Phosphorylation of Nanog is essential to regulate Bmi1 and promote tumorigenesis

RNA interference-mediated silencing of NANOG reduces cell proliferation and induces G0/G1 cell cycle arrest in breast cancer cells

(2012) Jinghua Han et al.   CANCER LETTERS

Cancer stem-like cells contribute to cisplatin resistance and progression in bladder cancer

(2012) Yi Zhang et al.   CANCER LETTERS

Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development

(2012) F. Lavial et al.   GENES & DEVELOPMENT

Nanog Increases Focal Adhesion Kinase (FAK) Promoter Activity and Expression and Directly Binds to FAK Protein to Be Phosphorylated

(2012) Baotran Ho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RAC1 activation mediates Twist1-induced cancer cell migration

(2012) Wen-Hao Yang et al.   NATURE CELL BIOLOGY

Stem-Like Cells with Luminal Progenitor Phenotype Survive Castration in Human Prostate Cancer

(2012) Markus Germann et al.   STEM CELLS

Alternative Splicing Produces Nanog Protein Variants with Different Capacities for Self-renewal and Pluripotency in Embryonic Stem Cells

(2011) Satyabrata Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Markedly increased Oct4 and Nanog expression correlates with cisplatin resistance in oral squamous cell carcinoma

(2011) Lo-Lin Tsai et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells

(2011) L Y W Bourguignon et al.   ONCOGENE

MicroRNA let-7a represses chemoresistance and tumourigenicity in head and neck cancer via stem-like properties ablation

(2011) Cheng-Chia Yu et al.   ORAL ONCOLOGY

CD133+ Cancer Stem Cell-like Cells Derived from Uterine Carcinosarcoma (Malignant Mixed Müllerian Tumor)

(2011) Batsuren Choijamts et al.   STEM CELLS

PEST Motif Sequence Regulating Human NANOG for Proteasomal Degradation

(2011) Suresh Ramakrishna et al.   STEM CELLS AND DEVELOPMENT

Bmi-1 expression predicts prognosis in squamous cell carcinoma of the tongue

(2010) V Häyry et al.   BRITISH JOURNAL OF CANCER

Over-expression of Nanog predicts tumor progression and poor prognosis in colorectal cancer

(2010) Hui-Min Meng et al.   CANCER BIOLOGY & THERAPY

Coexpression of Oct4 and Nanog Enhances Malignancy in Lung Adenocarcinoma by Inducing Cancer Stem Cell-Like Properties and Epithelial-Mesenchymal Transdifferentiation

(2010) S.-H. Chiou et al.   CANCER RESEARCH

Bmi-1 Is a Crucial Regulator of Prostate Stem Cell Self-Renewal and Malignant Transformation

(2010) Rita U. Lukacs et al.   Cell Stem Cell

NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53

(2010) Marie Zbinden et al.   EMBO JOURNAL

Kruppel-like Factor 4 (Klf4) Prevents Embryonic Stem (ES) Cell Differentiation by Regulating Nanog Gene Expression

(2010) Peilin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bmi1 is essential in Twist1-induced epithelial–mesenchymal transition

(2010) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

Phosphorylation stabilizes Nanog by promoting its interaction with Pin1

(2010) M. Moretto-Zita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncoprotein Bmi-1 Renders Apoptotic Resistance to Glioma Cells through Activation of the IKK-Nuclear Factor-κB Pathway

(2009) Jun Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Co-Expression of Bmi-1 and Podoplanin Predicts Overall Survival in Patients With Squamous Cell Carcinoma of the Head and Neck Treated With Radio(chemo)therapy

(2009) Laurenz Vormittag et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Hyaluronan-CD44 Interaction with Protein Kinase Cϵ Promotes Oncogenic Signaling by the Stem Cell Marker Nanog and the Production of MicroRNA-21, Leading to Down-regulation of the Tumor Suppressor Protein PDCD4, Anti-apoptosis, and Chemotherapy Resistance in Breast Tumor Cells

(2009) Lilly Y. W. Bourguignon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two potent transactivation domains in the C-terminal region of human NANOG mediate transcriptional activation in human embryonic carcinoma cells

(2009) Hyun-Jin Do et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Molecular Characterization of the Human NANOG Protein

(2009) David F. Chang et al.   STEM CELLS

Functional Evidence that the Self-Renewal GeneNANOGRegulates Human Tumor Development

(2009) Collene R. Jeter et al.   STEM CELLS

The pluripotency rheostat Nanog functions as a dimer

(2008) Nicholas P. Mullin et al.   BIOCHEMICAL JOURNAL

The Polycomb Gene Product BMI1 Contributes to the Maintenance of Tumor-Initiating Side Population Cells in Hepatocellular Carcinoma

(2008) T. Chiba et al.   CANCER RESEARCH

Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells

(2008) Xi Chen et al.   CELL

Positive Correlations of Oct-4 and Nanog in Oral Cancer Stem-Like Cells and High-Grade Oral Squamous Cell Carcinoma

(2008) S.-H. Chiou et al.   CLINICAL CANCER RESEARCH

Prognostic value of Bmi-1 oncoprotein expression in NSCLC patients: a tissue microarray study

(2008) Katerina Vrzalikova et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFκB and cooperating with Stat3

(2008) Josema Torres et al.   NATURE CELL BIOLOGY

Requirement of Nanog dimerization for stem cell self-renewal and pluripotency

(2008) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA