Ionizing radiation-induced oxidative stress, epigenetic changes and genomic instability: The pivotal role of mitochondria

Mitochondrial Respiratory Supercomplex Association Limits Production of Reactive Oxygen Species from Complex I

(2013) Evelina Maranzana et al.   ANTIOXIDANTS & REDOX SIGNALING

Function of oncogenes in cancer development: a changing paradigm

(2013) Carolina Vicente-Dueñas et al.   EMBO JOURNAL

Effects of ionizing radiation on mitochondria

(2013) Winnie Wai-Ying Kam et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics

(2013) Manti Guha et al.   MITOCHONDRION

Emerging roles for chromatin as a signal integration and storage platform

(2013) Aimee I. Badeaux et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Radiation damage on sub-cellular scales: beyond DNA

(2013) H L Byrne et al.   PHYSICS IN MEDICINE AND BIOLOGY

Mitochondrial Redox Signaling: Interaction of Mitochondrial Reactive Oxygen Species with Other Sources of Oxidative Stress

(2012) Eberhard Schulz et al.   ANTIOXIDANTS & REDOX SIGNALING

SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging

(2012) Albert Giralt et al.   BIOCHEMICAL JOURNAL

Epigenomics of cancer – emerging new concepts

(2012) Melanie R. Hassler et al.   BIOCHIMIE

Oxidative stress, DNA damage and repair in carcinogenesis: Have we established a connection?

(2012) Alexandros G. Georgakilas   CANCER LETTERS

The Interplay Between Inflammation and Oxidative Stress in Carcinogenesis

(2012) S. Nowsheen et al.   CURRENT MOLECULAR MEDICINE

Cancer epigenomics: beyond genomics

(2012) Juan Sandoval et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Molecular Link Mechanisms between Inflammation and Cancer

(2012) D. B. Vendramini-Costa et al.   CURRENT PHARMACEUTICAL DESIGN

Rejuvenating Sirtuins: The Rise of a New Family of Cancer Drug Targets

(2012) Santina Bruzzone et al.   CURRENT PHARMACEUTICAL DESIGN

Bivalent histone modifications in stem cells poise miRNA loci for CpG island hypermethylation in human cancer

(2012) Maria S. Iliou et al.   Epigenetics

Mitochondrial regulation of epigenetics and its role in human diseases

(2012) Sheroy Minocherhomji et al.   Epigenetics

Manganese superoxide dismutase regulation and cancer

(2012) Sanjit Kumar Dhar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Quantitative proteomic analysis of mitochondrial proteins reveals prosurvival mechanisms in the perpetuation of radiation-induced genomic instability

(2012) Stefani N. Thomas et al.   FREE RADICAL BIOLOGY AND MEDICINE

Manganese superoxide dismutase interacts with a large scale of cellular and mitochondrial proteins in low-dose radiation-induced adaptive radioprotection

(2012) Angela Eldridge et al.   FREE RADICAL BIOLOGY AND MEDICINE

Emerging avenues linking inflammation and cancer

(2012) Joydeb Kumar Kundu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ionizing radiation induces mitochondrial reactive oxygen species production accompanied by upregulation of mitochondrial electron transport chain function and mitochondrial content under control of the cell cycle checkpoint

(2012) Tohru Yamamori et al.   FREE RADICAL BIOLOGY AND MEDICINE

SIRT3 gene expression: A link between inherited mitochondrial DNA variants and oxidative stress

(2012) Patrizia D'Aquila et al.   GENE

Wilson's disease: Changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease

(2012) Valentina Medici et al.   HEPATOLOGY

Acriflavine enhances radiosensitivity of colon cancer cells through endoplasmic reticulum stress-mediated apoptosis

(2012) Min-Jin Lim et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Epigenetics, epidemiology and mitochondrial DNA diseases

(2012) Patrick F Chinnery et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Chronic low-dose radiation inhibits the cells death by cytotoxic high-dose radiation increasing the level of AKT and acinus proteins via NF-κB activation

(2012) Hyung Sun Park et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Transcriptional changes of mitochondrial genes in irradiated cells proficient or deficient in p53

(2012) M. AHMAD CHAUDHRY et al.   JOURNAL OF GENETICS

Mitochondria-Targeted Superoxide Dismutase (SOD2) Regulates Radiation Resistance and Radiation Stress Response in HeLa Cells

(2012) Ayaka HOSOKI et al.   JOURNAL OF RADIATION RESEARCH

Second Malignant Neoplasms and Cardiovascular Disease Following Radiotherapy

(2012) Lois B. Travis et al.   JNCI-Journal of the National Cancer Institute

Chronic inflammation as a promotor of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development?

(2012) Hans Carl Hasselbalch   LEUKEMIA RESEARCH

Sealing the Mitochondrial Respirasome

(2012) D. R. Winge   MOLECULAR AND CELLULAR BIOLOGY

Non-targeted effects of ionising radiation—Implications for low dose risk

(2012) Munira Kadhim et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Minimizing the damage: repair pathways keep mitochondrial DNA intact

(2012) Lawrence Kazak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Perceiving the epigenetic landscape through histone readers

(2012) Catherine A Musselman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genetic instability: tipping the balance

(2012) A Janssen et al.   ONCOGENE

The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies

(2012) B Luo et al.   ONCOGENE

Exposure to Heavy Ion Radiation Induces Persistent Oxidative Stress in Mouse Intestine

(2012) Kamal Datta et al.   PLoS One

Radiation-responsive transcriptome analysis in human lymphoid cells

(2012) M. Chiba   RADIATION PROTECTION DOSIMETRY

Exploring Two Two-Edged Swords

(2012) David J. Brenner   RADIATION RESEARCH

Gene Expression Comparisons Performed for Biodosimetry Purposes onIn VitroPeripheral Blood Cellular Subsets and Irradiated Individuals

(2012) A. Riecke et al.   RADIATION RESEARCH

Metabolic regulation by SIRT3: implications for tumorigenesis

(2012) Lydia W.S. Finley et al.   TRENDS IN MOLECULAR MEDICINE

CyclinB1/Cdk1 phosphorylates mitochondrial antioxidant MnSOD in cell adaptive response to radiation stress

(2012) D. Candas et al.   Journal of Molecular Cell Biology

DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway

(2012) M A Kang et al.   Cell Death & Disease

Global DNA methylation levels are modulated by mitochondrial DNA variants

(2012) Dina Bellizzi et al.   Epigenomics

Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns

(2012) Duncan Sproul et al.   GENOME BIOLOGY

Role of DNA Damage and Epigenetic DNA Methylation Changes in Radiation-Induced Genomic Instability and Bystander Effects in Germline In Vivo

(2012) Jan Tamminga et al.   Current Molecular Pharmacology

Nitric Oxide is a Key Molecule Serving as a Bridge between Radiation-Induced Bystander and Adaptive Responses

(2012) Hideki Matsumoto et al.   Current Molecular Pharmacology

Redox Regulation of p53, Redox Effectors Regulated by p53: A Subtle Balance

(2011) Agnès Maillet et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitophagy: A Complex Mechanism of Mitochondrial Removal

(2011) Ivana Novak   ANTIOXIDANTS & REDOX SIGNALING

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

Functional complementation between transcriptional methylation regulation and post-transcriptional microRNA regulation in the human genome

(2011) Zhixi Su et al.   BMC GENOMICS

Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands

(2011) Heather M. O'Hagan et al.   CANCER CELL

Tumor suppressor genes and ROS: complex networks of interactions

(2011) Beyza Vurusaner et al.   FREE RADICAL BIOLOGY AND MEDICINE

Radiation-Induced Micro-RNA Expression Changes in Peripheral Blood Cells of Radiotherapy Patients

(2011) Thomas Templin et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Mitochondrial Dysfunction Impairs Tumor Suppressor p53 Expression/Function

(2011) Shannon Compton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence for Two Sites of Superoxide Production by Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex I)

(2011) Jason R. Treberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detection of Novel Human MiRNAs Responding to X-ray Irradiation

(2011) Nan DING et al.   JOURNAL OF RADIATION RESEARCH

NADPH oxidase inhibition attenuates total body irradiation-induced haematopoietic genomic instability

(2011) S. K. Pazhanisamy et al.   MUTAGENESIS

Non-targeted radiation effects—An epigenetic connection

(2011) Yaroslav Ilnytskyy et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Role of oxidative stress and DNA damage in human carcinogenesis

(2011) Thomas B. Kryston et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Increased methylation variation in epigenetic domains across cancer types

(2011) Kasper Daniel Hansen et al.   NATURE GENETICS

Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains

(2011) Benjamin P Berman et al.   NATURE GENETICS

Radiation–Induced Signaling Results in Mitochondrial Impairment in Mouse Heart at 4 Weeks after Exposure to X-Rays

(2011) Zarko Barjaktarovic et al.   PLoS One

Up-regulation of peroxisome proliferator-activated receptor gamma in radiation-induced heart injury in rats

(2011) Song Gao et al.   RADIATION AND ENVIRONMENTAL BIOPHYSICS

The role of miRNA in the direct and indirect effects of ionizing radiation

(2011) Jennifer S. Dickey et al.   RADIATION AND ENVIRONMENTAL BIOPHYSICS

Oxidative stress and oxidative damage in chemical carcinogenesis

(2011) James E. Klaunig et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Evaluating mitochondrial DNA in cancer occurrence and development

(2010) Lijun Shen et al.   Annals of the New York Academy of Sciences

Multi-site control and regulation of mitochondrial energy production

(2010) G. Benard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species

(2010) Andreas Daiber   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial respiratory chain super-complex I–III in physiology and pathology

(2010) Giorgio Lenaz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

DNA methylation status of nuclear-encoded mitochondrial genes underlies the tissue-dependent mitochondrial functions

(2010) Masaki Takasugi et al.   BMC GENOMICS

Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer

(2010) Turki Y. Alhazzazi et al.   CANCER

Mitochondrial control of epigenetics

(2010) Robert K. Naviaux   CANCER BIOLOGY & THERAPY

A novel role for mitochondria in regulating epigenetic modifications in the nucleus

(2010) Dominic Smiraglia et al.   CANCER BIOLOGY & THERAPY

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

ER stress induced by ionising radiation in IEC-6 cells

(2010) Bo Zhang et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Radiation-induced genomic instability: Are epigenetic mechanisms the missing link?

(2010) Umut Aypar et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Altered mitochondrial function and genome frequency post exposure to γ-radiation and bystander factors

(2010) Sharon Nugent et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

Towards a unifying theory of late stochastic effects of ionizing radiation

(2010) Keith Baverstock et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Methyltransferases mediate cell memory of a genotoxic insult

(2010) R E Rugo et al.   ONCOGENE

Sensitivity to Low-Dose/Low-LET Ionizing Radiation in Mammalian Cells Harboring Mutations in Succinate Dehydrogenase Subunit C is Governed by Mitochondria-Derived Reactive Oxygen Species

(2010) Nukhet Aykin-Burns et al.   RADIATION RESEARCH

Mutator phenotypes due to DNA replication infidelity

(2010) Mercedes E. Arana et al.   SEMINARS IN CANCER BIOLOGY

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

(2010) Robert B. Hamanaka et al.   TRENDS IN BIOCHEMICAL SCIENCES

Chemical Biology of Peroxynitrite: Kinetics, Diffusion, and Radicals

(2009) Gerardo Ferrer-Sueta et al.   ACS Chemical Biology

Mechanisms and Implications of Reactive Oxygen Species Generation During the Unfolded Protein Response: Roles of Endoplasmic Reticulum Oxidoreductases, Mitochondrial Electron Transport, and NADPH Oxidase

(2009) Célio X.C. Santos et al.   ANTIOXIDANTS & REDOX SIGNALING

Structure and Organization of Mitochondrial Respiratory Complexes: A New Understanding of an Old Subject

(2009) Giorgio Lenaz et al.   ANTIOXIDANTS & REDOX SIGNALING

Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis

(2009) Maria A. Lebedeva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mobility and function of Coenzyme Q (ubiquinone) in the mitochondrial respiratory chain

(2009) Giorgio Lenaz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Structure and function of mitochondrial supercomplexes

(2009) Natalya V. Dudkina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Reactive oxygen species and peroxisomes: Struggling for balance

(2009) Nina A. Bonekamp et al.   BIOFACTORS

Epigenetics in cancer

(2009) S. Sharma et al.   CARCINOGENESIS

Radioprotection by short-term oxidative preconditioning: Role of manganese superoxide dismutase

(2009) Natalia A. Belikova et al.   FEBS LETTERS

Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells

(2009) Yong Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structural and functional organization of the mitochondrial respiratory chain: A dynamic super-assembly

(2009) Giorgio Lenaz et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Radiosensitive gene therapy through imRNA expression for silencing manganese superoxide dismutase

(2009) Yaming Qu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Oxidative stress induced lung cancer and COPD: opportunities for epigenetic therapy

(2009) Matthew W. Lawless et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Energetics, epigenetics, mitochondrial genetics

(2009) Douglas C. Wallace et al.   MITOCHONDRION

Strong association between cancer and genomic instability

(2009) Christian Streffer   RADIATION AND ENVIRONMENTAL BIOPHYSICS

Novel Role of Protein Disulfide Isomerase in the Regulation of NADPH Oxidase Activity: Pathophysiological Implications in Vascular Diseases

(2008) Francisco R.M. Laurindo et al.   ANTIOXIDANTS & REDOX SIGNALING

Hydrogen peroxide mediates the radiation-induced mutator phenotype in mammalian cells

(2008) Disha Dayal et al.   BIOCHEMICAL JOURNAL

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Reactive species: A cell damaging rout assisting to chemical carcinogens

(2008) Mario E. Goetz et al.   CANCER LETTERS

Inflammation and Chronic Oxidative Stress in Radiation-Induced Late Normal Tissue Injury: Therapeutic Implications

(2008) Weiling Zhao et al.   CURRENT MEDICINAL CHEMISTRY

Epigenetic changes and nontargeted radiation effects—Is there a link?

(2008) Olga Kovalchuk et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Radiation-induced bystander effects in vivo are epigenetically regulated in a tissue-specific manner

(2008) Yaroslav Ilnytskyy et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

NADPH oxidase mediates radiation-induced oxidative stress in rat brain microvascular endothelial cells

(2008) J. Racquel Collins-Underwood et al.   FREE RADICAL BIOLOGY AND MEDICINE

Epigenetic silencing of SOD2 by histone modifications in human breast cancer cells

(2008) Michael J. Hitchler et al.   FREE RADICAL BIOLOGY AND MEDICINE

ROS and p53: A versatile partnership

(2008) Bin Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Environmental toxicity, redox signaling and lung inflammation: The role of glutathione

(2008) Saibal K. Biswas et al.   MOLECULAR ASPECTS OF MEDICINE

Epigenetic interplay between histone modifications and DNA methylation in gene silencing

(2008) T VAISSIERE et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Intrinsic Radiation Sensitivity: Cellular Signaling is the Key

(2008) I. Szumiel   RADIATION RESEARCH

Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG Island

(2008) Heather M. O'Hagan et al.   PLoS Genetics