Article
Medicine, Research & Experimental
Yuan-Chin Tsai, Chao-Yuan Huang, Yu-Mei Hsueh, Yu-Ching Fan, Yu-Cin Fong, Shu-Pin Huang, Jiun-Hung Geng, Lih-Chyang Chen, Te-Ling Lu, Bo-Ying Bao
Summary: This study investigated the association of MAPK cascade genes with renal cell carcinoma risk and survival, revealing that a specific single nucleotide polymorphism in the MAPK10 gene is linked to lower RCC risk and metastasis. High MAPK10 expression is associated with a favorable prognosis, and MAPK10 activation can inhibit RCC cell growth.
Article
Dentistry, Oral Surgery & Medicine
Minyan Yuan, Xueqing Zheng, Jiaojiao Jing, Yang Li, Nianke Liu, Yaling Song
Summary: This study evaluated the association between SYN2, PPARG, RAF1, TIMP4, and IQSEC1 polymorphisms in 3p25 and oral squamous cell carcinoma (OSCC) in the Chinese Han population. IQSEC1-rs2686742 was found to be correlated with the onset of OSCC, and several SNPs in IQSEC1 and PPARG genes were significantly associated with clinical characteristics of OSCC. IQSEC1-rs2600322 was shown to have an important role in the survival of OSCC patients, and various SNPs influenced survival outcomes. Functional annotation revealed changes in transcript levels of IQSEC1 and PPARG genes in OSCC tissues.
Article
Cell Biology
Zhen Guo, Mei-Hua Bao, Yun-Xia Fan, Yan Zhang, Hai-Yan Liu, Xiao-Long Zhou, Ben Wu, Qing-Qing Lu, Bin-Sheng He, Xu-Ying Nan, Jiao-Yang Lu
Summary: The genetic polymorphisms of linc00312 may serve as potential biomarkers for NPC carcinogenesis and prognosis, as they can influence the expression and secondary structure of linc00312, thus affecting the sensitivity and survival of NPC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Virology
Gloria Perez-Rubio, Marco Antonio Ponce-Gallegos, Bruno Andre Dominguez-Mazzocco, Jaime Ponce-Gallegos, Roman Alejandro Garcia-Ramirez, Ramces Falfan-Valencia
Summary: Research has shown that genetic susceptibility to Influenza A virus infection is influenced by multiple pathways, including innate immune response, complement activation, and variants in inflammatory response genes. Specific gene polymorphisms such as SNPs play key roles in host immune responses, affecting viral replication and host response, representing important factors in genetic susceptibility to IAV infection.
Article
Multidisciplinary Sciences
Nicolas Millet, Norma Solis, Diane Aguilar, Michail S. Lionakis, Robert T. Wheeler, Nicholas Jendzjowsky, Marc Swidergall
Summary: This study reveals the role of the beta-glucan receptor EphA2 in modulating renal immunopathology during disseminated candidiasis through IL-23 signaling and ferroptotic cell death.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
ChunYan Yuan
Summary: IL-33 is a cytokine that modulates inflammation and immune responses, primarily associated with the development of Th2 immunological responses. It has been shown to be elevated in various autoimmune disorders, suggesting a role in inducing autoimmunity and inflammatory damage. The IL-33/ST2 axis holds promising potential as a therapeutic target for autoimmune disease treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hila Yousefi, Morteza Gholami, Marziyeh Zoughi, Nima Rezaei, Aria Chuppani, Shekoufeh Nikfar, Mahsa M. Amoli
Summary: This study aimed to investigate the genetic polymorphisms in RAS. The results showed that polymorphisms in serotonin transporter, IL-10-819, IL-10-592, IL-10-1082, IL-1 beta-511, IL-6-174, and IL-1 beta+3954 were associated with susceptibility to RAS.
Article
Medicine, General & Internal
Makedonka Atanasovska Velkovska, Katja Goricar, Tanja Blagus, Vita Dolzan, Barbara Cvenkel
Summary: The study found that GSTM1 gene deletion is associated with decreased risk of ocular hypertension, and genetic variability in IL1B and IL6 may be linked to glaucoma risk. Additionally, GPX and TNF genes may be associated with the glaucoma phenotype. This suggests potential new strategies and personalized treatment for glaucoma based on genetic factors.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Jianrong Shi, Lin He, Huiwen Zheng, Wei Li, Shuangshuang Huang, Yunling Li, Ran Tao
Summary: This study investigated the association of IL-4 and IL-18 gene polymorphisms with the susceptibility and severity of atopic dermatitis (AD) in Chinese children. The results showed that IL-4 rs2243283 G allele, CG genotype, and CG+GG genotype were significantly decreased in AD patients, while IL-18 rs7106524 A allele, AA genotype, and AG+AA genotype were significantly increased in severe AD patients.
FRONTIERS IN PEDIATRICS
(2023)
Article
Oncology
Yulong Chen, Xunjun Yang, Yao Chen, Guorong Chen, Cheryl A. Winkler, Ping An, Jianxin Lyu
Summary: This study identified for the first time an association between genetic variations in SOAT1 and the occurrence of HCC, indicating a potential role of SOAT1 in the development of HCC that requires further investigation.
Review
Biochemistry & Molecular Biology
Matteo Trimarchi, Dorina Lauritano, Gianpaolo Ronconi, Alessandro Caraffa, Carla E. Gallenga, Ilias Frydas, Spyros K. Kritas, Vittorio Calvisi, Pio Conti
Summary: The etiopathogenesis of periodontal disease involves autoimmunity, inflammation affecting periodontal tissues and bone, and dysbiosis of oral microbiota triggering immune responses. Mast cells and cytokines play crucial roles in the inflammatory process in the gingiva.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Pio Conti, Fabrizio E. Pregliasco, Rosa G. Bellomo, Carla E. Gallenga, Alessandro Caraffa, Spyros K. Kritas, Dorina Lauritano, Gianpaolo Ronconi
Summary: Psoriasis is a skin disease characterized by autoimmune features and inflammatory symptoms, often accompanied by various comorbidities. Immune cells like MCs and cytokines such as IL-36 play significant roles in the inflammation process of psoriasis, while IL-38 and IL-37 may serve as potential therapeutic tools for inhibiting inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Kenta Fujimura, Tadayoshi Karasawa, Takanori Komada, Naoya Yamada, Yoshiko Mizushina, Chintogtokh Baatarjav, Takayoshi Matsumura, Kinya Otsu, Norihiko Takeda, Hiroaki Mizukami, Kazuomi Kario, Masafumi Takahashi
Summary: Sepsis is a life-threatening syndrome, and its associated mortality is increased when cardiac dysfunction and damage (septic cardiomyopathy [SCM]) occur. The NLRP3 inflammasome plays a critical role in the pathophysiology of SCM, with the activation of IL-1 beta and IL-18 contributing to the development of SCM.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Dermatology
Burak Aksan, Aysegul Basak Akadam-Teker
Summary: The TT genotype and T allele of IL-17A rs10484879 are associated with an increased risk of psoriasis in the Turkish population. This study suggests that IL-17A polymorphism may play a role in the pathogenesis of the disease. The IL-17A serum levels were also found to be associated with the genotype distribution.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Article
Immunology
Jean-Claude Lecron, Sandrine Charreau, Jean-Francois Jegou, Nadjet Salhi, Isabelle Petit-Paris, Emmanuel Guignouard, Christophe Burucoa, Laure Favot-Laforge, Charles Bodet, Anne Barra, Vincent Huguier, Jiad Mcheik, Laure Dumoutier, Julien Garnier, Francois-Xavier Bernard, Bernhard Ryffel, Franck Morel
Summary: This study found that the proinflammatory cytokines IL-22 and IL-17 induced by bacterial infection delay the healing process of skin wounds, regardless of the presence of bacteria. This discovery reveals the underlying mechanisms of bacterial infection on wound healing.
FRONTIERS IN IMMUNOLOGY
(2022)