Neurotrophins and Neuropathic Pain: Role in Pathobiology

Regulation of Neurotrophin-3 and Interleukin-1βand Inhibition of Spinal Glial Activation Contribute to the Analgesic Effect of Electroacupuncture in Chronic Neuropathic Pain States of Rats

(2015) Wenzhan Tu et al.   Evidence-based Complementary and Alternative Medicine

Neuropathic Pain Is Constitutively Suppressed in Early Life by Anti-Inflammatory Neuroimmune Regulation

(2015) R. McKelvey et al.   JOURNAL OF NEUROSCIENCE

A systematic review of the efficacy and general safety of antibodies to NGF in the treatment of OA of the hip or knee

(2015) T.J. Schnitzer et al.   OSTEOARTHRITIS AND CARTILAGE

Exploring the Role of Tanezumab as a Novel Treatment for the Relief of Neuropathic Pain

(2015) Candace Bramson et al.   PAIN MEDICINE

Analgesic mechanism of electroacupuncture in a rat L5 spinal nerve ligation model

(2015) CHUNCHUN XUE et al.   Experimental and Therapeutic Medicine

Role of nerve growth factor-tyrosine kinase receptor A signaling in paclitaxel-induced peripheral neuropathy in rats

(2014) Yusuke Nakahashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pro-neurotrophins, sortilin, and nociception

(2014) Gary R. Lewin et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Endocannabinoids and neuropathic pain: focus on neuron-glia and endocannabinoid-neurotrophin interactions

(2014) Livio Luongo et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Brain-derived neurotrophic factor as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target?

(2014) Jo Nijs et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Nerve safety of tanezumab, a nerve growth factor inhibitor for pain treatment

(2014) Mark T. Brown et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods

(2014) Nemat Khan et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Mechanisms of Acupuncture–Electroacupuncture on Persistent Pain

(2013) Ruixin Zhang et al.   ANESTHESIOLOGY

BDNF parabrachio-amygdaloid pathway in morphine-induced analgesia

(2013) Maysa Sarhan et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

TrkB.T1 Contributes to Neuropathic Pain after Spinal Cord Injury through Regulation of Cell Cycle Pathways

(2013) J. Wu et al.   JOURNAL OF NEUROSCIENCE

Repetitive Hyperbaric Oxygen Treatment Attenuates Complete Freund's Adjuvant-Induced Pain and Reduces Glia-Mediated Neuroinflammation in the Spinal Cord

(2013) Jie Hui et al.   JOURNAL OF PAIN

The p75NTR signaling cascade mediates mechanical hyperalgesia induced by nerve growth factor injected into the rat hind paw

(2013) A. Khodorova et al.   NEUROSCIENCE

CB1 cannabinoid receptor agonist prevents NGF-induced sensitization of TRPV1 in sensory neurons

(2013) Thomas S. McDowell et al.   NEUROSCIENCE LETTERS

Interventional management of neuropathic pain: NeuPSIG recommendations

(2013) Robert H. Dworkin et al.   PAIN

Treadmill exercise reduces spinal cord injury-induced apoptosis by activating the PI3K/Akt pathway in rats

(2013) SUN-YOUNG JUNG et al.   Experimental and Therapeutic Medicine

Involvement of TrkB- and p75NTR-signaling pathways in two contrasting forms of long-lasting synaptic plasticity

(2013) Shigeo Sakuragi et al.   Scientific Reports

Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models

(2013) Nemat Khan et al.   INFLAMMOPHARMACOLOGY

Characterization of nerve growth factor-induced mechanical and thermal hypersensitivity in rats

(2012) C.D. Mills et al.   EUROPEAN JOURNAL OF PAIN

Nerve growth factor-mediated regulation of pain signalling and proposed new intervention strategies in clinical pain management

(2012) Laura McKelvey et al.   JOURNAL OF NEUROCHEMISTRY

Tanezumab Reduces Osteoarthritic Knee Pain: Results of a Randomized, Double-Blind, Placebo-Controlled Phase III Trial

(2012) Mark T. Brown et al.   JOURNAL OF PAIN

Nerve growth factor: from the early discoveries to the potential clinical use

(2012) Luigi Aloe et al.   Journal of Translational Medicine

Neurotrophic Factor Changes in the Rat Thick Skin following Chronic Constriction Injury of the Sciatic Nerve

(2012) Jennifer C Peleshok et al.   Molecular Pain

Selective inhibition of extracellular signal-regulated kinases 1/2 blocks nerve growth factor to brain-derived neurotrophic factor signaling and suppresses the development of and reverses already established pain behavior in rats

(2012) Y. Matsuoka et al.   NEUROSCIENCE

Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: Effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment

(2012) Josée Guindon et al.   PHARMACOLOGICAL RESEARCH

p75 neurotrophin receptor signaling in nervous system injury and degeneration: paradox and opportunity

(2012) Carlos F. Ibáñez et al.   TRENDS IN NEUROSCIENCES

Sortilin: a receptor to regulate neuronal viability and function

(2012) Anders Nykjaer et al.   TRENDS IN NEUROSCIENCES

Antagonism of Nerve Growth Factor-TrkA Signaling and the Relief of Pain

(2011) Patrick W. Mantyh et al.   ANESTHESIOLOGY

Electroacupuncture attenuates mechanical and warm allodynia through suppression of spinal glial activation in a rat model of neuropathic pain

(2011) Gyeong-Taek Gim et al.   BRAIN RESEARCH BULLETIN

Differential effects of brain-derived neurotrophic factor and neurotrophin-3 on hindlimb function in paraplegic rats

(2011) Vanessa S. Boyce et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The role of dorsal root ganglia activation and brain-derived neurotrophic factor in multiple sclerosis

(2011) Wenjun Zhu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Immune cell NT-3 expression is associated with brain atrophy in multiple sclerosis patients

(2011) Alicja Kalinowska-Łyszczarz et al.   JOURNAL OF NEUROIMMUNOLOGY

Are Voltage-Gated Sodium Channels on the Dorsal Root Ganglion Involved in the Development of Neuropathic Pain?

(2011) Wei Wang et al.   Molecular Pain

Efficacy and safety of tanezumab in the treatment of chronic low back pain

(2011) Nathaniel Katz et al.   PAIN

Understanding proneurotrophin actions: Recent advances and challenges

(2010) Kenneth K. Teng et al.   Developmental Neurobiology

Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation

(2010) Shan-Jing Geng et al.   EXPERIMENTAL NEUROLOGY

Central modulation of pain

(2010) Michael H. Ossipov et al.   JOURNAL OF CLINICAL INVESTIGATION

Reduction in voltage-gated K+ channel activity in primary sensory neurons in painful diabetic neuropathy: role of brain-derived neurotrophic factor

(2010) Xue-Hong Cao et al.   JOURNAL OF NEUROCHEMISTRY

Recommendations for the Pharmacological Management of Neuropathic Pain: An Overview and Literature Update

(2010) Robert H. Dworkin et al.   MAYO CLINIC PROCEEDINGS

Injury Induced Activation of Extracellular Signal-Regulated Kinase (ERK) in the Rat Rostral Ventromedial Medulla (RVM) is Age Dependant and Requires the Lamina I Projection Pathway

(2010) Sandrine M Géranton et al.   Molecular Pain

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling

(2010) Christian B Vaegter et al.   NATURE NEUROSCIENCE

Acetyl-l-carnitine increases artemin level and prevents neurotrophic factor alterations during neuropathy

(2010) E. Vivoli et al.   NEUROSCIENCE

Tanezumab for the Treatment of Pain from Osteoarthritis of the Knee

(2010) Nancy E. Lane et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intrathecal NGF Administration Reduces Reactive Astrocytosis and Changes Neurotrophin Receptors Expression Pattern in a Rat Model of Neuropathic Pain

(2009) Giovanni Cirillo et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Biological Activity of Nerve Growth Factor Precursor Is Dependent upon Relative Levels of Its Receptors

(2009) Raheleh Masoudi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nerve Growth Factor Mediates Mechanical Allodynia in a Mouse Model of Type 2 Diabetes

(2009) Hsinlin T. Cheng et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

TrkB Signaling Is Required for Both the Induction and Maintenance of Tissue and Nerve Injury-Induced Persistent Pain

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

NGF induces non-inflammatory localized and lasting mechanical and thermal hypersensitivity in human skin

(2009) Roman Rukwied et al.   PAIN

Targeting Nerve Growth Factor in Pain

(2008) Judy J Watson et al.   BIODRUGS

Neurotrophin-3 significantly reduces sodium channel expression linked to neuropathic pain states

(2008) Tracy D. Wilson-Gerwing et al.   EXPERIMENTAL NEUROLOGY

Proneurotrophins Require Endocytosis and Intracellular Proteolysis to Induce TrkA Activation

(2008) Jacqueline Boutilier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain-derived neurotrophic factor enhances the excitability of rat sensory neurons through activation of the p75 neurotrophin receptor and the sphingomyelin pathway

(2008) Y. H. Zhang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Neurotrophins giveth and they taketh away

(2008) Alun M Davies   NATURE NEUROSCIENCE

Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons

(2008) Uma Anand et al.   PAIN

Neuropathic pain behaviours in a chronic-relapsing model of experimental autoimmune encephalomyelitis (EAE)

(2008) Camille J. Olechowski et al.   PAIN

Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain

(2007) M D Jhaveri et al.   BRITISH JOURNAL OF PHARMACOLOGY

Brain derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in rats

(2007) Ken-ichiro Hayashida et al.   PAIN