Article
Biophysics
Francesca Della Sala, Teresa Silvestri, Assunta Borzacchiello, Laura Mayol, Luigi Ambrosio, Marco Biondi
Summary: The study found that the molecular weight of hyaluronic acid plays a significant role in the uptake and selectivity of nanoparticles in CD44-overexpressing breast carcinoma cells. Specifically, HA 800 kDa nanoparticles exhibited the highest uptake response, while HA 1400 kDa nanoparticles showed the lowest uptake. The interaction between nanoparticles and tumor cells is influenced by the rearrangement and conformation of the HA chain segment protruding from the nanoparticles.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Mengying Zhang, Huimin Yu, Jinglu Hu, Zhengyu Zhao, Lei Liu, Gaomin Yang, Tingli Wang, Guang Han, Shiyong Song
Summary: This study prepared a nanocarrier based on hyaluronic acid and solanesol, which showed great potential in cancer therapy. Loading doxorubicin into the nanocarrier enabled pH-sensitive drug release, with lower cardiotoxicity and hepatotoxicity compared to free doxorubicin.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Xiuxiu Wang, Ru Cheng, Zhiyuan Zhong
Summary: High-efficacy targeted nanotherapeutics based on FDA approved polymers like PLGA, such as HA-sPLGA XNPs, show promise in achieving enhanced treatment of A549 lung tumor, with fast cellular uptake and significantly improved potency compared to other nanoparticles. These nanoparticles demonstrate prolonged elimination half-life and notable tumor accumulation, making them a unique and potentially translatable platform for chemotherapy of CD44-overexpressing tumors.
ACTA BIOMATERIALIA
(2021)
Review
Polymer Science
Lisa Efriani Puluhulawa, I. Made Joni, Khaled M. Elamin, Ahmed Fouad Abdelwahab Mohammed, Muchtaridi Muchtaridi, Nasrul Wathoni
Summary: Chitosan-hyaluronic acid nanoparticles have the potential to be an effective and targeted treatment for various types of cancer, with good characteristics and active targeting capabilities.
Article
Medicine, Research & Experimental
Hantao Xue, Liya Qin, Longxiang Zhang, Xiaocheng Li, Fei Wu, Weiyu Wang, Chen Wang, Wenbin Diao, Bin Jiang, Bo Lian, Jingliang Wu, Jingkun Bai, Tongyi Sun, Chunling Zhao, Meihua Qu, Wenjing Yu, Yubing Wang, Zhiqin Gao
Summary: Liver cancer chemotherapy is limited by high toxicity and poor specificity, but targeted drug delivery systems have emerged as a novel therapeutic strategy for delivering precise drug doses to target sites. In this study, DTX/GA-HA-NPs were successfully prepared with high monodispersity and desirable particle size, showing strong inhibitory effects on HepG2 cell proliferation and promoting apoptosis. The results suggest promising liver-targeting and antitumor activities of DTX/GA-HA-NPs in vitro, laying the foundation for future in vivo studies.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Polymer Science
Hong Wang, Yanwei Zhang, Yaru Liu, Yi Ren, Jianhong Wang, Baolong Niu, Wenfeng Li
Summary: This paper focuses on the development of targeted drug delivery systems for cancer therapy. HA-SS-PLGA copolymer was used to form reduction-sensitive amphiphilic micelles, which actively targeted tumor cells and inhibited cancer cell proliferation. This research provides a promising drug carrier for cancer therapy.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Renshuai Zhang, Xiaohua Zhao, Ang Jia, Chao Wang, Hongfei Jiang
Summary: Hyaluronic acid (HA) is a natural polysaccharide that has gained significant attention for its improved tumor targeting capacity, enzyme degradation capacity, and excellent biocompatibility. Its receptor, CD44, is overexpressed in various cancer cells and is closely related to tumor progress and metastasis. Therefore, researchers have designed HA-based drug delivery platforms for CD44-mediated tumor targeting. HA-based nanoprodrugs possess distinct advantages such as good bioavailability, long circulation time, and controlled drug release and retention ability, and have been extensively studied in the past years.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Tingting Peng, Yao Huang, Xiaoqian Feng, Chune Zhu, Shi Yin, Xinyi Wang, Xuequn Bai, Xin Pan, Chuanbin Wu
Summary: The utilization of dissolving microneedles for locally delivering functionalized nanoparticles with combined chemotherapy and photothermal therapy has shown promising results in enhancing anti-tumor effects and reducing adverse reactions.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Pharmacology & Pharmacy
Shwe Phyu Hlaing, Jiafu Cao, Juho Lee, Jihyun Kim, Aruzhan Saparbayeva, Dongmin Kwak, Hyunwoo Kim, Seonghwan Hwang, Hwayoung Yun, Hyung Ryong Moon, Yunjin Jung, Jin-Wook Yoo
Summary: In this study, curcumin-loaded nanoparticles targeted inflamed colitis tissue and demonstrated better therapeutic efficacy compared to non-targeted nanoparticles. The nanoparticles reduced inflammation and accelerated recovery, making them a promising delivery platform for treating ulcerative colitis.
Article
Medicine, Research & Experimental
Fakhrossadat Emami, Ramesh Duwa, Asmita Banstola, Seon Min Woo, Taeg Kyu Kwon, Simmyung Yook
Summary: Dual-receptor targeted (DRT) nanoparticles with two distinct targeting agents were prepared for the delivery of docetaxel (DTX) to EGFR and PD-L1 positive cancer cells. The DRT-DTX-PLGA nanoparticles exhibited high cytotoxicity and enhanced apoptotic cell death compared to single ligand-targeted nanoparticles. The dual receptor mediated endocytosis of DRT-DTX-PLGA resulted in high intracellular DTX concentration and cytotoxic properties. DRT nanoparticles have the potential to improve cancer therapy by providing selectivity over single-ligand-targeted nanoparticles.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Analytical
Amir Khajavinia, Mehran Yarahmadi, Anas El-Aneed, Azita Haddadi
Summary: In this study, an efficient LC-MS/MS method was developed to quantify docetaxel in PLGA nanoparticles. By optimizing the nanoparticle formulation and using MS/MS fingerprints, a reliable quantification method was developed. This is of importance for future research on docetaxel-loaded polymeric nanodelivery systems.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Instruments & Instrumentation
Iago Fernandez-Marino, Clement Anfray, Jose Crecente-Campo, Akihiro Maeda, Aldo Ummarino, Carmen Teijeiro-Valino, Dario Blanco-Martinez, Francis Mpambani, Laurence Poul, Julie Devalliere, Matthieu Germain, Juan Correa, Marcos Fernandez-Villamarin, Paola Allavena, Eduardo Fernandez-Megia, Maria Jose Alonso, Fernando Torres Andon
Summary: This work describes the development and biological evaluation of hyaluronic acid nanocapsules (NCs) designed to target tumor-associated macrophages (TAMs). The results showed that HA nanocapsules functionalized with mannose significantly increased uptake by M2 macrophages and accumulated more in the tumor. This study provides new options for nanomedicine and immunotherapy-based cancer treatments.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Arindam Pramanik, Zexi Xu, Nicola Ingram, Patricia Louise Coletta, Paul A. Millner, Arwen I. I. Tyler, Thomas A. Hughes
Summary: Delivery of chemotherapy drugs specifically to cancer cells raises local drug doses in tumors and therefore kills more cancer cells while reducing side effects in other tissues, thereby improving oncological and quality of life outcomes. Cubosomes, liquid crystalline lipid nanoparticles, are potential vehicles for delivery of chemotherapy drugs.
MOLECULAR PHARMACEUTICS
(2022)
Article
Engineering, Biomedical
Minjun Ye, Bingyi Li, Wanyu Shi, Huaize Liu, Yi Wang, Weiqing Chen, Jian Wang, Guixue Wang
Summary: Radiation therapy is commonly used in the treatment of tumors, but it often causes damage to normal tissues. Boron neutron capture therapy (BNCT) is a targeted approach that has shown advantages in tumor treatment. This study developed a tumor-targeting nano-boron drug by using albumin as a drug carrier and modifying the nanoparticles with hyaluronic acid. The results showed that the modified nanoparticles effectively delayed drug release, enhanced aggregation in tumors, and had good safety with no noticeable toxicity. These findings provide valuable insights for the application of boron drugs in BNCT.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Biochemistry & Molecular Biology
Keita Yamana, Riku Kawasaki, Yu Sanada, Anri Tabata, Kaori Bando, Kouhei Yoshikawa, Hideki Azuma, Yoshinori Sakurai, Shin-ichiro Masunaga, Minoru Suzuki, Kouta Sugikawa, Takeshi Nagasaki, Atsushi Ikeda
Summary: The study introduced a fluorescent nano complex for high boron concentration and tumor-selectivity in cancer therapy, which could be actively internalized by tumor cells and exhibited excellent cytotoxicity post-thermal neutron irradiation, potentially offering a more suitable alternative to boron agents in BNCT.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Chemistry, Applied
In-Soo Yoon, Seung-Sik Cho
Summary: The study found that LBT weakly inhibits xanthine oxidase (XO) activity through a mixed type mechanism, and the effect of oral LBT on serum XO activity in hyperuricemic mice is limited. However, oral LBT at a dose of 50 mg/kg significantly reduces hepatic XO activity in vivo.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biochemical Research Methods
Seong-Wook Seo, Ji-Min Kim, Dong-Gyun Han, Dongho Geum, Hwayoung Yun, In -Soo Yoon
Summary: Alpelisib, an oral anticancer agent for treating breast cancer, exhibits nonlinear pharmacokinetics in rats. A new HPLC-FLD method was developed to determine alpelisib in plasma.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Medicine, Research & Experimental
Hanju Lee, Sohee Park, Sanghyun Ju, Soojin Kim, Jin-Wook Yoo, In-Soo Yoon, Do Sik Min, Yunjin Jung
Summary: The study showed that colon-targeted microbial metabolite 3-IPA alleviated rat colitis, and its anti-colitic activity could be enhanced by co-delivery with the GPR109A agonist 5-ANA.
MOLECULAR PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Min-Hwan Kim, Ju-Hwan Park, Duy-Thuc Nguyen, Sungyun Kim, Da In Jeong, Hyun-Jong Cho, Dae-Duk Kim
Summary: An HAase inhibitor-incorporated hyaluronic acid hydrogel was designed to reduce toxicity risk and slow biodegradation rate in subcutaneous tissue. The hydrogel, formulated with Quercetin as an HAase inhibitor and quetiapine as a model drug, exhibited sustained drug release and improved pharmacokinetic parameters in rats following subcutaneous injection. All results supported the designed hydrogel as a biocompatible formulation for sustained drug delivery.
Article
Pharmacology & Pharmacy
Dong-Gyun Han, Eunju Cha, Jeongmin Joo, Ji Sun Hwang, Sanghyun Kim, Taeuk Park, Yoo-Seong Jeong, Han-Joo Maeng, Sang-Bum Kim, In-Soo Yoon
Summary: Acacetin, an important ingredient found in acacia honey and medicinal plants, exhibits therapeutic effects such as antioxidative and anticancer activities. However, its oral bioavailability is low mainly due to poor solubility and stability in the gastrointestinal tract.
Article
Pharmacology & Pharmacy
Nae-Won Kang, So-Yeon Yoon, Sungho Kim, Na-Young Yu, Ju-Hwan Park, Jae-Young Lee, Hyun-Jong Cho, Dae-Duk Kim
Summary: The study developed a hybrid hydrogel containing microstructured lipid carriers and human serum albumin for sustained release of donepezil, which prolonged drug release and reduced initial plasma concentration in rats. The hydrogel exhibited good biocompatibility and therapeutic efficacy.
Article
Medicine, Research & Experimental
Seong-Wook Seo, Dong-Gyun Han, Eugene Choi, Taeuk Park, Jong Hyuk Byun, Hyun-Jong Cho, Il Hyo Jung, In-Soo Yoon
Summary: Entrectinib is an oral antineoplastic agent approved for treating specific types of cancer. Further investigation is needed on the oral bioavailability and systemic exposure of the drug. The established PBPK model accurately reflects the drug exposure in both rats and humans.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Changyu Kang, Jaejeong Kim, Sanghyun Ju, Sohee Park, Jin-Wook Yoo, In-Soo Yoon, Min-Soo Kim, Yunjin Jung
Summary: Dapsone is an antimicrobial and antiprotozoal agent with anti-inflammatory activity, used in the treatment of leprosy and autoimmune diseases. A new compound AS-DpS-AS, a combination of DpS and 5-ASA, showed better efficacy against colitis in rats compared to SSZ, suggesting higher therapeutic efficacy due to the combined anti-colitic effects of 5-ASA and DpS.
Article
Biochemistry & Molecular Biology
Gi-Sang Seong, Seong-Wook Seo, Ji Young Cho, Kye Wan Lee, Beom-Jin Lee, In-Soo Yoon, Hyo-Eon Jin
Summary: In this study, a simple UPLC-MS/MS method was developed for the simultaneous determination of leuprolide and leuprolide-oleic acid conjugate (LOC) levels. The pharmacokinetics of leuprolide and LOCs were evaluated and it was found that conjugation with fatty acids significantly altered the pharmacokinetics of leuprolide.
Article
Plant Sciences
Seong-Wook Seo, Dong-Gyun Han, Eugene Choi, Min-Jeong Seo, Im-Sook Song, In-Soo Yoon
Summary: This study investigates the oral absorption and systemic disposition of zeaxanthin. The results show that zeaxanthin has poor solubility and stability in simulated gut luminal fluids. It is primarily absorbed in the duodenum, but a large fraction remains unabsorbed. Zeaxanthin accumulates in the liver, lung, and spleen after intravenous injection, with the liver being the major eliminating organ.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Changyu Kang, Jaejeong Kim, Sanghyun Ju, Heeyeong Cho, Hyun Young Kim, In-Soo Yoon, Jin-Wook Yoo, Yunjin Jung
Summary: Colon-targeted trans-cinnamic acid (tCA) and its conjugates with glutamic acid (tCA-GA) and aspartic acid (tCA-AA) were designed and synthesized. The anti-colitic activity of colon-targeted tCA was evaluated using a rat colitis model. The conjugates decreased the distribution coefficient and cell permeability of tCA and produced more tCA in the cecum, particularly with tCA-GA. Oral administration of tCA-GA delivered a higher amount of tCA to the cecum and exhibited better anti-colitic effects compared to tCA and the current treatment, sulfasalazine (SSZ).
Article
Chemistry, Medicinal
Seong-Wook Seo, Dong-Gyun Han, Young Mee Baek, Min Chul Park, Jin-Wook Yoo, Yunjin Jung, Han-Joo Maeng, Heejoon Myung, In-Soo Yoon
Summary: This study comprehensively investigated the oral absorption and intestinal/hepatic metabolism of alizarin. It found that alizarin has low stability in the intestine and low hepatic metabolism, resulting in a low oral bioavailability.
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Min-Jun Baek, Duy-Thuc Nguyen, Dahan Kim, So-Yeol Yoo, Sang Min Lee, Jae-Young Lee, Dae-Duk Kim
Summary: The study presents the design of a tailored structure for renal-clearable zwitterionic cyclodextrin for selective drug delivery in colorectal cancer. Twenty cyclodextrin derivatives were synthesized and screened for colloidal stability, resulting in five candidates that were evaluated for biodistribution and an optimized structure was identified. The optimized cyclodextrin demonstrated high tumour accumulation and improved antitumour efficacy in colorectal cancer models.
NATURE NANOTECHNOLOGY
(2023)
Article
Nutrition & Dietetics
Min-Ji Keem, Seong-Wook Seo, Taeyoung Kim, Beom-Geun Jo, Su-Nam Kim, In-Soo Yoon, Min Hye Yang
Summary: This study developed a simultaneous analysis method for three marker components isolated from Wikstroemia ganpi and investigated their effects on drug metabolism. The developed method exhibited good linearity and validation parameters. One of the components showed the highest content. The plant extract was found to inhibit drug metabolism in vitro but not in vivo.
Article
Pharmacology & Pharmacy
Jaejeong Kim, Changyu Kang, Jin-Wook Yoo, In-Soo Yoon, Yunjin Jung
Summary: Riluzole azo-linked to salicylic acid (RAS) is a colon-targeted prodrug of riluzole (RLZ) with improved efficacy against rat colitis. This study synthesized and evaluated N-succinylaspart-1-ylRLZ (SAR) and N-succinylglutam-1-ylRLZ (SGR) as me-better colon-targeted prodrugs of RLZ. SAR demonstrated better colon specificity, anticolitic potency, and reduced systemic absorption compared to RAS, making it a potentially safer alternative.
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
