Polysulfide Evokes Acute Pain through the Activation of Nociceptive TRPA1 in Mouse Sensory Neurons

Transient Receptor Potential Ankyrin 1 in Spinal Cord Dorsal Horn is Involved in Neuropathic Pain in Nerve Root Constriction Rats

(2014) Tsuyoshi Miyakawa et al.   Molecular Pain

The physiological role of hydrogen sulfide and beyond

(2014) Hideo Kimura   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling

(2014) T. Ida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins

(2014) Victor Meseguer et al.   Nature Communications

Polysulfides Link H2S to Protein Thiol Oxidation

(2013) Romy Greiner et al.   ANTIOXIDANTS & REDOX SIGNALING

Transient Receptor Potential Ankyrin 1 Receptor Stimulation by Hydrogen Peroxide Is Critical to Trigger Pain During Monosodium Urate-Induced Inflammation in Rodents

(2013) Gabriela Trevisan et al.   ARTHRITIS AND RHEUMATISM

Polysulfides are possible H2S-derived signaling molecules in rat brain

(2013) Yuka Kimura et al.   FASEB JOURNAL

The Molecular Basis for Species-specific Activation of Human TRPA1 Protein by Protons Involves Poorly Conserved Residues within Transmembrane Domains 5 and 6

(2013) Jeanne de la Roche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory acidic pH enhances hydrogen sulfide-induced transient receptor potential ankyrin 1 activation in RIN-14B cells

(2013) Kenji Takahashi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mechanisms underlying transient receptor potential ankyrin 1 (TRPA1)-mediated hyperalgesia and edema

(2013) Andressa Perin-Martins et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Involvement of TRPA1 Activation in Acute Pain Induced by Cadmium in Mice

(2013) Saeko Miura et al.   Molecular Pain

Physiological role of hydrogen sulfide and polysulfide in the central nervous system

(2013) Hideo Kimura   NEUROCHEMISTRY INTERNATIONAL

Species differences and molecular determinant of TRPA1 cold sensitivity

(2013) Jun Chen et al.   Nature Communications

Sulfhydration mediates neuroprotective actions of parkin

(2013) M. Scott Vandiver et al.   Nature Communications

A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells

(2013) Norihiro Shibuya et al.   Nature Communications

H2S functions as a nociceptive messenger through transient receptor potential ankyrin 1 (TRPA1) activation

(2012) H. Ogawa et al.   NEUROSCIENCE

TRPA1 Has a Key Role in the Somatic Pro-Nociceptive Actions of Hydrogen Sulfide

(2012) David A. Andersson et al.   PLoS One

TRPA1 Contributes to the Acute Inflammatory Response and Mediates Carrageenan-Induced Paw Edema in the Mouse

(2012) Lauri J. Moilanen et al.   Scientific Reports

Molecular Cloning and Functional Characterization ofXenopus tropicalisFrog Transient Receptor Potential Vanilloid 1 Reveal Its Functional Evolution for Heat, Acid, and Capsaicin Sensitivities in Terrestrial Vertebrates

(2011) Masashi Ohkita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

4-Oxo-2-nonenal (4-ONE): Evidence of Transient Receptor Potential Ankyrin 1-Dependent and -Independent Nociceptive and Vasoactive Responses In Vivo

(2011) R. Graepel et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

TRPA1 underlies a sensing mechanism for O2

(2011) Nobuaki Takahashi et al.   Nature Chemical Biology

TRP Channels as Sensors and Signal Integrators of Redox Status Changes

(2011) Nobuaki Takahashi et al.   Frontiers in Pharmacology

Hydrogen sulfide: its production, release and functions

(2010) Hideo Kimura   AMINO ACIDS

Nociception, neurogenic inflammation and thermoregulation in TRPV1 knockdown transgenic mice

(2010) Dániel Márton Tóth et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Glucocorticoids suppress cystathionine gamma-lyase expression and H2S production in lipopolysaccharide-treated macrophages

(2010) Xiao-Yan Zhu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators

(2010) Nobuaki Takahashi et al.   Channels

Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis*

(2010) Seah-Fang Ang et al.   CRITICAL CARE MEDICINE

TRP channels of intracellular membranes

(2010) Xian-Ping Dong et al.   JOURNAL OF NEUROCHEMISTRY

Signaling mechanisms involved in the intestinal pro-secretory actions of hydrogen sulfide

(2010) D. Krueger et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Upregulation of Cav3.2 T-type calcium channels targeted by endogenous hydrogen sulfide contributes to maintenance of neuropathic pain

(2010) Tomoko Takahashi et al.   PAIN

Roles of transient receptor potential channels in pain

(2009) Cheryl L. Stucky et al.   BRAIN RESEARCH REVIEWS

Hyperalgesia induced by spinal and peripheral hydrogen sulfide: Evidence for involvement of Cav3.2 T-type calcium channels

(2009) Yumi Maeda et al.   PAIN

TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells

(2009) K. Nozawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H2S Signals Through Protein S-Sulfhydration

(2009) A. K. Mustafa et al.   Science Signaling

A Source of Hydrogen Sulfide and a Mechanism of Its Release in the Brain

(2008) Mari Ishigami et al.   ANTIOXIDANTS & REDOX SIGNALING

Luminal hydrogen sulfide plays a pronociceptive role in mouse colon

(2008) M Matsunami et al.   GUT

Novel Gating and Sensitizing Mechanism of Capsaicin Receptor (TRPV1)

(2008) Toshio Ohta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular alkalization causes pain sensation through activation of TRPA1 in mice

(2008) Fumitaka Fujita et al.   JOURNAL OF CLINICAL INVESTIGATION

TRPA1 is a major oxidant sensor in murine airway sensory neurons

(2008) Bret F. Bessac et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutaneous Nociception Evoked by 15-delta PGJ2 via Activation of Ion Channel TRPA1

(2008) Lillian Cruz-Orengo et al.   Molecular Pain

A nociceptive-intensity-dependent role for hydrogen sulphide in the formalin model of persistent inflammatory pain

(2007) A.T.-H. Lee et al.   NEUROSCIENCE