Thapsigargin—From Thapsia L. to Mipsagargin

Botanical identification and ethno-medicinal uses of some underground part of medicinal plants collected and traded in Marrakech region

(2016) Abderrahim Ouarghidi et al.   Journal of Medicinal Plants Research

Targeting thapsigargin towards tumors

(2015) Nhu Thi Quynh Doan et al.   STEROIDS

Stable heterologous expression of biologically active terpenoids in green plant cells

(2015) N. Kusaira B. K. Ikram et al.   Frontiers in Plant Science

Resurrecting deadly carrots: towards a revision ofThapsia(Apiaceae) based on phylogenetic analysis of nrITS sequences and chemical profiles

(2014) Corinna Weitzel et al.   BOTANICAL JOURNAL OF THE LINNEAN SOCIETY

Acyloxylation of Cyclic Enones: Synthesis of Densely Oxygenated Guaianolides

(2014) Rubén Marín-Barrios et al.   JOURNAL OF ORGANIC CHEMISTRY

Abstract B244: A first-in-human phase 1 clinical study of G-202, a thapsigargin-based Prostate-Specific Membrane Antigen (PSMA) activated prodrug, in patients with advanced solid tumors.

(2014) D. Mahalingam et al.   MOLECULAR CANCER THERAPEUTICS

Large scale purification of the SERCA inhibitor Thapsigargin from Thapsia garganica L. roots using centrifugal partition chromatography

(2013) Anthony Ollivier et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

High-level semi-synthetic production of the potent antimalarial artemisinin

(2013) C. J. Paddon et al.   NATURE

The metabolite chemotype ofNicotiana benthamianatransiently expressing artemisinin biosynthetic pathway genes is a function ofCYP71AV1type and relative gene dosage

(2013) Hieng-Ming Ting et al.   NEW PHYTOLOGIST

Cytochrome P450-enzymes involved in the biosynthesis of mono- and sesquiterpenes

(2013) Corinna Weitzel et al.   PHYTOCHEMISTRY REVIEWS

A Trojan Horse in Drug Development: Targeting of Thapsigargins Towards Prostate Cancer Cells

(2012) S. Christensen et al.   Anti-Cancer Agents in Medicinal Chemistry

Identification and characterization of a kunzeaol synthase fromThapsia garganica: implications for the biosynthesis of the pharmaceutical thapsigargin

(2012) Benjamin Pickel et al.   BIOCHEMICAL JOURNAL

Species Substitution in Medicinal Roots and Possible Implications for Toxicity of Herbal Remedies in Morocco

(2012) Abderrahim Ouarghidi et al.   ECONOMIC BOTANY

Targeting Carcinoma-Associated Fibroblasts Within the Tumor Stroma With a Fibroblast Activation Protein-Activated Prodrug

(2012) W. N. Brennen et al.   JNCI-Journal of the National Cancer Institute

Asymmetric synthesis of a highly functionalized enantioenriched system close to thapsigargin framework

(2012) Aurélien Tap et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Engineering a Prostate-Specific Membrane Antigen-Activated Tumor Endothelial Cell Prodrug for Cancer Therapy

(2012) S. R. Denmeade et al.   Science Translational Medicine

Relative expression of genes of terpene metabolism in different tissues of Artemisia annua L

(2011) Linda Olofsson et al.   BMC PLANT BIOLOGY

Lettuce Costunolide Synthase (CYP71BL2) and Its Homolog (CYP71BL1) from Sunflower Catalyze Distinct Regio- and Stereoselective Hydroxylations in Sesquiterpene Lactone Metabolism

(2011) Nobuhiro Ikezawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reconstitution of the Costunolide Biosynthetic Pathway in Yeast and Nicotiana benthamiana

(2011) Qing Liu et al.   PLoS One

Guaianolides in apiaceae: perspectives on pharmacology and biosynthesis

(2009) Damian Paul Drew et al.   PHYTOCHEMISTRY REVIEWS

The Plastidial 2-C-Methyl-D-Erythritol 4-Phosphate Pathway Provides the Isoprenyl Moiety for Protein Geranylgeranylation in Tobacco BY-2 Cells

(2009) E. Gerber et al.   PLANT CELL

Production of taxa-4(5),11(12)-diene by transgenic Physcomitrella patens

(2009) Aldwin Anterola et al.   TRANSGENIC RESEARCH

Genetic Evidence for the Role of Isopentenyl Diphosphate Isomerases in the Mevalonate Pathway and Plant Development in Arabidopsis

(2008) Kazunori Okada et al.   PLANT AND CELL PHYSIOLOGY