show that PCPs with highly open channel nanostructures exhibit significantly higher catalytic activity compared to those with closed channel nanostructures.
Article
Chemistry, Multidisciplinary
Yunjie Lu, Zhaohui Li, Zewei Li, Shihao Zhou, Ning Zhang, Jianming Zhang, Lu Zong
Summary: A tough, long-lasting adhesive and highly conductive nanocomposite hydrogel (PACPH) was fabricated via the synergy of interfacial entanglement and adhesion group densification. PACPH possesses excellent mechanical properties, interfacial adhesion strength, and conductivity, making it a promising material for long-term monitoring of human activities and electrocardiogram signals.
Article
Chemistry, Multidisciplinary
Zichao Wei, Audrey Vandergriff, Chung-Hao Liu, Maham Liaqat, Mu-Ping Nieh, Yu Lei, Jie He
Summary: We have developed a simple method to prepare polymer-grafted plasmonic metal nanoparticles with pH-responsive surface-enhanced Raman scattering. By using pH-responsive polymers as ligands, the aggregation of nanoparticles can be controlled, leading to enhanced SERS. The pH-responsive polymer-grafted nanoparticles show high reproducibility and sensitivity in solution, providing a novel approach for SERS without the need for sample pre-concentration.
Article
Chemistry, Multidisciplinary
Melis Ozge Alas Colak, Ahmet Gungor, Merve Buldu Akturk, Emre Erdem, Rukan Genc
Summary: This research investigates the effect of functionalizing carbon dots with hydroxyl polymers on their performance as electrode materials in a supercapacitor. The results show that the functionalized carbon dots exhibit excellent electrochemical performance and improved stability.