Emerging roles of system antiporter and its inhibition in CNS disorders

Neurological effects of inorganic arsenic exposure: altered cysteine/glutamate transport, NMDA expression and spatial memory impairment

(2015) Lucio A. Ramos-Chávez et al.   Frontiers in Cellular Neuroscience

Reactive oxygen species-mediated therapeutic response and resistance in glioblastoma

(2015) E Singer et al.   Cell Death & Disease

IGF-I Regulates Redox Status in Breast Cancer Cells by Activating the Amino Acid Transport Molecule xC−

(2014) Yuzhe Yang et al.   CANCER RESEARCH

Phosphoinositide 3-Kinases Upregulate System xc− via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in Glioblastomas and Epilepsy

(2013) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Microwave accelerated synthesis of isoxazole hydrazide inhibitors of the system xc- transporter: Initial homology model

(2013) Afnan A. Matti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Novel Transcription Mechanism Activated by Ethanol

(2013) Xinghua Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel di-aryl-substituted isoxazoles act as noncompetitive inhibitors of the system xc- cystine/glutamate exchanger

(2013) J.L. Newell et al.   NEUROCHEMISTRY INTERNATIONAL

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Non-Cell Autonomous Influence of the Astrocyte System xc− on Hypoglycaemic Neuronal Cell Death

(2012) Nicole A Jackman et al.   ASN Neuro

Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP

(2012) Hiroyuki Kusuhara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glutamate hypothesis of depression and its consequences for antidepressant treatments

(2012) Laura Musazzi et al.   Expert Review of Neurotherapeutics

Sulfasalazine prevents the increase in TGF-β, COX-2, nuclear NFκB translocation and fibrosis in CCl4-induced liver cirrhosis in the rat

(2012) E Chávez et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

SLC7 amino acid transporters of the yellow fever mosquito Aedes aegypti and their role in fat body TOR signaling and reproduction

(2012) Victoria K. Carpenter et al.   JOURNAL OF INSECT PHYSIOLOGY

Glutamate-based depression GBD

(2012) Dennis J. McCarthy et al.   MEDICAL HYPOTHESES

Increased xCT Expression Correlates With Tumor Invasion and Outcome in Patients With Glioblastomas

(2012) Satoru Takeuchi et al.   NEUROSURGERY

The Effect of N-Acetylcysteine in the Nucleus Accumbens on Neurotransmission and Relapse to Cocaine

(2011) Yonatan M. Kupchik et al.   BIOLOGICAL PSYCHIATRY

Inhibition of transporter-mediated cystine uptake by sulfasalazine analogs

(2011) Krupa Shukla et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

System xc- cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS

(2011) Richard J Bridges et al.   BRITISH JOURNAL OF PHARMACOLOGY

Comments on “Hyponatremia-induced change in mood mimicking late-onset bipolar disorder”

(2011) Branimir Margetić et al.   GENERAL HOSPITAL PSYCHIATRY

Regulation of the System x−C cystine/glutamate exchanger by intracellular glutathione levels in rat astrocyte primary cultures

(2011) Todd Michael Seib et al.   GLIA

Insulin-like Growth Factor 1 and Transforming Growth Factor-β Stimulate Cystine/Glutamate Exchange Activity in Dental Pulp Cells

(2011) Katherine Pauly et al.   JOURNAL OF ENDODONTICS

Increased expression of cystine/glutamate antiporter in multiple sclerosis

(2011) Olatz Pampliega et al.   Journal of Neuroinflammation

Loss of System xFormula Does Not Induce Oxidative Stress But Decreases Extracellular Glutamate in Hippocampus and Influences Spatial Working Memory and Limbic Seizure Susceptibility

(2011) D. De Bundel et al.   JOURNAL OF NEUROSCIENCE

Chronic N-Acetylcysteine during Abstinence or Extinction after Cocaine Self-Administration Produces Enduring Reductions in Drug Seeking

(2011) C. M. Reichel et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Molecular Diffusion Model of Neurotransmitter Homeostasis Around Synapses Supporting Gradients

(2011) Ashwin Mohan et al.   NEURAL COMPUTATION

Functional upregulation of system xc− by fibroblast growth factor-2

(2011) XiaoQian Liu et al.   NEUROPHARMACOLOGY

Towards a glutamate hypothesis of depression

(2011) Gerard Sanacora et al.   NEUROPHARMACOLOGY

Hypoxic preconditioning involves system Xc− regulation in mouse neural stem cells

(2011) Brian Sims et al.   Stem Cell Research

N-acetylcysteine prevents loss of dopaminergic neurons in theEAAC1−/−mouse

(2010) Ari E. Berman et al.   ANNALS OF NEUROLOGY

Dopaminergic neurons of system xc−-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity

(2010) Ann Massie et al.   FASEB JOURNAL

Glial solute carrier transporters in drosophila and mice

(2010) David E. Featherstone   GLIA

Glutamate and the biology of gliomas

(2010) John de Groot et al.   GLIA

Hypoxia Increases the Dependence of Glioma Cells on Glutathione

(2010) Toyin Adeyemi Ogunrinu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drug-Induced Plasticity Contributing to Heightened Relapse Susceptibility: Neurochemical Changes and Augmented Reinstatement in High-Intake Rats

(2010) A. Madayag et al.   JOURNAL OF NEUROSCIENCE

Repeated N-Acetyl Cysteine Reduces Cocaine Seeking in Rodents and Craving in Cocaine-Dependent Humans

(2010) Shelley L Amen et al.   NEUROPSYCHOPHARMACOLOGY

Expression and Functions of Fibroblast Growth Factor 2 (FGF-2) in Hippocampal Formation

(2010) Sabrina Zechel et al.   NEUROSCIENTIST

Oral N-Acetyl-Cysteine Attenuates Loss of Dopaminergic Terminals in α-Synuclein Overexpressing Mice

(2010) Joanne Clark et al.   PLoS One

Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse

(2010) K. Moussawi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The environment and susceptibility to schizophrenia

(2010) Alan S. Brown   PROGRESS IN NEUROBIOLOGY

The Bermuda Triangle of cocaine-induced neuroadaptations

(2010) Marina E. Wolf   TRENDS IN NEUROSCIENCES

Alterations of Cortical GABA Neurons and Network Oscillations in Schizophrenia

(2010) Guillermo Gonzalez-Burgos et al.   Current Psychiatry Reports

Neuroprotective effects of zonisamide target astrocyte

(2009) Masato Asanuma et al.   ANNALS OF NEUROLOGY

Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of Sulfasalazine for the treatment of progressing malignant gliomas in adults

(2009) Pierre A Robe et al.   BMC CANCER

Antioxidative enzymes and increased oxidative stress in depressive women

(2009) Jana Kodydková et al.   CLINICAL BIOCHEMISTRY

Glutathione—a review on its role and significance in Parkinson’s disease

(2009) Heather L. Martin et al.   FASEB JOURNAL

Antioxidant-induced modification of INrf2 cysteine 151 and PKC-δ-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance

(2009) Suryakant K. Niture et al.   JOURNAL OF CELL SCIENCE

Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxonein vitro

(2009) Jan Lewerenz et al.   JOURNAL OF NEUROCHEMISTRY

The glutamate homeostasis hypothesis of addiction

(2009) Peter W. Kalivas   NATURE REVIEWS NEUROSCIENCE

Decreased glutathione levels and antioxidant enzyme activities in untreated and treated schizophrenic patients

(2009) Monia Raffa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Beneficial effects ofN-acetylcysteine in treatment resistant schizophrenia

(2009) Mahmut Bulut et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

N-Acetyl Cysteine as a Glutathione Precursor for Schizophrenia—A Double-Blind, Randomized, Placebo-Controlled Trial

(2008) Michael Berk et al.   BIOLOGICAL PSYCHIATRY

The Role of Cystine-Glutamate Exchange in Nicotine Dependence in Rats and Humans

(2008) Lori A. Knackstedt et al.   BIOLOGICAL PSYCHIATRY

Receptor Actions of Synaptically Released Glutamate: The Role of Transporters on the Scale from Nanometers to Microns

(2008) Kaiyu Zheng et al.   BIOPHYSICAL JOURNAL

Molecular regulation of antioxidant ability in the hippocampus of EL mice

(2008) Mayuko Takaki et al.   BRAIN RESEARCH

Glutamate: The New Frontier in Pharmacotherapy for Cocaine Addiction

(2008) Joachim Uys et al.   CNS & Neurological Disorders-Drug Targets

CNS Disorders—Current Treatment Options and the Prospects for Advanced Therapies

(2008) James C. DiNunzio et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Basal Levels of eIF2α Phosphorylation Determine Cellular Antioxidant Status by Regulating ATF4 and xCT Expression

(2008) Jan Lewerenz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The xc− cystine/glutamate antiporter: A potential target for therapy of cancer and other diseases

(2008) Maisie Lo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Small interfering RNA–mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema

(2008) Nicolai E Savaskan et al.   NATURE MEDICINE

Time-dependent changes in striatal xCT protein expression in hemi-Parkinson rats

(2008) Ann Massie et al.   NEUROREPORT

Blunted cystine–glutamate antiporter function in the nucleus accumbens promotes cocaine-induced drug seeking

(2008) K.S. Kau et al.   NEUROSCIENCE

GABA Neurons and the Mechanisms of Network Oscillations: Implications for Understanding Cortical Dysfunction in Schizophrenia

(2008) G. Gonzalez-Burgos et al.   SCHIZOPHRENIA BULLETIN

N-Acetyl-l-cysteine protects SHSY5Y neuroblastoma cells from oxidative stress and cell cytotoxicity: effects on β-amyloid secretion and tau phosphorylation

(2003) G. Olivieri et al.   JOURNAL OF NEUROCHEMISTRY