Organometallic nucleosides induce non-classical leukemic cell death that is mitochondrial-ROS dependent and facilitated by TCL1-oncogene burden

Mitochondrial metabolism contributes to oxidative stress and reveals therapeutic targets in chronic lymphocytic leukemia

(2014) R. Jitschin et al.   BLOOD

AKT-pathway Inhibition in Chronic Lymphocytic Leukemia Reveals Response Relationships Defined by TCL1

(2014) Alexandra Schrader et al.   CURRENT CANCER DRUG TARGETS

Management of chronic lymphocytic leukemia

(2014) P. Ghia et al.   HAEMATOLOGICA

Organometallic Nucleoside Analogues with Ferrocenyl Linker Groups: Synthesis and Cancer Cell Line Studies

(2014) Huy V. Nguyen et al.   JOURNAL OF MEDICINAL CHEMISTRY

CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia

(2013) O. Fedorchenko et al.   BLOOD

Nucleoside Analogues with a 1,3-DieneFe(CO)3Substructure: Stereoselective Synthesis, Configurational Assignment, and Apoptosis-Inducing Activity

(2013) Christoph Hirschhäuser et al.   CHEMISTRY-A EUROPEAN JOURNAL

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

Molecular characterization of neoplastic and normal “sister” lymphoblastoid B-cell lines from chronic lymphocytic leukemia

(2013) Anna Lanemo Myhrinder et al.   LEUKEMIA & LYMPHOMA

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Prolonged Production of Reactive Oxygen Species in Response to B Cell Receptor Stimulation Promotes B Cell Activation and Proliferation

(2012) Matthew L. Wheeler et al.   JOURNAL OF IMMUNOLOGY

Stromal cells modulate TCL1 expression, interacting AP-1 components and TCL1-targeting micro-RNAs in chronic lymphocytic leukemia

(2012) M Sivina et al.   LEUKEMIA

Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia

(2012) Wan Zhang et al.   NATURE CELL BIOLOGY

Mechanism of tiron as scavenger of superoxide ions and free electrons

(2012) Fatai A. Taiwo   SPECTROSCOPY-AN INTERNATIONAL JOURNAL

Inhibition of Mitochondrial Respiration and Rapid Depletion of Mitochondrial Glutathione by β-Phenethyl Isothiocyanate: Mechanisms for Anti-Leukemia Activity

(2011) Gang Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

Tcl1 interacts with Atm and enhances NF- B activation in hematologic malignancies

(2011) E. Gaudio et al.   BLOOD

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration

(2011) Ganta Chaitanya et al.   Cell Communication and Signaling

ATM activation in the presence of oxidative stress 

(2011) Zhi Guo et al.   CELL CYCLE

Targeting the disturbed redox equilibrium in chronic lymphocytic leukemia by novel reactive oxygen species-catalytic ‘sensor/effector’ compounds

(2011) Nils Lilienthal et al.   LEUKEMIA & LYMPHOMA

Understanding and Managing Ultra High-Risk Chronic Lymphocytic Leukemia

(2011) S. Stilgenbauer et al.   Hematology-American Society of Hematology Education Program

N-acetylcysteine, reactive oxygen species and beyond

(2010) Shi-Yong Sun   CANCER BIOLOGY & THERAPY

Synthesis and Selective Anticancer Activity of Organochalcogen Based Redox Catalysts

(2010) Mandy Doering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial

(2010) M Hallek et al.   LANCET

Pharmacologic interception in T-cell leukemia 1A associated pathways as a treatment rationale for chronic lymphocytic leukemia

(2010) Wagma Popal et al.   LEUKEMIA & LYMPHOMA

Arsenic trioxide and ascorbic acid demonstrate promising activity against primary human CLL cells in vitro

(2010) Sabyasachi Biswas et al.   LEUKEMIA RESEARCH

HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species

(2010) Melania Capasso et al.   NATURE IMMUNOLOGY

ROS-mediated upregulation of Noxa overcomes chemoresistance in chronic lymphocytic leukemia

(2010) S H Tonino et al.   ONCOGENE

High TCL1 levels are a marker of B-cell receptor pathway responsiveness and adverse outcome in chronic lymphocytic leukemia

(2009) M. Herling et al.   BLOOD

The microenvironment in mature B-cell malignancies: a target for new treatment strategies

(2009) J. A. Burger et al.   BLOOD

Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance

(2009) A. V. Kurtova et al.   BLOOD

Treatment resistance in chronic lymphocytic leukemia–the role of the p53 pathway

(2009) Thorsten Zenz et al.   LEUKEMIA & LYMPHOMA

Molecular and cellular mechanisms of CLL: novel therapeutic approaches

(2009) Lisa Pleyer et al.   Nature Reviews Clinical Oncology

The TCL1A Oncoprotein Interacts Directly with the NF-κB Inhibitor IκB

(2009) Virginie Ropars et al.   PLoS One

Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism

(2008) D. Trachootham et al.   BLOOD

Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines

(2008) M. Hallek et al.   BLOOD

Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis

(2008) Veronique Nogueira et al.   CANCER CELL

Role of Smac/DIABLO in cancer progression

(2008) Gustavo Martinez-Ruiz et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Tcl1 functions as a transcriptional regulator and is directly involved in the pathogenesis of CLL

(2008) Y. Pekarsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA