Article
Agriculture, Dairy & Animal Science
Tori E. Rudolph, Crystal M. Roach, Lance H. Baumgard, Jason W. Ross, Aileen F. Keating, Josh T. Selsby
Summary: The study found that heat stress and Zearalenone exposure can induce oxidative stress in porcine skeletal muscle, with potentially different responses in muscle fiber types. However, the combination of heat stress and Zearalenone did not significantly increase oxidative stress levels compared to individual exposures.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Chemistry, Physical
Fei Gao, Tingbin Zhang, Yuqing Miao, Huijun Ma, Hui Guo, Ruyi Jin, Zhi Li, Haifang Wang, Haiming Fan, Lingyun Zhao
Summary: A novel nanostructure, combining mild hyperthermia and chemotherapy, was designed to improve the efficacy of cancer treatment. Through exquisite microstructure design and physiochemical properties of the nanoplatform, the cancer therapeutic effect was significantly improved with minimal side effects.
Review
Food Science & Technology
Pavan Kumar, Muideen Adewale Ahmed, Abubakar Ahmed Abubakar, Muhammad Nizam Hayat, Ubedullah Kaka, Mokrish Ajat, Yong Meng Goh, Awis Qurni Sazili
Summary: Stress biomarkers such as blood profiles, serum hormones, and physiological conditions can be used to assess the stress status of animals. Factors including previous exposure, genetics, stress adaptation, intensity, duration, and rearing practices contribute to variations in the expression of stress biomarkers. Meat proteomics, specifically the analysis of muscle protein expression, can predict meat quality and stress in animals before slaughter. Finding non-invasive, rapid, and accurate stress biomarkers is essential for objectively assessing stress in animals.
Article
Agriculture, Dairy & Animal Science
Ivan Nastasijevic, Milica Glisic, Milan Milijasevic, Sasa Jankovic, Radmila Mitrovic, Jelena Babic Milijasevic, Marija Boskovic Cabrol
Summary: The modern pig meat production chain focuses on farm biosecurity, meat quality, and safety. To ensure consistent pork meat quality (and safety), an effective and reliable monitoring system based on selected biomarkers is needed in a farm-abattoir continuum.
Article
Neurosciences
Abderrezak Bouchama, Mamoon Rashid, Shuja Shafi Malik, Saeed Al Mahri, Yara Yassin, Mashan Abdullah, Nour Abdulmalek, Fuad Maashi, Abdulaziz Mashi, Altaf Khan, Badriah Alotaibi, Cynthia Lehe, Sameer Mohammad, Haitham Alkadi, Deemah Al Waadani, Saber Yezli
Summary: An evolutionary heat shock response (HSR) protects most living species, including humans, from heat-induced macromolecular damage. However, its role in the pathogenesis of heat stroke is unknown. We examined the whole genome transcriptome in peripheral blood mononuclear cells of subjects who developed heat stroke versus those who did not. The findings reveal the molecular signature of heat stroke and suggest that a powerful HSR may not be sufficient to protect against heat injury.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Virology
Cristina Moraru
Summary: In recent years, there have been significant changes in the classification criteria and taxonomy of viruses. The current classification scheme, known as megataxonomy of viruses, identifies six viral realms based on the presence of viral hallmark genes. Within these realms, viruses are further classified using hierarchical taxons based on the phylogeny of their shared genes. To assist with virus clustering and classification, a novel reference-free tool called VirClust has been developed. This tool allows for protein clustering, hierarchical clustering of viruses, identification of core proteins, and annotation of viral proteins.
Article
Engineering, Biomedical
Yue Wang, Shuqi Wang, Shanshan Li, Wenyao Zhen, Xiaodan Jia, Xiue Jiang
Summary: The polydopamine (PDA) photothermal agent's conversion efficiency in the NIR-II region is improved through the development of novel hollow cavity CaO2@PDA nanocomposites. The pH-responsive degradation of CaO2 transforms its structure into a stacked nano-mesh with enhanced light absorption and enlarged effective irradiation area, promoting efficient mild hyperthermia in the NIR-II region.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Cell Biology
Li Li, Daopeng Li, Di Sun, Xueqin Zhang, Wanying Lei, Mei Wu, Qiuying Huang, Ximing Nian, Wenxiu Dai, Xiaoyun Lu, Zhihao Zhou, Yanqin Zhu, Yunshan Xiao, Ling Zhang, Wei Mo, Zhixiong Liu, Liang Zhang
Summary: Mutation in Hikeshi gene is associated with leukodystrophy, but the underlying mechanisms are unclear. This study demonstrates the essential role of Hikeshi in central nervous system myelination and reveals the interaction between nuclear-localized HSP70s and SOX10, which protects SOX10 from degradation. Furthermore, the study shows that Hikeshi-dependent hyperthermia therapy can promote remyelination.
DEVELOPMENTAL CELL
(2023)
Article
Multidisciplinary Sciences
Ke-Jun Chen, Feng-Zeng Li, Qian Ye, Meng Jia, Sheng Fang
Summary: Heat shock protein 105 (HSP105) is overexpressed in cutaneous malignant melanoma (CMM) and is closely associated with different clinicopathological variables. Lesions in exposed sites, recurrent and metastatic lesions, nodular melanoma, and lentigo maligna melanoma show higher HSP105 expression, suggesting HSP105 as a potential target for the diagnosis, treatment, and prognostic prediction of CMM.
Article
Biochemistry & Molecular Biology
Chae-Ryeong Ahn, Seung-Ho Baek
Summary: Gastric cancer is a global health threat, especially in Asian countries. Current treatment methods have limitations, and hyperthermia therapy using heat to destroy cancer cells has limited efficacy. This study investigated the synergistic anticancer effects of cotreatment with Linderae Radix (LR) and hyperthermia in gastric cancer cells, and found that LR has the potential to enhance the therapeutic efficacy of hyperthermia treatment.
Article
Cell Biology
Lina Y. Abou Zeid, Shanmugapriya Shanmugapriya, Rebecca L. Rumney, Dick D. Mosser
Summary: Cells respond to stress by limiting cellular damage and preventing cell death through adaptive mechanisms. Research shows that in apoptotic cells, key proteins involved in miRNA biogenesis are cleaved by caspases, but overexpression of the molecular chaperone protein HSP70 can prevent this degradation.
CELL STRESS & CHAPERONES
(2022)
Article
Biochemistry & Molecular Biology
Chae Ryeong Ahn, Hyo In Kim, Jai-Eun Kim, In Jin Ha, Kwang Seok Ahn, Jinbong Park, Young Woo Kim, Seung Ho Baek
Summary: Gastric cancer has a high incidence and mortality rate with poor prognosis. Hyperthermia therapy combined with Ponciri Fructus Immaturus (PF) showed synergistic effects in suppressing AGS gastric cancer cell proliferation, inducing cell cycle arrest, and inhibiting metastasis-related factors. The combination treatment also increased reactive oxygen species (ROS) levels and suppressed heat shock factor 1 and heat shock proteins (HSPs), suggesting a potential promising therapy for gastric cancer.
Article
Veterinary Sciences
Nikola Cobanovic, Silvana Stajkovic, Jasna Kureljusic, Jadranka Zutic, Branislav Kureljusic, Sanja D. J. Stankovic, Nedjeljko Karabasil
Summary: This study found a significant association between lung lesions and growth performance, biochemical indicators, and carcass and meat quality in slaughtered pigs, with pigs without lung lesions having better meat quality. Pigs with severe lung lesions may be simultaneously infected with multiple respiratory pathogens.
PREVENTIVE VETERINARY MEDICINE
(2021)
Article
Oncology
Petros X. E. Mouratidis, Gail ter Haar
Summary: Sub-ablative heat combined with HSP90 inhibition can enhance cell death and induce a pro-immune phenotype in colon cancer cells. The study found that exposure to specific thermal doses decreased cell viability, while treatment with a combination of heat and HSP90 inhibitor resulted in a synergistic decrease in cell viability and induction of apoptosis. This suggests a potential therapeutic strategy for targeting colon cancer cells.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Review
Oncology
Aisha Babi, Karashash Menlibayeva, Torekhan Bex, Aidos Doskaliev, Serik Akshulakov, Maxim Shevtsov
Summary: This review examines the role and prognostic value of heat shock proteins (HSPs) in neuro-oncology, as well as the potential for using HSPs as therapeutic targets. Preclinical studies have shown the therapeutic potential of HSP inhibitors for targeting brain tumors, either as monotherapy or in combination with other treatment approaches.
Article
Food Science & Technology
Laetitia Theron, Thierry Sayd, Christophe Chambon, Antoine Vautier, Claude Ferreira, Laurent Aubry, Vincenza Ferraro, Veronique Sante-Lhoutellier
Article
Food Science & Technology
Julia Bechaux, Vincenza Ferraro, Thierry Sayd, Christophe Chambon, Jean Francois Le Page, Yoan Drillet, Philippe Gatellier, Veronique Sante-Lhoutellier
FOOD RESEARCH INTERNATIONAL
(2020)
Article
Agriculture, Dairy & Animal Science
Anna-Maria Reiche, Frigga Dohme-Meier, E. M. Claudia Terlouw
APPLIED ANIMAL BEHAVIOUR SCIENCE
(2020)
Article
Food Science & Technology
Angeline Duval, Thierry Sayd, Laurent Aubry, Claude De Oliviera Ferreira, Vincenza Ferraro, Veronique Sante-Lhoutellier
Review
Food Science & Technology
E. M. Claudia Terlouw, Brigitte Picard, Veronique Deiss, Cecile Berri, Jean-Francois Hocquette, Benedicte Lebret, Florence Lefevre, Ruth Hamill, Mohammed Gagaoua
Summary: Lack of robust models for predicting meat quality traits using muscle biochemical characteristics may be due to neglect of various aspects of the model paradigm, including the impact of preslaughter stress on meat quality, the fact that phenotypic similarity does not imply similarity in biological causes, and the complexity of biological systems, which can reach homeostatic equilibrium in countless ways involving thousands of interacting processes and molecules.
Article
Food Science & Technology
E. M. Claudia Terlouw, Veronique Deiss, Thierry Astruc
Summary: The study found that compared to electrical stunning, gas stunning resulted in a faster pH decline in the Longissimus lumborum muscle, but had minor effects on other muscles, as well as color and drip loss. The impact of stress and muscle contractions during unconsciousness induction was slightly greater with gas stunning, but differences were limited to certain muscles only.
Article
Food Science & Technology
E. M. Claudia Terlouw, Veronique Deiss, Thierry Astruc
Summary: The study used thirty-one pigs to investigate induction of unconsciousness and behavioral reactions in different gas mixtures. All pigs lost consciousness, experienced respiratory difficulties, and involuntary muscle contractions. Differences were found in behavior latency and delays between behaviors among the mixtures. Overall, discomfort was caused by all mixtures, and the addition of O2 or N2O to the CO2 mixture did not provide an advantage.
Article
Food Science & Technology
Laetitia Theron, Aline Bonifacie, Jeremy Delabre, Thierry Sayd, Laurent Aubry, Philippe Gatellier, Christine Ravel, Christophe Chambon, Thierry Astruc, Jacques Rouel, Veronique Sante-Lhoutellier, Matthieu Refregiers, Frank Wien
Summary: Food processing can impact the structure and chemical state of proteins, potentially leading to oxidation and impairment of properties, affecting protein digestibility. This study aims to understand how oxidative processes influence the structure and activity of pepsin during digestion.
Article
Nutrition & Dietetics
Christophe Chambon, Eric Neyraud, Thierry Sayd, Pauline Bros, Romane Di Biagio, Frank Hyvrier, Catherine Feart, Perrine Andre, Fernando Rodriguez-Artalejo, Esther Lopez-Garcia, Esther Garcia-Esquinas, David Gomez-Cabrero, Gordon Proctor, Martine Morzel
Summary: The study aimed to evaluate whether the saliva protein composition of elderly individuals can reflect their dietary habits and investigated the impact of type 2 diabetes on the saliva-diet correlation. Results showed that the saliva proteome composition was associated with the intake level of certain food groups, especially vegetables, fruits, sweet snacks, and red meat. The study also identified some biological processes consistently affected by diet.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Laurent Aubry, Thierry Sayd, Claude Ferreira, Christophe Chambon, Annie Venien, Sylvie Blinet, Marie Bourin, Angelique Travel, Maeva Halgrain, Veronique Sante-Lhoutellier, Laetitia Theron
Summary: This study successfully developed a method to distinguish frozen-thawed poultry livers from fresh livers using mass spectrometry and chemometrics. It provides a promising opportunity for agencies to implement a reference method to combat fraud in the marketing of poultry livers.
Article
Multidisciplinary Sciences
Christophe Chambon, Thierry Sayd, Sylvie Bourillon, Laetitia Theron, Vincent Niderkorn
Summary: The protein degradation of alfalfa hay after tannin supplementation was monitored, and the digestomic dataset revealed the protein regions protected by tannin supplementation, providing valuable information for studying protein use efficiency by ruminants.
Article
Chemistry, Multidisciplinary
Laurent Aubry, Khady Sy, Thierry Sayd, Vincenza Ferraro
Summary: Food-grade animal by-products, such as bovine bone, contain bioactive peptides that can be used as natural antioxidant compounds. This study investigated the effect of enzymes of different origins and processing parameters on the antioxidant activity of collagen peptides. Collagenase B showed the highest antioxidant capacity, which was further improved by peptide mixing and concentration. These findings suggest that bovine bone and other animal by-products have potential applications in high-value food and health products.
APPLIED SCIENCES-BASEL
(2023)
Editorial Material
Food Science & Technology
Claudia Terlouw, Mohammed Gagaoua
Article
Chemistry, Applied
Stephane Portanguen, Charlotte Dumoulin, Anne Duconseille, Maia Meurillon, Jason Sicard, Laetitia Theron, Christophe Chambon, Thierry Sayd, Pierre-Sylvain Mirade, Thierry Astruc
Summary: The increasing number of people around the world suffering from chewing disorders necessitates the design of foods adapted to their needs. Glycation could be considered as one of the possible texturing methods. This study focuses on the impact of initial water content and Bloom index on the glycation reaction and texture of gelatin gels, highlighting the importance of controlling these factors for food texturing.
FOOD HYDROCOLLOIDS
(2023)
Article
Biochemistry & Molecular Biology
M-A. Peyron, T. Sayd, J. Sicard, P-S. Mirade, J. Pinguet, C. Chambon, V. Sante-Lhoutellier
Summary: The study compared the fate of food in elderly and adult digestive conditions, finding that inadequate chewing leads to harder and more oxidized food boluses, with a smaller impact on the elderly. Protein digestion kinetics were studied using modeling, and a large number of peptides were identified. The results showed different trajectories and rates of protein hydrolysis between elderly and adult digestive conditions.