Pro-neurotrophins, sortilin, and nociception

Tanezumab Reduces Osteoarthritic Hip Pain: Results of a Randomized, Double-Blind, Placebo-Controlled Phase III Trial

(2013) Mark T. Brown et al.   ARTHRITIS AND RHEUMATISM

ProNGF promotes neurite growth from a subset of NGF-dependent neurons by a p75NTR-dependent mechanism

(2013) L. Howard et al.   DEVELOPMENT

Comprehensive phenotyping of group III and IV muscle afferents in mouse

(2013) Michael P. Jankowski et al.   JOURNAL OF NEUROPHYSIOLOGY

The Pro-Neurotrophin Receptor Sortilin Is a Major Neuronal Apolipoprotein E Receptor for Catabolism of Amyloid-  Peptide in the Brain

(2013) A.-S. Carlo et al.   JOURNAL OF NEUROSCIENCE

Sortilin and SorLA Display Distinct Roles in Processing and Trafficking of Amyloid Precursor Protein

(2013) C. Gustafsen et al.   JOURNAL OF NEUROSCIENCE

Modality-Specific Nociceptor Sensitization Following UV-B Irradiation of Human Skin

(2013) Benjamin Weinkauf et al.   JOURNAL OF PAIN

proNGF Inhibits Neurogenesis and Induces Glial Activation in Adult Mouse Dentate Gyrus

(2013) Jingjing Guo et al.   NEUROCHEMICAL RESEARCH

Injection of nerve growth factor into a low back muscle induces long-lasting latent hypersensitivity in rat dorsal horn neurons

(2013) Ulrich Hoheisel et al.   PAIN

Nerve growth factor induces sensitization of nociceptors without evidence for increased intraepidermal nerve fiber density

(2013) Michael Hirth et al.   PAIN

SorLA Controls Neurotrophic Activity by Sorting of GDNF and Its Receptors GFRα1 and RET

(2013) Simon Glerup et al.   Cell Reports

Direct intracellular selection and biochemical characterization of a recombinant anti-proNGF single chain antibody fragment

(2012) Francesca Paoletti et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Characterization of nerve growth factor-induced mechanical and thermal hypersensitivity in rats

(2012) C.D. Mills et al.   EUROPEAN JOURNAL OF PAIN

Microglia and intractable chronic pain

(2012) Makoto Tsuda et al.   GLIA

Mapping of the Interaction Site between Sortilin and the p75 Neurotrophin Receptor Reveals a Regulatory Role for the Sortilin Intracellular Domain in p75 Neurotrophin Receptor Shedding and Apoptosis

(2012) Sune Skeldal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NGF Sensitizes Nociceptors for Cowhage- but Not Histamine-Induced Itch in Human Skin

(2012) Roman R. Rukwied et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Tanezumab Reduces Osteoarthritic Knee Pain: Results of a Randomized, Double-Blind, Placebo-Controlled Phase III Trial

(2012) Mark T. Brown et al.   JOURNAL OF PAIN

Neurotrophic Factor Changes in the Rat Thick Skin following Chronic Constriction Injury of the Sciatic Nerve

(2012) Jennifer C Peleshok et al.   Molecular Pain

The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons

(2012) Hawon Cho et al.   NATURE NEUROSCIENCE

Neurotrophin regulation of neural circuit development and function

(2012) Hyungju Park et al.   NATURE REVIEWS NEUROSCIENCE

NGF-evoked sensitization of muscle fascia nociceptors in humans

(2012) Saskia Deising et al.   PAIN

Sortilin: a receptor to regulate neuronal viability and function

(2012) Anders Nykjaer et al.   TRENDS IN NEUROSCIENCES

Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons

(2012) L. Lapatsina et al.   Open Biology

Antagonism of Nerve Growth Factor-TrkA Signaling and the Relief of Pain

(2011) Patrick W. Mantyh et al.   ANESTHESIOLOGY

Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?

(2011) Sune Skeldal et al.   BIOESSAYS

Differential effects of lidocaine on nerve growth factor (NGF)-evoked heat- and mechanical hyperalgesia in humans

(2011) B. Weinkauf et al.   EUROPEAN JOURNAL OF PAIN

Neuronal Brain-derived Neurotrophic Factor Is Synthesized in Excess, with Levels Regulated by Sortilin-mediated Trafficking and Lysosomal Degradation

(2011) Sarah Felice Evans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proof of Concept Trial of Tanezumab for the Treatment of Symptoms Associated With Interstitial Cystitis

(2011) R.J. Evans et al.   JOURNAL OF UROLOGY

KCNQ4 K+ channels tune mechanoreceptors for normal touch sensation in mouse and man

(2011) Matthias Heidenreich et al.   NATURE NEUROSCIENCE

TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat

(2011) Joris Vriens et al.   NEURON

NGF enhances electrically induced pain, but not axon reflex sweating

(2011) Otilia Obreja et al.   PAIN

Nerve growth factor selectively decreases activity-dependent conduction slowing in mechano-insensitive C-nociceptors

(2011) Otilia Obreja et al.   PAIN

Preventive or late administration of anti-NGF therapy attenuates tumor-induced nerve sprouting, neuroma formation, and cancer pain

(2011) Juan Miguel Jimenez-Andrade et al.   PAIN

Taking Pain Out of NGF: A “Painless” NGF Mutant, Linked to Hereditary Sensory Autonomic Neuropathy Type V, with Full Neurotrophic Activity

(2011) Simona Capsoni et al.   PLoS One

Neuronal Growth Cone Retraction Relies on Proneurotrophin Receptor Signaling Through Rac

(2011) K. Deinhardt et al.   Science Signaling

The Sugar Is sIRVed: Sorting Glut4 and Its Fellow Travelers

(2011) Konstantin V. Kandror et al.   TRAFFIC

Evidence for a protein tether involved in somatic touch

(2010) Jing Hu et al.   EMBO JOURNAL

A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy

(2010) O. P. Carvalho et al.   JOURNAL OF MEDICAL GENETICS

Rab11 and Its Effector Rab Coupling Protein Contribute to the Trafficking of  1 Integrins during Axon Growth in Adult Dorsal Root Ganglion Neurons and PC12 Cells

(2010) R. Eva et al.   JOURNAL OF NEUROSCIENCE

Cutaneous C-polymodal Fibers Lacking TRPV1 are Sensitized to Heat following Inflammation, but Fail to Drive Heat Hyperalgesia in the Absence of TPV1 Containing C-heat Fibers

(2010) H Richard Koerber et al.   Molecular Pain

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling

(2010) Christian B Vaegter et al.   NATURE NEUROSCIENCE

Blockade of nerve sprouting and neuroma formation markedly attenuates the development of late stage cancer pain

(2010) W.G. Mantyh et al.   NEUROSCIENCE

Tanezumab for the Treatment of Pain from Osteoarthritis of the Knee

(2010) Nancy E. Lane et al.   NEW ENGLAND JOURNAL OF MEDICINE

In vitro receptor binding properties of a “painless” NGF mutein, linked to hereditary sensory autonomic neuropathy type V

(2009) Sonia Covaceuszach et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

New Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function

(2009) M. E. Greenberg et al.   JOURNAL OF NEUROSCIENCE

Axonal Targeting of Trk Receptors via Transcytosis Regulates Sensitivity to Neurotrophin Responses

(2009) M. Ascano et al.   JOURNAL OF NEUROSCIENCE

WNK4 Enhances the Degradation of NCC through a Sortilin-Mediated Lysosomal Pathway

(2009) B. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Single-fiber recordings of unmyelinated afferents in pig

(2009) Otilia Obreja et al.   NEUROSCIENCE LETTERS

NGF induces non-inflammatory localized and lasting mechanical and thermal hypersensitivity in human skin

(2009) Roman Rukwied et al.   PAIN

Differential effects of pro-BDNF on sensory neurons after sciatic nerve transection in neonatal rats

(2008) Yong-jun Fan et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Proneurotrophins Require Endocytosis and Intracellular Proteolysis to Induce TrkA Activation

(2008) Jacqueline Boutilier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The p75 receptor is associated with inflammatory thermal hypersensitivity

(2008) Tomoko Watanabe et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Nerve growth factor R221W responsible for insensitivity to pain is defectively processed and accumulates as proNGF

(2008) Elin Larsson et al.   NEUROBIOLOGY OF DISEASE

Effects of NGF-induced muscle sensitization on proprioception and nociception

(2008) Peter Svensson et al.   EXPERIMENTAL BRAIN RESEARCH

Spatial and temporal aspects of muscle hyperalgesia induced by nerve growth factor in humans

(2008) Helle Andersen et al.   EXPERIMENTAL BRAIN RESEARCH

Commercial Recombinant Human β-Nerve Growth Factor and Adult Rat Dorsal Root Ganglia Contain an Identical Molecular Species of Nerve Growth Factor Prohormone

(2003) Max Reinshagen et al.   JOURNAL OF NEUROCHEMISTRY