Article
Radiology, Nuclear Medicine & Medical Imaging
Wan-Ming Chen, Mingchih Chen, Jeng-Guan Hsu, Tian-Shyug Lee, Ben-Chang Shia, Szu-Yuan Wu
Summary: The use of preoperative PET/CT is associated with a lower risk of death in patients with resectable stage IIIA-IIIB non-small cell lung cancer, but it does not improve survival rates in patients with stage I-II cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Kailin Qiao, Xueting Qin, Shuai Fu, Jiazhong Ren, Jing Jia, Xinying Hu, Yuanyuan Tao, Shuanghu Yuan, Yuchun Wei
Summary: The uptake of [F-18]AlF-NOTA-FAPI-04 and [F-18]FDG imaging tracers varies in malignant and inflammatory lung lesions, with lower uptake observed in inflammatory lesions. This difference in uptake can be valuable for distinguishing between malignancy and various inflammatory findings.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stephan Waelti, Stephan Skawran, Thomas Sartoretti, Moritz Schwyzer, Antonio G. Gennari, Cacilia Mader, Valerie Treyer, Christian J. Kellenberger, Irene A. Burger, Thomas Hany, Alexander Maurer, Martin W. Huellner, Michael Messerli
Summary: This study retrospectively assessed the evolution of administered radiotracer activity for F-18-fluorodeoxyglucose PET/CT or PET/MR in pediatric patients between 2000 and 2021. The results showed that children have benefited from a significant reduction in the administered F-18-FDG dose over the past 20 years without compromising objective image quality.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qianrui Li, Wenxiu Hou, Mei Wu, Ling Li, Minggang Su, Bin Ma, Futao Cui, Yan Ren, Jiayue Xu, Kang Zou, Rong Tian, Xin Sun
Summary: This study systematically appraised the methodologies used for PET imaging guidelines and compared the consistency of these recommendations. The findings showed that current guidelines for PET imaging vary in methodological quality and provided considerably inconsistent recommendations. Efforts are needed to improve adherence to guideline development methodologies, to synthesize high-quality evidence, and to adopt standard terminologies.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hui Tan, Chi Qi, Yanyan Cao, Danjie Cai, Wujian Mao, Haojun Yu, Xiuli Sui, Guobing Liu, Hongcheng Shi
Summary: This study validates the efficacy of ultralow-dose [F-18]FDG PET/CT (0.37 MBq/kg) and compares it to imaging at half-dose (1.85 MBq/kg). The results show no significant differences between the two groups in terms of dynamic and static parameters, and the ultralow-dose group has a higher lesion detection rate.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kazufumi Kikuchi, Osamu Togao, Koji Yamashita, Daichi Momosaka, Tomohiro Nakayama, Yoshiyuki Kitamura, Yoshitomo Kikuchi, Shingo Baba, Koji Sagiyama, Keisuke Ishimatsu, Ryotaro Kamei, Nobutaka Mukae, Koji Iihara, Satoshi O. Suzuki, Toru Iwaki, Akio Hiwatashi
Summary: The study demonstrated that FDG-PET/MRI had higher sensitivity and visual scores compared to FDG-PET/CT and standalone MRI in patients with epilepsy, leading to improved diagnostic accuracy in detecting the epileptogenic zone (EZ). EZs were histopathologically confirmed through surgical resection, with common pathologies including hippocampal sclerosis, gliosis, focal cortical dysplasia, and brain tumors. FDG-PET/MRI showed significant improvement over FDG-PET/CT and standalone MRI, increasing visual scores and enhancing detection of EZs.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jianan Zhang, Ruixue Cui, Jian Li, Xinxin Cao, Yaping Luo
Summary: In this retrospective study of 38 RDD patients, the clinical and [F-18]FDG PET/CT features were characterized. RDD commonly affected the upper respiratory tract, cutaneous/subcutaneous lesions, lymph nodes, bones, central nervous system, and cardiovascular system. In PET/CT, RDD lesions showed FDG avidity, and the SUVmax of the hottest lesion in an individual patient was correlated with C-reactive protein levels and hemoglobin levels. The overall response rate of the first-line treatment was 80.8% for newly diagnosed RDD patients and 72.7% for relapsed/progressive RDD patients.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Suk-Hyun Lee, Jee-Soo Park, Hyunjeong Kim, Dongwoo Kim, Seung-Hwan Lee, Won-Sik Ham, Woong-Kyu Han, Young-Deuk Choi, Mijin Yun
Summary: The heterogeneous uptake of both F-18 FDG and C-11 methionine on PET/CT in renal cell carcinomas is associated with higher grades of cancer. The metabolic tumour volume on F-18 FDG PET/CT but not C-11 methionine PET/CT is significant in predicting advanced-stage renal cell carcinoma. These metabolic features derived from PET/CT imaging may aid in the development of new drugs targeting glucose and amino acid metabolic pathways.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yun Hye Song, Jung Won Moon, Yoo Na Kim, Ji Young Woo, Hye Joo Son, Suk Hyun Lee
Summary: This study aimed to investigate the reduction of [F-18]FDG uptake in dependent lungs by performing [F-18]FDG PET/CT in the prone position. The results showed that dependent lungs had significantly higher SUVmean and HU compared to nondependent lungs on both supine and prone position PET/CT. The study concluded that prone position PET/CT can effectively reduce gravity-dependent opacity-related [F-18]FDG uptake.
EUROPEAN RADIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Benjamin Koa, Austin J. Borja, Mahmoud Aly, Sayuri Padmanabhan, Joseph Tran, Vincent Zhang, Chaitanya Rojulpote, Sheila K. Pierson, Mark-Avery Tamakloe, Johnson S. Khor, Thomas J. Werner, David C. Fajgenbaum, Abass Alavi, Mona-Elisabeth Revheim
Summary: Castleman disease is a rare hematologic condition involving lymphadenopathy and clinical abnormalities, classified into UCD and MCD; MCD is further divided based on etiological driver; FDG-PET/CT plays an important role in differential diagnosis and monitoring treatment responses.
INSIGHTS INTO IMAGING
(2021)
Review
Oncology
Federica Matteucci, Giovanni Paganelli, Giovanni Martinelli, Claudio Cerchione
Summary: Recent advances in the diagnosis and treatment of multiple myeloma have emphasized the importance of imaging methods, particularly PET/CT, in providing accurate information for disease localization, prognosis, and therapy response evaluation. While 18F-FDG tracer is commonly used and has high sensitivity, limitations such as physiological uptake in the bone marrow and brain have prompted research on other PET tracers for improved accuracy in multiple myeloma management.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Virginia Liberini, Michael Messerli, Lars Husmann, Ken Kudura, Hannes Grunig, Alexander Maurer, Stephan Skawran, Erika Orita, Daniele A. Pizzuto, Desiree Deandreis, Reinhard Dummer, Joanna Mangana, Daniela Mihic-Probst, Niels Rupp, Martin W. Huellner
Summary: BSREM detects significantly more ITM than OSEM, with higher SUVmax, higher TBR, and less blurring. BSREM is particularly helpful in small and less avid lesions, which are more often missed with OSEM.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyung Ju Lee, Hye Joo Son, Mijin Yun, Jung Won Moon, Yoo Na Kim, Ji Young Woo, Suk Hyun Lee
Summary: Prone position PET/CT is more valuable than standard supine position PET/CT in evaluating lung nodules, reducing respiratory motion artefacts and enabling more precise measurements of PET parameters.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Roberta Matheoud, Ronald Boellaard, Lucy Pike, Jaroslav Ptacek, Gabriel Reynes-Llompart, Marine Soret, Stefaan Vandenberghe, Alessandra Zorz, Peter Julyan, Ivo Rausch, Bernhard Sattler, Sanchez-Garcia Manuel, Giovanni Tosi, Kostantinos Dalianis, Pedro Miguel Dinis Almeida, Cinzia Fabbri, Joanna Gawel, Panayiotis Hadjitheodorou, Maria Kotzasarlidou, Thiago Viana Miranda Lima, Jim O'Doherty, Kirill Skovorodko, Dmitri Sutov, Ahmed Taher, Marco Valenti, Eleonora Vanzi
Summary: This article presents the protocol on Quality Controls in PET/CT and PET/MRI published by EFOMP in May 2022. The protocol provides simple and practical procedures for identifying changes in system performance and maintaining quality. It includes quality control procedures for various systems and parameters directly linked to image quality. A regular QC based on this protocol ensures optimal conditions and performance for clinical tasks.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Naveen Rajamohan, Hala Khasawneh, Aparna Singh, Garima Suman, Geoffrey B. Johnson, Shounak Majumder, Thorvardur R. Halfdanarson, Ajit H. Goenka
Summary: Advanced molecular imaging, especially somatostatin receptor PET, has become essential in the management of GEP-NENs. SSTR PET/MRI with liver-specific contrast agent shows strong potential for comprehensive evaluation of GEP-NENs. The development of novel radiotracers can address the existing limitations in molecular imaging of GEP-NENs, and quantitative evaluation of molecular imaging studies is an active research area.
ABDOMINAL RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tyler J. Bradshaw, Ronald Boellaard, Joyita Dutta, Abhinav K. Jha, Paul Jacobs, Quanzheng Li, Chi Liu, Arkadiusz Sitek, Babak Saboury, Peter J. H. Scott, Piotr J. Slomka, John J. Sunderland, Richard L. Wahl, Fereshteh Yousefirizi, Sven Zuehlsdorff, Arman Rahmim, Irene Buvat
Summary: This article provides recommendations on technical best practices for developing AI algorithms in nuclear medicine, aiming to help users and developers avoid pitfalls of AI.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Coreline N. Burggraaff, Jakoba J. Eertink, Pieternella J. Lugtenburg, Otto S. Hoekstra, Anne I. J. Arens, Bart de Keizer, Martijn W. Heymans, Bronno van der Holt, Sanne E. Wiegers, Simone Pieplenbosch, Ronald Boellaard, Henrica C. W. de Vet, Josee M. Zijlstra
Summary: The study aimed to determine the additional value of baseline metabolic tumor volume (MTV) and interim PET (I-PET) in predicting 2-year progression-free survival (PFS) in diffuse large B-cell lymphoma. The results showed that Delta SUVmax outperformed Deauville score in predicting 2-year PFS.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julia Driessen, Gerben J. C. Zwezerijnen, Heiko Schoder, Esther E. E. Drees, Marie Jose Kersten, Alison J. Moskowitz, Craig H. Moskowitz, Jakoba J. Eertink, Henrica C. W. de Vet, Otto S. Hoekstra, Josee M. Zijlstra, Ronald Boellaard
Summary: Consensus on a standard segmentation method to derive metabolic tumor volume in classical Hodgkin lymphoma is lacking. This study aimed to evaluate different segmentation methods and their influence on PET features in cHL patients. The results showed variations in lesion selection and completeness with different segmentation methods, but high correlations and similar prognostic performance among the methods. The study highlights the importance of considering small lesions with low FDG avidity in future research and clinical practice.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Oncology
Lalitha K. Shankar, Erich Huang, Saskia Litiere, Otto S. Hoekstra, Larry Schwartz, Sandra Collette, Ronald Boellaard, Jan Bogaerts, Lesley Seymour, Elisabeth G. E. deVries
Summary: Currently, guidelines for PET with FDG-PET interpretation for therapy response in oncology involve visual evaluation of FDG-PET/CT scans. However, quantitative measurements of metabolic activity in tumors may be more useful. Guidelines based on such measurements have been proposed, but more analysis is needed for regular use.
CLINICAL CANCER RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anne M. Smith, Nancy A. Obuchowski, Norman L. Foster, Gregory Klein, P. David Mozley, Adriaan A. Lammertsma, Richard L. Wahl, John J. Sunderland, Jean-Luc Vanderheyden, Tammie L. S. Benzinger, Paul E. Kinahan, Dean F. Wong, Eric S. Perlman, Satoshi Minoshima, Dawn Matthews
Summary: Standardized approach in acquiring amyloid PET images increases their value as disease and drug response biomarkers. The Quantitative Imaging Biomarkers Alliance amyloid PET biomarker committee developed and validated a profile to characterize and reduce the variability of SUVRs, increasing statistical power for these assessments.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Immunology
Mark R. Silvis, Dilru Silva, Riley Rohweder, Sophia Schuman, Swapna Gudipaty, Amanda Truong, Jeffrey Yap, Kajsa Affolter, Martin McMahon, Conan Kinsey
Summary: Pharmacological inhibition of KRAS>RAF>MEK1/2>ERK1/2 signaling does not benefit patients with pancreatic ductal adenocarcinoma (PDAC). However, combining MEK1/2 inhibition with autophagy inhibition shows anti-tumor effects. Resistance to the treatment is associated with c-MYC gene amplification, which can be overcome by using a CDK4/6 inhibitor along with chloroquine or hydroxychloroquine.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Babak Saboury, Tyler Bradshaw, Ronald Boellaard, Irene Buvat, Joyita Dutta, Mathieu Hatt, Abhinav K. Jha, Quanzheng Li, Chi Liu, Helena McMeekin, Michael A. Morris, Peter J. H. Scott, Eliot Siegel, John J. Sunderland, Neeta Pandit-Taskar, Richard L. Wahl, Sven Zuehlsdorff, Arman Rahmim
Summary: Trustworthiness is crucial in medicine as the patient-physician relationship evolves in the era of artificial intelligence. This report provides a roadmap for establishing trustworthy AI ecosystems in nuclear medicine, discussing both the opportunities and challenges associated with AI applications in this field. The plan emphasizes the importance of engaging stakeholders while ensuring the rational and safe deployment of AI technology in order to protect patients and society.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
William Hunter, Sergei Dolinsky, Paul Kinahan, Robert Miyaoka
Summary: We evaluated the 3-D spatial, energy, and timing resolution of the BING PET detector. The BING detector consists of stacked slats of LYSO scintillator with silicon-photomultiplier (SiPM) arrays to determine interaction positions and timing. The performance of the BING detector was measured and it showed effective resolution for a small field of view PET system.
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Prabhakar Shantha Rajiah, Maria Jose Sarda, Ravi Ashwath, Harold Goerne
Article
Radiology, Nuclear Medicine & Medical Imaging
Abhejit Rajagopal, Yutaka Natsuaki, Kristen Wangerin, Mahdjoub Hamdi, Hongyu An, John J. Sunderland, Richard Laforest, Paul E. Kinahan, Peder E. Z. Larson, Thomas A. Hope
Summary: In this article, a deep learning technique is demonstrated to generate realistic PET sinograms from whole-body MRI data for PET/MRI reconstruction algorithm development. The synthetic PET data generated can be used interchangeably with real PET data for PET quantification, achieving small errors in comparison between CTAC and MRAC methods.
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Donna M. Peehl, Cristian T. Badea, Thomas L. Chenevert, Heike E. Daldrup-Link, Li Ding, Lacey E. Dobrolecki, A. McGarry Houghton, Paul E. Kinahan, John Kurhanewicz, Michael T. Lewis, Shunqiang Li, Gary D. Luker, Cynthia X. Ma, H. Charles Manning, Yvonne M. Mowery, Peter J. O'Dwyer, Robia G. Pautler, Mark A. Rosen, Raheleh Roudi, Brian D. Ross, Kooresh I. Shoghi, Renuka Sriram, Moshe Talpaz, Richard L. Wahl, Rong Zhou
Summary: The availability of high-fidelity animal models has increased, allowing for preclinical studies relevant to cancer research. Co-clinical trials conducted on animal models that mirror patients' tumors have seen increased opportunities. However, quantitative imaging in co-clinical trials still needs optimization.
Review
Radiology, Nuclear Medicine & Medical Imaging
Paul E. Kinahan
Article
Radiology, Nuclear Medicine & Medical Imaging
Harald Keller, Tina Shek, Brandon Driscoll, Yiwen Xu, Brian Nghiem, Sadek Nehmeh, Milan Grkovski, Charles Ross Schmidtlein, Mikalai Budzevich, Yoganand Balagurunathan, John J. Sunderland, Reinhard R. Beichel, Carlos Uribe, Ting-Yim Lee, Fiona Li, David A. Jaffray, Ivan Yeung
Summary: Characterizing the robustness of image-derived radiomics features is crucial for multicenter clinical studies. This study investigates the effectiveness of a simple harmonization strategy in improving feature robustness and agreement. The results show that the harmonization strategy significantly improves feature agreement and suggests a way to select suitable features for predictive models.
