New insights into PDE4B inhibitor selectivity: CoMFA analyses and molecular docking studies

Synthesis, biological evaluation and 3D QSAR study of 2,4-disubstituted quinolines as anti-tuberculosis agents

(2015) Sanjay R. Patel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of triazines as selective PDE4B versus PDE4D inhibitors

(2014) Timothy J. Hagen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

3D-QSAR/CoMFA-Based Structure-Affinity/Selectivity Relationships of Aminoalkylindoles in the Cannabinoid CB1 and CB2 Receptors

(2014) Jaime Mella-Raipán et al.   MOLECULES

Phosphodiesterase-4 (PDE4) Molecular Pharmacology and Alzheimer’s Disease

(2014) Mark E. Gurney et al.   Neurotherapeutics

Combined 2D and 3D-QSAR, molecular modelling and docking studies of pyrazolodiazepinones as novel phosphodiesterase 2 inhibitors

(2014) S.G. Bhansali et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Identification of the 5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine derivatives as highly selective PDE4B inhibitors

(2013) Taiji Goto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural basis for the design of selective phosphodiesterase 4B inhibitors

(2013) David Fox et al.   CELLULAR SIGNALLING

Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D

(2013) A.S.R. Sierksma et al.   NEUROPHARMACOLOGY

GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses

(2011) O Bruno et al.   BRITISH JOURNAL OF PHARMACOLOGY

Homology modeling in tandem with 3D-QSAR analyses: A computational approach to depict the agonist binding site of the human CB2 receptor

(2011) Elena Cichero et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Docking-based CoMFA and CoMSIA analyses of tetrahydro-β-carboline derivatives as type-5 phosphodiesterase inhibitors

(2011) Elena Cichero et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Docking-based 3D-QSAR analyses of pyrazole derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors

(2011) Elena Cichero et al.   JOURNAL OF MOLECULAR MODELING

Phosphodiesterase-4D Knock-Out and RNA Interference-Mediated Knock-Down Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling

(2011) Y.-F. Li et al.   JOURNAL OF NEUROSCIENCE

The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors

(2010) Renee Aspiotis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

CoMFA and CoMSIA analyses on 1,2,3,4-tetrahydropyrrolo[3,4-b]indole and benzimidazole derivatives as selective CB2 receptor agonists

(2010) Elena Cichero et al.   JOURNAL OF MOLECULAR MODELING

3,4,5-Trisubstituted-1,2,4-4H-triazoles as WT and Y188L mutant HIV-1 non-nucleoside reverse transcriptase inhibitors: docking-based CoMFA and CoMSIA analyses

(2010) Elena Cichero et al.   JOURNAL OF MOLECULAR MODELING

Discovery of selective PDE4B inhibitors

(2009) Kenji Naganuma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

CoMFA and CoMSIA analyses on 4-oxo-1,4-dihydroquinoline and 4-oxo-1,4-dihydro-1,5-, -1,6- and -1,8-naphthyridine derivatives as selective CB2 receptor agonists

(2009) Elena Cichero et al.   JOURNAL OF MOLECULAR MODELING

Acylthiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors: docking studies and ligand-based CoMFA and CoMSIA analyses

(2009) Elena Cichero et al.   JOURNAL OF MOLECULAR MODELING

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

(2009) Alex B Burgin et al.   NATURE BIOTECHNOLOGY

Subtype Selectivity in Phosphodiesterase 4 (PDE4): A Bottleneck in Rational Drug Design

(2008) P. Srivani et al.   CURRENT PHARMACEUTICAL DESIGN

Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors: Docking-based CoMFA and CoMSIA analyses

(2008) Elena Cichero et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY