Article
Immunology
Huilei Zhang, Shuangqing Liu, Yanan Li, Jianru Li, Chen Ni, Ming Yang, Jun Dong, Zhaoqing Wang, Zhihai Qin
Summary: The study reveals that S100A4 drives dysfunction in CD8(+) T-EM cells, leading to the loss of their protective memory response and promoting asthma worsening. CD8(+) T-EM cells can be divided into dysfunctional subsets and subsets inclined towards apoptosis based on the expression of S100A4. S100A4 affects mitochondrial metabolism, leading to a decrease in acetyl-CoA levels, which impairs the transcription of effector genes (especially IFN-γ), facilitating cell survival, tolerance, and memory potential.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Dermatology
Pawit Phadungsaksawasdi, Toshiharu Fujiyama, Kazuo Kurihara, Taisuke Ito, Tetsuya Honda, Yoshiki Tokura
Summary: In human psoriasis, PD-1 expressing CD8(+) CD103(+) T cells in the skin are associated with disease severity and histopathology, indicating a potential pathogenic subset that may play a role in psoriasis pathogenesis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Oncology
Weidong Shen, Xiangdong Wang, Huihui Xiang, Shunsuke Shichi, Hiroki Nakamoto, Saori Kimura, Ko Sugiyama, Akinobu Taketomi, Hidemitsu Kitamura
Summary: This study revealed that IFN-gamma-STAT1-mediated NK2R expression is involved in the induction of antitumor effector CD8(+) T cells in the tumor microenvironment, which contributes to suppressing the tumorigenesis of liver cancer cells in vivo.
Article
Oncology
Snehanshu Chowdhury, Anwesha Kar, Debaleena Bhowmik, Anupam Gautam, Debashree Basak, Ishita Sarkar, Puspendu Ghosh, Deborpita Sarkar, Alvina Deka, Paramita Chakraborty, Asima Mukhopadhyay, Shikhar Mehrotra, Soumen Basak, Sandip Paul, Shilpak Chatterjee
Summary: IL-12 stimulation increases intracellular acetyl CoA levels in CD8(+) T cells, allowing them to maintain effector function in nutrient-deprived tumor microenvironments. Inhibition of ATP-citrate lyase, an enzyme involved in the glucose-citrate-acetyl CoA pathway, impairs IFN gamma production and viability of CD8(+) T cells in nutrient-restricted conditions. CD8(+) T cells cultured in high pyruvate-containing media acquire metabolic features of IL-12-stimulated CD8(+) T cells and display improved antitumor potential.
Article
Cardiac & Cardiovascular Systems
Janine van Duijn, Maaike J. M. de Jong, Naomi Benne, Romain J. T. Leboux, Marieke E. van Ooijen, Nicky Kruit, Amanda C. Foks, Wim Jiskoot, Ilze Bot, Johan Kuiper, Bram Slutter
Summary: In an atherosclerotic mouse model, a lesion-localized increase in Tc17 cells was found. Tc17 cells appeared to be non-atherogenic compared to their Tc0 counterparts.
CARDIOVASCULAR RESEARCH
(2021)
Article
Endocrinology & Metabolism
Kirsten I. M. Looman, Susana Santos, Henriette A. Moll, Charlotte W. E. Leijten, Christina Grosserichter-Wagener, Trudy Voortman, Vincent V. W. Jaddoe, Menno C. van Zelm, Jessica C. Kiefte-de Jong
Summary: The study found significant associations between child adiposity measures and specific immune cell subsets, particularly with visceral fat index. Excessive fat in children may already indicate the presence of adiposity-related inflammation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Cell Biology
Zhijuan Qiu, Timothy H. Chu, Brian S. Sheridan
Summary: CD8 tissue-resident memory T (T-RM) cells are a subset of memory CD8 T cells that primarily reside in nonlymphoid tissues, providing front-line protective immunity against infections and cancers. They can be divided into CD103(-) T-RM cells and CD103(+) T-RM cells. TGF-beta plays a critical role in the development and maintenance of CD103(+) CD8 T-RM cells, and the review highlights the importance of TGF-beta in regulating this unique subset of memory CD8 T cells for potential vaccine design improvements.
Article
Immunology
Ellen Duong, Tim B. Fessenden, Emi Lutz, Teresa Dinter, Leon Yim, Sarah Blatt, Arjun Bhutkar, Karl Dane Wittrup, Stefani Spranger
Summary: In this study, the researchers investigated the different roles of tumor-infiltrating dendritic cells (DCs) in anti-tumor immunity. By comparing spontaneously regressing and progressing tumors, they found that tumor-reactive CD8+ T cells were lost in progressing tumors but preserved in regressing tumors. They also identified a specific type of DCs (ISG(+) DCs) in regressing tumors that activated CD8+ T cells and played an important role in presenting tumor-derived antigens. Furthermore, they showed that exogenous IFN-b stimulation could restore the lost anti-tumor immunity in progressing tumors. These findings suggest that targeting this functional DC state may be a potential approach for the treatment of human diseases.
Editorial Material
Neurosciences
Lisa Johann, Ari Waisman
Summary: The study reveals a novel mechanism by which astrocytes maintain an anti-inflammatory state in the CNS. This mechanism involves IFNg-induced TRAIL expression on astrocytes, leading to effector T cell apoptosis and suppression of inflammation.
Article
Immunology
Ella Bhagyaraj, Hongbin Wang, Xinghong Yang, Carol Hoffman, Ali Akgul, Zakia Goodwin, David W. Pascual
Summary: znBAZ infection induces an increase and activation of lung NK cells in mice, which play a crucial role in promoting lung DC activation, migration, and the development of protective CD8(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Gretchen Harms Pritchard, Anthony T. Phan, David A. Christian, Trevor J. Blain, Qun Fang, John Johnson, Nathan H. Roy, Lindsey Shallberg, Ross M. Kedl, Christopher A. Hunter
Summary: T-bet is a key regulator of CD4(+) Th1 differentiation and IFN-gamma production, but its importance in CD8(+) T cell response has been less certain. In this study, we found that T-bet expression in CD8(+) T cells is required for optimal expansion of parasite-specific effector CD8(+) T cells following vaccination with a replication-deficient strain of Toxoplasma gondii. Analysis of early T cell activation events revealed that T-bet regulates the upregulation of LFA1 alpha chain CD11a in CD8(+) T cells, which influences the initial priming of CD8(+) effector T cells. These findings suggest that early expression of T-bet is an intrinsic factor in T cells that optimizes T-DC interactions necessary for generating effector responses.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Zhiqiang Zhu, Yuanyuan Qin, Qi Liang, Wei Xia, Tong Zhang, Wen Wang, Mengmeng Zhang, Taiyi Jiang, Hao Wu, Ye Tian
Summary: The coinfection rate of HBV in HIV patients increases as HIV disease progresses, possibly due to the reduced numbers of HBV-specific IFN-gamma-producing CD8+ T cells. Close monitoring of HBV serum markers from the early stage of HIV infection is necessary.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Qi Li, Simeng Wei, Yue Li, Fengjiao Wu, Xiaoling Qin, Zhongsha Li, Jingyu Li, Chang Chen
Summary: Blocking of PD-L1 promotes CD8+IFN-gamma+ T cell-mediated immune responses, exacerbating inflammation and increasing the burden of atherosclerosis under high-cholesterol diet. However, further studies are needed to explore whether PD-L1 activation could be a novel immunotherapy strategy for atherosclerosis.
INFLAMMATION RESEARCH
(2023)
Article
Immunology
Andrea M. Amitrano, Brandon J. Berry, Kihong Lim, Kyun-Do Kim, Richard E. Waugh, Andrew P. Wojtovich, Minsoo Kim
Summary: Cancer immunotherapy is more effective against hematological malignancies than solid tumors due to metabolic challenges in the tumor microenvironment. Mitochondria play a key role in CD8(+) T cell activation and effector function. Enhanced mitochondrial function is associated with improved T cell migration and effector function, highlighting the importance of mitochondrial metabolism in T cell responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Romain Banchereau, Avantika S. Chitre, Alexis Scherl, Thomas D. Wu, Namrata S. Patil, Patricia de Almeida, Edward E. Kadel, Shravan Madireddi, Amelia Au-Yeung, Chikara Takahashi, Ying-Jiun Chen, Zora Modrusan, Jacqueline McBride, Rhea Nersesian, Ehab A. El-Gabry, Mark D. Robida, Jeffrey C. Hung, Marcin Kowanetz, Wei Zou, Mark McCleland, Patrick Caplazi, Shadi Toghi Eshgi, Hartmut Koeppen, Priti S. Hegde, Ira Mellman, W. Rodney Mathews, Thomas Powles, Sanjeev Mariathasan, Jane Grogan, William E. O'Gorman
Summary: CD8+ tissue-resident memory T (T-RM) cells expressing CD103 (ITGAE) are believed to actively suppress cancer progression, and their presence in tumors may predict response to immunotherapy. This study found that in inflamed tumors, CD103+ CD8+ T-RM cells exhibit a complex phenotype characterized by increased clonal expansion, expression of checkpoint regulators, and cytotoxic proteins, suggesting their involvement in antitumor response.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Hanif Javanmard Khameneh, Adrian W. S. Ho, Roberto Spreafico, Heidi Derks, Hazel Q. Y. Quek, Alessandra Mortellaro
JOURNAL OF IMMUNOLOGY
(2017)
Article
Pharmacology & Pharmacy
Wan Shun Daniel Tan, Wupeng Liao, Shuo Zhou, Dan Mei, Wai-Shiu Fred Wong
CURRENT OPINION IN PHARMACOLOGY
(2018)
Editorial Material
Respiratory System
Sanjay H. Chotirmall, Sven-Erik Dahlen, Christopher Carlsten, W. S. Fred Wong, Kian F. Chung, Reinoud Gosens, Darryl A. Knight
Article
Medicine, Research & Experimental
Jinrui Dong, Wupeng Liao, Hong Yong Peh, W. S. Daniel Tan, Shuo Zhou, W. S. Fred Wong
MOLECULAR THERAPY-NUCLEIC ACIDS
(2018)
Article
Immunology
Andrew Aswani, Joanna Manson, Kiyoshi Itagaki, Fausto Chiazza, Massimo Collino, Winston Liao Wupeng, Tze Khee Chan, W. S. Fred Wong, Carl J. Hauser, Chris Thiemermann, Karim Brohi
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Pharmacology & Pharmacy
Jinrui Dong, Wupeng Liao, Lay Hong Tan, Amy Yong, Wen Yan Peh, W. S. Fred Wong
PHARMACOLOGICAL RESEARCH
(2019)
Article
Pharmacology & Pharmacy
W. S. Daniel Tan, Wupeng Liao, Hong Yong Peh, Merima Vila, Jinrui Dong, Han-Ming Shen, W. S. Fred Wong
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2018)
Article
Pharmacology & Pharmacy
Dan Mei, Wan Shun Daniel Tan, Wai Shiu Fred Wong
CURRENT OPINION IN PHARMACOLOGY
(2019)
Article
Chemistry, Medicinal
Quy T. N. Tran, W. S. Fred Wong, Christina L. L. Chai
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Review
Pharmacology & Pharmacy
W. S. Daniel Tan, Han-Ming Shen, W. S. Fred Wong
PHARMACOLOGICAL RESEARCH
(2019)
Article
Pharmacology & Pharmacy
Wupeng Liao, Albert Y. H. Lim, W. S. Daniel Tan, John Abisheganaden, W. S. Fred Wong
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Article
Medicine, Research & Experimental
Taichi Kuramochi, Siok Wan Gan, Adrian W. S. Ho, Bei Wang, Nagisa Kageji, Takeru Nambu, Sayaka Iida, Momoko Okuda-Miura, Wei Shan Chia, Chiew Ying Yeo, Dan Chen, Wen-Hsin Lee, Eve Zi Xian Ngoh, Siti Nazihah Mohd Salleh, Cheng- Wang, Tomoyuki Igawa, Hideaki Shimada
Summary: This study demonstrates that through comprehensive engineering of the variable region, the engineered antibody, 5A6CCS1, is able to neutralize SARS-CoV-2 variants that escaped neutralization by the original antibody. In addition to improved affinity against variants, 5A6CCS1 was optimized for high solubility and low viscosity, enabling a high concentration formulation for subcutaneous injection. In animal experiments, 5A6CCS1 showed promising characteristics, highlighting the potential of antibody engineering to counteract escape variants.
Article
Pharmacology & Pharmacy
Wupeng Liao, Hazel Yu Ci Foo, Thi Ngoc Quy Tran, Christina Li Lin Chai, Wai Shiu Fred Wong
Summary: This study evaluated the protective effects of CalD in a house dust mite (HDM)-induced asthma mouse model. CalD reduced various inflammatory markers and improved lung function in the mice. It modulated the function of alveolar macrophages and had potential as a novel anti-inflammatory compound for allergic asthma.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Engineering, Biomedical
Nhan Dai Thien Tram, Quy Thi Ngoc Tran, Jian Xu, Jeannie Ching Ting Su, Wupeng Liao, Wai Shiu Fred Wong, Pui Lai Rachel Ee
Summary: Due to the failure of target-specific strategies, a novel multifunctional biomaterial based on peptide nanonets has been developed to selectively trap lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) in order to suppress inflammation and restore the antimicrobial activity of the last-resort antibiotic colistin. In addition to its ability to simultaneously trap and kill bacteria, the peptide nanonets have shown remarkable potential as a holistic anti-infective and anti-septic biomaterial.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Quy T. N. Tran, W. S. Daniel Tan, W. S. Fred Wong, Christina L. L. Chai
Summary: Andrographolide, a widely studied plant secondary metabolite, has diverse pharmacological targets associated with prevalent diseases. Despite documented efficacy in disease models, challenges such as multi-targeting properties and discrepancies in bioavailability have hindered its development as a therapeutic agent.
NATURAL PRODUCT REPORTS
(2021)