The changes in mycolic acid structures caused byhadCmutation have a dramatic effect on the virulence ofMycobacterium tuberculosis

Mycolic Acids: Structures, Biosynthesis, and Beyond

(2014) Hedia Marrakchi et al.   CHEMISTRY & BIOLOGY

New Approaches to Target the Mycolic Acid Biosynthesis Pathway for the Development of Tuberculosis Therapeutics

(2014) E. North et al.   CURRENT PHARMACEUTICAL DESIGN

Mycobacterium tuberculosis evolutionary pathogenesis and its putative impact on drug development

(2014) Fabien Le Chevalier et al.   Future Microbiology

A glimpse into the past and predictions for the future: the molecular evolution of the tuberculosis agent

(2014) Eva C. Boritsch et al.   MOLECULAR MICROBIOLOGY

Conformational folding of mycobacterial methoxy- and ketomycolic acids facilitated by  -methyl trans-cyclopropane groups rather than cis-cyclopropane units

(2013) M. Villeneuve et al.   MICROBIOLOGY-SGM

Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis

(2013) Philip Supply et al.   NATURE GENETICS

Keto-Mycolic Acid-Dependent Pellicle Formation Confers Tolerance to Drug-Sensitive Mycobacterium tuberculosis

(2013) D. Sambandan et al.   mBio

Point Mutations within the Fatty Acid Synthase Type II Dehydratase Components HadA or HadC Contribute to Isoxyl Resistance in Mycobacterium tuberculosis

(2012) Laila Gannoun-Zaki et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Common Mechanism of Inhibition of theMycobacterium tuberculosisMycolic Acid Biosynthetic Pathway by Isoxyl and Thiacetazone

(2012) Anna E. Grzegorzewicz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural elucidation and genomic scrutiny of the C60-C100 mycolic acids of Segniliparus rotundus

(2012) M.-A. Laneelle et al.   MICROBIOLOGY-SGM

Mutations in the essential FAS II β-hydroxyacyl ACP dehydratase complex confer resistance to thiacetazone inMycobacterium tuberculosisandMycobacterium kansasii

(2012) Juan M. Belardinelli et al.   MOLECULAR MICROBIOLOGY

Towards understanding the functional diversity of cell wall mycolic acids of Mycobacterium tuberculosis

(2012) Jan A. Verschoor et al.   PROGRESS IN LIPID RESEARCH

ESAT-6 Secretion-Independent Impact of ESX-1 Genes espF and espG1 on Virulence of Mycobacterium tuberculosis

(2011) Daria Bottai et al.   JOURNAL OF INFECTIOUS DISEASES

A novel mycolic acid species defines two novel genera of the Actinobacteria, Hoyosella and Amycolicicoccus

(2011) M.-A. Laneelle et al.   MICROBIOLOGY-SGM

The Mycobacterium Tuberculosis FAS-II Dehydratases and Methyltransferases Define the Specificity of the Mycolic Acid Elongation Complexes

(2011) Sylvain Cantaloube et al.   PLoS One

Molecular structure of the Mycobacterium tuberculosis virulence factor, mycolic acid, determines the elicited inflammatory pattern

(2010) Seppe Vander Beken et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TubercuList – 10 years after

(2010) Jocelyne M. Lew et al.   TUBERCULOSIS

S-Adenosyl-N-decyl-aminoethyl, a Potent Bisubstrate Inhibitor ofMycobacterium tuberculosisMycolic Acid Methyltransferases

(2009) Julien Vaubourgeix et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutation in the Transcriptional Regulator PhoP Contributes to Avirulence of Mycobacterium tuberculosis H37Ra Strain

(2008) Jong Seok Lee et al.   Cell Host & Microbe

Growth ofMycobacterium tuberculosisbiofilms containing free mycolic acids and harbouring drug-tolerant bacteria

(2008) Anil K. Ojha et al.   MOLECULAR MICROBIOLOGY

Genetic Basis of Virulence Attenuation Revealed by Comparative Genomic Analysis of Mycobacterium tuberculosis Strain H37Ra versus H37Rv

(2008) Huajun Zheng et al.   PLoS One

Control of M. tuberculosis ESAT-6 Secretion and Specific T Cell Recognition by PhoP

(2008) Wafa Frigui et al.   PLoS Pathogens

Mycolic Acid Modification by the mmaA4 Gene of M. tuberculosis Modulates IL-12 Production

(2008) Dee N. Dao et al.   PLoS Pathogens