Subtyping Non–Small Cell Lung Cancer

Crizotinib and Testing for ALK

(2017) Alice T. Shaw et al.   Journal of the National Comprehensive Cancer Network

ΔNp63 (p40) Distribution Inside Lung Cancer

(2013) Giuseppe Pelosi et al.   INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY

Simultaneous Multi-Antibody Staining in Non-Small Cell Lung Cancer Strengthens Diagnostic Accuracy Especially in Small Tissue Samples

(2013) Gian Kayser et al.   PLoS One

Tissue-Sparing Application of the Newly Proposed IASLC/ATS/ERS Classification of Adenocarcinoma of the Lung Shows Practical Diagnostic and Prognostic Impact

(2012) William Sterlacci et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Comparison of Monoclonal Napsin A, Polyclonal Napsin A, and TTF-1 for Determining Lung Origin in Metastatic Adenocarcinomas

(2012) Sanjay Mukhopadhyay et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Napsin A, a New Marker for Lung Adenocarcinoma, Is Complementary and More Sensitive and Specific Than Thyroid Transcription Factor 1 in the Differential Diagnosis of Primary Pulmonary Carcinoma: Evaluation of 1674 Cases by Tissue Microarray

(2012) Bradley M. Turner et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Evaluation of Napsin A, Cytokeratin 5/6, p63, and Thyroid Transcription Factor 1 in Adenocarcinoma Versus Squamous Cell Carcinoma of the Lung

(2012) Kenneth Whithaus et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Validation of Interobserver Agreement in Lung Cancer Assessment: Hematoxylin-Eosin Diagnostic Reproducibility for Non–Small Cell Lung Cancer: The 2004 World Health Organization Classification and Therapeutically Relevant Subsets

(2012) Juneko E. Grilley-Olson et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Diagnosis of Lung Cancer in Small Biopsies and Cytology: Implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification

(2012) William D. Travis et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Clarifying the Spectrum of Driver Oncogene Mutations in Biomarker-Verified Squamous Carcinoma of Lung: Lack of EGFR/KRAS and Presence of PIK3CA/AKT1 Mutations

(2012) N. Rekhtman et al.   CLINICAL CANCER RESEARCH

Large-scale comparative analyses of immunomarkers for diagnostic subtyping of non-small-cell lung cancer biopsies

(2012) Arne Warth et al.   HISTOPATHOLOGY

Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial

(2012) Rafael Rosell et al.   LANCET ONCOLOGY

Impact of non-small cell lung cancer histology on survival predicted from the graded prognostic assessment for patients with brain metastases

(2012) Susan Guo et al.   LUNG CANCER

Influence of histology and biomarkers on first-line treatment of advanced non-small cell lung cancer in routine care setting: Baseline results of an observational study (FRAME)

(2012) Philipp A. Schnabel et al.   LUNG CANCER

Cyto-histologic agreement in pathologic subtyping of non small cell lung carcinoma: Review of 602 fine needle aspirates with follow-up surgical specimens over a nine year period and analysis of factors underlying failure to subtype

(2012) Gilda da Cunha Santos et al.   LUNG CANCER

Reproducibility of histopathological subtypes and invasion in pulmonary adenocarcinoma. An international interobserver study

(2012) Erik Thunnissen et al.   MODERN PATHOLOGY

Thyroid Transcription Factor-1 Is Not Expressed in Squamous Cell Carcinomas of the Lung

(2012) Nelson G. Ordóñez   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Expression of Squamous Cell Carcinoma Markers and Adenocarcinoma Markers in Primary Pulmonary Neuroendocrine Carcinomas

(2012) Kyohei Masai et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Usefulness of Immunohistochemical and Histochemical Studies in the Classification of Lung Adenocarcinoma and Squamous Cell Carcinoma in Cytologic Specimens

(2011) Rebecca Ocque et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Heterogeneity of Large Cell Carcinoma of the Lung

(2011) Mattia Barbareschi et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

miR-205 Expression Levels in Nonsmall Cell Lung CancerDo Not Always Distinguish Adenocarcinomas From Squamous Cell Carcinomas

(2011) Valerio Del Vescovo et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

A Word of Caution Regarding Napsin A Expression in Squamous Cell Carcinomas of the Lung

(2011) Nelson G. Ordóñez   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Immunohistochemical subtyping of nonsmall cell lung cancer not otherwise specified in fine-needle aspiration cytology

(2011) Luisella Righi et al.   CANCER

Swedish Lung Cancer Radiation Study Group: Predictive value of histology for radiotherapy response in patients with non-small cell lung cancer

(2011) Georg Holgersson et al.   EUROPEAN JOURNAL OF CANCER

Biomarker Analyses and Final Overall Survival Results From a Phase III, Randomized, Open-Label, First-Line Study of Gefitinib Versus Carboplatin/Paclitaxel in Clinically Selected Patients With Advanced Non–Small-Cell Lung Cancer in Asia (IPASS)

(2011) Masahiro Fukuoka et al.   JOURNAL OF CLINICAL ONCOLOGY

Utility of 10 Immunohistochemical Markers Including Novel Markers (Desmocollin-3, Glypican 3, S100A2, S100A7, and Sox-2) for Differential Diagnosis of Squamous Cell Carcinoma from Adenocarcinoma of the Lung

(2011) Koji Tsuta et al.   Journal of Thoracic Oncology

Immunhistochemistry by Means of Widely Agreed-Upon Markers (Cytokeratins 5/6 and 7, p63, Thyroid Transcription Factor-1, and Vimentin) on Small Biopsies of Non-small Cell Lung Cancer Effectively Parallels the Corresponding Profiling and Eventual Diagnoses on Surgical Specimens

(2011) Giuseppe Pelosi et al.   Journal of Thoracic Oncology

Subtyping of Non-small Cell Lung Carcinoma: A Comparison of Small Biopsy and Cytology Specimens

(2011) Carlie S. Sigel et al.   Journal of Thoracic Oncology

Suitability of Thoracic Cytology for New Therapeutic Paradigms in Non-small Cell Lung Carcinoma: High Accuracy of Tumor Subtyping and Feasibility of EGFR and KRAS Molecular Testing

(2011) Natasha Rekhtman et al.   Journal of Thoracic Oncology

Accuracy of Fine Needle Aspiration Cytology in the Pathological Typing of Non-small Cell Lung Cancer

(2011) Rita Nizzoli et al.   Journal of Thoracic Oncology

International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma

(2011) William D. Travis et al.   Journal of Thoracic Oncology

ΔNp63 (p40) and Thyroid Transcription Factor-1 Immunoreactivity on Small Biopsies or Cellblocks for Typing Non-small Cell Lung Cancer: A Novel Two-Hit, Sparing-Material Approach

(2011) Giuseppe Pelosi et al.   Journal of Thoracic Oncology

Optimal combination of immunohistochemical markers for subclassification of non-small cell lung carcinomas: A tissue microarray study of poorly differentiated areas

(2011) Songmi Noh et al.   LUNG CANCER

The challenge of NSCLC diagnosis and predictive analysis on small samples. Practical approach of a working group

(2011) Erik Thunnissen et al.   LUNG CANCER

Immunohistochemical algorithm for differentiation of lung adenocarcinoma and squamous cell carcinoma based on large series of whole-tissue sections with validation in small specimens

(2011) Natasha Rekhtman et al.   MODERN PATHOLOGY

p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma

(2011) Justin A Bishop et al.   MODERN PATHOLOGY

Pathological Diagnosis and Classification of Lung Cancer in Small Biopsies and Cytology: Strategic Management of Tissue for Molecular Testing

(2011) William Travis et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Combination of Napsin A and TTF-1 Immunohistochemistry Helps in Differentiating Primary Lung Adenocarcinoma From Metastatic Carcinoma in the Lung

(2011) Jiqing Ye et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Thyroid Transcription Factor-1 Expression in Breast Carcinomas

(2010) Judith Robens et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Optimal Immunohistochemical Markers For Distinguishing Lung Adenocarcinomas From Squamous Cell Carcinomas in Small Tumor Samples

(2010) Jefferson Terry et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Subclassification of Non-small Cell Lung Carcinomas Lacking Morphologic Differentiation on Biopsy Specimens

(2010) Sanjay Mukhopadhyay et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Should we continue to use the term non-small-cell lung cancer?

(2010) A. F. Gazdar   ANNALS OF ONCOLOGY

Accurate Classification of Non-Small Cell Lung Carcinoma Using a Novel MicroRNA-Based Approach

(2010) J. A. Bishop et al.   CLINICAL CANCER RESEARCH

The Classification of Lung Carcinoma: Time to Change the Morphology-Based Approach?

(2010) Giuseppe Pelosi et al.   INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY

Pathologic Diagnosis of Advanced Lung Cancer Based on Small Biopsies and Cytology: A Paradigm Shift

(2010) William D. Travis et al.   Journal of Thoracic Oncology

Subtyping of Undifferentiated Non-small Cell Carcinomas in Bronchial Biopsy Specimens

(2010) Peh Sun Loo et al.   Journal of Thoracic Oncology

Refining the Diagnosis and EGFR Status of Non-small Cell Lung Carcinoma in Biopsy and Cytologic Material, Using a Panel of Mucin Staining, TTF-1, Cytokeratin 5/6, and P63, and EGFR Mutation Analysis

(2010) Andrew G. Nicholson et al.   Journal of Thoracic Oncology

A Systematic Review of the Interobserver Variability for Histology in the Differentiation between Squamous and Nonsquamous Non-small Cell Lung Cancer

(2010) Daniel C. Paech et al.   Journal of Thoracic Oncology

Treatment-by-Histology Interaction Analyses in Three Phase III Trials Show Superiority of Pemetrexed in Nonsquamous Non-small Cell Lung Cancer

(2010) Giorgio Scagliotti et al.   Journal of Thoracic Oncology

Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer

(2010) Eunice L. Kwak et al.   NEW ENGLAND JOURNAL OF MEDICINE

Histology Matters: Individualizing Treatment in Non-Small Cell Lung Cancer

(2010) J. W. Neal   ONCOLOGIST

The Use of P63 Immunohistochemistry for the Identification of Squamous Cell Carcinoma of the Lung

(2010) Esther Conde et al.   PLoS One

Comparison of Thyroid Transcription Factor-1 Expression by 2 Monoclonal Antibodies in Pulmonary and Nonpulmonary Primary Tumors

(2010) Andres Matoso et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Differential Thymidylate Synthase Expression in Different Variants of Large-Cell Carcinoma of the Lung

(2009) V. Monica et al.   CLINICAL CANCER RESEARCH

Value of P63 and CK5/6 in distinguishing squamous cell carcinoma from adenocarcinoma in lung fine-needle aspiration specimens

(2009) Said Khayyata et al.   DIAGNOSTIC CYTOPATHOLOGY

Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma

(2009) Justin A. Bishop et al.   HUMAN PATHOLOGY

Review Article: A Reevaluation of the Clinical Significance of Histological Subtyping of Non—Small-Cell Lung Carcinoma: Diagnostic Algorithms in the Era of Personalized Treatments

(2009) Giulio Rossi et al.   INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY

Morphology and a Limited Number of Immunohistochemical Markers May Efficiently Subtype Non–Small-Cell Lung Cancer

(2009) Giulio Rossi et al.   JOURNAL OF CLINICAL ONCOLOGY

Diagnostic Assay Based on hsa-miR-205 Expression Distinguishes Squamous From Nonsquamous Non–Small-Cell Lung Carcinoma

(2009) Danit Lebanony et al.   JOURNAL OF CLINICAL ONCOLOGY

Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study

(2009) Tudor Ciuleanu et al.   LANCET

Desmocollin-3: a new marker of squamous differentiation in undifferentiated large-cell carcinoma of the lung

(2009) Valentina Monica et al.   MODERN PATHOLOGY

Gefitinib or Carboplatin–Paclitaxel in Pulmonary Adenocarcinoma

(2009) Tony S. Mok et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Differential Efficacy of Pemetrexed According to NSCLC Histology: A Review of Two Phase III Studies

(2009) G. Scagliotti et al.   ONCOLOGIST

Sox2 Expression in Pulmonary Non-small Cell and Neuroendocrine Carcinomas

(2009) Lynette M. Sholl et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

If it's not CK5/6 positive, TTF-1 negative it's not a squamous cell carcinoma of lung

(2008) PAUL DOWNEY et al.   APMIS

Phase III Study Comparing Cisplatin Plus Gemcitabine With Cisplatin Plus Pemetrexed in Chemotherapy-Naive Patients With Advanced-Stage Non–Small-Cell Lung Cancer

(2008) Giorgio Vittorio Scagliotti et al.   JOURNAL OF CLINICAL ONCOLOGY