Article
Endocrinology & Metabolism
Aiping Xu, Xiuli Xia, Ting Xu, Ruxia Liu
Summary: This study investigated the effects of TIGAR on lung ischemia/reperfusion injury (LIRI) and its mechanism of action. The results showed that overexpression of TIGAR exerts protective roles in LIRI rats through activation of the PI3K/Akt signaling pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Immunology
Lichen Chen, Jixiang Yuan, Hang Li, Yi Ding, Xuejia Yang, Ziwei Yuan, Zujian Hu, Yuanyuan Gao, Xilong Wang, Hong Lu, Yong Cai, Yongheng Bai, Xiaodong Pan
Summary: Trans-cinnamaldehyde (TCA) extracted from cinnamon bark has anti-inflammatory properties and can attenuate renal ischemia-reperfusion injury (IRI) through inhibiting the JNK/p38 MAPK signaling pathway, thus reducing kidney pathological changes and dysfunction.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Anatomy & Morphology
Bokang Zhang, Wan Yang, Lanren Chen
Summary: This study found that Secreted phosphoprotein 1 (SPP1) expression is upregulated in renal ischemia-reperfusion injury (IRI) and can promote cell apoptosis, exacerbating kidney damage. Further experiments revealed that downregulation of SPP1 activates the PI3K/AKT signaling pathway, inhibiting cell apoptosis.
Article
Environmental Sciences
Hanan Saleh, Mohamed Salama, Rehab Mohamed Hussein
Summary: This study investigated the protective effect of polyethylene glycol capped gold nanoparticles (PEG-AuNPs) on renal ischemia-reperfusion injury (I/R)-induced acute kidney injury (AKI) in diabetic mice by activating the AMPK-Nrf2 pathway. Results showed that PEG-AuNPs reduced blood urea nitrogen (BUN) and creatinine levels in diabetic mice and decreased renal damage and inflammation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Immunology
Leiying Zhang, Qingxia Wei, Xiaomin Liu, Ting Zhang, Shuying Wang, Lingling Zhou, Liyang Zou, Fengyan Fan, Hongxu Chi, Jiayi Sun, Deqing Wang
Summary: Exosomal miR-98-5p derived from hypoxia-induced BMSCs protects against myocardial ischemia-reperfusion injury by promoting cardiac function, suppressing inflammation response and oxidative stress, and targeting TLR4 to activate the PI3K/Akt signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Lei Mi, Nan Zhang, Jiyun Wan, Ming Cheng, Jianping Liao, Xiao Zheng
Summary: The study demonstrated that remote ischemic post-conditioning (RIPOC) can attenuate the histopathological features of intestinal mucosa in intestinal I/R injury mouse models through the ERK pathway. RIPOC also showed significant antioxidant and anti-inflammatory effects mediated via the ERK pathway, while suppressing the NF-kappa B (p65)/NLRP3 inflammatory pathways in the intestinal I/R injury mouse models.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Immunology
Kongwei Guo, Yanxing Shang, Zhao Wang, Yu Li, Jinliang Chen, Baofeng Zhu, Dongmei Zhang, Jianrong Chen
Summary: BRG1 plays a key role in apoptosis and oxidative damage, but its role in the pathophysiology of ischemic stroke is unclear. We found that BRG1 expression was increased during cerebral ischemia and reperfusion, particularly in activated microglia. Modulating BRG1 expression levels significantly affected microglial activation and the expression of antioxidant and pro-oxidant proteins after ischemic stroke. Our findings suggest that BRG1 protects against brain ischemia/reperfusion injury by reducing oxidative damage through the KEAP1-NRF2/HO-1 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Meijuan Yin, Zhenyi Liu, Jing Wang, Weijuan Gao
Summary: The aim of this study was to investigate the molecular mechanism of Buyang Huanwu Decoction (BYHWD) in attenuating cerebral ischemia-reperfusion (I/R) oxidative damage by activating the PKC epsilon/Nrf2/HO-1 pathway. The results showed that BYHWD improved neural function, reduced neuronal damage, inhibited ROS production, decreased MDA and 8-OHdG levels, increased SOD and GSH-PX activity, and restored mitochondrial membrane potential. BYHWD activated the expression of Nrf2 and PKC epsilon, promoted Nrf2 translocation, and enhanced HO-1 expression. Therefore, BYHWD attenuates oxidative damage and reduces brain I/R injury by activating the PKC epsilon/Nrf2/HO-1 pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Oncology
Xiao Liu, Meng Jiang, Chenggang Pang, Jianning Wang, Lijuan Hu
Summary: In this study, sodium selenite (SSE) was found to inhibit proliferation and migration and induce apoptosis in renal cancer cells. The underlying mechanism involves the regulation of reactive oxygen species (ROS) levels and inhibition of NF-kappa B signaling. The inhibitory effect of SSE on tumor growth was also confirmed in animal models.
Article
Medicine, Research & Experimental
Yuhong Qin, Yani Shi, Qi Yu, Shenglan Yang, Ying Wang, Xiaojia Dai, Guoxing Li, Zhe Cheng
Summary: The aim of this study was to investigate the protective effect of vitamin B12 against myocardial ischemia/reperfusion (I/R) injury and its underlying mechanism. The results showed that high doses of vitamin B12 could inhibit myocardial I/R injury by reducing oxidative stress, apoptosis, and inflammation through the modulation of the SIRT3/AMPK signaling pathway. These findings suggest that high-dose vitamin B12 supplementation might be a potential therapy for myocardial I/R damage.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Medicinal
Yi Zhang, Mengmeng Liu, Yaoyuan Zhang, Mi Tian, Peng Chen, Yu Lan, Benhong Zhou
Summary: This study demonstrated that UA can alleviate oxidative stress and promote autophagy by activating the p62-Keap1-Nrf2 signaling pathway, which could protect the kidneys from ischemia reperfusion injury.
PHYTOTHERAPY RESEARCH
(2022)
Review
Immunology
Yuchen Yang, Li Wang, Ivonne Peugnet-Gonzalez, Daniela Parada-Venegas, Gerard Dijkstra, Klaas Nico Faber
Summary: The intestinal mucosa serves as a barrier and is involved in nutrient absorption. Genetic susceptibility and environmental factors play a critical role in the development of intestinal diseases. The innate immune system recognizes potential threats through pattern recognition receptors (PRRs), including the cGAS-STING pathway. However, the role of the cGAS-STING pathway in intestinal diseases is still debated.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Yi Zhong, Bo Yin, Yingze Ye, Omar Y. A. T. Dekhel, Xiaoxing Xiong, Zhihong Jian, Lijuan Gu
Summary: The JAK2/STAT3 signaling pathway plays a crucial role in ischemic stroke by regulating inflammatory response, apoptosis, oxidative stress, and angiogenesis.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Medicine, Research & Experimental
Zhe Tang, Yong Wang, Yan Liu, Chenglong Li
Summary: This study demonstrates the protective effects of Salidroside against renal ischemia/reperfusion injury (RIRI), including mitigation of oxidative damage, reduction of reactive oxygen species accumulation, and inhibition of ferroptosis. The protective mechanism is mediated through the activation of the PI3K/AKT signaling pathway.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Chemistry, Medicinal
Tao Yang, Haiqiong Liu, Chaobo Yang, Huaqiang Mo, Xianbao Wang, Xudong Song, Luping Jiang, Ping Deng, Ran Chen, Pengcui Wu, Aihua Chen, Jing Yan
Summary: This study aimed to investigate the pharmacological effects of Gal on myocardial ischemic reperfusion injury (MIRI). The results showed that Gal alleviates myocardial injury, enhances cardiac function, and reduces cell death by targeting the Nrf2/Gpx4 signaling pathway to prevent iron overload and lipid peroxidation.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Oncology
Li-Na Chen, Qiang Sun, Shu-Qing Liu, Hao Hu, Juan Lv, Wen-Jun Ji, Meng Wang, Ming-Xia Chen, Jun Zhou
MOLECULAR MEDICINE REPORTS
(2015)
Article
Multidisciplinary Sciences
Juan Lu, Wenjun Ji, Mei Zhao, Meng Wang, Wenhui Yan, Mingxia Chen, Shuting Ren, Bingxiang Yuan, Bing Wang, Lina Chen
SCIENTIFIC REPORTS
(2016)