Article
Pharmacology & Pharmacy
S-J Xiao, Y-F Zhou, H. Jia, Q. Wu, D-F Pan
Summary: The study evaluated predictive noninvasive biomarkers for Staphylococcus aureus-induced infective endocarditis through bioinformatics analysis, identifying several pivotal genes and pathways with potential for early detection.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Faisal A. Alzahrani, Mohd Faheem Khan, Varish Ahmad
Summary: In this study, differentially expressed genes associated with COVID-19 in glioblastoma (GBM) were identified using gene expression data and bioinformatics methods. Potential therapeutic drugs were also predicted. The study found that these genes are involved in pathways related to viral infection, immune system, and neuronal system, providing important clues for understanding the common mechanisms of GBM and COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
S-J Xiao, Y-F Zhou, Q. Wu, W-R Ma, M-L Chen, D-F Pan
Summary: This study identified important genes and miRNAs involved in the progression from stable coronary artery disease (SCAD) to acute myocardial infarction (AMI), with inflammation and the immune response playing crucial roles in this process.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Genetics & Heredity
Basdeo Kushwaha, Neha Srivastava, Murali S. Kumar, Ravindra Kumar
Summary: This study aimed to understand the interaction of the brain-gonad system in Clarias magur reproduction by analyzing differentially expressed genes (DEG). Thirteen key genes in female brain & ovary and twelve key genes in male brain & testis were identified based on network analysis. Functional annotation revealed their involvement in important reproduction-related pathways. This study provides insights into the interaction between the brain and gonads in the regulation of Clarias magur reproduction through a protein-protein interaction network.
Article
Biochemistry & Molecular Biology
Harish K. Datta, Marianne K. Kringen, Stephen P. Tuck, Georgia Salpingidou, Ole K. Olstad, Kaare M. Gautvik, Simon J. Cockell, Vigdis T. Gautvik, Michael Prediger, Jun Jie Wu, Mark A. Birch, Sjur Reppe
Summary: Mechanical loading plays a significant role in bone density and architecture. The study demonstrates that the transcriptional factor ZIC1 is strongly associated with genes characteristically associated with bone cells. The findings also suggest a link between mechanical stress and epigenetic control of gene expression, with implications for bone pathophysiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maria Vincenza Chiantore, Marco Iuliano, Roberta Maria Mongiovi, Fabiola Luzi, Giorgio Mangino, Lorenzo Grimaldi, Luisa Accardi, Gianna Fiorucci, Giovanna Romeo, Paola Di Bonito
Summary: Actinic keratosis (AK) is a precursor to cutaneous squamous cell carcinoma (cSCC) and is highly prevalent in the elderly population, particularly among those with sun-exposed skin. This study identified 43 dysregulated microRNAs (miRNAs) in AK samples and validated the expression of several key miRNAs. Pathway analysis revealed that these miRNAs targeted pathways involved in tumorigenesis, highlighting the importance of miRNA regulation in keratinocyte cancer.
Article
Medicine, General & Internal
Defeng Pan, Yufei Zhou, Shengjue Xiao, Yue Hu, Chunyan Huan, Qi Wu, Xiaotong Wang, Qinyuan Pan, Jie Liu, Hong Zhu
Summary: This study aimed to explore the molecular mechanisms of atrial fibrillation (AF) and identified several key genes and pathways involved in AF pathogenesis. The results indicated that macrophage migration inhibitory factor (MIF), MYC proto-oncogene, bHLH transcription factor (MYC), and inhibitor of differentiation 1 (ID1) may participate in the progression of AF through the TGF-beta and Hippo signaling pathways.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Medicine, General & Internal
Fuxing Tang, Xiaohong Jiang, Shijie Liao, Yun Liu, Maolin He
Summary: This study investigates the potential regulatory mechanism of transcription factor (TF)-miRNA-mRNA in osteosarcoma using bioinformatics methods and validates the findings through qRT-PCR. The study identifies differentially expressed miRNAs and genes and constructs a TF-miRNA-mRNA regulatory network. Two genes, LAMC1 and THBS1, in the network are found to have prognostic value. Survival analysis and experimental validation establish a TF-miRNA-mRNA sub-network, providing insights into the pathological mechanisms of osteosarcoma for diagnosis and treatment.
Article
Medicine, General & Internal
Hailong Zhou, Jianmin Jiang, Xiaohua Chen, Zhiwei Zhang
Summary: This study investigated the genes, miRNAs, pathways, and miRNA-gene interaction pairs involved in female osteoporosis. The results revealed the important roles of miRNAs and genes in the pathogenesis of osteoporosis, and identified several pathways related to the disease.
Article
Endocrinology & Metabolism
Qianqian Dong, Ziqi Han, Limin Tian
Summary: The study identified DE mRNAs, DE miRNAs, and DE circRNAs associated with postmenopausal osteoporosis (PMOP) and found that these genes were mainly related to inflammatory responses. Through gene enrichment analysis, the potential roles and related signaling pathways of these genes in the development of osteoporosis were determined.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nilubon Kurubanjerdjit, Ka-Lok Ng
Summary: This study investigates the role of the oncogenic FoxM1 pathway in controlling the cell cycle process in lung cancer. The findings suggest that a combination of various phytochemicals is effective in the treatment of lung cancer. A web-based system displaying the results of this study has been established for researchers to query.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Health Care Sciences & Services
Xiufen Tian, Juan Zheng, Yuanyuan Luo, Chengshi Wei, Jing Ma, Dawei Wang, Keyi Li
Summary: This study integrated methylation and gene expression datasets to identify differentially expressed genes related to chronic periodontitis. The findings revealed 122 hypomethylated and highly expressed genes enriched in biological mechanisms associated with extracellular matrix organization, extracellular structure organization, and cell chemotaxis. IL1B, KDR, and MMP9 were identified as hub genes in the protein-protein interaction network. Additionally, 122 hypermethylated and lowly expressed genes were identified, and processes such as cornification, epidermis development, skin development, and keratinocyte differentiation were enriched. CDSN, DSG1, and KRT2 were identified as the top 3 hub genes in the PPI network.
TECHNOLOGY AND HEALTH CARE
(2023)
Article
Biochemical Research Methods
Enfa Zhao, Hang Xie, Yushun Zhang
Summary: Idiopathic pulmonary arterial hypertension (IPAH) is a fatal cardiovascular disease with significant morbidity and mortality. In this study, differentially expressed genes (DEGs) were identified in individuals with IPAH and normal controls, revealing potential key genes and pathways involved in the pathogenesis of IPAH. Hub genes such as TLR7, JUN, and CXCR4 showed high diagnostic value in discriminating IPAH from normal individuals, suggesting they may serve as novel biomarkers for IPAH diagnosis.
JOURNAL OF COMPUTATIONAL BIOLOGY
(2021)
Article
Genetics & Heredity
Weitao Hu, Taiyong Fang, Xiaoqing Chen
Summary: This study identified DEGs associated with ulcerative colitis (UC) using bioinformatics analysis, providing potential diagnostic and therapeutic targets. The DEGs, hub genes and miRNAs identified may serve as biomarkers for UC, but further research is needed to understand their biological roles in the disease.
FRONTIERS IN GENETICS
(2022)
Article
Plant Sciences
Fazal Munsif, Xiangjun Kong, Aziz Khan, Tariq Shah, Muhammad Arif, Muhammad Jahangir, Kashif Akhtar, Danfeng Tang, Jie Zheng, Xiaofang Liao, Shah Faisal, Izhar Ali, Anas Iqbal, Parvaiz Ahmad, Ruiyang Zhou
Summary: The study found that the cytoplasmic male sterile kenaf genotype showed higher salt stress tolerance compared to the maintainer genotype, and this tolerance may be associated with photosynthesis, photosynthesis antenna-protein, and plant hormone signal transduction pathways.
PHYSIOLOGIA PLANTARUM
(2021)