Article
Immunology
Charles Ezeamuzie, Muddanna S. Rao, Ahmed Z. El-Hashim, Elizabeth Philip, Oludotun A. Phillips
Summary: This study reports a new dual inhibitor, PH-251, which can simultaneously inhibit 5-lipoxygenase and mast cell degranulation, with demonstrated in vivo activity in animal models. This compound may offer potential advantages for the treatment of asthma and other allergic and inflammatory diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anna Sobiepanek, Lukasz Kuryk, Mariangela Garofalo, Sandeep Kumar, Joanna Baran, Paulina Musolf, Frank Siebenhaar, Joachim Wilhelm Fluhr, Tomasz Kobiela, Roberto Plasenzotti, Karl Kuchler, Monika Staniszewska
Summary: Mast cells play important roles in immune responses, including defense against antigens, modulation of inflammation, and immune responses to microorganisms. Controlling mast cell activation or stabilization is crucial for tissue homeostasis and pathogen clearance. Additionally, mast cells contribute to maintaining the balance between host and resident microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Elizabeth Proano-Perez, Laia Olle, Yanru Guo, Cristina Aparicio, Mario Guerrero, Rosa Munoz-Cano, Margarita Martin
Summary: Activating mutations in KIT (CD117) are associated with various diseases, and recent research found that the SH3BP2 pathway regulates MITF through miR-1246 and miR-5100, suggesting that MITF may be a potential therapeutic target for gastrointestinal stromal tumors and mastocytosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kuan-Ming Chiu, Yen-Ling Hung, Su-Jane Wang, Yi-Ju Tsai, Nan-Lin Wu, Cher-Wei Liang, Der-Chen Chang, Chi-Feng Hung
Summary: Neferine has anti-allergic and anti-inflammatory effects on mast cells by inhibiting degranulation and cytokine expression, decreasing intracellular calcium levels, and reducing the phosphorylation of the MAPK/NF-kappa B pathway. In vivo studies demonstrate that neferine improves dermatitis appearance, mast cell infiltration, and restores barrier protein expression. Neferine also reduces scratching behavior induced by compound 48/80, suggesting its potential as a natural product for skin allergy and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Xiaohui Yang, Dohyeon Lee, Hyun-Woo Kim, Byung-Hyun Park, Changjin Lim, Eun Ju Bae
Summary: The study investigates the effects of cannabidiol (CBD) on mast cell degranulation and passive cutaneous anaphylaxis in mice. CBD suppresses antigen-stimulated mast cell degranulation by inhibiting downstream signaling molecules and calcium mobilization. In addition, CBD inhibits the development of mast cells and suppresses passive cutaneous anaphylaxis in mice.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Chemistry, Medicinal
Rui Liu, Yonghui Zhang, Yuejin Wang, Yihan Huang, Jiapan Gao, Xi Tian, Tianyou Ma, Tao Zhang
Summary: Herb-derived dictamnine has pharmacological effects on IgE-induced MC activation and OVA-induced murine AR model, reducing local allergic reactions and systemic anaphylaxis. Dictamnine inhibits MC activation via the LYN kinase-mediated molecular signaling pathway, making it a promising treatment for AR.
PHYTOTHERAPY RESEARCH
(2023)
Article
Microbiology
Shu-Ting Song, Meng-Li Wu, Hai-Jiao Zhang, Xiao Su, Jian-Hua Wang
Summary: Mast cells play a critical role in immune surveillance of pathogens, but their role and mechanisms in viral infection remain unclear.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Cell Biology
Bo-Gie Yang, A-Ram Kim, Dajeong Lee, Seong Beom An, Yaein Amy Shim, Myoung Ho Jang
Summary: Mast cells are important effectors of inflammation and their degranulation is induced by various cell surface receptors. These receptors have different expression patterns, contributing to varied involvement in inflammatory responses. This review focuses on mast cell receptors involved in allergic inflammation, their role in degranulation induction, tissue-specific expression, and potential new drugs for allergy-related diseases.
Review
Biochemistry & Molecular Biology
Dorina Lauritano, Filiberto Mastrangelo, Cristian D'Ovidio, Gianpaolo Ronconi, Alessandro Caraffa, Carla E. Gallenga, Ilias Frydas, Spyros K. Kritas, Matteo Trimarchi, Francesco Carinci, Pio Conti
Summary: Mast cells (MCs) are tissue cells derived from bone marrow stem cells and play a role in various diseases and disorders. They communicate with microglia in the brain through the production of mediators and can have pathological effects. MCs release preformed chemical mediators and cytokines, and can interact with neuropeptides, leading to inflammation in the central nervous system. This article explores the activation of MCs by neuropeptides and the therapeutic potential of anti-inflammatory cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Kazuki Nagata, Chiharu Nishiyama
Summary: Mast cells play critical roles in immune responses as initiators and suppressors, with IL-10 serving as a key anti-inflammatory cytokine in regulating their functions. IL-10 exerts diverse effects on mast cells in vivo and in vitro, influencing tissue homeostasis and immune-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Multidisciplinary
Meitong Liu, Jing Lu, Yuelin Chen, Xiaolei Shi, YaZhuo Li, Shuting Yang, Jing Yu, Shuang Guan
Summary: The study revealed that sodium sulfite triggers pyroptosis, an inflammatory form of programmed cell death, in mast cells, leading to cell membrane rupture and degranulation. Reactive oxygen species and NLRP3 play crucial roles in this process.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yuka Nagasaka, Yuki Nakamura, Nguyen Quoc Vuong Tran, Yoshiaki Kobayashi, Nobuhiro Nakano, Atsuhito Nakao
Summary: This study found that Bmal1 plays a regulatory role in the expression of anti-oxidative genes in mast cells, and deficiency of Bmal1 enhances IgE-dependent mast cell degranulation associated with promotion of ROS generation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Immunology
Yuji Huang, Zhehui Zhu, Weize Li, Yiqin Ge, Yanning Li, Juan Wang, Xia Peng, Lihui Lin, Jia Li, Chen-Ying Liu, Li Li
Summary: In this study, it was found that mast cell proliferation decreased after activation for 3-4 hours, indicating differential regulation of mast cell degranulation and cell proliferation. ELK4, a downstream effector of MAPK signaling, was identified to be involved in cell proliferation. ELK4 expression was downregulated in activated mast cells, and its knockout suppressed cell proliferation and affected the cell cycle. The study also revealed that ELK4 modulated the transcription of cell cycle genes, cytokines, chemokines, and degranulation-related genes, highlighting its role in mast cell proliferation and activation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Lulu Zhang, Hongfang Jin, Yunjia Song, Selena Ying Chen, Yi Wang, Yan Sun, Chaoshu Tang, Junbao Du, Yaqian Huang
Summary: The study revealed the presence of an endogenous SO2/AAT pathway in MCs, where SO2 serves as an MC stabilizer by upregulating the cAMP pathway under hypoxic conditions.
JOURNAL OF ADVANCED RESEARCH
(2021)
Review
Cell Biology
Joanna Baran, Anna Sobiepanek, Anna Mazurkiewicz-Pisarek, Marta Rogalska, Aleksander Gryciuk, Lukasz Kuryk, Soman N. Abraham, Monika Staniszewska
Summary: Mast cells are immune cells found in various tissues and their overactivity can lead to health hazards. They can cause allergic reactions and play a role in tumor biology. However, the mechanisms of mast cell actions are still poorly understood, making it challenging to develop therapies for their pathological condition.
Article
Pharmacology & Pharmacy
Brandi Johnson-Weaver, Hae Woong Choi, Soman N. Abraham, Herman F. Staats
CURRENT OPINION IN PHARMACOLOGY
(2018)
Article
Multidisciplinary Sciences
Mohammad Arifuzzaman, Yuvon R. Mobley, Hae Woong Choi, Pradeep Bist, Cristina A. Salinas, Zachary D. Brown, Swaine L. Chen, Herman F. Staats, Soman N. Abraham
Article
Biochemical Research Methods
Hae Woong Choi, Cliburn Chan, Ivo D. Shterev, Heather E. Lynch, Taylor J. Robinette, Brandi T. Johnson-Weaver, Jianling Shi, Gregory D. Sempowski, So Young Kim, John K. Dickson, David M. Gooden, Soman N. Abraham, Herman F. Staats
Article
Cell Biology
Andrea Mencarelli, Merry Gunawan, Kylie Su Mei Yong, Pradeep Bist, Wilson Wei Sheng Tan, Sue Yee Tan, Min Liu, Edwin Kunxiang Huang, Yong Fan, Jerry Kok Yen Chan, Hae Woong Choi, Soman N. Abraham, Qingfeng Chen
JOURNAL OF LEUKOCYTE BIOLOGY
(2020)
Article
Immunology
Ashley L. St John, Hae Woong Choi, Q. David Walker, Bruce Blough, Cynthia M. Kuhn, Soman N. Abraham, Herman F. Staats
Article
Immunology
Jianxuan Wu, Byron W. Hayes, Cassandra Phoenix, Gustavo Sosa Macias, Yuxuan Miao, Hae Woong Choi, Francis M. Hughes, J. Todd Purves, R. Lee Reinhardt, Soman N. Abraham
Article
Multidisciplinary Sciences
Jorn Karhausen, Hae Woong Choi, Krishna Rao Maddipati, Joseph P. Mathew, Qing Ma, Yacine Boulaftali, Robert Hugh Lee, Wolfgang Bergmeier, Soman N. Abraham
Article
Immunology
Brandi T. Johnson-Weaver, Hae Woong Choi, Hang Yang, Josh A. Granek, Cliburn Chan, Soman N. Abraham, Herman F. Staats
Summary: Through high-throughput screening, three novel small molecule mast cell activators were identified, which showed efficacy comparable to traditional mast cell activators and provided similar levels of protective immune responses in nasal vaccines.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bohm Lee, Yeonsoo Oh, Eunhye Cho, Aaron DiAntonio, Valeria Cavalli, Jung Eun Shin, Hae Woong Choi, Yongcheol Cho
Summary: This study identified FKBPL and FKBP8 as novel interacting proteins that regulate the stability of DLK through the ubiquitin-proteasome and lysosomal protein degradation pathways.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Medicine, General & Internal
Sang Wook Lee, Si Hyun Kim, Kwang Woo Lee, Woong Bin Kim, Hae Woong Choi, Ji Eun Moon, Ahrim Moon, Young Ho Kim
Summary: The study found that the expression of BD-2 in the urine of patients with Hunner type IC was 18 times higher than in patients with non-Hunner type IC. The increased secretion of BD-2 in urine of Hunner type IC patients was strongly correlated with increased mast cell counts associated with bladder IC pathology, showing potential as a biomarker.
Review
Biochemistry & Molecular Biology
Hae Woong Choi, Manisha Naskar, Ho Kyung Seo, Hye Won Lee
Summary: Urothelial bladder cancer (UBC) is a common and aggressive malignancy, with the tumor microenvironment (TME) and mast cells (MCs) playing potential key roles in tumor progression and treatment. Early-stage UBC patients may have infiltration of MCs, which could impact prognosis based on tumor type and location. Immunotherapeutic methods are common in treating UBC, and understanding MC involvement may be crucial in unlocking the full potential of immunotherapy.
Article
Biotechnology & Applied Microbiology
Eun Young Jeon, Da-som Choi, Seunghyun Choi, Ju-young Won, Yunju Jo, Hye-bin Kim, Youngmee Jung, Sang Chul Shin, Hophil Min, Hae Woong Choi, Myeong Sup Lee, Yoon Park, Justin J. Chung, Hyung-seung Jin
Summary: This study developed a complex coacervate to deliver IL-2 in a sustained manner and enhance the activity of immune cells within tumors. The use of this coacervate allowed for localized delivery of IL-2 and protection against the acidic tumor microenvironment.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Medicine, General & Internal
Veronika Friedrich, Hae Woong Choi
Summary: Dysbiosis of the urinary microbiome can contribute to the development of bladder cancer by creating a chronically inflammatory urothelial microenvironment. Modulating the urinary microbiome can alter the host immune system and cytokine responses, potentially providing a therapeutic approach for bladder cancer.
Article
Urology & Nephrology
Hae Woong Choi, Kwang Woo Lee, Young Ho Kim
Summary: This review describes the association between the human urinary microbiome and urinary diseases, as well as its interconnection with microbiota of other organs. The microbiota of the gastrointestinal, vaginal, kidney, and bladder play a role in the development and progression of urinary diseases through dynamic bidirectional communication along the bladder-centered axis. Disturbances in the microbial communities can lead to the emergence of urinary diseases.
INVESTIGATIVE AND CLINICAL UROLOGY
(2023)
Article
Medicine, Research & Experimental
Mohammad Arifuzzaman, W. X. Gladys Ang, Hae Woong Choi, Matthew L. Nilles, Ashley L. St John, Soman N. Abrahamn