Article
Oncology
Shruti Jain, Nimrah Nadeem, Benjamin Ulfenborg, Maria Makela, Shamima Afrin Ruma, Joonas Terava, Kaisa Huhtinen, Janne Leivo, Bjorg Kristjansdottir, Kim Pettersson, Karin Sundfeldt, Kamlesh Gidwani
Summary: Our study discovered and evaluated nanoparticle aided sensitive assays for glycovariants of MUC16 and MUC1 in ovarian cyst fluids and serum samples. The glycovariants showed improved separation capability compared to conventional assays in differentiating ovarian carcinoma from controls. The STn glycovariants in serum performed the best, especially in postmenopausal and early-stage disease.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Medical Laboratory Technology
Mukulika Bose, Alexa Sanders, Chandrav De, Ru Zhou, Priyanka Lala, Sophia Shwartz, Bhaskar Mitra, Cory Brouwer, Pinku Mukherjee
Summary: Pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDA), is a major cause of cancer-related deaths in the United States. Surgical resection is the best treatment option, but only a small percentage of patients are eligible. Recurrence and metastasis are the main reasons for mortality. A monoclonal antibody named TAB004 has been developed to target tumor-associated MUC1 (tMUC1), which is expressed in over 80% of PDAs. Treatment with TAB004 has shown significant effects in reducing colony-forming potential in PDA cells and inducing cell death. The mechanism involves disruption of cellular integrity, activation of ER stress and anoikis, and inhibition of oncogenic signaling pathways. TAB004 also exhibited promising results in mouse models, indicating its potential as a prophylactic agent to prevent tumor relapse, metastasis, and increase the efficacy of chemotherapy.
TRANSLATIONAL RESEARCH
(2023)
Article
Microbiology
Nobuhide Kobayashi, Kimihiro Abe, Sachiyo Akagi, Mayu Kitamura, Yoshitake Shiraishi, Aki Yamaguchi, Masahiro Yutani, Sho Amatsu, Takuhiro Matsumura, Nobuhiko Nomura, Noriyuki Ozaki, Nozomu Obana, Yukako Fujinaga
Summary: Bacterial membrane vesicles produced by Clostridium botulinum and related species induce host inflammatory responses and immune reactions.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Nutrition & Dietetics
Eric C. Bredahl, Joan M. Eckerson, Steven M. Tracy, Thomas L. McDonald, Kristen M. Drescher
Summary: The use of dietary supplements has become increasingly common over the past 20 years, extending beyond elite athletes to include recommendations from healthcare professionals to patients. Creatine is a widely used supplement that has been well-studied for its positive effects on performance and health, especially in recovery from exercise. However, limited research exists on the effects of creatine on children and the elderly.
Article
Biochemistry & Molecular Biology
Yanchao Gu, Jingjing Tang, Fuhua Zhang, Yichen Qu, Min Zhao, Mengyuan Li, Zhen Xie, Xiao Wang, Li Song, Zhengfan Jiang, Yao Wang, Xihui Shen, Lei Xu
Summary: Divalent metal ions such as Mn2+ and Zn2+ have immunostimulatory effects and can enhance the expression of genes involved in innate immune responses induced by lipopolysaccharide. The enhancement of gene expression by Mn2+ is dose-dependent and partially relies on the cGAS-STING pathway independent of TLR4. Mn2+ has the potential to be a therapeutic target for preventing excessive immune responses.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Immunology
Amanda L. Verzosa, Lea A. McGeever, Shun-Je Bhark, Tracie Delgado, Nicole Salazar, Erica L. Sanchez
Summary: This article discusses the transmission and lifecycle of alphaherpesviruses, with a focus on the impact of HSV-1 on host cell innate immune responses. It highlights how HSV-1 suppresses immune responses through various mechanisms, primarily in neuronal and epithelial cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Stavros Garantziotis, Rashmin C. Savani
Summary: The extracellular matrix (ECM) is not only a structure but also plays key roles in cellular responses. Proteoglycans (PGs), a component of ECM, have been found to be crucial in both health maintenance and disease development by activating the innate immune system and influencing cell fate.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Anna L. Aalto, Veera Luukkonen, Annika Meinander
Summary: Cells respond to pathogens and danger signals by adapting gene expression and activating molecular pathways in order to protect the organism. The fruit fly Drosophila melanogaster serves as a model organism to study immune signaling and defense mechanisms. The immune response in fruit flies includes cellular and humoral responses, which are regulated by ubiquitination and changes in protein levels.
Article
Neurosciences
Ruthe Storgaard Dieu, Vian Wais, Michael Zaucha Sorensen, Joanna Marczynska, Magdalena Dubik, Stephanie Kavan, Mads Thomassen, Mark Burton, Torben Kruse, Reza Khorooshi, Trevor Owens
Summary: Studies have shown that modulation of innate receptors TLR7 and TLR9 signaling in the central nervous system can induce different inflammatory responses, with potential therapeutic implications for diseases such as multiple sclerosis.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Cell Biology
Christine M. O'Connor, Ganes C. Sen
Summary: When a host cell is infected by a viral pathogen, the interferon system will initiate attacks, accumulating antiviral proteins and protective cytokines. However, viruses often evolve mechanisms to undermine host immune responses.
Article
Chemistry, Multidisciplinary
Xuan Liu, Lunzhi Yuan, Jijing Chen, Yali Zhang, Peiwen Chen, Ming Zhou, Jiaxuan Xie, Jian Ma, Jianzhong Zhang, Kun Wu, Qiyi Tang, Quan Yuan, Huachen Zhu, Tong Cheng, Yi Guan, Gang Liu, Ningshao Xia
Summary: Highly pathogenic coronavirus infection leads to defective innate immune response and excessive release of proinflammatory cytokines, resulting in acute respiratory distress syndrome (ARDS). A new antiviral nanobiologic, CoVR-MV, has been developed to interfere with viral infection and promote innate antiviral defenses. CoVR-MV absorbs viruses through its viral spike target interface, interacts with macrophages to clear the virus, and stimulates the production of endogenous type I interferon. These processes modulate the innate immune responses, activate antiviral defenses, and rescue Syrian hamsters from ARDS caused by SARS-CoV-2 and its variants.
Article
Ophthalmology
Edward J. Wladis, Alejandro P. Adam
Summary: Rosacea is a common chronic skin disease that predominantly affects people aged 40 and above, with no current cure. When it affects the eyelids and periocular skin, it can lead to dry eye and potential corneal damage. Research in the past decade has shed light on potential mechanisms leading to skin hypersensitivity and has provided promising avenues for development of novel therapeutics aimed at reducing skin inflammation.
Review
Immunology
Shasha Chen, Zhiyong Liao, Pinglong Xu
Summary: Mitochondria play versatile roles in cellular processes and have emerged as critical components in innate immunity. This review provides a comprehensive exploration of the multifaceted mechanisms underlying the interactions between mitochondria and innate immune responses. It discusses the roles of healthy mitochondria as platforms for signalosome assembly, the release of mitochondrial components as signaling messengers, and the regulation of signaling via mitophagy. Additionally, it explores the impacts of mitochondrial proteins and metabolites on modulating innate immune responses, immune cell polarization, and their implications in infectious and inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Parasitology
Nicolas Salcedo-Porras, Pedro Lagerblad Oliveira, Alessandra Aparecida Guarneri, Carl Lowenberger
Summary: This study reveals time-dependent and pathogen-specific regulation of immune responses in triatomines, suggesting strong interactions between the immune deficiency and Toll pathways.
PARASITES & VECTORS
(2022)
Article
Immunology
Melanie D. Balhuizen, Chantal M. Versluis, Monica O. van Grondelle, Edwin J. A. Veldhuizen, Henk P. Haagsman
Summary: Antibiotic resistance is increasing, and bacterial vaccines, such as outer membrane vesicles (OMVs) produced by Gram-negative bacteria, can be used to prevent resistance development. Host defense peptides (HDPs), specifically cathelicidins, have been found to modulate immune responses by interacting with OMVs and neutralizing LPS-induced TLR4 activation. Additionally, TLR2, 4, 5, and 9 play a role in macrophage stimulation by OMVs.
Article
Endocrinology & Metabolism
Joseph F. Arboleda-Velasquez, Cammi N. Valdez, Christina K. Marko, Patricia A. D'Amore
CURRENT DIABETES REPORTS
(2015)
Article
Pathology
Christina K. Marko, Balaraj B. Menon, Gang Chen, Jeffrey A. Whitsett, Hans Clevers, Ilene K. Gipson
AMERICAN JOURNAL OF PATHOLOGY
(2013)
Article
Audiology & Speech-Language Pathology
Christina L. Kaiser, Brittany J. Chapman, Jessica L. Guidi, Caitlin E. Terry, Dominic A. Mangiardi, Douglas A. Cotanche
Review
Audiology & Speech-Language Pathology
Douglas A. Cotanche, Christina L. Kaiser
Article
Medicine, Research & Experimental
Christina L. Kaiser, Andrew J. Kamien, Priyanka A. Shah, Brittany J. Chapman, Douglas A. Cotanche
Article
Neurosciences
H. E. Karnes, C. L. Kaiser, D. Durham
Article
Ophthalmology
Dhanesh Amarnani, Arturo Israel Machuca-Parra, Lindsay L. Wong, Christina K. Marko, James A. Stefater, Tomasz P. Stryjewski, Dean Eliott, Joseph E. Arboleda-Velasquez, Leo A. Kim
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2017)
Article
Biochemistry & Molecular Biology
Leo A. Kim, Lindsay L. Wong, Dhanesh S. Amarnani, Alexander A. Bigger-Allen, Yang Hu, Christina K. Marko, Dean Eliott, Vinay A. Shah, Declan McGuone, Anat O. Stemmer-Rachamimov, Xiaowu Gai, Patricia A. D'Amore, Joseph F. Arboleda-Velasquez
Article
Ophthalmology
Christina Kaiser Marko, Ann S. Tisdale, Sandra Spurr-Michaud, Christopher Evans, Ilene K. Gipson
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2014)
Article
Audiology & Speech-Language Pathology
CL Kaiser, DA Girod, D Durham