Article
Biotechnology & Applied Microbiology
Qin Zhu, Xian Zhang, Hong-Yan Zai, Wei Jiang, Ke-Jing Zhang, Yu-Qiong He, Yu Hu
Summary: The study suggests that circSLC8A1 plays a role in breast cancer by regulating the miR-671 and PTEN/PI3k/Akt signaling pathways, leading to inhibition of tumor growth and metastasis.
Article
Cell Biology
Yan Sun, Huan Zhang, Junpeng Meng, Feng Guo, Dianyun Ren, Heshui Wu, Xin Jin
Summary: This study demonstrates that aberrant PCSK9 upregulation promotes cell proliferation and sorafenib resistance in HCC by inducing AKT activation. Additionally, competitive inhibition of PCSK9 palmitoylation enhances the antitumor effects of sorafenib in HCC.
Review
Biochemistry & Molecular Biology
Maricedes Acosta-Martinez, Maria Zulema Cabail
Summary: Obesity is a global epidemic and a major risk factor for cardiovascular disease, stroke, and mortality. Meta-inflammation, characterized by immune cell accumulation, dysregulation of adipokine synthesis, and increased production of proinflammatory factors, is believed to contribute to obesity's negative health consequences. The crosstalk between macrophages and adipocytes and the impairment of the PI3K/Akt signaling pathway play crucial roles in the development of meta-inflammation and insulin resistance associated with obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Haijun Kang, Dongmei Huang, Heng Li, Xuejun Deng, Siyuan Liu, Wenjun Gou, Linglin Liu, Yuyan Qiu, Xu Yang
Summary: This study found that the long non-coding RNA lncNALT plays an important role in the pathogenesis of hypertensive retinopathy. Knockdown of lncNALT enhances the viability, proliferation, migration, and invasion of human retinal microvascular endothelial cells (RMECs) via the PTEN/PI3K/AKT pathway.
Review
Medicine, Research & Experimental
Martina S. Savova, Liliya Mihaylova, Daniel Tews, Martin Wabitsch, Milen I. Georgiev
Summary: Obesity is a growing disorder that damages patients' quality of life and increases healthcare costs. Developing safe and innovative prevention strategies and treatments for obesity is crucial. The pathophysiology of obesity is complex and involves multiple signaling pathways, including the PI3K/AKT pathway, which plays a critical role in metabolic homeostasis. Natural compounds have been shown to target the PI3K/AKT signaling pathway and have potential for managing obesity. This paper evaluates the druggability of PI3K as a target and suggests perspectives on using natural compounds to modulate the PI3K/AKT pathway for obesity management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Xi Yu, Shenglan Li, Mingrui Pang, Yang Du, Tao Xu, Tao Bai, Kang Yang, Juncheng Hu, Shaoming Zhu, Lei Wang, Xiuheng Liu
Summary: This study revealed that downregulation of TSPAN7 in bladder cancer is associated with tumor progression and poor prognosis, and demonstrated the inhibitory effects of TSPAN7 on cancer cell proliferation and migration through multiple experiments. TSPAN7 inhibits bladder cancer cell growth by activating Bax, cleaved caspase-3, and PTEN pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biology
Chao Xu, Qinwen Ye, Chao Ye, Shaojun Liu
Summary: circACTR2 is down-regulated in pancreatic cancer cells and can reverse chemoresistance by inhibiting the PI3K/AKT signaling pathway through sponge miR-221-3p and upregulating PTEN expression.
Article
Agriculture, Dairy & Animal Science
Soo-Hyeon Kim, Byung-Joon Seung, Seung-Hee Cho, Ha-Young Lim, Min-Kyung Bae, Jung-Hyang Sur
Summary: The frequency of PIK3CA H1047R mutation in canine mammary tumors is 14.3%, leading to dysregulation of downstream molecules Akt2, p-Akt, and PTEN, with the exception of a higher level of PTEN in mutated tumors. No significant correlation was found between PIK3CA H1047R mutation and expression of downstream molecules, suggesting the dysregulation of components in the PI3K/Akt/PTEN pathway is a feature in canine mammary tumors distinct from the mutation.
Article
Oncology
Yongwei Lu, Qiaoyan Lin, Cuibo Lin, Jian Chen, Xinyan Jiang, Haixi He
Summary: The study suggests that miR-424 inhibitor can inhibit cell proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) process, while promoting apoptosis in endometrial carcinoma (EC) by suppressing PTEN/PI3K/AKT signaling. However, the effects of miR-424 inhibitor were reversed by sh-PTEN.
Review
Pharmacology & Pharmacy
Ayda Baghery Saghchy Khorasani, Atieh Pourbagheri-Sigaroodi, Ali Pirsalehi, Ava Safaroghli-azar, Mohammad Reza Zali, Davood Bashash
Summary: Genetic and epigenetic alterations have long been the focus of cancer pathogenesis research, with dysregulated genes and protein products potentially affecting cancer cell growth through signaling cascades regulating cell survival and metabolism. The activation of the phosphatidylinositol-3-kinase (PI3K) axis in about one-third of human cancers, including gastric cancer, plays a significant role in the development of malignancies. This indicates the potential importance of targeting this axis in therapeutic strategies for such cancers.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Plant Sciences
Tao Wang, Zhiyuan Chen, Hui Chen, Xi Yu, Lei Wang, Xiuheng Liu
Summary: The study aimed to investigate the mechanism by which brusatol regulates the growth of renal cancer cells through the PTEN/PI3K/AKT signaling pathway. The results showed that brusatol significantly inhibited the proliferation, migration, and invasion of A498, ACHN, and OSRC-2 renal cancer cell lines, and increased apoptosis rates.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Cell Biology
Sakshi Gupta, Mukund Kumar, Soumi Chaudhuri, Arun Kumar
Summary: The PI3K-AKT-MTOR signaling pathway is essential for various cellular functions and has been found to be involved in nuclear processes such as DNA replication, transcription, DNA repair, maintenance of genomic integrity, chromatin architecture, and cell cycle control. Effector molecules of this pathway can translocate to the nucleus and regulate nuclear signaling.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Environmental Sciences
Yiming Zhang, Zhaoyi Liu, Jing Lan, Jinliang Wang, Zhiqiang Shen, Guangliang Shi, Shu Li
Summary: Cadmium accumulation in pigs can induce apoptosis in thymus cells and activate oxidative stress pathways, leading to oxidative damage to immune tissues. Additionally, exposure to cadmium can affect antioxidant indices and alter the levels of related genes in the PTEN/PI3K/AKT pathway, ultimately impacting cell survival.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Cell & Tissue Engineering
Linwen Zhu, Zhe Li, Xiuchong Yu, Yao Ruan, Yijing Shen, Yongfu Shao, Xinjun Zhang, Guoliang Ye, Junming Guo
Summary: tRF-5026a is downregulated in gastric cancer patients and has a certain diagnostic value for predicting overall survival. It suppresses proliferation, migration, and cell cycle progression of gastric cancer cells.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Plant Sciences
Songjun Liu, Xinran Cao, Tao Zhang, Chenyang Zhang, Jiao Qu, Yang Sun, Wen Lv, Fan Qu
Summary: The study aimed to investigate the molecular mechanism underlying the protective role of Paeonol (Pae) against endometrial hyperplasia (EH). Results showed that Pae reduced the viability of endometrial epithelial cells and alleviated uterus weight and morphology changes in mice. Further experiments revealed that Pae exerted its effects through the regulation of ferroptosis via the PI3K/AKT signaling pathway.
Article
Medicine, General & Internal
Orla Fitzpatrick, Roisin Ni Dhonaill, Anna Linehan, Zac Coyne, Maeve Hennessy, Maeve Clarke, Elizabeth McGee, Fiona Barrett, Deborah O'Doherty, Carla Matassa, Teresa Doyle, Allyson Christie, Bryan Hennessy, Liam Grogan, Patrick G. Morris, Oscar S. Breathnach, Darren Cowzer
Summary: By implementing screening measures for COVID-19 symptoms and ensuring safety protocols, it was possible to safely and continuously deliver systemic anti-cancer therapy during the COVID-19 pandemic.
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Oncology
Felipe Batalini, Niya Xiong, Nabihah Tayob, Madeline Polak, Julia Eismann, Lewis C. Cantley, Geoffrey Shapiro, Viktor Adalsteinsson, Eric P. Winer, Panagiotis A. Konstantinopoulos, Alan D'Andrea, Elizabeth M. Swisher, Ursula A. Matulonis, Gerburg M. Wulf, Erica L. Mayer
Summary: This study aimed to evaluate the safety and recommended dose of olaparib in combination with alpelisib in patients with breast cancer, and explore its effects on different subtypes. The results showed that this combination therapy was tolerable for pre-treated TNBC patients and demonstrated activity in non-BRCA mutant patients. Analysis of circulating-free DNA also provided important prognostic information.
CLINICAL CANCER RESEARCH
(2022)
Correction
Biochemistry & Molecular Biology
Andrew R. Tee, Brendan D. Manning, Philippe P. Roux, Lewis C. Cantley, John Blenis
Review
Oncology
Giulia Petroni, Lewis C. Cantley, Laura Santambrogio, Silvia C. Formenti, Lorenzo Galluzzi
Summary: Targeted anticancer agents have been successful in inhibiting specific molecular alterations in cancer cells, while radiotherapy activates cytotoxic pathways and protective mechanisms that can enhance the efficacy of these agents. By promoting non-oncogene dependence on targetable signaling pathways, radiotherapy has the potential to benefit a greater number of patients who may not respond to targeted therapies alone.
NATURE REVIEWS CLINICAL ONCOLOGY
(2022)
Correction
Oncology
Giulia Petroni, Lewis C. Cantley, Laura Santambrogio, Silvia C. Formenti, Lorenzo Galluzzi
NATURE REVIEWS CLINICAL ONCOLOGY
(2022)
Review
Oncology
Neil Vasan, Lewis C. Cantley
Summary: This review discusses the efforts made in the past and present to improve the clinical efficacy of PI3K pathway inhibitors in cancer treatment, including optimizing inhibitor specificity, patient selection, and biomarkers. It highlights the advantages and limitations of laboratory-based model systems and proposes technologies and experiments to guide the future clinical deployment of PI3K pathway inhibitors.
NATURE REVIEWS CLINICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Ankur Chakravarthy, Ian Reddin, Stephen Henderson, Cindy Dong, Nerissa Kirkwood, Maxmilan Jeyakumar, Daniela Rothschild Rodriguez, Natalia Gonzalez Martinez, Jacqueline McDermott, Xiaoping Su, Nagayasau Egawa, Christina S. Fjeldbo, Vilde Eide Skingen, Heidi Lyng, Mari Kylleso Halle, Camilla Krakstad, Afschin Soleiman, Susanne Sprung, Matt Lechner, Peter J. I. Ellis, Mark Wass, Martin Michaelis, Heidi Fiegl, Helga Salvesen, Gareth J. Thomas, John Doorbar, Kerry Chester, Andrew Feber, Tim R. Fenton
Summary: This study conducted a comprehensive analysis of 643 cervical squamous cell carcinomas (CSCC) from different regions and identified two subtypes with different prognosis. One subtype was associated with HPV16 and the other subtype was associated with HPV18. However, the prognosis difference cannot be solely attributed to HPV types. The C2 subtype showed distinct genomic alterations and immune-related differences, which may explain its shorter survival.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Hege F. Berg, Hilde Engerud, Madeleine Myrvold, Hilde E. Lien, Marta Espevold Hjelmeland, Mari K. Halle, Kathrine Woie, Erling A. Hoivik, Ingfrid S. Haldorsen, Olav Vintermyr, Jone Trovik, Camilla Krakstad
Summary: This study found that immunohistochemical staining of MSH6, MSH2, PMS2, and MLH1 can determine mismatch repair (MMR) status in endometrial cancer patients. The expression levels of MMR proteins, especially MSH6, provide prognostic information for endometrial cancer.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Smruthy Sivakumar, Dexter X. Jin, Ruchita Rathod, Jeffrey Ross, Lewis C. Cantley, Maurizio Scaltriti, Jessica W. Chen, Katherine E. Hutchinson, Timothy R. Wilson, Ethan S. Sokol, Neil Vasan
Summary: The purpose of this study was to characterize the tissue-specific and molecular subclasses of multiple PIK3CA mutations and their impact on therapeutic outcomes. The results showed that multi-PIK3CA mutations accounted for 11% of all PIK3CA-mutant tumors and were enriched in breast and gynecologic cancers. These mutations frequently occurred in cis on the same allele and at characteristic positions across tumor types. Different classes of multi-PIK3CA mutant estrogen receptor-positive, HER2-negative breast cancers responded similarly to PI3K inhibition.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Nigar Sofiyeva, Camilla Krakstad, Mari K. Halle, Tracy A. O'Mara, Pal Romundstad, Kristian Hveem, Lars Vatten, Per E. Lonning, Liv B. Gansmo, Stian Knappskog
Summary: The APOBEC3A/B deletion variant is associated with a decreased risk of endometrial cancer in Norwegian women.
Editorial Material
Oncology
Luis A. Diaz, Lewis C. Cantley
Article
Medicine, General & Internal
Hilde E. Lien, Hege F. Berg, Mari K. Halle, Jone Trovik, Ingfrid S. Haldorsen, Lars A. Akslen, Camilla Krakstad
Summary: The identification of aggressive low-stage endometrial cancers is difficult. This study found that vimentin is a robust marker for predicting recurrence and prognosis in these patients, and may help identify a previously unidentified subgroup of high-risk patients.
Article
Oncology
Marike S. Lombaers, Karlijn M. C. Cornel, Nicole C. M. Visser, Johan Bulten, Heidi V. N. Kuesters-Vandevelde, Frederic Amant, Dorry Boll, Peter Bronsert, Eva Colas, Peggy M. A. J. Geomini, Antonio Gil-Moreno, Dennis van Hamont, Jutta Huvila, Camilla A. Krakstad, Arjan A. Kraayenbrink, Martin Koskas, Gemma Mancebo, Xavier Matias-Guiu, Huy M. Ngo, Brenda M. Pijlman, Maria Caroline Vos, Vit Weinberger, Marc P. L. M. W. Snijders, Sebastiaan W. S. van Koeverden, Ingfrid S. Haldorsen, Casper Reijnen, Johanna M. A. Pijnenborg
Summary: Patients with high-grade uterine cancer have a higher risk of cancer spreading to the lymph nodes compared to patients with low-grade uterine cancer. CA125, a marker detectable in blood, is associated with increased tumor spread. This study aimed to assess the predictive value of CA125 for uterine cancer spread and survival and the additional value of CT scan in high-grade uterine cancer. The findings showed that elevated CA125 was associated with advanced stage, lymph node metastasis, and a worse prognosis in high-grade uterine cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Kristine E. Fasmer, Ankush Gulati, Julie A. Dybvik, Kari S. Wagner-Larsen, Njal Lura, Oyvind Salvesen, David Forsse, Jone Trovik, Johanna M. A. Pijnenborg, Camilla Krakstad, Ingfrid S. Haldorsen
Summary: This study evaluated the diagnostic performance of four different preoperative imaging workups for predicting lymph node metastases in endometrial cancer. The results showed that selective use of [F-18]FDG-PET/CT in patients with high-risk MRI findings detected lymph node metastases better than MRI alone.
EUROPEAN RADIOLOGY
(2023)
Review
Oncology
Samuel R. Taylor, John N. Falcone, Lewis C. Cantley, Marcus D. Goncalves
Summary: This Review discusses metabolic alterations and vulnerabilities in different types of cancer, and suggests using dietary interventions in combination with pharmacologic therapies to target these changes. However, diet studies in cancer patients are rare and lack robust evidence. The article also explores how dietary strategies can be combined with pharmacological therapies in treating cancer.
NATURE REVIEWS CANCER
(2022)
Article
Oncology
Andra S. Martinikova, Miroslav Stoyanov, Anna Oravetzova, Yannick P. Kok, Shibo Yu, Jana Dobrovolna, Pavel Janscak, Marcel van Vugt, Libor Macurek
Summary: Oncogene-induced replication stress is a major cause of genome instability in cancer cells. This study reveals that increased activity of PPM1D exacerbates replication stress caused by cyclin E1 overexpression, leading to abnormal cell cycle progression and accumulation of DNA copy number alterations. Pharmacological inhibition of PPM1D can alleviate replication stress-induced genome instability.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Alamelu G. Bharadwaj, Meghan E. McLean, Margaret L. Dahn, Hannah F. Cahill, Marie-Claire D. Wasson, Raj Pranap Arun, Olivia L. Walker, Brianne M. Cruickshank, Wasundara Fernando, Jaganathan Venkatesh, Penelope J. Barnes, Gillian Bethune, Gregory Knapp, Lucy K. Helyer, Carman A. Giacomantonio, David M. Waisman, Paola Marcato
Summary: ALDH1A3 regulates the plasminogen activation pathway to promote breast cancer metastasis. Co-expression of ALDH1A3 and tPA is associated with TNBC subtype, high tumor grade, and recurrent metastatic disease.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Nayela N. Chowdhury, Yi Yang, Ananya Dutta, Michelle Luo, Zimu Wei, Sara R. Abrahams, Alexey S. Revenko, Fenil Shah, Lindsey A. Miles, Robert J. Parmer, Bas de Laat, Alisa S. Wolberg, James P. Luyendyk, Melissa L. Fishel, Matthew J. Flick
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal metastatic disease associated with robust activation of the coagulation and fibrinolytic systems. Primary fibrinolytic protease plasminogen promotes PDAC tumor growth and metastatic potential through engaging plasminogen receptors on tumor cells.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Nuria Gendrau-Sanclemente, Agnes Figueras, Kristina Gracova, Alvaro Lahiguera, Elisenda Alsina-Sanchis, Juan A. Marin-Jimenez, August Vidal, Xavier Matias-Guiu, Sergi Fernandez-Gonzalez, Marc Barahona, Lola Marti, Jordi Ponce, Francesc Vinals
Summary: High-grade serous ovarian cancer (HGSOC), the deadliest gynecological malignancy, spreads through transcoelomic dissemination. This study reveals that platelet-derived growth factor receptor beta (PDGFRβ) is essential for the formation of tumorspheres in HGSOC. Inhibition of PDGFRβ blocks the clustering of ovarian cancer cells and prevents peritoneal dissemination.
MOLECULAR ONCOLOGY
(2024)