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Cell Biology
Violette Azzoni, Julien Wicinski, Manon Macario, Martin Castagne, Pascal Finetti, Katerina Ambrosova, Celia D. Rouault, Arnaud Serge, Anne Farina, Emilie Agavnian, Sergiu Coslet, Emmanuelle Josselin, Arnaud Guille, Jose Adelaide, Emmanouil Zacharioudakis, Remy Castellano, Francois Bertucci, Daniel Birnbaum, Raphael Rodriguez, Emmanuelle Charafe-Jauffret, Christophe Ginestier
Summary: This study reveals the mechanism of breast cancer stem cells' response to replication stress and highlights the role of BMI1 protein in this process. Understanding this response is crucial for improving therapeutic resistance.
CELL DEATH & DISEASE
(2022)
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Oncology
Yan Chen, Ji-Lin Yang, Zhen-Zhen Xue, Qiu-Chen Cai, Chun Hou, Hong-Juan Li, Liu-Xin Zhao, Yin Zhang, Cheng-Wei Gao, Li Cong, Tian-Zuo Wang, Dong-Mei Chen, Guo-Sheng Li, Shi-Qing Luo, Qian Yao, Chan-Juan Yang, Qi-Shun Zhu, Chuan-Hai Cao
Summary: The study found that miR-218 expression was significantly lower in XWLC-05 cells compared to BEAS-2B cells. Overexpression of miR-218 reduced cell proliferation, invasion, viability, and migration in XWLC-05 and NCI-H157 cell lines. This indicates that miR-218 may play a crucial role in the tumorigenesis and progression of Xuanwei lung cancer, offering a potential novel approach for treatment.
MOLECULAR MEDICINE REPORTS
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Cell Biology
Jingwei Zhang, Zeyu Wang, Hao Zhang, Ziyu Dai, Xisong Liang, Shuwang Li, Xun Zhang, Fangkun Liu, Zhixiong Liu, Kui Yang, Quan Cheng
Summary: This study investigates the role of RING finger proteins in low-grade glioma (LGG) and identifies three key markers related to immune infiltration, which may serve as novel therapeutic targets for immunotherapy in the future.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
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Behavioral Sciences
James S. Brown Jr
Summary: The risk of cancer in schizophrenia has been debated, with confounders such as smoking and antipsychotic medications. In this study, the author compared schizophrenia with cancer and found that both tumor-suppressive and tumor-promoting characteristics exist in schizophrenia. Additionally, schizophrenia shares more oncogenic similarity with asbestos-related lung cancer and mesothelioma.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
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Medicine, Research & Experimental
Zhou Xu, Xingruo Zeng, Mingchang Li, Jianming Liao, Qianxue Chen
Summary: The study demonstrated that downregulation of PRDX3 by miR-383 induced cell apoptosis and mitochondrial ROS production in U87 cells, thereby promoting oxidative stress-induced autophagy.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
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Biochemistry & Molecular Biology
Jingyi Zhao, Yongqiang Yang, Yuanyuan Pan, Pengcheng Zhou, Juan Wang, Yingjuan Zheng, Xiangxian Zhang, Suna Zhai, Xiqian Zhang, Liming Li, Daoke Yang
Summary: This study investigates the role of the transcription factor glioma-associated oncogene family zinc finger 1 (GLI1) in the sonic hedgehog signaling pathway in adamantinomatous craniopharyngioma (ACP). The study reveals that GLI1 regulates the expression of IL-6, triggering inflammatory responses and influencing tumor progression in ACP.
ACS CHEMICAL NEUROSCIENCE
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Multidisciplinary Sciences
Yan Wang, Jingwei Peng, Chenchen Song, Yining Yang, Tao Qin
Summary: This study characterized the expression and function of ZSCAN18 in human glioblastoma cell lines. ZSCAN18 was significantly down-regulated in glioblastoma cell lines compared to normal astrocytes. Overexpression of ZSCAN18 suppressed glioblastoma cell proliferation, sphere formation, and the expression of SOX2 and OCT4.
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Biochemistry & Molecular Biology
Veronica Freire-Beneitez, Nicola Pomella, Thomas O. Millner, Anaelle A. Dumas, Maria Victoria Niklison-Chirou, Eleni Maniati, Jun Wang, Vinothini Rajeeve, Pedro Cutillas, Silvia Marino
Summary: Glioblastoma (GBM) is a common and aggressive brain tumor in adults, with dysregulated epigenetic mechanisms. BMI1, a component of PRC1, is upregulated in GBM and has been shown to play a tumorigenic role. Research has identified new regulatory functions of PRC1 in mRNA splicing and cholesterol transport in GBM, potentially offering novel targetable mechanisms for treatment.
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Oncology
Yanyao Deng, Liuyang Cheng, Zhicheng Lv, Hongwei Zhu, Xiangrui Meng
Summary: The study found that SNHG7 expression was upregulated in glioma tissues and cell lines, while miR-138-5p expression was downregulated, and the knockdown of SNHG7 expression decreased glioma cell proliferation. Mechanistic studies revealed that SNHG7 downregulated miR-138-5p expression, affecting the expression levels of its target gene EZH2.
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Medicine, Research & Experimental
Jing-Bo Wu, Xiao-Jing Li, Hui Liu, Yong-Juan Liu, Xiu-Ping Liu
Summary: This study investigated the relationship between KRAS, NRAS, BRAF and PIK3CA gene mutations and the clinicopathological features and prognosis of colorectal cancer (CRC). The results showed that KRAS is the most commonly mutated gene and may be a poor prognostic factor for CRC patients. Furthermore, BRAF mutations may be associated with the expression of RNF215 in CRC patients.
BIOMEDICAL REPORTS
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Oncology
Bo Li, Wenxing Zhao, Lina Xu, Jingfu Sun, Bo Chen, Guanying Yu, Lan Ye, Maosong Gong, Wei Cong, Yuzhong Qi
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
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Oncology
Guanying Yu, Lan Ye, Wei Tan, Xuguo Zhu, Yaonan Li, Duyin Jiang
MOLECULAR MEDICINE REPORTS
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Oncology
Guanying Yu, Yaonan Li, Lan Ye, Xinglei Wang, Jixun Zhang, Zhengxue Dong, Duyin Jiang
MOLECULAR MEDICINE REPORTS
(2017)
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Oncology
Chang Ge, Mengxia Wu, Guifang Chen, Guanying Yu, Dehui Ji, Shaozhao Wang
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Oncology
Lan Ye, Cuihong Wang, Guanying Yu, Yuhua Jiang, Dianshui Sun, Zaiyun Zhang, Xiaoming Yu, Xiaomei Li, Wei Wei, Ping Liu, Jian Cheng, Bin Du, Likuan Hu
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Neurosciences
Lan Ye, Shanthi Srinivasan
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Gastroenterology & Hepatology
Simon Musyoka Mwangi, Ge Li, Lan Ye, Yunshan Liu, Francois Reichardt, Samantha M. Yeligar, C. Michael Hart, Mark J. Czaja, Shanthi Srinivasan
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Medicine, Research & Experimental
Lan Ye, Ge Li, Anna Goebel, Abhinav Raju, Feng Kong, Yanfei Lv, Kailin Li, Yuanjun Zhu, Shreya Raja, Peijian He, Fang Li, Simon Musyoka Mwangi, Wenhui Hu, Shanthi Srinivasan
JOURNAL OF CLINICAL INVESTIGATION
(2020)
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Oncology
Cuihong Wang, Guanying Yu, Ying Xu, Chengfei Liu, Qian Sun, Wenqing Li, Junhua Sun, Yuhua Jiang, Lan Ye
Summary: The study found that HCP5 levels were significantly higher in glioma cells compared to human astrocytes, while miR-128 levels were lower in glioma cells. Inhibiting HCP5 suppressed cell proliferation and increased radiosensitivity in glioma cells. Furthermore, the impact of HCP5 knockdown on the radiosensitivity of glioma cells was attenuated by a miR-128 inhibitor.
CANCER MANAGEMENT AND RESEARCH
(2021)
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Genetics & Heredity
Lin Yuan, Zhenyu Yang, Jing Zhao, Tao Sun, Chunyu Hu, Zhen Shen, Guanying Yu
Summary: This paper focuses on studying the differential mechanism of gene expression of UBE2C in various tumors and its correlation with prognosis, clinical features, immunity, methylation, and other characteristics, based on public databases.
FRONTIERS IN GENETICS
(2022)