Review
Medicine, General & Internal
S. Sharif, P. T. Heath, S. J. Oddie, W. McGuire
Summary: The study aims to evaluate the effect of enteral supplementation with synbiotics versus placebo or no treatment, or versus probiotics or prebiotics alone on the risk of necrotising enterocolitis and associated morbidity and mortality in very preterm or very low birth weight infants.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Nutrition & Dietetics
Jorge Amil Dias, Edmundo Santos, Ines Asseiceira, Sylvia Jacob, Carmen Ribes Koninckx
Summary: The incidence of allergic diseases is increasing globally, and experts discuss the role of infant formulas in preventing allergies in infants who cannot be breastfed and are at risk of developing allergies. They focus on risk assessment, the impact of microbiota on immune tolerance, and the importance of certain formula characteristics. The article provides the latest evidence and recommendations for parents in choosing a formula for infants at risk of allergy.
Review
Food Science & Technology
Parisa Janmohammadi, Zeinab Nourmohammadi, Siavash Fazelian, Atieh Mirzababaei, Shahab Alizadeh, Mahtab Zarei, Elnaz Daneshzad, Kurosh Djafarian
Summary: Several studies have suggested that formulas containing synbiotics (composed of prebiotics and probiotics) may have a positive effect on anthropometric indices. However, the results of these studies are inconsistent. This meta-analysis found that the consumption of formulas containing synbiotics did not significantly affect the growth of healthy infants.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biotechnology & Applied Microbiology
Manoj Kumar Yadav, Indu Kumari, Bijender Singh, Krishna Kant Sharma, Santosh Kumar Tiwari
Summary: Probiotics are an economical and safe alternative for treating chronic diseases and improving human health. They modulate the host immunity and protect against infectious and non-infectious diseases. Additionally, prebiotics and non-digestible food substances promote the growth of probiotics and human health through modulation of gut microbiota and immune system.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Agnieszka Chlebicz-Wojcik, Katarzyna Slizewska
Summary: Irritable bowel syndrome is not life-threatening but significantly impacts quality of life and economic loss. Research focuses on the role of intestinal microbiota in disease development, with an emphasis on therapies modulating the microbiota such as probiotics, prebiotics, and synbiotics. Most studies have focused on probiotics, but there are also promising results from studies on prebiotics and synbiotics.
Review
Nutrition & Dietetics
Melissa Basso, Nicola Johnstone, Paul Knytl, Arjen Nauta, Andre Groeneveld, Kathrin Cohen Kadosh
Summary: This article reviews psychobiotic interventions in children and adolescents, aiming to evaluate the effectiveness of pre- and probiotic supplements on stress, anxiety, and cognitive outcomes. The findings indicate limited consistent effects of psychobiotics in developing human populations, possibly due to trial heterogeneity.
Review
Pediatrics
Maddalena Petraroli, Eleonora Castellone, Viviana Patianna, Susanna Esposito
Summary: Obesity has become a serious public health issue, with the gut microbiota playing a key role in its development. Specific probiotic strains have been shown to impact some secondary metabolic consequences of obesity without affecting weight loss. Further targeted studies are needed to fully understand the influence of microbiota on weight.
FRONTIERS IN PEDIATRICS
(2021)
Article
Gastroenterology & Hepatology
Raakel Luoto, Anna Paertty, Josef K. Vogt, Samuli Rautava, Erika Isolauri
Summary: This study investigated the composition and function of the gut microbiome in moderately and late preterm infants. Probiotic and prebiotic treatments were found to mitigate the changes in the microbiome, indicating their potential in promoting healthy gut microbiome development in preterm infants.
Review
Biochemistry & Molecular Biology
Katarzyna Logon, Gabriela Swirkosz, Monika Nowak, Martyna Wrzesniewska, Aleksandra Szczygiel, Krzysztof Gomulka
Summary: The role of the microbiome in asthma pathology and treatment is significant, as highlighted in this article. The interplay between asthma and the microbiome is complex, and further research is needed to clarify the factors that moderate this relationship. The pre-treatment bronchial microbiome in asthmatic patients influences their response to treatment. The gut microbiota and its dysbiosis can contribute to immune system modulation and the development of asthma. An appropriate gut microbiome and its intestinal metabolites are protective factors for asthma development. Prebiotics and specific dietary strategies may have prophylactic or therapeutic effects, but further research is needed for definitive conclusions. While evidence regarding probiotics is inconclusive, recent studies have shown promising effects. Future studies should focus on investigating specific strains and examining their mechanisms and genetic aspects.
Review
Immunology
Shuting Tong, Peiyu Zhang, Qi Cheng, Mo Chen, Xin Chen, Zitao Wang, Xiaoyong Lu, Huaxiang Wu
Summary: This article summarizes the role of gut microbiota in the onset and progression of gout, discusses its importance in the diagnosis and treatment of gout, and explores potential therapeutic approaches targeting the gut microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Nutrition & Dietetics
Lien Meirlaen, Elvira Ingrid Levy, Yvan Vandenplas
Summary: This study investigates whether the prevention and treatment of allergic rhinitis and asthma can be achieved through administration of pro-, pre- and/or synbiotics, with disappointing outcomes in infant clinical studies likely due to multiple confounding factors.
Review
Entomology
Carlotta Savio, Loretta Mugo-Kamiri, Jennifer K. Upfold
Summary: Insect farming is becoming increasingly important in the livestock market, but the high-density and closed environment conditions can lead to higher risks of insect diseases and decreased reproductive and growth performances. The role of microbiota composition in insect behavior and health maintenance needs further study for selecting microorganisms that act as probiotics and enhance host performances while reducing risks related to insect diseases. When specific microorganisms are provided as dietary supplements, they can improve insect reproduction, food conversion, growth, and health in cases of nutritional deficiency or pathogen infection. This review provides an overview of insect-microbiota interactions, reviews the role of probiotics in insects reared for food and feed, and discusses methods for selecting and measuring the effectiveness of a probiotic. Future perspectives on probiotic applications in mass-reared insects are also outlined.
Review
Nutrition & Dietetics
Kathrin Cohen Kadosh, Leilani Muhardi, Panam Parikh, Melissa Basso, Hamid Jan Jan Mohamed, Titis Prawitasari, Folake Samuel, Guansheng Ma, Jan M. W. Geurts
Summary: Proper nutrition is essential for normal brain and neurocognitive development in children, particularly during the first 1000 days after birth. In addition to lipids and proteins, the balance of microbial diversity and gut-brain axis also play crucial roles in brain development and behavior.
Article
Food Science & Technology
Michal Wlodarczyk, Katarzyna Slizewska
Summary: Research indicates a correlation between gut microbiota and metabolic disorders, with noticeable differences in composition between lean and obese individuals. Maintaining a proper balance of intestinal microbiota through proper diet and use of probiotics and prebiotics is crucial for preserving the host's health. The impact of gastrointestinal microbes, probiotics, and prebiotics on processes leading to metabolic disorders is further discussed for a clear overview.
Review
Biochemistry & Molecular Biology
Mengyi Xu, Kangkang Luo, Junjie Li, Yu Li, Yuxuan Zhang, Zhiyao Yuan, Qiang Xu, Xudong Wu
Summary: The recent advancements in intestinal microbial sequencing technologies have significantly impacted our understanding of the role of intestinal microbes in various chronic liver diseases. Intestinal factors such as microbial dysbiosis and increased permeability play a crucial role in the pathogenesis of liver diseases. Potential therapeutic approaches, including antibiotics, probiotics, and prebiotics, show promise in improving liver diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
D. Declercq, K. Huysentruyt, B. Hauser, E. De Wachter, S. Van Daele, F. De Baets, S. Van Biervliet
Summary: This study observed the long-term effect of enteral tube feeding (ETF) on weight, height, growth velocity, and BMI in children with cystic fibrosis. It found that ETF led to rapid weight gain and improved growth, but FEV1% remained lower compared to controls. The study suggests that early introduction of ETF in malnourished children with CF may be beneficial for growth.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Pediatrics
Constance Carels, Lucas Wauters, An Outtier, Filip Baert, Peter Bossuyt, Arnaud Colard, Danny De Looze, Marc Ferrante, Alexander Goegebuer, Bruno Hauser, Robert Hilbrands, Ilse Hoffman, Bart Keymeulen, Isabelle Paquot, Isabelle Ruytjens, Marc Simoens, Clara Thienpont, Annelies Verreth, Bram Verstockt, Severine Vermeire, Gigi Veereman
Summary: Young Belgian adults with Crohn's disease for over 5 years have similar and sufficient health literacy compared to patients with type 1 diabetes. However, Crohn's disease patients requiring hospitalization or surgery have lower health literacy, indicating the need for targeted educational programs.
FRONTIERS IN PEDIATRICS
(2021)
Review
Gastroenterology & Hepatology
Jutta Keller, Heinz F. Hammer, Bruno Hauser
Summary: C-13-gastric emptying breath tests are validated, reliable, and non-invasive tools for measuring gastric emptying velocity, but test results are influenced by various factors.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Matjaz Homan, Bruno Hauser, Claudio Romano, Christos Tzivinikos, Filippo Torroni, Frederic Gottrand, Iva Hojsak, Luigi Dall'Oglio, Mike Thomson, Patrick Bontems, Priya Narula, Raoul Furlano, Salvatore Oliva, Jorge Amil-Dias
Summary: A multidisciplinary approach is essential for the best treatment of children with PEGs, with individualized indications for PEG insertion and consideration of all appropriate circumstances by a MDT. Timely enteral nutrition is crucial to treat faltering growth and avoid complications, with device choice and method of insertion dependent on local expertise and collaboration with the MDT and family. Major complications should be avoided through attention to good technique and experience of the operating team.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Nutrition & Dietetics
Charlotte De Geyter, Kris Van de Maele, Bruno Hauser, Yvan Vandenplas
Summary: The study found that measuring CH4 may contribute to the diagnosis of lactose intolerance, with a portion of patients being negative for H-2 but positive for CH4 and experiencing symptoms.
Review
Gastroenterology & Hepatology
Heinz F. Hammer, Mark R. Fox, Jutta Keller, Silvia Salvatore, Guido Basilisco, Johann Hammer, Loris Lopetuso, Marc Benninga, Osvaldo Borrelli, Dan Dumitrascu, Bruno Hauser, Laszlo Herszenyi, Radislav Nakov, Daniel Pohl, Nikhil Thapar, Marc Sonyi
Summary: This clinical practice guideline on H2-CH4-breath tests was developed based on consensus among experts from multiple European countries. It incorporates new insights into the role of symptom assessment in diagnosing carbohydrate intolerance and highlights confounding factors associated with the interpretation of breath tests for different indications. The guideline aims to harmonize diagnostic approaches in gastroenterology practice across Europe and identifies areas for future research on diagnostic and therapeutic approaches.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Review
Gastroenterology & Hepatology
Jutta Keller, Heinz F. Hammer, Paul R. Afolabi, Marc Benninga, Osvaldo Borrelli, Enrique Dominguez-Munoz, Dan Dumitrascu, Oliver Goetze, Stephan L. Haas, Bruno Hauser, Daniel Pohl, Silvia Salvatore, Marc Sonyi, Nikhil Thapar, Kristin Verbeke, Mark R. Fox
Summary: C-13-breath tests are valuable diagnostic tools for assessing gastrointestinal symptoms and diseases, but lack standardization in performance and interpretation. This clinical practice guideline aims to define the indications, performance, and interpretation of these tests, with input from experts across Europe.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Review
Pediatrics
Iva Hojsak, Marc A. Benninga, Bruno Hauser, Aydan Kansu, Veronica B. Kelly, Alison M. Stephen, Ana Morais Lopez, Joanne Slavin, Kieran Tuohy
Summary: Fiber is an essential nutrient in the human diet that provides various benefits through the fermentation process by the gut microbiome. Lack of fiber is associated with multiple disorders in children. Current recommendations for daily fiber intake focus on quantity rather than quality.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Gastroenterology & Hepatology
Marc Sonyi, Johann Hammer, Guido Basilisco, Oana Belei, Marc A. Benninga, Dmitry S. Bordin, Dan Dumitrascu, Bruno Hauser, Laszlo Herszenyi, Loris Lopetuso, Francois Mion, Agata Mulak, Radislav Nakov, Ventsislav Nakov, Bojan Tepes, Heinz F. Hammer
Summary: This study developed and implemented a centrally organized process for the translation of validated questionnaires, following a predefined procedure. The structured procedure may aid in future efforts to standardize and harmonize the translation of validated questionnaires.
JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES
(2022)
Article
Gastroenterology & Hepatology
Oren Ledder, Matjaz Homan, Raoul Furlano, Alexandra Papadopoulou, Salvatore Oliva, Jorge Amil Dias, Luigi Dall'oglio, Simona Faraci, Priya Narula, Dominique Schluckebier, Bruno Hauser, Andreia Nita, Claudio Romano, Christos Tzivinikos, Patrick Bontems, Mike Thomson
Summary: Crohn's disease often leads to bowel strictures, causing obstructive symptoms and complications. Endoscopic balloon dilatation has emerged as a safe and effective technique for relieving these strictures, but it is underutilized in pediatric cases. This position paper aims to promote the integration of this therapeutic strategy in pediatric Crohn's disease management by discussing its potential applications, evaluation, technique, and complications.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2023)
Article
Gastroenterology & Hepatology
R. Garces-Duran, S. Kindt, K. Kotilea, S. Francois, G. Rasschaert, A. Smet, B. Hauser, A. Driessen, M. Nkuize, A. Burette, V. Lamy, P. Bontems, H. Louis, R. Ntounda, V. Y. Miendje Deyi, F. Mana
ACTA GASTRO-ENTEROLOGICA BELGICA
(2023)
Article
Endocrinology & Metabolism
E. Nauwynck, J. Vanbesien, J. De Schepper, I Gies, A. Van Leynseele, E. De Wachter, B. Hauser, W. Staels
Summary: Vitamin D intoxication is rare but increasing in children, especially those with cystic fibrosis, due to incorrect compounded preparations. This case report highlights the importance of considering vitamin D intoxication in children with cystic fibrosis presenting with specific symptoms and emphasizes the need for prompt treatment and regular monitoring of serum calcium and 25-hydroxyvitamin D levels.
ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS
(2022)
Review
Pediatrics
Yvan Vandenplas, Bruno Hauser, Silvia Salvatore
PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION
(2019)
Review
Pediatrics
Roel Lemmens, Thierry Devreker, Bruno Hauser, Elisabeth Degreef, Annieta Goossens, Yvan Vandenplas
PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION
(2019)
Review
Pediatrics
Jeaneth Indira Gonzalez Ayerbe, Bruno Hauser, Silvia Salvatore, Yvan Vandenplas
PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION
(2019)