Article
Radiology, Nuclear Medicine & Medical Imaging
Fourat Ridouani, Mohamed M. Soliman, Ryan W. England, Meier Hsu, Chaya S. Moskowitz, Raphael Doustaly, Constantinos T. Sofocleous, F. Edward Boas, Hooman Yarmohammadi, Amy R. Deipolyi
Summary: This study aimed to investigate the relationship between tumoral and nontumoral radiation doses and response/toxicity in breast cancer patients with liver metastasis undergoing TARE. The results indicated that higher tumoral radiation doses were associated with objective response and longer survival, while pre-existing liver dysfunction was linked to increased hepatotoxicity and reduced survival.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Oncology
Runmin Cao, Honghe Jiang, Guangpeng Liang, Weibin Zhang
Summary: This study developed and validated a nomogram and risk stratification system to evaluate overall survival in non-cirrhotic hepatocellular carcinoma patients. Independent prognostic indicators included AFP levels, surgical intervention, T-stage, tumor size, and M-stage. The nomogram showed better prognostic accuracy compared to the AJCC staging system.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Pathology
Linh Pham, Konstantina Kyritsi, Tianhao Zhou, Ludovica Ceci, Leonardo Baiocchi, Lindsey Kennedy, Sanjukta Chakraborty, Shannon Glaser, Heather Francis, Gianfranco Alpini, Keisaku Sato
Summary: This review summarizes the roles of immune cells in primary liver cancer, including HCC and CCA, and discusses the potential of immunotherapy as a treatment for liver cancer.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Oncology
Yue Li, Jing Gong, Xigang Shen, Menglei Li, Huan Zhang, Feng Feng, Tong Tong
Summary: This study aimed to establish and validate a machine learning-based CT radiomics model to predict metachronous liver metastasis in patients with colorectal cancer. The results showed that the fusion model combining radiomics and clinical features performed the best and could provide valuable biomarkers to identify patients with a high risk of colorectal liver metastases.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Pradipta Mukherjee, Arata Miyazawa, Shinichi Fukuda, Toshiharu Yamashita, Donny Lukmanto, Kosuke Okada, Ibrahim Abd El-Sadek, Lida Zhu, Shuichi Makita, Tetsuro Oshika, Yoshiaki Yasuno
Summary: This study demonstrated label-free imaging of the functional and structural properties of microvascular complex in mice liver using a custom-built Jones-matrix based polarization sensitive optical coherence tomography. Longitudinal time-course imaging showed distinct tissue dynamics beneath the vessels in healthy livers and revealed network vascular structure in early fibrotic liver models. High dynamics signals faded and decreased over time in the fibrotic liver models.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Charles J. Zhang, Sophia R. Meyer, Matthew J. O'Meara, Sha Huang, Meghan M. Capeling, Daysha Ferrer-Torres, Charlie J. Childs, Jason R. Spence, Robert J. Fontana, Jonathan Z. Sexton
Summary: In this study, the utility of human liver organoids (HLOs) for high-throughput drug-induced liver injury (DILI) risk prediction and organ-on-chip system was evaluated. The results showed that HLOs have similar DILI predictive capacity as intact HLOs and can predict hepatotoxicity associated with DILI. The organ-on-chip system exhibits in vivo-like functions and is beneficial for DILI risk assessment.
JOURNAL OF HEPATOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wei Zhang, Chengwu Huang, Tinghui Yin, Xiaoyan Miao, Huan Deng, Rongqin Zheng, Jie Ren, Shigao Chen
Summary: This study aimed to evaluate the feasibility of ultrasensitive US microvessel imaging in visualizing and quantifying hepatic microvessels in healthy and cirrhotic rats. The findings showed that ultrasensitive US microvessel imaging could detect minute vessels below the liver capsule and quantify the perfusion, tortuosity, and integrity of microvessels. Cirrhotic rats had lower vessel density and fractional moving blood volume, and higher tortuosity compared to control rats, which were strongly correlated with pathologically derived vessel density and hepatic tissue hypoxia.
Article
Oncology
Pi-Xiao Zhou, Ying Zhang, Quan-Bin Zhang, Guo-Qian Zhang, Hui Yu, Shu-Xu Zhang
Summary: This study evaluated the dosimetric and clinical benefits of functional liver-sparing planning radiotherapy and found that it may reduce the dose to the liver, predict the risk of radiation-induced liver toxicity, and provide clinical benefits.
FRONTIERS IN ONCOLOGY
(2022)
Review
Food Science & Technology
Hyun Kil Shin, Ruili Huang, Minjun Chen
Summary: New approach methods (NAMs) using deep learning and in vitro data based on adverse outcome pathways (AOPs) have been developed to predict liver injury caused by drugs or dietary supplements. These models show enhanced predictive performance and interpretability, and have also been applied to hepatotoxicity caused by herbal products. Advancements in machine learning algorithms and expansion of in vitro databases with relevant biological knowledge have greatly improved in silico modeling for drug-induced liver injury prediction.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Gastroenterology & Hepatology
Nina Bastati, Lucian Beer, Ahmed Ba-Ssalamah, Sarah Poetter-Lang, Raphael Ambros, Antonia Kristic, David Lauber, Katharina Pomej, Teresa Binter, Benedikt Simbrunner, Georg Semmler, Lorenz Balcar, Yesim Bican, Jacqueline C. Hodge, Thomas Wrba, Michael Trauner, Thomas Reiberger, Mattias Mandorfer
Summary: The combination of FLIS and SCCD showed high accuracy in predicting hepatic decompensation, ACLF, and mortality in patients with advanced CLD. SCCD was an independent risk factor for hepatic decompensation in cACLD patients, and the combination of FLIS and SCCD provided complementary information for risk stratification in patients with different severity of CLD.
JOURNAL OF HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Xiaoyun Li, Jieting Tang, Yimin Mao
Summary: The epidemiology and aetiology of drug-induced liver injury (DILI) vary across different countries and populations. Antibiotics are the leading cause of DILI in Western countries, while traditional Chinese medicine is the primary cause in Eastern countries. The incidence of hepatotoxicity induced by herbal and dietary supplements is increasing globally. Although several risk factors for DILI have been described, there are no confirmed risk factors for all-cause DILI.
LIVER INTERNATIONAL
(2022)
Article
Pediatrics
Yu-ming Guo, Fei-lin Ge, Hai-bo Song, Peng Xiong, Jing Jing, Ming Niu, Xu Zhao, Zhao-fang Bai, Jia-bo Wang, Xiao-he Xiao
Summary: Children, especially infants, are sensitive to liver-related adverse drug reactions caused by several specific drug categories.
JOURNAL OF PEDIATRICS
(2021)
Review
Chemistry, Multidisciplinary
Dan Cheng, Wang Xu, Xiangyang Gong, Lin Yuan, Xiao-Bing Zhang
Summary: Drug-induced acute liver injury (DIALI) is a significant challenge, and molecular optical probes are considered potent tools for its detection. Existing challenges include signal errors and limitations in clinical applications.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Letter
Medicine, General & Internal
You-Wen Tan
Summary: This article discusses the risk stratification of primary liver cancer and highlights the limitations of single studies in summarizing its risk factors. The Chinese research societies have developed guidelines for screening high-risk populations in hospitals and communities.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Toxicology
Anja Lehmann, Ina Geburek, Anja These, Stefanie Hessel-Pras, Jan G. Hengstler, Wiebke Albrecht, Hans Mielke, Christine Mueller-Graf, Xiaojing Yang, Charlotte Kloft, Christoph Hethey
Summary: A physiologically based toxicokinetic model was developed to study the toxicokinetics of retrorsine in mice and rats. The model was validated to determine the hepatic toxicity of retrorsine and translate in vitro toxicity data to in vivo dose-response data. This study provides a flexible tool for the risk assessment of retrorsine.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Oncology
Jessica M. Frakes, Arash O. Naghavi, Stephanie K. Demetriou, Tobin J. Strom, Jeffery S. Russell, Julie A. Kish, Judith C. McCaffrey, Kristen J. Otto, Tapan A. Padhya, Louis B. Harrison, Andy M. Trotti, Jimmy J. Caudell
Article
Biochemistry & Molecular Biology
Tiffany K. Dong, Katherine Ona, Amy E. Scandurra, Stephanie K. Demetriou, Dennis H. Oh
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2016)
Article
Oncology
Ryan G. Price, Smith Apisarnthanarax, Stephanie K. Schaub, Matthew J. Nyflot, Tobias R. Chapman, Manuela Matesan, Hubert J. Vesselle, Stephen R. Bowen
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2018)
Review
Oncology
Stephanie K. Schaub, Pehr E. Hartvigson, Michael I. Lock, Morten Hoyer, Thomas B. Brunner, Higinia R. Cardenes, Laura A. Dawson, Edward Y. Kim, Nina A. Mayr, Simon S. Lo, Smith Apisarnthanarax
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2018)
Article
Oncology
Arash O. Naghavi, Michelle Echevarria, Tobin J. Strom, Yazan A. Abuodeh, Puja S. Venkat, Kamran A. Ahmed, Stephanie Demetriou, Jessica M. Frakes, Youngchul Kim, Julie A. Kish, Jeffery S. Russell, Kristen J. Otto, Christine H. Chung, Louis B. Harrison, Andy Trotti, Jimmy J. Caudell
Review
Clinical Neurology
Stephanie K. Schaub, Yolanda D. Tseng, Eric L. Chang, Arjun Sahgal, Rajiv Saigal, Christoph P. Hofstetter, Matthew Foote, Andrew L. Ko, William T. C. Yuh, Mahmud Mossa-Basha, Nina A. Mayr, Simon S. Lo
Article
Oncology
Jan C. Peeken, Rebecca Asadpour, Katja Specht, Eleanor Y. Chen, Olena Klymenko, Victor Akinkuoroye, Daniel S. Hippe, Matthew B. Spraker, Stephanie K. Schaub, Hendrik Dapper, Carolin Knebel, Nina A. Mayr, Alexandra S. Gersing, Henry C. Woodruff, Philippe Lambin, Matthew J. Nyflot, Stephanie E. Combs
Summary: The research demonstrates that MRI-based delta-radiomics improves prediction of pCR compared to tumor volume and RECIST. Delta-radiomics may one day function as a biomarker for personalized treatment adaptations.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Mario R. Fernandez, Franz X. Schaub, Chunying Yang, Weimin Li, Seongseok Yun, Stephanie K. Schaub, Frank C. Dorsey, Min Liu, Meredith A. Steeves, Andrea Ballabio, Alexandar Tzankov, Zhihua Chen, John M. Koomen, Anders E. Berglund, John L. Cleveland
Article
Pathology
Erica Y. Kao, Abbye E. McEwen, James K. Aden, Stephanie K. Schaub, Robert W. Ricciotti, Jose G. Mantilla
Summary: Radiation-associated sarcomas, an uncommon complication of therapeutic radiation, have unclear clinical, pathologic, and genetic characteristics. This study reviewed 94 cases of radiation-associated sarcomas from 1993 to 2018 and compared them with sporadic sarcomas. The findings showed that radiation-associated sarcomas have a wide clinico-pathologic spectrum and tend to be more aggressive.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2023)
Review
Oncology
Peter Zaki, Michael D. Chuong, Stephanie K. Schaub, Simon S. Lo, Mariam Ibrahim, Smith Apisarnthanarax
Summary: External beam radiation therapy (EBRT) has become more commonly used in the treatment of hepatocellular carcinoma (HCC) due to advancements in technology and positive clinical outcomes. Innovations in EBRT include improved image guidance, motion management, treatment planning, and techniques such as intensity-modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT).
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stephanie K. Schaub, Ralph P. Ermoian, Carolyn L. Wang, Ryan B. O'Malley, Edward Y. Kim, William P. Shuman, Kristi Hendrickson, Smith Apisarnthanarax
CURRENT PROBLEMS IN DIAGNOSTIC RADIOLOGY
(2020)
Article
Oncology
Pehr E. Hartvigson, Smith Apisarnthanarax, Stephanie Schaub, Stacey Cohen, Greta Bernier, Wui-Jin Koh, Edward Y. Kim
ADVANCES IN RADIATION ONCOLOGY
(2019)
Article
Oncology
Tobias R. Chapman, Stephen R. Bowen, Stephanie K. Schaub, Rosanna H. Yeung, Sharon W. Kwan, James O. Park, Lei Yu, William P. Harris, Guy E. Johnson, Iris W. Liou, Matthew J. Nyflot, Smith Apisarnthanarax
PRACTICAL RADIATION ONCOLOGY
(2018)
Article
Oncology
Meghan W. Macomber, Stephanie K. Schaub, Smith Apisarnthanarax
PRACTICAL RADIATION ONCOLOGY
(2018)