Article
Food Science & Technology
Margherita Modesti, Monica Macaluso, Isabella Taglieri, Andrea Bellincontro, Chiara Sanmartin
Summary: Ozone is widely used as a sanitizing agent in the agri-food and food processing industries, but it can also enhance the production of antioxidant and stress-related secondary metabolites in living tissues. This may improve the health-related properties of grapes and wine, with factors such as cultivar and application method influencing the effectiveness of ozone treatment. Studies show an increase in antioxidant compounds and stress-related volatiles, suggesting that ozone could be used to enhance the quality of berries and wine.
Article
Biology
Ahmed Ismail, Pranavkumar Gajjar, Minkyu Park, Abdulla Mahboob, Violeta Tsolova, Jayasankar Subramanian, Ahmed G. Darwish, Islam El-Sharkawy
Summary: Transcriptome profiling and mutational analysis suggest a potential deficiency in anthocyanin transport and degradation mechanisms that may cause unpigmented berries. Genome-wide association studies highlight a region on chromosome-4 and its relationship with genes encoding glutathione S-transferases. The presence of GST4b2/2 alleles is associated with the unpigmented trait.
COMMUNICATIONS BIOLOGY
(2022)
Article
Food Science & Technology
Yanlun Ju, La Yang, Xiaofeng Yue, Yunkui Li, Rui He, Shenglin Deng, Xin Yang, Yulin Fang
Summary: The study found that wines made from spine grapes have higher anthocyanin content and good color properties, which could be beneficial to the wine industry.
FOOD SCIENCE AND HUMAN WELLNESS
(2021)
Article
Food Science & Technology
Xiaofeng Yue, Yanlun Ju, Tianyi Zhang, Runze Yu, Huaide Xu, Zhenwen Zhang
Summary: This study found that exogenous salicylic acid affected the anthocyanins and monoterpene compounds in Muscat Hamburg grapes. The treatment of 50 mg/L salicylic acid significantly increased the anthocyanins content and promoted the accumulation of free or bound monoterpenes in mature grapes. It also increased the concentration of monoterpene components in the wine and accelerated the synthesis and accumulation of monoterpene components in grapes by upregulating key genes related to monoterpene biosynthesis. These findings provide fundamental knowledge for future improvements to grape aromas and anthocyanins.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Xiaofeng Yue, Pengbao Shi, Yali Tang, Huaixin Zhang, Xin Ma, Yanlun Ju, Zhenwen Zhang
Summary: This study found that preharvest treatments with methyl jasmonate (MeJA) can increase the levels of monoterpenes in Muscat Hamburg grapes and wine. The expression of genes related to monoterpene production was positively correlated with the accumulation of monoterpenes in grapes.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Agronomy
Maria Ines Rouxinol, Maria Rosario Martins, Gabriela Carneiro Murta, Joao Mota Barroso, Ana Elisa Rato
Summary: This study developed predictive models using NIR spectroscopy to quantify important quality attributes in red wine grapes. The models showed high accuracy and predictive ability for soluble solids content, titratable acidity, total anthocyanins, and total tannins.
Article
Agricultural Engineering
Alessandro Benelli, Chiara Cevoli, Luigi Ragni, Angelo Fabbri
Summary: A non-destructive method based on hyperspectral imaging technology was used to monitor the quality attributes of ‘Sangiovese’ grapes in a vineyard, successfully predicting the soluble solids content and classifying the samples. The study demonstrates the potential of using HSI technology for predicting harvest time under natural light conditions.
BIOSYSTEMS ENGINEERING
(2021)
Article
Chemistry, Applied
Agnes Dienes-Nagy, Frederic Vuichard, Sandrine Belcher, Marie Blackford, Johannes Roesti, Fabrice Lorenzini
Summary: A fast, sensitive, and reproducible LC-MS/MS method was developed, optimised, and applied for simultaneous quantification of glutathione (GSH), glutathione disulfide (GSSG), and glutathione-S-sulfonate (GSSO3H) in grape juice and wine samples. The results showed that GSH and GSSG were found in grape juice without added SO2, while GSSO3H was detected in must samples treated with SO2. In wine samples, GSSO3H was the dominant form of glutathione, indicating the importance of its quantification. The formation of GSSO(3)H in wine was correlated with the total SO2 level.
Article
Agriculture, Multidisciplinary
Chenchen Kang, Geraldine Diverres, Manoj Karkee, Qin Zhang, Markus Keller
Summary: This study developed a decision-support system for managing precision regulated deficit irrigation in vineyards, which included a soil moisture prediction model and an irrigation scheduling model based on artificial neural networks. Validation test results showed that the system was capable of accurately predicting soil moisture changes and creating an adequate irrigation plan to control soil moisture at desired levels.
COMPUTERS AND ELECTRONICS IN AGRICULTURE
(2023)
Article
Agriculture, Multidisciplinary
Marine Gammacurta, Justine Laboyrie, Andrei Prida, Valerie Lavigne, Virginie Moine, Philippe Darriet, Axel Marchal
Summary: The study investigated the influence of winemaking parameters on pyrrole concentrations in Chardonnay wines, finding significantly higher levels of pyrroles in wines made in new barrels compared to other containers, suggesting a significant contribution of oak wood during winemaking. The research also developed a method to assay pyrroles in oak wood extracts, and observed significant differences in pyrrole concentrations based on different cooperage parameters. These findings provide new insights for monitoring winemaking and aging of Chardonnay wines.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Applied
Yan-lun Ju, La Yang, Xiao-feng Yue, Rui He, Sheng-lin Deng, Xin Yang, Xu Liu, Yu-lin Fang
Summary: This study investigated the effects of variety on the astringency and chemistry of condensed tannins in spine grapes and wines. Different varieties showed significant differences in condensed tannin content and composition, impacting astringency. A positive correlation between the mean degree of polymerization of condensed tannins and astringency was observed.
Article
Biotechnology & Applied Microbiology
M. Margarida Baleiras-Couto, Rita Guedes, Filomena L. Duarte, Ana Margarida Fortes, Maria-Luisa Serralheiro
Summary: The metabolic composition of grapes and wine was examined to identify biomarkers for terroir differentiation. Anthocyanin was found to be a potential biomarker for terroir. Sensory analysis revealed that wines from site 1 scored higher than wines from site 2.
FERMENTATION-BASEL
(2023)
Letter
Green & Sustainable Science & Technology
Massimiliano Borrello, Luigi Cembalo, Riccardo Vecchio
Summary: Over the past 20 years, sustainability has become increasingly important in the wine industry, leading to the emergence of wines labeled as organic, biodynamic or natural due to heightened awareness among producers and interest from consumers. This letter encourages future research to focus on consumers' acceptance and interest in wines with sustainability characteristics, particularly emphasizing fungus resistant grape (FRG) varieties as a potential key innovation for the wine industry going forward.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Agricultural Engineering
Alessandro Benelli, Chiara Cevoli, Luigi Ragni, Angelo Fabbri
Summary: This study developed a non-destructive method based on hyperspectral imaging (HSI) technology to monitor and predict the ripeness and optimal harvest time of grapes. By analyzing grape samples from a 'Sangiovese' vineyard, using a Vis/NIR hyperspectral camera and a portable digital refractometer, the study predicted the soluble solids content (SSC) and classified the samples into ripe and not-ripe categories using partial least squares regression (PLS) and discriminant analysis (PLS-DA) respectively.
BIOSYSTEMS ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Maria del Valle Palenzuela, Nieves Lopez de Lerma, Fernando Sanchez-Suarez, Rafael Martinez-Garcia, Rafael Andres Peinado, Antonio Rosal
Summary: The application of wheat-straw spent mushroom substrate amendments to agriculture, specifically for growing Pleurotus ostreatus, was analyzed. The study examined the effects on soil properties, leaf characteristics, and wine composition. The amendments increased organic matter and macronutrient contents in the soil, and the use of vermicompost resulted in higher nitrate and potassium contents in the leaves. Furthermore, vermicompost treatment led to distinctive color and aroma profiles in the resulting wine.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Organic
Gregorio Cullia, Roberto Fanelli, Rome Voulhoux, Pascal Arnoux, Florine Cavelier
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2020)
Review
Chemistry, Applied
Hugo Bonnaffoux, Aurelie Roland, Remi Schneider, Florine Cavelier
Summary: This review focuses on volatile thiols in beverages and how they are released from precursors during processing. Volatile thiols in beverages can be classified into those with low molecular weight that negatively impact smell, and those with higher boiling points that contribute positively to aroma. Processing methods and growing methods can influence the amounts of thiols and their precursors.
Article
Biochemical Research Methods
Roberto Fanelli, Adrien Chastel, Santo Previti, Elif Hindie, Delphine Vimont, Paolo Zanotti-Fregonara, Philippe Fernandez, Philippe Garrigue, Frederic Lamare, Romain Schollhammer, Laure Balasse, Benjamin Guillet, Emmanuelle Remond, Clement Morgat, Florine Cavelier
BIOCONJUGATE CHEMISTRY
(2020)
Article
Pharmacology & Pharmacy
Pascal Tetreault, Elie Besserer-Offroy, Rebecca L. Brouillette, Adeline Rene, Alexandre Murza, Roberto Fanelli, Karyn Kirby, Alexandre J. Parent, Isabelle Dubuc, Nicolas Beaudet, Jerome Cote, Jean-Michel Longpre, Jean Martinez, Florine Cavelier, Philippe Sarret
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Article
Chemistry, Medicinal
Simon Gonzalez, Maria Dumitrascuta, Emilie Eiselt, Stevany Louis, Linda Kunze, Annalisa Blasiol, Melanie Vivancos, Santo Previti, Elke Dewolf, Charlotte Martin, Dirk Tourwe, Florine Cavelier, Louis Gendron, Philippe Sarret, Mariana Spetea, Steven Ballet
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Review
Chemistry, Medicinal
Synthia Michon, Florine Cavelier, Xavier J. Salom-Roig
Summary: Aurilides, a class of depsipeptides found mainly in marine cyanobacteria, have shown strong cytotoxicity against various cancer cell lines. Numerous studies on aurilides have emerged since 1996, summarizing both their biological activities and total syntheses of natural compounds and synthetic analogues.
Article
Behavioral Sciences
Melanie Vivancos, Roberto Fanelli, Elie Besserer-Offroy, Sabrina Beaulieu, Magali Chartier, Martin Resua-Rojas, Christine E. Mona, Santo Previti, Emmanuelle Remond, Jean-Michel Longpre, Florine Cavelier, Philippe Sarret
Summary: The chemically-modified NT(8-13) analog JMV5296 showed a prolonged plasma half-life, peptide selectivity toward NTS2, and induced a strong antinociceptive effect in acute, tonic, and chronic pain models without inducing hypothermia, suggesting it as a promising avenue for new stable NT agonists development and improvement of pain management.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Emmanuelle Remond, Jean-Alain Fehrentz, Laure Lienart, Sebastien Clement, Jean-Louis Baneres, Florine Cavelier
Summary: The study demonstrates a new method of synthesizing fluorescent P-hydroxybinaphtylphosphole-oxide or -sulfide for labeling biomolecules, particularly for characterizing GHSR ligands.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Santo Previti, Michael Desgagne, Dirk Tourwe, Florine Cavelier, Philippe Sarret, Steven Ballet
Summary: Chronic pain is a global health issue and opioid drugs are commonly used for pain management. However, they come with adverse effects. Neurotensin (NT) ligands have shown promising potential for pain management, without the adverse effects of opioids.
JOURNAL OF PEPTIDE SCIENCE
(2023)
Article
Agriculture, Multidisciplinary
Luigi Clerat, Emmanuelle Remond, Remi Schneider, Florine Cavelier, Eric Vives
Summary: Varietal thiols contribute to the aroma of various wines and beers, and their production depends on the metabolism of non-odorant aroma precursors by yeast. The conversion of these precursors is limited, so the use of exogenous carbon-sulfur beta-lyase (CSL) enzyme from Lactobacillus delbrueckii subsp. bulgaricus was explored to enhance the conversion. The study investigated the activity of the enzyme on different precursors, its behavior in the presence of competing analogues and at different pH values, and provided insights for substrate recognition, paving the way for aroma release in beer and wine.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Oncology
Romain Schollhammer, Marie-Laure Quintyn Ranty, Henri de Clermont Gallerande, Florine Cavelier, Ibai E. Valverde, Delphine Vimont, Elif Hindie, Clement Morgat
Summary: The accurate assessment of primary prostate cancer lesions is crucial for treatment decision making. PSMA Positron-Emission tomography/computed Tomography (PET/CT) may miss around 15% of lesions. Our study reveals that targeting both PSMA and neurotensin receptors could detect all intraprostatic lesions, which has implications for future theranostics of primary prostate cancer.
Article
Chemistry, Multidisciplinary
Sacha Bodin, Santo Previti, Emmanuelle Jestin, Delphine Vimont, Imade Ait-Arsa, Frederic Lamare, Emmanuelle Remond, Elif Hindie, Florine Cavelier, Clement Morgat
Summary: This study describes the development of a radiometalated neurotensin analogue (JMV 7488) targeting NTS2. The results demonstrate that JMV 7488 has high hydrophilicity, strong affinity and selectivity for NTS2, and can induce internalization in cells. In vivo experiments showed significant uptake of [68Ga]Ga-JMV 7488 in tumor tissue.
Article
Chemistry, Multidisciplinary
Sacha Bodin, Santo Previti, Emmanuelle Jestin, Delphine Vimont, Imade Ait-Arsa, Emmanuelle Remond, Elif Hindie, Florine Cavelier, Clement Morgat, Frederic Lamare
Summary: This study describes the radiometalated neurotensin analogue JMV 7488 targeting NTS2. It shows good hydrophilicity and affinity towards NTS2, as well as significant tumor uptake in biodistribution studies.
Meeting Abstract
Biochemistry & Molecular Biology
Santo Previti, Melanie Vivancos, Sacha Bodin, Emmanuelle Remond, Jean-Michel Longpre, Clement Morgat, Philippe Sarret, Florine Cavelier
JOURNAL OF PEPTIDE SCIENCE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Emmanuelle Remond, Jean Alain Fehrentz, Laure Lienart, Sebastien Clement, Jean Louis Baneres, Florine Cavelier
JOURNAL OF PEPTIDE SCIENCE
(2022)
