Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System

Thromboxane A2 stimulates neurite outgrowth in cerebral cortical neurons via mitogen activated protein kinase signaling

(2015) Satoko Sumimoto et al.   BRAIN RESEARCH

Low-dose aspirin (acetylsalicylate) prevents increases in brain PGE2, 15-epi-lipoxin A4 and 8-isoprostane concentrations in 9 month-old HIV-1 transgenic rats, a model for HIV-1 associated neurocognitive disorders

(2015) Helene C. Blanchard et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Lithium and the Other Mood Stabilizers Effective in Bipolar Disorder Target the Rat Brain Arachidonic Acid Cascade

(2014) Stanley I. Rapoport   ACS Chemical Neuroscience

The prostaglandin EP1 receptor potentiates kainate receptor activation via a protein kinase C pathway and exacerbates status epilepticus

(2014) Asheebo Rojas et al.   NEUROBIOLOGY OF DISEASE

Immunohistochemical analysis of cyclooxygenase-2 and brain fatty acid binding protein expression in grades I-II meningiomas: Correlation with tumor grade and clinical outcome after radiotherapy

(2014) Hyun-Cheol Kang et al.   NEUROPATHOLOGY

Seizure susceptibility in immature brain due to lack of COX-2-induced PGF2α

(2013) Jee-In Chung et al.   EXPERIMENTAL NEUROLOGY

Microsomal prostaglandin E synthase-1 is induced in alzheimer's disease and its deletion mitigates alzheimer's disease-like pathology in a mouse model

(2013) Yoshiharu Akitake et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The Role of Secretory Phospholipase A2 in the Central Nervous System and Neurological Diseases

(2013) Tatsurou Yagami et al.   MOLECULAR NEUROBIOLOGY

Prostaglandin D2 toxicity in primary neurons is mediated through its bioactive cyclopentenone metabolites

(2013) Hao Liu et al.   NEUROTOXICOLOGY

Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation

(2013) Jianxiong Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adjunctive Use of Nonsteroidal Anti-inflammatory Drugs for Schizophrenia: A Meta-analytic Investigation of Randomized Controlled Trials

(2013) Masahiro Nitta et al.   SCHIZOPHRENIA BULLETIN

RETRACTED: Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in the postmortem frontal cortex from schizophrenia patients

(2013) Jagadeesh Sridhara Rao et al.   SCHIZOPHRENIA RESEARCH

COX-2 in the neurodegenerative process of Parkinson's disease

(2012) Peter Teismann   BIOFACTORS

Anti-inflammatory treatment in schizophrenia

(2012) Norbert Müller et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Signaling via the prostaglandin E2 receptor EP4 exerts neuronal and vascular protection in a mouse model of cerebral ischemia

(2011) Xibin Liang et al.   JOURNAL OF CLINICAL INVESTIGATION

Nonsteroidal Anti-Inflammatory Drugs in Schizophrenia

(2011) Iris E. Sommer et al.   JOURNAL OF CLINICAL PSYCHIATRY

The cyclooxygenase-2 pathway via the PGE2 EP2 receptor contributes to oligodendrocytes apoptosis in cuprizone-induced demyelination

(2011) Sara Palumbo et al.   JOURNAL OF NEUROCHEMISTRY

PGE2 EP1 receptor exacerbated neurotoxicity in a mouse model of cerebral ischemia and Alzheimer's disease

(2011) Gehua Zhen et al.   NEUROBIOLOGY OF AGING

Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity

(2010) Y Ikeda-Matsuo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy

(2009) L. Holtman et al.   EPILEPSY RESEARCH

Endothelial microsomal prostaglandin E synthase-1 exacerbates neuronal loss induced by kainate

(2009) Takako Takemiya et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Altered arachidonic acid cascade enzymes in postmortem brain from bipolar disorder patients

(2009) H-W Kim et al.   MOLECULAR PSYCHIATRY

PGF2α FP Receptor Contributes to Brain Damage Following Transient Focal Brain Ischemia

(2009) Sofiyan Saleem et al.   NEUROTOXICITY RESEARCH

Cyclooxygenase-2/PGE2 pathway facilitates pentylenetetrazol-induced seizures

(2008) Mauro Schneider Oliveira et al.   EPILEPSY RESEARCH

Celecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder: a double-blind, randomized, placebo-controlled study

(2008) Fabiano G. Nery et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Cytosolic Phospholipase A2α Is Targeted to the p47phox-PX Domain of the Assembled NADPH Oxidase via a Novel Binding Site in Its C2 Domain

(2008) Zeev Shmelzer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deregulation of sphingolipid metabolism in Alzheimer's disease

(2008) Xingxuan He et al.   NEUROBIOLOGY OF AGING

No advantage of A 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies

(2008) C. A. Szekely et al.   NEUROLOGY

Astrocytes in the Epileptic Brain

(2008) Jonathon Wetherington et al.   NEURON

Incidence and 10-Year Survival of Intracerebral Hemorrhage in a Population-Based Registry

(2008) Simona Sacco et al.   STROKE

Elevated microsomal prostaglandin-E synthase–1 in Alzheimer’s disease

(2007) Uzma A. Chaudhry et al.   Alzheimers & Dementia

15-Deoxy-Δ12,14-prostaglandin J2: An Electrophilic Trigger of Cellular Responses

(2007) Koji Uchida et al.   CHEMICAL RESEARCH IN TOXICOLOGY