RNAi Therapeutics and Applications of MicroRNAs in Cancer Treatment

Lipid-Based Nanoparticles for siRNA Delivery in Cancer Therapy: Paradigms and Challenges

(2012) Lígia C. Gomes-da-Silva et al.   ACCOUNTS OF CHEMICAL RESEARCH

miRNA-34 Prevents Cancer Initiation and Progression in a Therapeutically Resistant K-ras and p53-Induced Mouse Model of Lung Adenocarcinoma

(2012) A. L. Kasinski et al.   CANCER RESEARCH

Single-Stranded RNAs Use RNAi to Potently and Allele-Selectively Inhibit Mutant Huntingtin Expression

(2012) Dongbo Yu et al.   CELL

Single-Stranded siRNAs Activate RNAi in Animals

(2012) Walt F. Lima et al.   CELL

siRNA-mediated knock-down of NOX3: therapy for hearing loss?

(2012) Leonard P. Rybak et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Adeno-associated virus-delivered polycistronic microRNA-clusters for knockdown of vascular endothelial growth factor in vivo

(2012) Maria Pihlmann et al.   JOURNAL OF GENE MEDICINE

Generation of miRNA sponge constructs

(2012) Joost Kluiver et al.   METHODS

The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α

(2012) Shu Zhu et al.   NATURE MEDICINE

Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation

(2012) Dan Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma

(2012) I. A. Babar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of hepatitis C virus replicon by adenovirus vector-mediated expression of tough decoy RNA against miR-122a

(2012) Fuminori Sakurai et al.   VIRUS RESEARCH

EGFR-specific PEGylated immunoliposomes for active siRNA delivery in hepatocellular carcinoma

(2011) Jie Gao et al.   BIOMATERIALS

MicroRNA therapeutics

(2011) J A Broderick et al.   GENE THERAPY

Epigenetic regulation of miR-34b and miR-129 expression in gastric cancer

(2011) Kuo-Wang Tsai et al.   INTERNATIONAL JOURNAL OF CANCER

Cell penetrating peptide-mediated systemic siRNA delivery to the liver

(2011) Yasuhiro Hayashi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

miR-22 represses cancer progression by inducing cellular senescence

(2011) Dan Xu et al.   JOURNAL OF CELL BIOLOGY

MicroRNA-143 Regulates Human Osteosarcoma Metastasis by Regulating Matrix Metalloprotease-13 Expression

(2011) Mitsuhiko Osaki et al.   MOLECULAR THERAPY

Systemic Delivery of Tumor Suppressor microRNA Mimics Using a Neutral Lipid Emulsion Inhibits Lung Tumors in Mice

(2011) Phong Trang et al.   MOLECULAR THERAPY

Current prospects for RNA interference-based therapies

(2011) Beverly L. Davidson et al.   NATURE REVIEWS GENETICS

Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing

(2011) K. T. Al-Jamal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Aptamer-siRNA Chimera Suppresses HIV-1 Viral Loads and Protects from Helper CD4+ T Cell Decline in Humanized Mice

(2011) C. P. Neff et al.   Science Translational Medicine

miRNA therapeutics: delivery and biological activity of peptide nucleic acids targeting miRNAs

(2011) Enrica Fabbri et al.   Epigenomics

RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

(2010) C. Frank Bennett et al.   Annual Review of Pharmacology and Toxicology

Development of a Lung Cancer Therapeutic Based on the Tumor Suppressor MicroRNA-34

(2010) J. F. Wiggins et al.   CANCER RESEARCH

Thelet-7microRNA reduces tumor growth in mouse models of lung cancer

(2010) Aurora Esquela-Kerscher et al.   CELL CYCLE

Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer

(2010) Dmitri Lodygin et al.   CELL CYCLE

miR-301a as an NF-κB activator in pancreatic cancer cells

(2010) Zhongxin Lu et al.   EMBO JOURNAL

Dysregulation of microRNAs in cancer: Playing with fire

(2010) Sonia A. Melo et al.   FEBS LETTERS

Lipophilic siRNAs mediate efficient gene silencing in oligodendrocytes with direct CNS delivery

(2010) Qingmin Chen et al.   JOURNAL OF CONTROLLED RELEASE

Microprocessor of microRNAs: regulation and potential for therapeutic intervention

(2010) Kevin J Beezhold et al.   Molecular Cancer

Nanoparticles Modified With Tumor-targeting scFv Deliver siRNA and miRNA for Cancer Therapy

(2010) Yunching Chen et al.   MOLECULAR THERAPY

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Durable Protection from Herpes Simplex Virus-2 Transmission Following Intravaginal Application of siRNAs Targeting Both a Viral and Host Gene

(2009) Yichao Wu et al.   Cell Host & Microbe

Therapeutic silencing of an endogenous gene by siRNA cream in an arthritis model mouse

(2009) M Takanashi et al.   GENE THERAPY

Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice

(2009) Adam D. Judge et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNAs in Cancer: Small Molecules With a Huge Impact

(2009) Marilena V. Iorio et al.   JOURNAL OF CLINICAL ONCOLOGY

Systemic Delivery of Synthetic MicroRNA-16 Inhibits the Growth of Metastatic Prostate Tumors via Downregulation of Multiple Cell-cycle Genes

(2009) Fumitaka Takeshita et al.   MOLECULAR THERAPY

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors

(2009) Justin P Dassie et al.   NATURE BIOTECHNOLOGY

Many roads to maturity: microRNA biogenesis pathways and their regulation

(2009) Julia Winter et al.   NATURE CELL BIOLOGY

A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function

(2009) Sonia A Melo et al.   NATURE GENETICS

Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA activity in mammalian cells

(2009) Takeshi Haraguchi et al.   NUCLEIC ACIDS RESEARCH

MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells

(2009) Qing Ji et al.   PLoS One

MicroRNA-like off-target transcript regulation by siRNAs is species specific

(2009) J. Burchard et al.   RNA

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

(2009) R. E. Lanford et al.   SCIENCE

Atu027, a Liposomal Small Interfering RNA Formulation Targeting Protein Kinase N3, Inhibits Cancer Progression

(2008) M. Aleku et al.   CANCER RESEARCH

Cancer-associated genomic regions (CAGRs) and noncoding RNAs: bioinformatics and therapeutic implications

(2008) Simona Rossi et al.   MAMMALIAN GENOME

LNA-mediated microRNA silencing in non-human primates

(2008) Joacim Elmén et al.   NATURE

Efficient delivery of RNA Interference to peripheral neurons in vivo using herpes simplex virus

(2008) A.-M. Anesti et al.   NUCLEIC ACIDS RESEARCH

Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target

(2008) D. Peer et al.   SCIENCE