Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life
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Title
Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life
Authors
Keywords
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Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 111, Issue 11, Pages 4309-4314
Publisher
Proceedings of the National Academy of Sciences
Online
2014-03-04
DOI
10.1073/pnas.1317317111
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Note: Only part of the references are listed.- Loss of TDP-43 causes age-dependent progressive motor neuron degeneration
- (2013) Yohei Iguchi et al. BRAIN
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- (2013) Ryoko Ihara et al. HUMAN MOLECULAR GENETICS
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- (2013) Yi-Ting Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The application of hybrid pixel detectors for in-house SAXS instrumentation with a view to combined chromatographic operation
- (2013) Gareth S. A. Wright et al. JOURNAL OF SYNCHROTRON RADIATION
- Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43
- (2013) Peter J Lukavsky et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Characterizing TDP-43 interaction with its RNA targets
- (2013) Amit Bhardwaj et al. NUCLEIC ACIDS RESEARCH
- ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43
- (2013) E. S. Arnold et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ligand binding and aggregation of pathogenic SOD1
- (2013) Gareth S.A. Wright et al. Nature Communications
- Reducing TDP-43 aggregation does not prevent its cytotoxicity
- (2013) Rui Liu et al. Acta Neuropathologica Communications
- The N-terminus of TDP-43 promotes its oligomerization and enhances DNA binding affinity
- (2012) Chung-ke Chang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Spliceosome integrity is defective in the motor neuron diseases ALS and SMA
- (2012) Hitomi Tsuiji et al. EMBO Molecular Medicine
- The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth
- (2012) Claudia Fallini et al. HUMAN MOLECULAR GENETICS
- Accelerated Disease Onset with Stabilized Familial Amyotrophic Lateral Sclerosis (ALS)-linked Mutant TDP-43 Proteins
- (2012) Shoji Watanabe et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Requirements for Stress Granule Recruitment of Fused in Sarcoma (FUS) and TAR DNA-binding Protein of 43 kDa (TDP-43)
- (2012) Eva Bentmann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The structural plasticity of the human copper chaperone for SOD1: insights from combined size-exclusion chromatographic and solution X-ray scattering studies
- (2011) Gareth S. A. Wright et al. BIOCHEMICAL JOURNAL
- Folding stability of amyloid-β 40 monomer is an important determinant of the nucleation kinetics in fibrillization
- (2011) Chun-Lun Ni et al. FASEB JOURNAL
- TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1
- (2011) Karli K. McDonald et al. HUMAN MOLECULAR GENETICS
- The Effect of Parkinson's-Disease-Associated Mutations on the Deubiquitinating Enzyme UCH-L1
- (2011) Fredrik I. Andersson et al. JOURNAL OF MOLECULAR BIOLOGY
- Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
- (2011) Magdalini Polymenidou et al. NATURE NEUROSCIENCE
- Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
- (2011) James R Tollervey et al. NATURE NEUROSCIENCE
- An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity
- (2011) Weirui Guo et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Decreased stability and increased formation of soluble aggregates by immature superoxide dismutase do not account for disease severity in ALS
- (2011) K. A. Vassall et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TDP-43 regulates its mRNA levels through a negative feedback loop
- (2010) Youhna M Ayala et al. EMBO JOURNAL
- Exposure of Hydrophobic Surfaces Initiates Aggregation of Diverse ALS-Causing Superoxide Dismutase-1 Mutants
- (2010) Christian Münch et al. JOURNAL OF MOLECULAR BIOLOGY
- Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments
- (2010) Yong-Jie Zhang et al. Molecular Neurodegeneration
- TAR DNA-binding protein 43 in neurodegenerative disease
- (2010) Alice S. Chen-Plotkin et al. Nature Reviews Neurology
- Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy
- (2010) Tetsuaki Arai et al. NEUROPATHOLOGY
- ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS
- (2010) S.-C. Ling et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration
- (2010) Hans Wils et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Small-angle scattering for structural biology-Expanding the frontier while avoiding the pitfalls
- (2010) David A. Jacques et al. PROTEIN SCIENCE
- Combined sampler robot and high-performance liquid chromatography: a fully automated system for biological small-angle X-ray scattering experiments at the Synchrotron SOLEIL SWING beamline
- (2009) G. David et al. JOURNAL OF APPLIED CRYSTALLOGRAPHY
- TDP-43 is recruited to stress granules in conditions of oxidative insult
- (2009) Claudia Colombrita et al. JOURNAL OF NEUROCHEMISTRY
- No evidence for cognitive dysfunction or depression in patients with mild restless legs syndrome
- (2009) Erika Driver-Dunckley et al. MOVEMENT DISORDERS
- The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation
- (2009) Stephen Tam et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structural insights into TDP-43 in nucleic-acid binding and domain interactions
- (2009) P.-H. Kuo et al. NUCLEIC ACIDS RESEARCH
- Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity
- (2009) Y.-J. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
- (2008) Masato Hasegawa et al. ANNALS OF NEUROLOGY
- TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor
- (2008) I.-Fan Wang et al. JOURNAL OF NEUROCHEMISTRY
- TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
- (2008) Edor Kabashi et al. NATURE GENETICS
- A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity
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- TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
- (2008) J. Sreedharan et al. SCIENCE
- Protein Aggregation and Protein Instability Govern Familial Amyotrophic Lateral Sclerosis Patient Survival
- (2008) Qi Wang et al. PLOS BIOLOGY
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