Article
Radiology, Nuclear Medicine & Medical Imaging
Joseph V. Panetta, Iavor Veltchev, Robert A. Price, C-M Charlie Ma
Summary: This study investigates the effect of dose gradient on quality assurance passing rate in IMRT delivery. The results show that the passing rate is generally correlated to the dose gradient, but the correlation is not predictable and varies with the measurement location.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2023)
Article
Oncology
Jun Zhang, Xiuqing Li, Miaomiao Lu, Qilin Zhang, Xile Zhang, Ruijie Yang, Maria F. Chan, Junhai Wen
Summary: This study developed a novel model to predict EPID transmission images based on fluence maps from RT plans for in vivo treatment verification. The model was evaluated with 20 clinical plans and showed high accuracy, suggesting its potential utility for IMRT and VMAT treatment delivery verification.
RADIATION ONCOLOGY
(2021)
Article
Engineering, Biomedical
Odran Pivot, Patrick Pittet, Rolf Clackdoyle, Laurent Desbat, Simon Rit
Summary: This study developed a novel method to reconstruct MLC-shaped small irradiation fields from six projections, which can be used for quality assurance in radiotherapy. The results showed that the proposed method accurately reconstructed dose distributions and was suitable for water-equivalent real-time small irradiation fields QA.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Oncology
Ying Huang, Yifei Pi, Kui Ma, Xiaojuan Miao, Sichao Fu, Hua Chen, Hao Wang, Hengle Gu, Yan Shao, Yanhua Duan, Aihui Feng, Jiyong Wang, Ruxin Cai, Weihai Zhuo, Zhiyong Xu
Summary: Using UNet++ for quality assurance in radiotherapy allows for accurate classification of failed or pass fields, prediction of gamma passing rates for different gamma criteria, and prediction of dose differences. The results indicate that UNet++ based Virtual QA shows promise in quality assurance for radiotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Myeongsoo Kim, Boram Park, Haksoo Kim, Yeon-Joo Kim, Dong Ju Choi, Weonkuu Chung, Yeon Joo Kim, Hyun Soo Shin, Jung Ho Im, Chang-Ok Suh, Jin Hee Kim, Boram Ha, Mi Young Kim, Jongmoo Park, Jeongshim Lee, Sung-Ja Ahn, Sun Young Lee, Grace Kusumawidjaja, Faye Lim, Won Kyung Cho, Haeyoung Kim, Doo Ho Choi, Won Park
Summary: This study assessed inter-institutional dosimetric variations in radiation dose plans for breast cancer patients. Variations were found, particularly in the regional nodal areas. The study highlights the importance of collecting actual patient data for reliable research results.
RADIATION ONCOLOGY
(2022)
Article
Oncology
Huakang Huang, John Roberson, Wei Hou, Kartik Mani, Edward Valentine, Samuel Ryu, Alexander Stessin
Summary: This study analyzed breast cancer patients receiving SCV-directed RT and found that longer follow-up length and larger thyroid volume receiving less than 20 Gy were significant predictors of hypothyroidism. An NTCP model suggested that a thyroid volume receiving more than 8.5 cc and less than 20 Gy had a risk of hypothyroidism below 15%, with comparable performances to other published models.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
Tomppa Pakarinen, Jarkko Ojala
Summary: Profeel is an open-source dosimetry data visualization and analysis software based on Matlab, designed to support quality assurance, dosimetry, and research in radiotherapy. The software offers processing and analysis tools such as gamma analysis, data normalizations, and data filtering, and automatically performs one-dimensional profile and depth dose analysis according to international standards.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lando S. Bosma, Cornel Zachiu, Baudouin Denis de Senneville, Bas W. Raaymakers, Mario Ries
Summary: The purpose of this study is to investigate the ability of existing intensity-based quality assurance criteria, structural similarity and normalized mutual information, to quickly and reliably identify registration errors in radiotherapy. These criteria were tested using synthetic and simulated biomechanical deformations of 3D MR images as well as manually annotated 4D CT data. The results showed that the intensity-based criteria provide the required confidence in using mono-modal registrations in clinical workflows and enable automated quality assurance for deformable image registration in adaptive radiotherapy treatments.
Article
Radiology, Nuclear Medicine & Medical Imaging
Joseph Hanley, Sean Dresser, William Simon, Ryan Flynn, Eric E. Klein, Daniel Letourneau, Chihray Liu, Fang-Fang Yin, Bijan Arjomandy, Lijun Ma, Francisco Aguirre, Jimmy Jones, John Bayouth, Todd Holmes
Summary: The task group was charged with providing procedural guidelines for tests, estimating time and personnel needed, and providing sample QA forms. Some guidelines were based on literature, some on member experiences, and some on new technologies without literature support. Additional tests and criteria specific to VMAT were added due to its broad clinical adaptation.
Article
Health Care Sciences & Services
Michael Pinkawa, Amr Gharib, Marsha Schlenter, Ludmila Timm, Michael J. Eble
Summary: The study focused on the analysis of changes in quality of life post-radiotherapy, with findings showing an increase in urinary and bowel incontinence rates over time and with higher doses. There was also a decrease in sexual function scores. Higher doses were associated with increased urinary problems and larger stool incontinence rates. Age and comorbidities were relevant for baseline scores, but not for score changes.
QUALITY OF LIFE RESEARCH
(2021)
Review
Oncology
Kelsey L. Corrigan, Stephen Kry, Rebecca M. Howell, Ramez Kouzy, Joseph Abi Jaoude, Roshal R. Patel, Anuja Jhingran, Cullen Taniguchi, Albert C. Koong, Mary Fran McAleer, Paige Nitsch, Claus Roedel, Emmanouil Fokas, Bruce D. Minsky, Prajnan Das, C. David Fuller, Ethan B. Ludmir
Summary: This study investigated the utilization of quality assurance (QA) in randomized controlled trials (RCTs) involving radiotherapy (RT). The results showed a lack of QA utilization and transparency in RT clinical trials. Increased QA is necessary for safe, consistent, and high-quality RT planning and delivery in RT trials.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Gage Redler, Erik Pearson, Xinmin Liu, Inna Gertsenshteyn, Boris Epel, Charles Pelizzari, Bulent Aydogan, Ralph Weichselbaum, Howard J. Halpern, Rodney D. Wiersma
Summary: The study demonstrates the efficacy of using 3D-printed compensators for small-animal IMRT treatment plans and shows that the preclinical data provided can be translated into clinical practice. Compensators of varied thickness provide the desired attenuation, with spatial resolution capabilities investigated using 3D printing. The methodology was ultimately validated for accuracy and precision.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
David A. Roberts, Carlos Sandin, Panu T. Vesanen, Hannah Lee, Ian M. Hanson, Simeon Nill, Thijs Perik, Seng Boh Lim, Sastry Vedam, Jinzhong Yang, Simon W. Woodings, Jochem W. H. Wolthaus, Brian Keller, Geoff Budgell, Xinfeng Chen, X. Allen Li
Summary: Magnetic resonance image-guided radiotherapy systems have introduced new challenges to quality assurance due to the unique characteristics of the systems. There is currently no consensus guidance on QA equipment and test requirements, necessitating the development of an overview and recommendations for different aspects of QA for such systems. This consensus work aims to provide a foundation for future research and development in QA protocols and measurement methods.
Article
Radiology, Nuclear Medicine & Medical Imaging
Chaoqiong Ma, Ruoxi Wang, Shun Zhou, Meijiao Wang, Haizhen Yue, Yibao Zhang, Hao Wu
Summary: The combination of radiomics analysis on SSIM sub-index maps and machine learning techniques can effectively identify delivery errors in patient-specific dynamic IMRT QA. The ML model shows significantly higher classification accuracy compared to the traditional gamma analysis method.
Article
Oncology
Andrada Turcas, Sarah M. Kelly, Valerie Bernier-Chastagner, Stephanie Bolle, Alison Cameron, Coreen Corning, Enrico Clementel, Karin Dieckmann, Raquel Davila Fajardo, Mark N. Gaze, Anne Laprie, Henriette Magelssen, Silvia Meroni, Emanuele Pignoli, Akmal Safwat, Giovanni Scarzello, James Talbot, Beate Timmermann, Tom Boterberg, Henry C. Mandeille
Summary: Irradiation of the vertebrae in prepubertal patients, if non-homogeneous, can result in future growth deformities including kyphoscoliosis. Vertebral delineation and dosimetry were assessed for 101 paediatric cases reviewed within QUARTET-affiliated trials. Despite the availability of published consensus guidelines, a high variability in vertebral delineation was observed, with impact on dosimetry.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Guang Ma, Bingxin Gu, Jiyi Hu, Lin Kong, Jiangang Zhang, Zili Li, Yangbo Xue, Jiade Lu, Junning Cao, Jingyi Cheng, Yingjian Zhang, Shaoli Song, Zhongyi Yang
Summary: The study examined the value of pretreatment F-18-FDG uptake heterogeneity in predicting the prognosis of locally recurrent nasopharyngeal carcinoma (LRNPC) patients treated with carbon ion radiotherapy (CIRT). Results showed that F-18-FDG uptake heterogeneity, particularly with a HI>=0.81, was significantly associated with poorer LRFS and PFS outcomes, indicating its potential as an independent predictor for LRNPC patients undergoing CIRT.
ANNALS OF NUCLEAR MEDICINE
(2021)
Article
Oncology
Wanzun Lin, Xianxin Qiu, Pian Sun, Yuling Ye, Qingting Huang, Lin Kong, Jiade J. Lu
Summary: While successful clinical trials of immunotherapy have shown promising strategies for many cancers, its application in glioma has lagged behind compared to other cancers. This study focused on the molecular alterations affecting therapeutic response in lower-grade glioma (LGG) and characterized the immunological phenotypes with different molecular subtypes to improve our understanding and application of immunotherapies in LGG. The research collected data from 1,052 patients, stratified them into three genetic subgroups, and discovered distinct immunological tumor microenvironments associated with IDH mutations and 1p/19q codeletions in LGG, ultimately leading to the construction of an immune-related prognostic signature that predicts overall survival time in LGG.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Review
Cell Biology
Vivek Kumar, Mohit Vashishta, Lin Kong, Xiaodong Wu, Jiade J. Lu, Chandan Guha, B. S. Dwarakanath
Summary: Resistance to therapy is a major challenge in cancer management, with cancer cells rewiring their cellular processes to resist the deleterious effects of various therapeutic approaches. Understanding the role of developmental pathways in cancer and their contribution to resistance can lead to insights for developing novel therapeutic approaches. Recognizing the importance of molecular networks in overcoming drug resistance can provide a rational basis for improving cancer treatment with safer and more effective combined therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Jian Chen, Jingfang Mao, Ningyi Ma, Kai-Liang Wu, Jiade Lu, Guo-Liang Jiang
Summary: The study evaluated the effects and toxicities of carbon ion radiotherapy in the management of tracheobronchial adenoid cystic carcinoma. Among 18 eligible patients, the 2-year overall survival, local control, and progression-free survival rates were 100%, 100%, and 61.4%, respectively, with an overall response rate of 88.2%. Only one patient experienced severe tracheal stenosis after CIRT, which was relieved after stent implantation.
Article
Immunology
Wanzun Lin, Yun Sun, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu
Summary: The study found that high expression of VMP1 in glioma patients is associated with faster disease progression and poorer prognosis. Depletion of VMP1 by CRISPR-Cas9 gene editing significantly inhibits cell proliferation, increases cell death, and induces cell cycle arrest. Knockout of VMP1 blocks autophagic flux and sensitizes glioma cells to radiotherapy and chemotherapy.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Oncology
Jiyi Hu, Qingting Huang, Jing Gao, Weixu Hu, Jing Yang, Xiyin Guan, Xianxin Qiu, Wenna Zhang, Lin Kong, Jiade J. Lu
Summary: The study demonstrated that the combination of IMRT with CIRT boost therapy provides excellent disease control and favorable toxicity profile for patients with non-metastatic nasopharyngeal carcinoma. The results suggest that this mixed treatment strategy is safe and well-tolerated, with promising outcomes in terms of disease control.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shubing Jia, Jian Chen, Ningyi Ma, Jingfang Zhao, Jingfang Mao, Guoliang Jiang, Jiade Lu, Kailiang Wu
Summary: This study demonstrates the dosimetric benefits of adaptive carbon ion radiotherapy (CIRT) for locally advanced non-small cell lung cancer (LANSCLC) and compares the differences between patients with and without adaptive plans. The results show that adaptive plans can ensure target coverage and reduce spinal cord dose. Patients with adaptive plans have larger tumor volumes and greater volume changes. iGTV volume changes and iGTV center movements are the main factors influencing adaptive planning.
Article
Immunology
Wanzun Lin, Yanyan Xu, Jing Gao, Haojiong Zhang, Yun Sun, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu
Summary: The study identifies B7-H3 as a novel biomarker for head and neck squamous cell carcinoma (HNSCC), predicting prognosis and response to immunotherapy; high expression of B7-H3 is associated with poor prognosis, immunotherapy resistance, and contributes to an immunosuppressive microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Ning-Yi Ma, Jian Chen, Xue Ming, Guo-Liang Jiang, Jiade J. Lu, Kai-Liang Wu, Jingfang Mao
Summary: The study found that proton plus carbon-ion radiotherapy combined with chemotherapy has good tolerability and promising survival rates in patients with limited-stage small cell lung cancer. Acute toxicities, both hematologically and non-hematologically related, were well managed, with some cases of late side effects observed.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Fangzhu Wan, Haojiong Zhang, Jiyi Hu, Li Chen, Shikai Geng, Lin Kong, Jiade J. Lu
Summary: This study identified miR-125a as highly expressed in normal nasopharyngeal epithelial tissue compared to nasopharyngeal carcinoma. It demonstrated that miR-125a inhibits the migration and vasculogenic mimicry (VM) formation in nasopharyngeal carcinoma cells, targeting TAZ. Additionally, artificial engineering of mesenchymal stem cells (MSCs) allowed the generation of miR-125a-overexpressing exosomes which attenuated VM formation and migration in nasopharyngeal carcinoma, providing a potential therapeutic approach.
FRONTIERS IN ONCOLOGY
(2022)
Article
Ophthalmology
Jingli Guo, Xianxin Qiu, Wenyi Tang, Gezhi Xu, Michael F. Moyers, Wei Ren, Ying Xing, Jin Gao, Jiayao Sun, Jiade Lu, Lin Kong, Wei Liu
Summary: The study demonstrates that PBI combined with IVC may help promote regression and closure of polyps in PCV, reduce central macular thickness, and improve BCVA with good safety profile after 12 months. Hence, PBI may be a useful adjuvant therapy for patients with refractory or recurrent PCV.
OPHTHALMOLOGY AND THERAPY
(2022)
Article
Oncology
Dong Yang, Weiwei Wang, Jiyi Hu, Weixu Hu, Xiyu Zhang, Xiaodong Wu, Jiade J. Lu, Lin Kong
Summary: This study investigated the feasibility of lattice radiotherapy (LRT) using proton or carbon-ion beams in the treatment of sinonasal malignancies. The results showed that proton and carbon-ion LRT plans can better protect critical organs compared to photon LRT plans, despite minimal differences in PVDR.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Robert L. Foote, Hirohiko Tsujii, Reiko Imai, Hiroshi Tsuji, Eugen B. Hug, Tatsuaki Kanai, Jiade J. Lu, Juergen Debus, Rita Engenhart-Cabillic, Anita Mahajan
Summary: As of December 31, 2020, there were 12 facilities in Asia and Europe providing carbon ion radiotherapy (CIRT) for cancer patients, with a total of 37,548 patients treated worldwide. The absence of CIRT facilities in the U.S. limits access to this treatment for American cancer patients and prevents their inclusion in phase III clinical trials, which are essential for FDA approval and insurance coverage. Overcoming this barrier would require establishing a limited number of CIRT facilities in the U.S.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Wanzun Lin, Jing Gao, Haojiong Zhang, Li Chen, Xianxin Qiu, Qingting Huang, Jiyi Hu, Lin Kong, Jiade J. Lu
Summary: This study classified lower-grade glioma (LGG) into inflammation-, low, -mid, and -high subtypes based on the inflammatory response, which have distinct clinicopathologic features, prognosis, and tumor microenvironment. An inflammation-related prognostic model was also established with strong predictive power for prognosis assessment.
INFLAMMATION AND REGENERATION
(2022)
Review
Oncology
Anna Lee, Sarin Kitpanit, Marina Chilov, Johannes A. Langendijk, Jiade Lu, Nancy Y. Lee
Summary: This study systematically reviewed the literature on proton therapy in nasopharyngeal cancer patients, finding that proton therapy can maintain good treatment outcomes while reducing toxic dose to normal tissues. Compared with intensity-modulated radiation therapy, proton therapy showed lower rates of feeding tube and mucositis, indicating an improved toxicity profile in NPC patients.
INTERNATIONAL JOURNAL OF PARTICLE THERAPY
(2021)
