Ubiquitin specific protease 4 positively regulates the WNT/β-catenin signaling in colorectal cancer

The DUSP–Ubl domain of USP4 enhances its catalytic efficiency by promoting ubiquitin exchange

(2014) Marcello Clerici et al.   Nature Communications

Wnt signaling in stem and cancer stem cells

(2013) Jane D Holland et al.   CURRENT OPINION IN CELL BIOLOGY

Ubiquitin-specific protease 4 promotes TNF-α-induced apoptosis by deubiquitination of RIP1 in head and neck squamous cell carcinoma

(2013) Xiaozhi Hou et al.   FEBS LETTERS

USP4 Positively Regulates RIG-I-Mediated Antiviral Response through Deubiquitination and Stabilization of RIG-I

(2013) L. Wang et al.   JOURNAL OF VIROLOGY

The ubiquitin specific protease-4 (USP4) interacts with the S9/Rpn6 subunit of the proteasome

(2012) Bin Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lysine 394 is a novel Rad6B-induced ubiquitination site on beta-catenin

(2012) Brigitte Gerard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cellular functions of the DUBs

(2012) M. J. Clague et al.   JOURNAL OF CELL SCIENCE

Ubiquitin-Specific Protease 4 Inhibits Mono-Ubiquitination of the Master Growth Factor Signaling Kinase PDK1

(2012) Iris Z. Uras et al.   PLoS One

K63-Linked Ubiquitination in Kinase Activation and Cancer

(2012) Guocan Wang et al.   Frontiers in Oncology

Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFα-induced cancer cell migration

(2011) Ning Xiao et al.   BIOCHEMICAL JOURNAL

USP4 targets TAK1 to downregulate TNFα-induced NF-κB activation

(2011) Y-H Fan et al.   CELL DEATH AND DIFFERENTIATION

USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1

(2011) Xinna Zhang et al.   EMBO JOURNAL

Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain

(2011) Mark P A Luna-Vargas et al.   EMBO REPORTS

Wnt signaling and colon tumorigenesis — A view from the periphery

(2011) Antony W. Burgess et al.   EXPERIMENTAL CELL RESEARCH

Specific Armadillo Repeat Sequences Facilitate β-Catenin Nuclear Transport in Live Cells via Direct Binding to Nucleoporins Nup62, Nup153, and RanBP2/Nup358

(2011) Manisha Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ubiquitin-Specific Protease USP34 Regulates Axin Stability and Wnt/ -Catenin Signaling

(2011) T. T. H. Lui et al.   MOLECULAR AND CELLULAR BIOLOGY

Winning WNT: Race to Wnt signaling inhibitors

(2011) K. Watanabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

USP10 Regulates p53 Localization and Stability by Deubiquitinating p53

(2010) Jian Yuan et al.   CELL

Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt

(2010) Akiko Mukai et al.   EMBO JOURNAL

The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome

(2010) E. J. Song et al.   GENES & DEVELOPMENT

Loss of the Tumor Suppressor CYLD Enhances Wnt/β-Catenin Signaling through K63-Linked Ubiquitination of Dvl

(2010) Daniele V.F. Tauriello et al.   MOLECULAR CELL

Wnt signal transduction pathways

(2010) Yuko Komiya et al.   Organogenesis

The multiple levels of regulation by p53 ubiquitination

(2009) J T Lee et al.   CELL DEATH AND DIFFERENTIATION

The ubiquitin specific protease 4 (USP4) is a new player in the Wnt signalling pathway

(2009) Bin Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Positive Reciprocal Regulation of Ubiquitin C-Terminal Hydrolase L1 and β-Catenin/TCF Signaling

(2009) Anjali Bheda et al.   PLoS One

Rac1 Activation Controls Nuclear Localization of β-catenin during Canonical Wnt Signaling

(2008) Ximei Wu et al.   CELL