Article
Polymer Science
Neha Parveen, Afsana Sheikh, Mohammed A. S. Abourehab, Ritu Karwasra, Surender Singh, Prashant Kesharwani
Summary: Pancreatic cancer is the fourth leading cause of death worldwide, with low survival rates. The difficulties in early detection and the unique characteristics of pancreatic cancer contribute to ineffective therapies and widespread metastasis. Novel approaches, such as combining nanotechnology with cancer targeting, have shown potential in improving treatment efficacy and reducing cytotoxic effects.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Biochemical Research Methods
Seokmu Kwon, Tobias W. Giessen
Summary: Protein nanocages, specifically encapsulin nanocompartments, have become a significant engineering platform for biotechnological and biomedical applications. This study presents a novel strategy to modify encapsulin shells with nucleic acid-binding peptides to allow the concurrent encapsulation of RNA and proteins, expanding the functionality of encapsulins. The designed encapsulins successfully self-assemble in vivo, show efficient size-selective RNA packaging, and can load multiple functional RNAs simultaneously.
ACS SYNTHETIC BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Made Budiarta, Sathi Roy, Tobias Katenkamp, Neus Feliu, Tobias Beck
Summary: Due to its pharmacological properties, ferritin (Ftn) is used as a drug delivery vehicle to reduce the cardiotoxicity of doxorubicin (DOX) in chemotherapy. However, DOX encapsulation in Ftn faces challenges such as precipitation and low protein recovery yield. A new strategy using cysteine-maleimide conjugation for DOX encapsulation in Ftn is proposed and shown to be more efficient. The surface charges of Ftn variants affect the cytotoxicity, DOX loading, and cellular uptake mechanism.
Article
Chemistry, Multidisciplinary
Merle Scherf, Florian Scheffler, Christopher Maffeo, Ulrich Kemper, Jingjing Ye, Aleksei Aksimentiev, Ralf Seidel, Uta Reibetanz
Summary: The development of DNA origami technique has inspired the use of three-dimensional DNA cages for targeted drug delivery. This study presents a method using DNA origami nanotubes for efficient loading and retention of cargo molecules within the DNA cages.
Article
Engineering, Biomedical
Eun-Jeong Won, Hyeji Park, Seung-Hee Chang, Jin Hyun Kim, Hojeong Kwon, Young-Seok Cho, Tae-Jong Yoon
Summary: Diagnosing patients with pancreatic ductal adenocarcinoma (PDAC) early on can be challenging, with treatment often being complex. Gemcitabine (GEM) is the first-line treatment for PDAC, but its efficacy is limited in most patients due to resistance caused by mutations in the KRAS and P53 genes. This study explores the correction of double gene mutations and therapeutic effects for GEM-resistant PDAC. By utilizing bioavailable nanoliposomes (NL) carrying Cas9-ribonucleoproteins and adenine-base editors for gene editing, a potent therapy for PDAC, potentially overcoming chemoresistance, is proposed.
Article
Pharmacology & Pharmacy
Filippo Silva, Leopoldo Sitia, Raffaele Allevi, Arianna Bonizzi, Marta Sevieri, Carlo Morasso, Marta Truffi, Fabio Corsi, Serena Mazzucchelli
Summary: Protein nanocages are promising candidates in nanoscaled delivery systems, but concerns about endotoxin contamination in their production have prompted the development of a combined protocol for effectively removing endotoxins while maintaining high purity and protein recovery rates. This protocol, involving affinity purification with Endotrap HD resin and treatment with Triton X-114, has demonstrated success in maintaining nanocage interactions with target cells and specific recognition of cancer cells, paving the way for potential clinical trials.
Article
Chemistry, Medicinal
Matan Soll, Vinay K. Sharma, Sally Khoury, Yehuda G. Assaraf, Zeev Gross
Summary: The nanoparticle-based system of 3-Ga NPs demonstrates remarkable tumor growth inhibition against human metastatic castration-resistant prostate cancer and shows potential as a sonodynamic agent for the treatment of pancreatic cancer.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Pei Huang, Changrong Wang, Hongzhang Deng, Yongfeng Zhou, Xiaoyuan Chen
Summary: The development of multifunctional nanoparticles with desired properties is important in the field of nanotechnology and is expected to revolutionize cancer diagnosis and treatment. Surface engineering of nanoparticles is crucial for their in vivo fate, bioavailability, and theranostic outcomes. Different surface functionalities have been utilized to enhance cancer therapy and imaging, including inorganic and organic materials, biomembranes, and targeting moieties. These surface modifications have the potential to be applied in various scenarios and contribute to the clinical translation of NP-based platforms for cancer theranostics.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Jie-Feng Zhao, Fei-Long Zou, Jin-Feng Zhu, Chao Huang, Fan-Qin Bu, Zheng-Ming Zhu, Rong-Fa Yuan
Summary: This study systematically uncovers the performance of nano drug delivery system (NDDS) for pancreatic cancer (PC) through bibliometric analysis. The results show that the number of papers in this field has been increasing over the past 20 years. The United States, China, and India are the leading contributors in terms of paper quantity, citations, and H-index. The topics of tumor microenvironment, PC treatment, and gene therapy are the research hotspots.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Jianlin Zhang, Dengfeng Cheng, Jiuyang He, Juanji Hong, Chang Yuan, Minmin Liang
Summary: Ferritins are iron storage proteins that can be used for targeted delivery of anticancer drugs and diagnostic molecules. This study provides detailed procedures for loading different types of cargoes into ferritin nanocages for controlled delivery.
Review
Biochemistry & Molecular Biology
Andreea Nedelcu, Teodora Mocan, Cristiana Grapa, Lucian Mocan
Summary: Pancreatic cancer is a deadly solid tumor with low survival rates, often requiring surgical treatment, and the development of active nanocarriers presents opportunities for improving outcomes in its treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Gi Beom Kim, Hyo-Dong Sung, Gi-Hoon Nam, Wonjun Kim, Seohyun Kim, Dayeon Kang, Eun Jung Lee, In-San Kim
Summary: In this study, nanocages were designed to enhance the efficacy of PD-1 blockade-based therapy by increasing binding affinity and improving antagonistic activity. The nanocages successfully targeted tumor-draining lymph nodes, promoting dendritic cell-mediated tumor-specific T cell activation and inhibiting tumor growth.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Biotechnology & Applied Microbiology
Jorge Joao, Duarte Miguel F. Prazeres
Summary: Protein nanocages are highly ordered structures formed by self-assembly of multiple monomers. They have attractive qualities such as high surface/volume ratio, multi-functionality, and biocompatibility. They have wide applications in areas like drug delivery, vaccine development, and bioimaging. Efficient manufacturing processes and characterization techniques are needed to make them clinically valuable and overcome current limitations.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Environmental
Xiao Fu, Xiaoxuan Zhang, Danqing Huang, Liang Mao, Yudong Qiu, Yuanjin Zhao
Summary: Inspired by the structures of octopus tentacles, researchers have developed a novel adhesive microneedle patch with gemcitabine encapsulation for the treatment of pancreatic cancer. The patch, made of gelatin methacryloyl, demonstrates good biocompatibility, flexibility, and drug loading efficiency. It can adhere to the irregular surfaces of tumors and efficiently release gemcitabine to penetrate tumor tissues, showing promising anti-tumor efficacy in vitro and in a mouse model.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Letter
Gastroenterology & Hepatology
Eiji Kamba, Takashi Murakami, Akihito Nagahara
DIGESTIVE ENDOSCOPY
(2022)
Review
Cardiac & Cardiovascular Systems
Hajime Yamazaki, Muneaki Matsubara, Hideyuki Kato, Kazuo Imagawa, Takashi Murakami, Bryan J. Mathis, Yuji Hiramatsu
Summary: Thin, metallic wires ingested can easily penetrate the gastrointestinal system and cause serious cardiac issues in children. We report a pediatric case of cardiac tamponade caused by a wire lodged in the left ventricle. The wire was extracted without cardiopulmonary bypass and the patient made a full recovery. Although rare, immediate surgery is required for resolution of cardiac issues after ingestion of foreign objects.
JOURNAL OF CARDIAC SURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Hirosuke Yamaji, Shunichi Higashiya, Takashi Murakami, Hiroshi Kawamura, Masaaki Murakami, Shigeshi Kamikawa, Shozo Kusachi
Summary: The study found that in patients undergoing CTIA adjunctive to AF ablation, the rates of clinical AFL occurrence and CTI reconduction were relatively low, demonstrating superiority compared to other ablation methods.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2022)
Correction
Infectious Diseases
Kazuo Imai, Noriomi Ishibashi, Masahiro Kodana, Norihito Tarumoto, Jun Sakai, Toru Kawamura, Shinichi Takeuchi, Yoshitada Taji, Yasuhiro Ebihara, Kenji Ikebuchi, Takashi Murakami, Takuya Maeda, Kotaro Mitsutake, Shigefumi Maesaki
BMC INFECTIOUS DISEASES
(2022)
Article
Oncology
Fumiaki Sato, Atsunobu Sagara, Kaede Tajima, Shotaro Miura, Kenjiro Inaba, Yusuke Ando, Teruaki Oku, Takashi Murakami, Yoshinori Kato, Tetsuro Yumoto
Summary: COL8A1 is highly expressed in TNBC cell lines, especially in the MSL subtype, and its overexpression promotes TNBC growth through FAK/Src activation. Loss of COL8A1 inhibits TNBC spheroid/tumor growth and metastasis. Targeting COL8A1 may be an effective treatment for TNBC.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Yasuyuki Bito, Takanobu Aoyama, Masanori Sakaguchi, Yuriko Kiriya, Akihiro Sumiya, Masataro Doi, Takashi Murakami
CIRCULATION JOURNAL
(2022)
Article
Immunology
Atsushi Morita, Sho Hosaka, Kazuo Imagawa, Takumi Ishiodori, Yoshihiro Nozaki, Takashi Murakami, Hidetoshi Takada
Summary: This study elucidates the immunological characteristics of a Japanese patient with MIS-C, revealing the time course of peripheral immunophenotypes along with the clinical course and suggesting that immunological activation against the SARS-CoV-2 spike protein plays a central role in the etiology of MIS-C.
CLINICAL IMMUNOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Ippei Ikoma, Takashi Murakami, Keiichi Haga, Noboru Yatagai, Hiroya Ueyama, Tomoyoshi Shibuya, Akihito Nagahara
ENDOSCOPY INTERNATIONAL OPEN
(2022)
Article
Cardiac & Cardiovascular Systems
Hitoshi Mori, Naokata Sumitomo, Kenta Tsutsui, Hideo Fukunaga, Hidemori Hayashi, Hiroshi Nakajima, Shota Muraji, Taisuke Nabeshima, Daisuke Kawano, Yoshifumi Ikeda, So Asano, Junichi Nitta, Shigeo Watanabe, Tatsunori Hokosaki, Seiichi Sato, Toshiyuki Chisaka, Takashi Higaki, Tadashi Nakajima, Shuntaro Tamura, Yoshiaki Kaneko, Kentaro Ikeda, Ayako Okada, Hideki Kobayashi, Hirohiko Motoki, Hitoshi Minamiguchi, Tomohiko Imamura, Satoshi Shizuta, Mitsuharu Kawamura, Yumi Munetsugu, Tsugutoshi Suzuki, Takashi Murakami, Hitoshi Horigome, Tsutomu Wada, Motoki Takamuro, Junichi Ozawa, Hiroshi Suzuki, Daisuke Izumi, Sou Otsuki, Masaomi Chinushi, Ken Kato, Masaru Miura, Jun Maeda, Masato Fukunaga, Hidekazu Kondo, Naohiko Takahashi, Takeshi Tobiume, Itsuro Morishima, Kenji Kuraishi, Kentaro Nakamura, Hiroshi Hayashi, Hirohiko Suzuki, Yukihiko Yoshida, Seiji Fukamizu, Rintaro Hojo, Norihito Nuruki, Masao Yoshinaga, Kentaro Hayashi, Hidehira Fukaya, Jun Kishihara, Toshiki Kobayashi, Ritsushi Kato
Summary: This study investigated the utility and safety of subcutaneous implantable cardioverter defibrillators (S-ICDs) in patients <= 18 years old. The results suggested that S-ICDs can effectively prevent sudden cardiac death in the pediatric population with a low incidence of lead complications or device infections. The number of suitable sensing vectors did not change during the patients' growth.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Respiratory System
Akimasa Morisaki, Yosuke Takahashi, Hiromichi Fujii, Yoshito Sakon, Takashi Murakami, Toshihiko Shibata
Summary: For patients with atriogenic tethering in AFMR, patch augmentation and valve replacement have comparable outcomes, and operative procedures should be chosen based on individual patient backgrounds.
JOURNAL OF THORACIC DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Hirosuke Yamaji, Shunichi Higashiya, Takashi Murakami, Hiroshi Kawamura, Masaaki Murakami, Shigeshi Kamikawa, Shozo Kusachi
Summary: The purpose of this study is to determine the optimal method for preventing right phrenic nerve injury (PNI) in superior vena cava isolation (SVCI). The introduction of various monitoring systems has led to a decrease in PNI incidence, but only the application of high-power, short-duration radiofrequency energy on risk points tagged by a 3-dimensional electro-anatomical mapping (EAM) system completely prevents PNI.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Showkat Rashid, Takashi Murakami, Hiroshi Koganezawa, Yusuke Yoshigoe, Shoichi Hosoya, Shinichi Saito
Summary: Oxidative dimerization of terminal alkynes (Glaser coupling) triggered by spirofluorene derived macrocyclic phenanthroline-Cu complexes was used to synthesize a series of novel [2]rotaxanes. The size and structural variations among the components and their effects on the dynamic behavior were investigated in detail using H-1 and F-19 NMR spectroscopy. Non-symmetric distribution of the ring component along the axle component was observed in the NMR spectra of rotaxanes with substituted macrocyclic components with low symmetry, and localization of the ring component near the 1,3-diyne moiety was observed in some [2]rotaxanes.
NEW JOURNAL OF CHEMISTRY
(2023)
Review
Clinical Neurology
Sho Hanai, Ai Muroi, Daisuke Hitaka, Takashi Murakami, Masayuki Sato, Yuji Matsumaru, Eiichi Ishikawa
Summary: We present a neonatal case of DSM that was diagnosed prenatally and treated via endovascular intervention in the early postnatal period. The patient presented with a large DSM involving the torcular Herophilion prenatal magnetic resonance imaging (MRI). The neonate underwent endovascular occlusion via the umbilical artery, successfully treating the DSM.
CHILDS NERVOUS SYSTEM
(2023)
Review
Obstetrics & Gynecology
Shunichiro Tsuji, Yuri Nobuta, Tetsuro Hanada, Aike Takebayashi, Ayako Inatomi, Akimasa Takahashi, Tsukuru Amano, Takashi Murakami
Summary: This review summarizes the definition, prevalence, and etiology of Cesarean scar defects (CSD), as well as the pathophysiology and treatment of Cesarean scar disorder (CSDi), focusing on surgical therapy and examining the effects and procedures of laparoscopy, hysteroscopy, and transvaginal surgery. The definition of CSD was proposed as an anechoic lesion with a depth of at least 2 mm, while the incidence of CSD depends on the number, procedure, and situation of cesarean sections. Histopathological findings in CSD include fibrosis and adenomyosis, and chronic inflammation in the uterine and pelvic cavities affects fertility in women with CSDi. Although the surgical procedures are not standardized, laparoscopic, hysteroscopic, and transvaginal surgeries have shown effectiveness.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2023)
Article
Engineering, Biomedical
Riki Toita, Masahiro Kitamura, Akira Tsuchiya, Jeong-Hun Kang, Shinjiro Kasahara
Summary: "A new surface engineering strategy is described, which involves the release of phosphatidylserine liposomes (PSLs) from an implant coating to modify macrophage phenotype and mitigate foreign body reactions (FBRs), resulting in improved tissue healing. Unlike other therapeutic approaches, PSL-multilayered coatings also promote muscle regeneration."
ADVANCED HEALTHCARE MATERIALS
(2023)
