Article
Radiology, Nuclear Medicine & Medical Imaging
Virginia Liberini, Michael Messerli, Lars Husmann, Ken Kudura, Hannes Grunig, Alexander Maurer, Stephan Skawran, Erika Orita, Daniele A. Pizzuto, Desiree Deandreis, Reinhard Dummer, Joanna Mangana, Daniela Mihic-Probst, Niels Rupp, Martin W. Huellner
Summary: BSREM detects significantly more ITM than OSEM, with higher SUVmax, higher TBR, and less blurring. BSREM is particularly helpful in small and less avid lesions, which are more often missed with OSEM.
EUROPEAN RADIOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sangwon Han, Sungmin Woo, Yong-il Kim, Dok Hyun Yoon, Jin-Sook Ryu
Summary: The systematic review and meta-analysis showed that (18)F-FDG PET/CT is a significant predictor for disease progression and survival in patients with newly diagnosed multiple myeloma. The presence of extramedullary disease, more than three focal lesions, and high FDG uptake were associated with shorter overall survival and progression-free survival.
EUROPEAN RADIOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
K. S. M. van der Geest, G. Treglia, A. W. J. M. Glaudemans, E. Brouwer, F. Jamar, R. H. J. A. Slart, O. Gheysens
Summary: [18F]FDG-PET/CT scanning can effectively diagnose polymyalgia rheumatica by identifying significant uptake of FDG at specific anatomic sites. The technique shows promise as an important diagnostic tool for patients with suspected PMR, but standardized interpretation criteria and procedural recommendations are necessary for its use.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Benjamin Koa, Austin J. Borja, Mahmoud Aly, Sayuri Padmanabhan, Joseph Tran, Vincent Zhang, Chaitanya Rojulpote, Sheila K. Pierson, Mark-Avery Tamakloe, Johnson S. Khor, Thomas J. Werner, David C. Fajgenbaum, Abass Alavi, Mona-Elisabeth Revheim
Summary: Castleman disease is a rare hematologic condition involving lymphadenopathy and clinical abnormalities, classified into UCD and MCD; MCD is further divided based on etiological driver; FDG-PET/CT plays an important role in differential diagnosis and monitoring treatment responses.
INSIGHTS INTO IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Na Niu, Haiqun Xing, Meiqi Wu, Yanru Ma, Yimin Liu, Jiantao Ba, Shikun Zhu, Fang Li, Li Huo
Summary: The meta-analysis aimed to evaluate the clinical use value of C-11-FMZ and F-18-FDG in PET for localizing the epileptogenic zone. The pooled concordance rates of FDG-PET, FMZ-PET, and FDG-PET/MRI were calculated to be 0.67, 0.75, and 0.93, respectively, showing that FDG-PET/MRI had the highest concordance rate. The overall sensitivity and specificity of F-18-FDG-PET were 0.66 and 0.71, while C-11-FMZ-PET had a sensitivity of 0.62 and specificity of 0.73.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dan Shao, Qiang Gao, You Cheng, Dong-Yang Du, Si-Yun Wang, Shu-Xia Wang
Summary: The study demonstrates that F-18-FDG PET/CT can predict the survival of patients with primary tracheal malignant tumors. Patients with higher metabolic tumor volume (MTV) and total lesion glycolysis (TLG) on PET/CT scans, squamous cell carcinoma, and non-E1 surgeries are more likely to have reduced overall survival.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yun Hye Song, Jung Won Moon, Yoo Na Kim, Ji Young Woo, Hye Joo Son, Suk Hyun Lee
Summary: This study aimed to investigate the reduction of [F-18]FDG uptake in dependent lungs by performing [F-18]FDG PET/CT in the prone position. The results showed that dependent lungs had significantly higher SUVmean and HU compared to nondependent lungs on both supine and prone position PET/CT. The study concluded that prone position PET/CT can effectively reduce gravity-dependent opacity-related [F-18]FDG uptake.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kazufumi Kikuchi, Osamu Togao, Koji Yamashita, Daichi Momosaka, Tomohiro Nakayama, Yoshiyuki Kitamura, Yoshitomo Kikuchi, Shingo Baba, Koji Sagiyama, Keisuke Ishimatsu, Ryotaro Kamei, Nobutaka Mukae, Koji Iihara, Satoshi O. Suzuki, Toru Iwaki, Akio Hiwatashi
Summary: The study demonstrated that FDG-PET/MRI had higher sensitivity and visual scores compared to FDG-PET/CT and standalone MRI in patients with epilepsy, leading to improved diagnostic accuracy in detecting the epileptogenic zone (EZ). EZs were histopathologically confirmed through surgical resection, with common pathologies including hippocampal sclerosis, gliosis, focal cortical dysplasia, and brain tumors. FDG-PET/MRI showed significant improvement over FDG-PET/CT and standalone MRI, increasing visual scores and enhancing detection of EZs.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Venkata Subramanian Krishnaraju, Rajender Kumar, Bhagwant Rai Mittal, Vishal Sharma, Harjeet Singh, Ritambhra Nada, Amanjit Bal, Manish Rohilla, Harmandeep Singh, Surinder S. Rana
Summary: The study aimed to differentiate malignant and benign pancreatic lesions by evaluating PSMA expression and comparing Ga-68 PSMA-PET/CT and F-18 FDG-PET/CT. Ga-68 PSMA-PET/CT showed higher specificity and accuracy in pre-operatively diagnosing primary pancreatic malignancy compared to FDG-PET/CT.
EUROPEAN RADIOLOGY
(2021)
Article
Medicine, General & Internal
Yi-Wen Sun, Chang-Feng Ji, Han Wang, Jian He, Song Liu, Yun Ge, Zheng-Yang Zhou
Summary: Texture analysis of PET images can help differentiate gastric lymphoma from gastric cancer, with inertia(GLCM) and entropy(GLCM) being the most discriminating features. This method shows promise in improving the differential diagnosis of gastric neoplasms, especially for tumors with similar levels of FDG uptake.
CHINESE MEDICAL JOURNAL
(2021)
Article
Oncology
Rong Niu, Yuetao Wang, Xiaoliang Shao, Zhenxing Jiang, Jianfeng Wang, Xiaonan Shao
Summary: The study reveals a significant association between SUV index and malignant risk of GGNs, with higher SUV index linked to lower probability of GGN malignancy. The trend of increasing SUV index is correlated with a reduction in malignant risk, indicating that SUV index is an independent factor for predicting malignancy risk of GGNs.
FRONTIERS IN ONCOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Seyed Ali Mirshahvalad, Aruz Mesci, Vanessa Murad, Andres Kohan, Claudia Ortega, Patrick Veit-Haibach, Ur Metser
Summary: This study conducted a meta-analysis to evaluate the diagnostic and prognostic value of PET in anal canal cancer patients. The results showed that PET had high sensitivity and specificity in distinguishing T3/T4 stages and detecting metastatic disease. PET also showed good sensitivity and specificity in therapy response assessment. Furthermore, pre-treatment total metabolic tumour volume was found to be predictive of survival, and complete metabolic response was associated with better prognosis. Overall, PET may be a valuable tool in therapy planning and prognostic assessment for anal canal cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yang Jiang, Honghong Wu, Yufei Zhao, Ying Cui, Jingyue Dai, Shanshan Huang, Cheng Li, Hui Mao, Shenghong Ju, Xin-Gui Peng
Summary: This study aims to investigate and develop imaging biomarkers for the diagnosis of cancer-associated cachexia based on the organ and tissue-specific abnormal metabolisms measured by fluorine-18-fluorodeoxyglucose (F-18-FDG) PET/CT. The study analyzed FDG PET/CT data from 390 cancer patients and divided them into a development cohort and a validation cohort. Logistic regression analysis was performed to identify independent variables associated with cachexia and a regression model was generated. The model showed promising results in both the development and validation cohorts, indicating that organ and tissue-specific abnormal glucose metabolism could be used as a biomarker for cancer-associated cachexia.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyung Ju Lee, Hye Joo Son, Mijin Yun, Jung Won Moon, Yoo Na Kim, Ji Young Woo, Suk Hyun Lee
Summary: Prone position PET/CT is more valuable than standard supine position PET/CT in evaluating lung nodules, reducing respiratory motion artefacts and enabling more precise measurements of PET parameters.
EUROPEAN RADIOLOGY
(2021)
Article
Health Care Sciences & Services
Jianxiong Gao, Yunmei Shi, Rong Niu, Xiaoliang Shao, Xiaonan Shao
Summary: The association between maximum standardized uptake value (SUVmax) based on F-18-FDG PET/CT and EGFR mutation status in lung adenocarcinoma was investigated. Smoking status was found to affect the relationship between SUVmax and EGFR mutation, especially in the subgroup with a positive smoking history.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Kevin D. Courtney, Judith B. Manola, Aymen A. Elfiky, Robert Ross, William K. Oh, Jeffrey T. Yap, Annick D. Van den Abbeele, Christopher W. Ryan, Tomasz M. Beer, Massimo Loda, Carmen Priolo, Philip Kantoff, Mary-Ellen Taplin
CLINICAL GENITOURINARY CANCER
(2015)
Article
Oncology
Nancy U. Lin, Hao Guo, Jeffrey T. Yap, Ingrid A. Mayer, Carla I. Falkson, Timothy J. Hobday, E. Claire Dees, Andrea L. Richardson, Rita Nanda, Mothaffar F. Rimawi, Nicole Ryabin, Julie S. Najita, William T. Barry, Carlos L. Arteaga, Antonio C. Wolff, Ian E. Krop, Eric P. Winer, Annick D. Van den Abbeele
JOURNAL OF CLINICAL ONCOLOGY
(2015)
Article
Radiology, Nuclear Medicine & Medical Imaging
Michael M. Graham, Richard L. Wahl, John M. Hoffman, Jeffrey T. Yap, John J. Sunderland, Ronald Boellaard, Eric S. Perlman, Paul E. Kinahan, Paul E. Christian, Otto S. Hoekstra, Gary S. Dorfman
JOURNAL OF NUCLEAR MEDICINE
(2015)
Article
Oncology
Kevin P. Horn, Jeffrey T. Yap, Neeraj Agarwal, Kathryn A. Morton, Dan J. Kadrmas, Britney Beardmore, Regan I. Butterfield, Kenneth Boucher, John M. Hoffman
Article
Oncology
E. Ben-Ami, C. M. Barysauskas, M. von Mehren, M. C. Heinrich, C. L. Corless, J. E. Butrynski, J. A. Morgan, A. J. Wagner, E. Choy, J. T. Yap, A. D. Van den Abbeele, S. M. Solomon, J. A. Fletcher, G. D. Demetri, S. George
ANNALS OF ONCOLOGY
(2016)
Article
Oncology
Allison F. O'Neill, Lei Qin, Patrick Y. Wen, John F. de Groot, Annick D. Van den Abbeele, Jeffrey T. Yap
JOURNAL OF NEURO-ONCOLOGY
(2016)
Article
Oncology
Jared J. Barrott, Ju-Fen Zhu, Kyllie Smith-Fry, Asia M. Susko, Dakota Nollner, Lance D. Burrell, Amir Pozner, Mario R. Capecchi, Jeffrey T. Yap, Lisa A. Cannon-Albright, Xingming Deng, Kevin B. Jones
MOLECULAR CANCER RESEARCH
(2017)
Article
Oncology
F. Stephen Hodi, Christopher L. Corless, Anita Giobbie-Hurder, Jonathan A. Fletcher, Meijun Zhu, Adrian Marino-Enriquez, Philip Friedlander, Rene Gonzalez, Jeffrey S. Weber, Thomas F. Gajewski, Steven J. O'Day, Kevin B. Kim, Donald Lawrence, Keith T. Flaherty, Jason J. Luke, Frances A. Collichio, Marc S. Ernstoff, Michael C. Heinrich, Carol Beadling, Katherine A. Zukotynski, Jeffrey T. Yap, Annick D. Van den Abbeele, George D. Demetri, David E. Fisher
JOURNAL OF CLINICAL ONCOLOGY
(2013)
Article
Oncology
Ingrid A. Mayer, Vandana G. Abramson, Steven J. Isakoff, Andres Forero, Justin M. Balko, Maria Gabriela Kuba, Melinda E. Sanders, Jeffrey T. Yap, Annick D. Van den Abbeele, Yisheng Li, Lewis C. Cantley, Eric Winer, Carlos L. Arteaga
JOURNAL OF CLINICAL ONCOLOGY
(2014)
Article
Oncology
Katherine Zukotynski, Jeffrey T. Yap, Anita Giobbie-Hurder, Jeffrey Weber, Rene Gonzalez, Thomas F. Gajewski, Steven O'Day, Kevin Kim, F. Stephen Hodi, Annick D. Van den Abbeele
Article
Oncology
F. Stephen Hodi, Donald Lawrence, Cecilia Lezcano, Xinqi Wu, Jun Zhou, Tetsuro Sasada, Wanyong Zeng, Anita Giobbie-Hurder, Michael B. Atkins, Nageatte Ibrahim, Philip Friedlander, Keith T. Flaherty, George F. Murphy, Scott Rodig, Elsa F. Velazquez, Martin C. Mihm, Sara Russell, Pamela J. DiPiro, Jeffrey T. Yap, Nikhil Ramaiya, Annick D. van den Abbeele, Maria Gargano, David McDermott
CANCER IMMUNOLOGY RESEARCH
(2014)
Article
Biochemistry & Molecular Biology
Conan G. Kinsey, Soledad A. Camolotto, Amelie M. Boespflug, Katrin P. Guillen, Mona Foth, Amanda Truong, Sophia S. Schuman, Jill E. Shea, Michael T. Seipp, Jeffrey T. Yap, Lance D. Burrell, David H. Lum, Jonathan R. Whisenant, G. Weldon Gilcrease, Courtney C. Cavalieri, Kaitrin M. Rehbein, Stephanie L. Cutler, Kajsa E. Affolter, Alana L. Welm, Bryan E. Welm, Courtney L. Scaife, Eric L. Snyder, Martin McMahon
Article
Immunology
Mark R. Silvis, Dilru Silva, Riley Rohweder, Sophia Schuman, Swapna Gudipaty, Amanda Truong, Jeffrey Yap, Kajsa Affolter, Martin McMahon, Conan Kinsey
Summary: Pharmacological inhibition of KRAS>RAF>MEK1/2>ERK1/2 signaling does not benefit patients with pancreatic ductal adenocarcinoma (PDAC). However, combining MEK1/2 inhibition with autophagy inhibition shows anti-tumor effects. Resistance to the treatment is associated with c-MYC gene amplification, which can be overcome by using a CDK4/6 inhibitor along with chloroquine or hydroxychloroquine.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Li-Ming Wang, Qi Wu, Ryan A. Kirk, Kevin P. Horn, Ahmed H. Ebada Salem, John M. Hoffman, Jeffrey T. Yap, Joshua A. Sonnen, Rheal A. Towner, Fernando A. Bozza, Rosana S. Rodrigues, Kathryn A. Morton
AMERICAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2018)
Article
Statistics & Probability
Mengye Guo, Jeffrey T. Yap, Annick D. Van den Abbeele, Nancy U. Lin, Armin Schwartzman