Review
Nanoscience & Nanotechnology
Batoul Dhaini, Bibigul Kenzhebayeva, Amina Ben-Mihoub, Mickael Gries, Samir Acherar, Francis Baros, Noemie Thomas, Joel Daouk, Herve Schohn, Tayssir Hamieh, Celine Frochot
Summary: Cancer is the second leading cause of death globally, with treatments including surgery, radiotherapy, chemotherapy, and photodynamic therapy. Using nanoparticles loaded with photosensitizers and coupled to peptides for targeted therapy is a promising approach in cancer treatment.
Review
Chemistry, Multidisciplinary
Houhe Liu, Fanwen Yang, Wenjie Chen, Teng Gong, Yi Zhou, Xiaoyan Dai, Wingnang Leung, Chuanshan Xu
Summary: This paper reviews the application of ERM in PDT and discusses the challenges ERM faces as carriers for delivering PS, in order to further advance the development of PDT in the management of malignancies.
FRONTIERS IN CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Houhe Liu, Yuan Jiang, Zhen Wang, Linping Zhao, Qianqian Yin, Min Liu
Summary: The main treatment for bacterial infections is antibiotic therapy, but bacterial resistance has limited its efficacy. Photodynamic antibacterial therapy (PDAT) is a promising alternative method that kills bacteria using reactive oxygen species (ROS) produced by photosensitizers (PS) under light irradiation. Recent research has shown that nanomaterials can enhance PDAT by delivering PS to specific targets or producing synergistic therapeutic effects.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Physical
Wenbo Wu, Leilei Shi, Yukun Duan, Shidang Xu, Xihui Gao, Xinyuan Zhu, Bin Liu
Summary: A highly efficient metabolizable type-II photosensitizer with aggregation-induced emission characteristics was developed in this study, demonstrating good anti-tumor PDT efficiency in mouse models. Importantly, the photosensitizer can be gradually oxidized by endogenous hypochlorite after PDT and subsequently excreted through urine within 24 hours of administration.
CHEMISTRY OF MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Deepika Thakur, Qui Thanh Hoai Ta, Jin-Seo Noh
Summary: ZnFe2O4-Ce6 nanocarriers operated with low-irradiance light exhibit excellent antibacterial activities, with Gram-negative Escherichia coli being more vulnerable. This study provides insights into a promising approach using photosensitizers in PDT for combating antibiotic-resistant bacteria.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Medicinal
Qiaoyun Jiang, Peixia Li, Jingru Qiu, Donghai Li, Guiling Li, Gang Shan
Summary: The development of safe and effective photosensitizers is crucial for improving photodynamic cancer therapy. In this study, a new redshift phenalenone derivative, SDU Red, was developed as a lysosome-targeting photosensitizer for triple-negative breast cancer therapy. SDU Red exhibited good photostability and a remarkable phototherapeutic index against triple-negative breast cancer cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Inorganic & Nuclear
Manjunatha Ankathatti Munegowda, Angelica Manalac, Madrigal Weersink, Sherri A. McFarland, Lothar Lilge
Summary: Ruthenium(II)-based coordination complexes have great potential as photosensitizers for photodynamic therapy. The modular architectures of these complexes allow for tuning of various properties such as cellular uptake, subcellular targeting, solubility, and light absorption. Many studies focus on systematic variation of ligands to investigate their impact on photophysical and photobiological performance. However, comparisons between Ru(II)-based PSs and other generations of PSs are scarce. Nonetheless, quantitative models based on PDT dose metrics are available for qualitative comparisons. This review summarizes the relevant studies on Ru(II)-containing PSs and their potential efficacy.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Inorganic & Nuclear
Manjunatha Ankathatti Munegowda, Angelica Manalac, Madrigal Weersink, Sherri A. McFarland, Lothar Lilge
Summary: Ruthenium(II)-based coordination complexes are promising photosensitizers for photodynamic therapy with potential in oncology and antimicrobial fields. These complexes can be tuned for different photophysical properties and studies comparing their efficacy to other PSs are limited but possible using PDT dose metrics.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Nanoscience & Nanotechnology
Carla I. M. Santos, Laura Rodriguez-Perez, Gil Goncalves, Cristina J. Dias, Fatima Monteiro, Maria do Amparo F. Faustino, Sandra Vieira, Luisa A. Helguero, Maria Angeles Herranz, Nazario Martin, M. Graca P. M. S. Neves, Jose M. G. Martinho, Ermelinda M. S. Macoas
Summary: Conjugation of porphyrins with graphene quantum dots improved internalization by cancer cells and showed promising results as phototherapeutic agents against breast cancer.
ACS APPLIED NANO MATERIALS
(2021)
Review
Nanoscience & Nanotechnology
Na Sun, Xue Wen, Song Zhang
Summary: This review discusses the latest progress in strategies to enhance the efficacy of photodynamic therapy using metal-free semiconducting conjugated polymers (SCPS) as photosensitizers. The current challenges and potential opportunities for further improvement are also presented.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biochemical Research Methods
Irving Trejo-Santillan, Citlali Cecilia Mendoza-Guevara, Maria del Pilar Ramos-Godinez, Eva Ramon-Gallegos
Summary: One of the main obstacles in Photodynamic Therapy (PDT) is the aggregation of most photosensitizers (Ps) in aqueous solutions without specificity. Nanotechnology provides a new method to enhance the specificity towards target cells. This study aimed to optimize the synthesis of chitosan polymeric nanoparticles conjugated with protoporphyrin IX and vitamin B9 for improved efficiency.
IEEE TRANSACTIONS ON NANOBIOSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Abdallah Mohamed Ayoub, Bernd Gutberlet, Eduard Preis, Ahmed Mohamed Abdelsalam, Alice Abu Dayyih, Ayat Abdelkader, Amir Balash, Jens Schafer, Udo Bakowsky
Summary: Antimicrobial photodynamic therapy (aPDT) is an alternative therapeutic option that can effectively eliminate antibiotic-resistant bacteria with lower risks of resistance development and systemic toxicity. This study explored the complexation of Parietin (PTN) with (2-hydroxypropyl)-beta-cyclodextrin (HP-beta-CD) to enhance its solubility, photophysical properties, and phototoxicity against bacteria. The complexation significantly increased the solubility and photostability of PTN, and the PTN/HP-beta-CD complexes showed a significant reduction in bacterial viability. This finding provides new opportunities for treating infections caused by multidrug-resistant bacteria.
Review
Biochemistry & Molecular Biology
Shujin Lin, Chun Liu, Xiao Han, Haowei Zhong, Cui Cheng
Summary: Photodynamic therapy (PDT) is a promising treatment method due to its efficiency and accuracy, with viral nanoparticles (VNPs) showing great potential as delivery vehicles for PDT. VNPs have favorable properties and are being explored for applications in tumor cell treatment and antimicrobial therapy, with future prospects focusing on developing novel viral nanocarriers or improving existing viral vectors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Alex Vasilev, Roba Sofi, Stuart J. Smith, Ruman Rahman, Anja G. Teschemacher, Sergey Kasparov
Summary: One of the most challenging problems in treating glioblastoma (GBM) is its highly infiltrative nature. Researchers have found that using tetramethylrhodamine methyl ester (TMRM) as a photosensitizer in combination with photodynamic therapy (PDT) can target GBM cells, inducing mitochondrial damage and cell death, making it a potential direction for clinical translation.
Article
Biochemistry & Molecular Biology
Takashi Kanamori, Yuto Miki, Masataka Katou, Shun-ichiro Ogura, Hideya Yuasa
Summary: We have developed a glucose-linked biphenyl photosensitizer with brighter fluorescence and enhanced photodamaging effect against cancer cells. This photosensitizer can pass through glucose transporters, allowing for selective uptake and potential use in cancer photodynamic therapy.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Correction
Chemistry, Multidisciplinary
Weizhong Zhang, Mengzhe Wang, Wei Tang, Ru Wen, Shiyi Zhou, Chaebin Lee, Hui Wang, Wen Jiang, Ian Michael Delahunty, Zipeng Zhen, Hongmin Chen, Matthew Chapman, Zhanhong Wu, Elizabeth W. Howerth, Houjian Cai, Zibo Li, Jin Xie
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yongwook Kim, Amine M. Laradji, Shubham Sharma, Weizhong Zhang, Nataraja S. Yadavalli, Jin Xie, Vladimir Popik, Sergiy Minko
Summary: The text explains the mechanism of separation methods, which achieve dynamic equilibrium through multiple adsorption-desorption steps. Sorting of colloidal particles faces energy barrier issues, but introducing oscillating repulsive force can facilitate rapid separation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Computer Science, Software Engineering
Shiyu Jia, Weizhong Zhang, Guodong Wang, Zhenkuan Pan, Xiaokang Yu
Summary: This paper proposes a novel method using two levels of voxels to decouple collision from rendering in the linked voxel model. Simulation tests show that this method achieves higher frame rates and comparable rendering qualities.
Article
Biochemical Research Methods
Jinghua Han, Wei Yang, Yuanke Li, Jianwen Li, Fangchao Jiang, Jin Xie, Xinglu Huang
Summary: In this study, a radiosensitizing strategy for lung cancer was explored by combining DOX-encapsulated polyaspartamide nanoparticles with 5-ALA. The results showed that this combination enhanced cancer cell killing and improved tumor suppression in vivo without causing toxicity to normal tissues.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Chemistry, Analytical
Mengxue Li, Yiwen Kuang, Ziyan Fan, Xiaoli Qin, Shiyu Hu, Zhanning Liang, Qilin Liu, Weizhong Zhang, Birui Wang, Zhaohong Su
Summary: A sensitive simultaneous electrochemical sensing method for plant hormones indole-3-acetic acid and salicylic acid was developed using a novel composite material consisting of multiwalled carbon nanotubes and poly(L-Proline) nanoparticles-carbon dots. The conductivity and sensing performance of the composite were significantly enhanced by the incorporation of poly(L-Proline) nanoparticles. The composite-modified electrode exhibited a wide linear range and low detection limits for both indole-3-acetic acid and salicylic acid. The proposed sensor was successfully applied to simultaneously detect indole-3-acetic acid and salicylic acid in real leaf samples.
Article
Chemistry, Multidisciplinary
Ian Delahunty, Jianwen Li, Wen Jiang, Chaebin Lee, Xueyuan Yang, Anil Kumar, Zhi Liu, Weizhong Zhang, Jin Xie
Summary: This study explores a radiosensitizer, 7-DHC, which can react with radiation-induced reactive oxygen species and promote lipid peroxidation, DNA double-strand breaks, and mitochondrial damage in cancer cells. By encapsulating into PLGA nanoparticles, 7-DHC shows efficient delivery and significantly enhances the efficacy of radiotherapy, leading to tumor eradication without side effects.
Article
Construction & Building Technology
Qinrong Kang, Yuandi Xia, Xiaoshuang Li, Weizhong Zhang, Chaoran Feng
Summary: This study investigates the deformation characteristics of silty clay under different normal pressure conditions through indoor direct shear experiments, and finds that dry density and moisture content have a significant influence on the shear strength of the silty clay.
ADVANCES IN CIVIL ENGINEERING
(2022)
Article
Geosciences, Multidisciplinary
Gao Peng, Gaoyi Dong, Jingsong Chen, Chunmei Zhou, Manqing Lin, Weizhong Zhang, Sun Yang
Summary: Reasonable stope structural parameters were determined through numerical simulation research and calculation analysis, verifying the significant impact of these parameters on the economy and safety of the mining area.
FRONTIERS IN EARTH SCIENCE
(2022)
Review
Surgery
Ke Xu, Guangzhi Wu, Weizhong Zhang, Wei Yu, Shusen Cui, Zhan Zhang
Summary: Neuropathic arthropathy of the wrist is a rare but clinically significant disease. It is important for surgeons to rule out this diagnosis when treating patients with wrist swelling and osteoarticular abnormalities to avoid inappropriate treatment.
FRONTIERS IN SURGERY
(2022)
Article
Computer Science, Information Systems
Cong Fang, Yihong Gu, Weizhong Zhang, Tong Zhang
Summary: This paper investigates the problem of overparameterized deep neural networks when fully trained. By characterizing the network through its features' distributions and proposing a metric to measure the usefulness of feature representations, the paper shows that under certain regularizers, deep neural networks can be reformulated as a convex optimization problem, guaranteeing effective feature representations. Empirical studies confirm the consistency between the theory's predictions and observed results.
IEEE TRANSACTIONS ON INFORMATION THEORY
(2022)
Article
Biotechnology & Applied Microbiology
Fangchao Jiang, Chaebin Lee, Weizhong Zhang, Wen Jiang, Zhengwei Cao, Harrison Byron Chong, Wei Yang, Shuyue Zhan, Jianwen Li, Yong Teng, Zibo Li, Jin Xie
Summary: This study presents a streamlined radiodynamic therapy (RDT) approach using CsI(Na)@MgO nanoparticles and 5-aminolevulinic acid (5-ALA) to overcome the shallow tissue penetration issue associated with conventional photodynamic therapy (PDT) and enhance the killing effect on cancer cells.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Qinrong Kang, Yuandi Xia, Minghan Shi, Weizhong Zhang, Weiqing Wang, Dehua Kong, Yunpeng Wang
Summary: This study focuses on the phosphate mining area of the Sujiapo phosphate mine and combines the characteristics and physical and mechanical properties of deep rockburst in this mine. By using a evaluation system that combines fuzzy mathematical methods and multiple evaluation methods, the propensity of rockburst in deep mining of Sujiapo phosphate mine can be determined comprehensively.
ADVANCES IN MATERIALS SCIENCE AND ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Laetitia Bardet, Herve Roussel, Stefano Saroglia, Masoud Akbari, David Munoz-Rojas, Carmen Jimenez, Aurore Denneulin, Daniel Bellet
Summary: The thermal instability of silver nanowires leads to increased electrical resistance in AgNW networks. Understanding the relationship between structural and electrical properties of AgNW networks is crucial for their integration as transparent electrodes in flexible optoelectronics. In situ X-ray diffraction measurements were used to study the crystallographic evolution of Ag-specific Bragg peaks during thermal ramping, revealing differences in thermal and structural transitions between bare and SnO2-coated AgNW networks.
Article
Chemistry, Multidisciplinary
Nathalia Cancino-Fuentes, Arnau Manasanch, Joana Covelo, Alex Suarez-Perez, Enrique Fernandez, Stratis Matsoukis, Christoph Guger, Xavi Illa, Anton Guimera-Brunet, Maria V. Sanchez-Vives
Summary: This study provides a comprehensive characterization of graphene-based solution-gated field-effect transistors (gSGFETs) for brain recordings, highlighting their potential clinical applications.
Article
Chemistry, Multidisciplinary
Sikandar Aftab, Hailiang Liu, Dhanasekaran Vikraman, Sajjad Hussain, Jungwon Kang, Abdullah A. Al-Kahtani
Summary: This study examines the effects of hybrid nanoparticles made of NiO@rGO and NiO@CNT on the active layers of polymer solar cells and X-ray photodetectors. The findings show that these hybrid nanoparticles can enhance the charge carrier capacities and exciton dissociation properties of the active layers. Among the tested configurations, the NiO@CNT device demonstrates superior performance in converting sunlight into electricity, and achieves the best sensitivity for X-ray detection.
Article
Chemistry, Multidisciplinary
Hyo Jung Shin, Seung Gyu Choi, Fengrui Qu, Min-Hee Yi, Choong-Hyun Lee, Sang Ryong Kim, Hyeong-Geug Kim, Jaewon Beom, Yoonyoung Yi, Do Kyung Kim, Eun-Hye Joe, Hee-Jung Song, Yonghyun Kim, Dong Woon Kim
Summary: This study investigates the role of SOX9 in reactive astrocytes following ischemic brain damage using a PLGA nanoparticle plasmid delivery system. The results demonstrate that PLGA nanoparticles can reduce ischemia-induced neurological deficits and infarct volume, providing a potential opportunity for stroke treatment.
Article
Chemistry, Multidisciplinary
Anurag Chaudhury, Koushik Debnath, Nikhil R. Jana, Jaydeep K. Basu
Summary: The study investigates the interaction between nanoparticles and cell membranes, and identifies key parameters, including charge, crowding, and membrane fluidity, that determine the adsorbed concentration and unbinding transition of nanoparticles.
Article
Chemistry, Multidisciplinary
Sina Sadeghi, Fazel Bateni, Taekhoon Kim, Dae Yong Son, Jeffrey A. Bennett, Negin Orouji, Venkat S. Punati, Christine Stark, Teagan D. Cerra, Rami Awad, Fernando Delgado-Licona, Jinge Xu, Nikolai Mukhin, Hannah Dickerson, Kristofer G. Reyes, Milad Abolhasani
Summary: In this study, an autonomous approach for the development of lead-free metal halide perovskite nanocrystals is presented, which integrates a modular microfluidic platform with machine learning-assisted synthesis modeling. This approach enables rapid and optimized synthesis of copper-based lead-free nanocrystals.
Article
Chemistry, Multidisciplinary
Zahir Abbas, Nissar Hussain, Surender Kumar, Shaikh M. Mobin
Summary: The rational construction of free-standing and flexible electrodes for electrochemical energy storage devices is an emerging research focus. In this study, a redox-active metal-organic framework (MOF) was prepared on carbon nanofibers using an in situ approach, resulting in a flexible electrode with high redox-active behavior and unique properties such as high flexibility and lightweight. The prepared electrode showed excellent cyclic retention and rate capability in supercapacitor applications. Additionally, it could be used as a freestanding electrode in flexible devices at different bending angles.
Article
Chemistry, Multidisciplinary
Lishan Zhang, Xiaoting Zhang, Hui Ran, Ze Chen, Yicheng Ye, Jiamiao Jiang, Ziwei Hu, Miral Azechi, Fei Peng, Hao Tian, Zhili Xu, Yingfeng Tu
Summary: Photodynamic therapy (PDT) is a promising local treatment modality in cancer therapy, but its therapeutic efficacy is restricted by ineffective delivery of photosensitizers and tumor hypoxia. In this study, a phototactic Chlorella-based near-infrared (NIR) driven green affording-oxygen microrobot system was developed for enhanced PDT. The system exhibited desirable phototaxis and continuous oxygen generation, leading to the inhibition of tumor growth in mice. This study demonstrates the potential of using a light-driven green affording-oxygen microrobot to enhance photodynamic therapy.
Article
Chemistry, Multidisciplinary
Yujin Li, Jing Xu, Xinqi Luo, Futing Wang, Zhong Dong, Ke-Jing Huang, Chengjie Hu, Mengyi Hou, Ren Cai
Summary: In this study, hollow heterostructured materials were constructed using an innovative template-engaged method as cathodes for zinc-ion batteries. The materials exhibited fast Zn2+ transport channels, improved electrical conductivity, and controlled volume expansion during cycling. The designed structure allowed for an admirable reversible capacity and high coulombic efficiency.
Article
Chemistry, Multidisciplinary
Paritosh Mahato, Shashi Shekhar, Rahul Yadav, Saptarshi Mukherjee
Summary: This study comprehensively elucidates the role of the core and electrostatic surface of metal nanoclusters in catalytic reduction reactions. The electrostatic surface dramatically modulates the reactivity of metal nanoclusters.
Article
Chemistry, Multidisciplinary
Pei Liu, Mengdi Liang, Zhengwei Liu, Haiyu Long, Han Cheng, Jiahe Su, Zhongbiao Tan, Xuewen He, Min Sun, Xiangqian Li, Shuai He
Summary: This study demonstrates a simple and environmentally-friendly method for the synthesis of zinc oxide nanozymes (ZnO NZs) using wasted hop extract (WHE). The WHE-ZnO NZs exhibit exceptional peroxidase-like activity and serve as effective catalysts for the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2). In addition, a straightforward colorimetric technique for detecting both H2O2 and glucose was developed using the WHE-ZnO NZs as peroxidase-like catalysts.
Article
Chemistry, Multidisciplinary
Hyunkyu Oh, Young Jun Lee, Eun Ji Kim, Jinseok Park, Hee-Eun Kim, Hyunsoo Lee, Hyunjoo Lee, Bumjoon J. Kim
Summary: Mesoporous carbon particles have unique structural properties that make them suitable as support materials for catalytic applications. This study investigates the impact of channel nanostructures on the catalytic activity of porous carbon particles (PCPs) by fabricating PCPs with controlled channel exposure on the carbon surface. The results show that PCPs with highly open channel nanostructures exhibit significantly higher catalytic activity compared to those with closed channel nanostructures.
Article
Chemistry, Multidisciplinary
Yunjie Lu, Zhaohui Li, Zewei Li, Shihao Zhou, Ning Zhang, Jianming Zhang, Lu Zong
Summary: A tough, long-lasting adhesive and highly conductive nanocomposite hydrogel (PACPH) was fabricated via the synergy of interfacial entanglement and adhesion group densification. PACPH possesses excellent mechanical properties, interfacial adhesion strength, and conductivity, making it a promising material for long-term monitoring of human activities and electrocardiogram signals.
Article
Chemistry, Multidisciplinary
Zichao Wei, Audrey Vandergriff, Chung-Hao Liu, Maham Liaqat, Mu-Ping Nieh, Yu Lei, Jie He
Summary: We have developed a simple method to prepare polymer-grafted plasmonic metal nanoparticles with pH-responsive surface-enhanced Raman scattering. By using pH-responsive polymers as ligands, the aggregation of nanoparticles can be controlled, leading to enhanced SERS. The pH-responsive polymer-grafted nanoparticles show high reproducibility and sensitivity in solution, providing a novel approach for SERS without the need for sample pre-concentration.
Article
Chemistry, Multidisciplinary
Melis Ozge Alas Colak, Ahmet Gungor, Merve Buldu Akturk, Emre Erdem, Rukan Genc
Summary: This research investigates the effect of functionalizing carbon dots with hydroxyl polymers on their performance as electrode materials in a supercapacitor. The results show that the functionalized carbon dots exhibit excellent electrochemical performance and improved stability.