Review
Medicine, General & Internal
Ashley Wysong
Summary: Squamous-cell carcinoma is a common type of cancer in humans, with most cases being localized and treatable, but a small percentage of cases that recur or spread can be fatal. Immunocompromised patients are at particularly high risk.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Xianfeng Li, Yan Wang, Qingjie Min, Weimin Zhang, Huajing Teng, Chao Li, Kun Zhang, Leisheng Shi, Bin Wang, Qimin Zhan
Summary: In this study, a comprehensive comparison of the transcriptomes of esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) was conducted, revealing shared and distinct transcriptomic signatures between these two cancer subtypes and uncovering possible common and unique mechanisms involved in tumorigenesis.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Medicine, Research & Experimental
Shan Wang, Mao Yang, Ruiying Li, Jie Bai
Summary: Oral squamous cell carcinoma (OSCC), a common type of cancer, is primarily diagnosed through tissue biopsy. However, there is a growing focus on more rapid, economical, and noninvasive screening methods due to the tumor heterogeneity and drawbacks of biopsy procedures. Liquid biopsy, optical detection systems, oral brush cytology, microfluidic detection, and artificial intelligence auxiliary diagnosis are examples of such methods, each with its own advantages and limitations. Extensive research is being conducted on liquid biopsy biomarkers such as novel microbiome components, noncoding RNAs, extracellular vesicles, and circulating tumor DNA, which have shown promising clinical outcomes in early OSCC detection. This review summarizes OSCC screening methods and provides new guiding strategies for diagnosis.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Surgery
Ahmad Sukari Halim, Nandinii Ramasenderan
Summary: Cutaneous squamous cell carcinoma (CSCC) is a common skin malignancy associated with high mutational load and difficulties in treatment. The article reviews the relevance of locoregional involvement in patient survival and recurrence risk, discusses the challenges and importance of sentinel lymph node biopsy (SLNB), and presents the latest developments in CSCC treatment.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Oncology
Brenna E. Swift, Melissa Tigert, Andra Nica, Al Covens, Danielle Vicus, Carlos Parra-Herran, Rachel Kupets, Raymond Osborne, Lilian T. Gien
Summary: This study assessed the accuracy of intraoperative pathologic examination in vulva cancer patients and evaluated patient outcomes. The results showed that intraoperative assessment of sentinel lymph nodes can accurately determine the need for lymphadenectomy and does not compromise patient outcomes.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Immunology
Na Li, Jiahong Wang, Xianquan Zhan
Summary: This study identified two reliable immune-related gene signature models that were significantly associated with prognosis and tumor microenvironment cell infiltration in LUAD and LUSC, respectively. Evaluation of these models could help predict response to immunotherapy and guide immunotherapy strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Jinyou Li, Gang Wu, Ju Yang, Jiai Yan, Dan Li, Qinyue Wang, Yanping Xia, Jie Zhu, Baoliang Guo, Fengyue Cheng, Jing Sun, Hong Cao, Feng Zhang
Summary: The composition of pulmonary microbiota in tissues adjacent to lung lesions showed significant differences between different lesion types. Ralstonia, Acinetobacter, and Microbacterium are the dominant genera in lung adenocarcinoma, lung squamous carcinoma, and benign lesions, respectively. The abundance ratio of Ralstonia to Acinetobacter in adenocarcinoma patients has diagnostic value. PICRUSt analysis revealed remarkable differences in metabolic pathways among different lesion types.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Rieko Nishimura, Mikinao Oiwa
Summary: Currently, core needle biopsy is replacing fine needle aspiration biopsy (FNAB) for pathological diagnosis of breast lesions. However, FNAB is extensively used for diagnosing breast lesions, including screened lesions, at our hospital. Furthermore, direct smears as well as cell blocks (CBs) from the FNAB specimens have been used.
ANALYTICAL CELLULAR PATHOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
S. Y. Yang, S. H. Li, J. L. Liu, X. Q. Sun, Y. Y. Cen, R. Y. Ren, S. C. Ying, Y. Chen, Z. H. Zhao, W. Liao
Summary: This study developed a deep learning model to assist pathologists in diagnosing oral squamous cell carcinoma (OSCC), demonstrating improved diagnostic accuracy and speed in both junior and senior pathologists.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Oncology
Zhenru Liu, Shudai Huang, Fang Li, Xiaoqing Wang, Mengxi Liu, Hoi Shiwn Wong, Jiayi Jiang, Yuan Zhou, Daguang Wang
Summary: The study investigated the use of dermoscopy in defining tumor margins for the appropriate surgical margin in cutaneous squamous cell carcinoma (cSCC). Results showed that dermoscopy was better in defining the tumor margins compared to visual inspection alone. Direct dermoscopic-guided surgery with at least 8-mm expansion was recommended for high-risk cSCC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Deepali Jain, Aruna Nambirajan, Gang Chen, Kim Geisinger, Kenzo Hiroshima, Lester Layfield, Yuko Minami, Andre L. Moreira, Noriko Motoi, Mauro Papotti, Natasha Rekhtman, Prudence A. Russell, Spasenija Savic Prince, Fernando Schmitt, Yasushi Yatabe, Serenella Eppenberger-Castori, Lukas Bubendorf
Summary: This study aims to identify specific algorithms based on known cytomorphologic features that aid accurate and successful subtyping of non-small cell lung cancer (NSCLC) on cytology. The study found that recognizing lung squamous cell carcinoma (LUSC) in the absence of keratinization remains a major challenge in cytology subtyping, with a risk of misclassification.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Oncology
Michael J. Poellmann, Jiyoon Bu, DaWon Kim, Mari Iida, Heejoo Hong, Deric L. Wheeler, Randall J. Kimple, Andrew Z. Wang, Seungpyo Hong
Summary: Head and neck squamous cell carcinoma (HNSCC) is a common and deadly cancer. Circulating tumor cell (CTC) abundance may serve as a valuable prognostic biomarker in low- and intermediate-risk patients, but detecting CTCs in these populations has been challenging.
Article
Biochemistry & Molecular Biology
Jingshi Liu, Yongdong Niu, Bin Zhang, Qisi Sun, Haiyi Li, Lu Bai, Zhongjing Su
Summary: The expression levels of GPER1 are found to be associated with tumor type and survival rates in esophageal carcinoma. In overall esophageal carcinoma, low expression of GPER1 is correlated with poor survival rates, while overexpression of GPER1 is associated with the development of esophageal adenocarcinoma and its pre-cancerous lesion. Furthermore, the protein expression of GPER1 is higher in esophageal adenocarcinoma tissues compared to normal esophageal tissues, whereas it is lower in esophageal squamous cell carcinoma tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Spectroscopy
Yafeng Qi, Lin Yang, Bangxu Liu, Li Liu, Yuhong Liu, Qingfeng Zheng, Dameng Liu, Jianbin Luo
Summary: In this study, Raman spectroscopy and deep learning were utilized for accurate and stain-free intraoperative diagnosis. By treating Raman spectral signals as sequences and converting them into two-dimensional Raman spectrograms using short-time Fourier transform as input, high performance deep learning models were achieved, surpassing traditional methods in accuracy and sensitivity.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Review
Pharmacology & Pharmacy
Xu Zhang, Yuxiang Wang, Linghua Meng
Summary: Esophageal cancer is a highly lethal disease with rapid progression and poor prognosis. The two major subtypes, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), have distinct risk factors and molecular characteristics. Although surgical and chemoradiotherapy approaches have been applied, molecularly targeted therapy for esophageal cancer is still in its early stages. Advances in large-scale next-generation sequencing have revealed genomic alterations in ESCC and EAC, providing insights into their roles in the development and progression of esophageal cancer. Potential therapeutic targets have been identified, and novel strategies are under development to combat this disease.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Pathology
Olca Basturk, Zhaohai Yang, Laura H. Tang, Ralph H. Hruban, Volkan Adsay, Chad M. McCall, Alyssa M. Krasinskas, Kee-Taek Jang, Wendy L. Frankel, Serdar Balci, Carlie Sigel, David S. Klimstra
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2015)
Article
Gastroenterology & Hepatology
Rashmi T. Samdani, Jaclyn F. Hechtman, Eileen O'Reilly, Ronald DeMatteo, Carlie S. Sigel
Article
Immunology
Keith Sigel, Rajwanth Veluswamy, Katherine Krauskopf, Anita Mehrotra, Grace Mhango, Carlie Sigel, Juan Wisnivesky
Article
Pathology
Gokce Askan, Vikram Deshpande, David S. Klimstra, Volkan Adsay, Carlie Sigel, Jinru Shia, Olca Basturk
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2016)
Article
Oncology
Carlie Sigel, Marcela S. Cavalcanti, Tanisha Daniel, Efsevia Vakiani, Jinru Shia, Keith Sigel
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2016)
Article
Oncology
K. Sigel, K. Crothers, R. Dubrow, K. Krauskopf, J. Jao, C. Sigel, A. Moskowitz, J. Wisnivesky
BRITISH JOURNAL OF CANCER
(2013)
Article
Oncology
Carlie S. Sigel, Dorota E. Rudomina, Camelia S. Sima, Natasha Rekhtman, William D. Travis, Kim R. Geisinger, Andre L. Moreira
CANCER CYTOPATHOLOGY
(2012)
Article
Oncology
Carlie S. Sigel, David S. Klimstra
CANCER CYTOPATHOLOGY
(2013)
Article
Oncology
Carlie S. Sigel, Marcia Edelweiss, Leung Chu Tong, Joanna Magda, Handy Oen, Keith M. Sigel, Maureen F. Zakowski
CANCER CYTOPATHOLOGY
(2015)
Article
Medical Laboratory Technology
Carlie S. Sigel, Kay J. Park, Samson W. Fine, Oscar Lin
DIAGNOSTIC CYTOPATHOLOGY
(2012)
Article
Oncology
Natasha Rekhtman, Suzanne M. Brandt, Carlie S. Sigel, Maria A. Friedlander, Gregory J. Riely, William D. Travis, Maureen F. Zakowski, Andre L. Moreira
JOURNAL OF THORACIC ONCOLOGY
(2011)
Article
Oncology
Carlie S. Sigel, Huimin Guo, Keith M. Sigel, Ming Zhang, Natasha Rekhtman, Oscar Lin, David S. Klimstra, Achim A. Jungbluth, Laura K. Tang
CANCER CYTOPATHOLOGY
(2017)
Article
Pathology
Olca Basturk, Volkan Adsay, Gokce Askan, Deepti Dhall, Giuseppe Zamboni, Michio Shimizu, Karina Cymes, Fatima Carneiro, Serdar Balci, Carlie Sigel, Michelle D. Reid, Irene Esposito, Helena Baldaia, Peter Allen, Gunter Kloppel, David S. Klimstra
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2017)
Meeting Abstract
Oncology
Maria Friedlander, Suzanne Brandt, Carlie Sigel, David Finley, Nabil Rizk, Andre Moreira, Maureen Zakowski, Natasha Rekhtman
CANCER CYTOPATHOLOGY
(2010)