Topoisomerase-1 and -2A gene copy numbers are elevated in mismatch repair-proficient colorectal cancers

Replication stress links structural and numerical cancer chromosomal instability

(2013) Rebecca A. Burrell et al.   NATURE

Mechanisms of Topoisomerase I (TOP1) Gene Copy Number Increase in a Stage III Colorectal Cancer Patient Cohort

(2013) David Hersi Smith et al.   PLoS One

Assessment of the topoisomerase I gene copy number as a predictive biomarker of objective response to irinotecan in metastatic colorectal cancer

(2013) Sune Boris Nygård et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Underpinning the repurposing of anthracyclines towards colorectal cancer: assessment of topoisomerase II alpha gene copy number alterations in colorectal cancer

(2013) Sune Boris Nygård et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Preventing Replication Stress to Maintain Genome Stability: Resolving Conflicts between Replication and Transcription

(2012) Rodrigo Bermejo et al.   MOLECULAR CELL

Topoisomerase 1(TOP1 ) gene copy number in stage III colorectal cancer patients and its relation to prognosis

(2012) Maria Unni Rømer et al.   Molecular Oncology

Thresholds of replication stress signaling in cancer development and treatment

(2012) Jiri Bartek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mammalian mismatch repair: error-free or error-prone?

(2012) Javier Peña-Diaz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Microsatellite Instability and Colorectal Cancer

(2011) Katherine B. Geiersbach et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

The role of topoisomerase IIα in predicting sensitivity to anthracyclines in breast cancer patients: a meta-analysis of published literatures

(2011) Yueyao Du et al.   BREAST CANCER RESEARCH AND TREATMENT

HER2 and TOP2A as predictive markers for anthracycline-containing chemotherapy regimens as adjuvant treatment of breast cancer: a meta-analysis of individual patient data

(2011) Angelo Di Leo et al.   LANCET ONCOLOGY

Lack of independent prognostic and predictive value of centromere 17 copy number changes in breast cancer patients with known HER2 and TOP2A status

(2011) Kirsten Vang Nielsen et al.   Molecular Oncology

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

Microsatellite instability as a marker of prognosis and response to therapy: A meta-analysis of colorectal cancer survival data

(2010) Cecilia Guastadisegni et al.   EUROPEAN JOURNAL OF CANCER

Topoisomerase I but not thymidylate synthase is associated with improved outcome in patients with resected colorectal cancer treated with irinotecan containing adjuvant chemotherapy

(2009) Ioannis Kostopoulos et al.   BMC CANCER

6003 The correlation between Topoisomerase-I (Topo1) expression and outcome of treatment with capecitabine and irinotecan in advanced colorectal cancer (ACC) patients (pts) treated in the CAIRO study of the Dutch Colorectal Cancer Group (DCCG)

(2009) M. Koopman et al.   EJC SUPPLEMENTS

Topoisomerase I and IIα protein expression in primary colorectal cancer and recurrences following 5-fluorouracil-based adjuvant chemotherapy

(2008) Nicolas Tsavaris et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Genomic and Epigenetic Instability in Colorectal Cancer Pathogenesis

(2008) William M. Grady et al.   GASTROENTEROLOGY

Predictive Biomarkers of Chemotherapy Efficacy in Colorectal Cancer: Results From the UK MRC FOCUS Trial

(2008) Michael S. Braun et al.   JOURNAL OF CLINICAL ONCOLOGY

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE