Article
Immunology
Ariana N. Renrick, Menaka C. Thounaojam, Maria Teresa P. de Aquino, Evan Chaudhuri, Jui Pandhare, Chandravanu Dash, Anil Shanker
Summary: The study demonstrates that bortezomib can enhance the function of anti-tumor CD8(+) T cells by inducing the downregulation of negative regulatory proteins SOCS1 and SHIP1 through the miR-155 pathway, thus overcoming T cell exhaustion in the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Ignacio Prieto, Maria Kavanagh, Luna Jimenez-Castilla, Marisa Pardines, Iolanda Lazaro, Isabel Herrero del Real, Monica Flores-Munoz, Jesus Egido, Oscar Lopez-Franco, Carmen Gomez-Guerrero
Summary: Diabetic kidney disease (DKD) is a common complication of diabetes, in which inflammation and oxidative stress play important roles. This study reveals the involvement of miR-155-5p and SOCS1 in the regulation of the JAK/STAT pathway, highlighting their potential as therapeutic targets for DKD.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Review
Biochemistry & Molecular Biology
Simone Tealdi, Elsi Ferro, Carlo Cosimo Campa, Carla Bosia
Summary: In this review, the focus is on microRNA-mediated gene regulatory networks characterized by time-dependent input signals, such as pulses, transient inputs, and oscillations. By identifying the general characteristic of the main motifs underlying temporal patterns, the impact of these patterns on commonly studied oncogenic networks is analyzed, demonstrating how dysfunction can lead to tumorigenesis.
Article
Immunology
Hui Yu, Lei Qin, Yunzhi Peng, Wenhui Bai, Zhanli Wang
Summary: The study revealed that exosomes released from hypertrophic cardiomyocytes induced inflammatory responses in macrophages through miR-155, activating various signaling pathways, which may play a crucial role in the development of cardiac hypertrophy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Md Gulam Musawwir Khan, Nadia Boufaied, Mehdi Yeganeh, Rajani Kandhi, Stephanie Petkiewicz, Ankur Sharma, Akihiko Yoshimura, Gerardo Ferbeyre, David P. Labbe, Sheela Ramanathan, Subburaj Ilangumaran
Summary: The SOCS1 protein protects liver cells from becoming cancerous and its deficiency increases susceptibility to liver cancer. CDKN1A is a protein that can protect against liver cancer but under certain circumstances, it can promote cancer growth. Our findings show that SOCS1 suppresses the expression of CDKN1A, preventing liver cells from withstanding the stress associated with cancer growth. This pathway could be targeted for therapeutic strategies in SOCS1-deficient liver cancers.
Article
Biochemistry & Molecular Biology
Juehua Cheng, Yuyao Zhang, Jingjing Yang, Yanting Wang, Juanyong Xu, Yuan Fan
Summary: This study found that miR-155-5p regulates the secretion of IL-6 and IL-8 in activated OLP associated-fibroblasts by downregulating the expression of SOCS1. These findings provide novel insights into the pathogenesis of OLP and identify a potential new target for OLP therapy.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Yanxia Wu, Yanxi Sun, Binchu Xu, Mo Yang, Xingwu Wang, Xiaocheng Zhao
Summary: The lncRNA SCARNA10 interacts with the DNA binding domain (DBD) of the tumor suppressor p53, promoting its acetylation modification and activating p53-mediated transcriptional activity. This involvement of SCARNA10 in various cellular processes such as cell cycle arrest, apoptosis, DNA repair, cell metabolism, and ferroptosis highlights its importance in tumor suppression.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Yang Shao, Yiming Li, Yingjian Jiang, Hongbo Li, Jiang Wang, Dianliang Zhang
Summary: Severe acute pancreatitis (SAP) is a common and serious disease that can lead to intestinal barrier dysfunction. The present study investigated the role of circulating exosomes in this barrier dysfunction. It was found that SAP-Exo induced pyroptotic cell death and barrier dysfunction in vitro, and miR-155-5p was significantly increased in SAP-Exo. MiR-155-5p targeted suppressor of cytokine signaling 1 (SOCS1) to activate NOD-like receptor protein 3 (NLRP3) inflammasome-mediated pyroptosis, leading to intestinal barrier damage.
Article
Plant Sciences
Yundong Yin, Hua Qu, Qiaoning Yang, Zhaohui Fang, Rui Gao
Summary: The study demonstrated that AST can promote autophagy activity in DPN Schwann cells by regulating the miR-155-mediated PI3K/Akt/mTOR signaling pathway, thus alleviating neuronal cell damage. Treatment with AST in DPN rats resulted in decreased blood glucose levels, improved neurological function, and reduced peripheral nerve myelin sheath injury, attributed to the inhibition of cell apoptosis through the suppression of the PI3K/Akt/mTOR signaling pathway.
Article
Biochemistry & Molecular Biology
Enjiang Chen, Enliang Li, Hao Liu, Yue Zhou, Liang Wen, Jianxin Wang, Yi Wang, Longyun Ye, Tingbo Liang
Summary: The study demonstrates that miR-26b enhances the sensitivity of HCC cells to doxorubicin, providing a potential therapeutic pathway involving the modulation of de-ubiquitination of p53 and regulation of autophagy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Hongqiong Fan, Shanshan Liu, Benzheng Jiao, Xinyue Liang
Summary: High glucose induces hepatic apoptosis by upregulating miR-155 and downregulating SOCS1 levels, and stimulates the secretion of inflammatory factors. However, low-dose radiation can inhibit high glucose-induced damage and protect the liver by regulating the miR-155-SOCS1 axis.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Pharmacology & Pharmacy
Charalampia Amerikanou, Efstathia Papada, Aristea Gioxari, Ilias Smyrnioudis, Stamatia-Angeliki Kleftaki, Evdokia Valsamidou, Victoria Bruns, Rajarshi Banerjee, Maria Giovanna Trivella, Natasa Milic, Milica Medic-Stojanoska, Amalia Gastaldelli, Aimo Kannt, George Dedoussis, Andriana C. Kaliora
Summary: This study investigated the anti-inflammatory activity of Mastiha by regulating miRNA levels, finding that the increase of miR-155 in ulcerative colitis patients was prevented by Mastiha, while the levels did not significantly change in patients with less advanced fibrosis in NAFLD.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Salvatore Pulcrano, Roberto De Gregorio, Claudia De Sanctis, Laura Lahti, Carla Perrone-Capano, Donatella Ponti, Umberto di Porzio, Thomas Perlmann, Massimiliano Caiazzo, Floriana Volpicelli, Gian Carlo Bellenchi
Summary: The development of midbrain dopaminergic neurons requires precise regulation of a specific gene expression program, which is controlled by the Lmx1a-miR-204/211-Nurr1 axis. The miR-204/211 acts as a molecular switch to regulate the timing of Nurr1 expression, ultimately leading to the differentiation of mature midbrain dopaminergic neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Tohar S. Yarden, Adi Mizrahi, Israel Nelken
Summary: This study investigated the role of inhibition in auditory cortex in stimulus-specific adaptation (SSA). Using two-photon targeted cell-attached recordings and optogenetic manipulations, the researchers found that parvalbumin (PV), somatostatin (SST), and vasoactive intestinal polypeptide (VIP) expressing interneurons showed early-onset SSA. Surprisingly, inhibiting PV neurons enhanced responses to deviant stimuli more than to standard stimuli, while inhibiting VIP neurons decreased responses to standard stimuli but not to deviant stimuli.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Immunology
Elena Skourti, Alessia Volpe, Cameron Lang, Preeth Johnson, Fani Panagaki, Gilbert O. Fruhwirth
Summary: MicroRNAs play a crucial role in physiology and disease, especially in cancer development and progression. In this study, a novel in vivo microRNA detector platform was developed, allowing non-invasive quantification of microRNA changes in tumor models. The platform was found to accurately report on microRNA presence and revealed immune-mediated phenotypic changes in breast cancer tumors as they progressed.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Renata Parissi Buainain, Matheus Negri Boschiero, Bruno Camporeze, Paulo Henrique Pires de Aguiar, Fernando Augusto Lima Marson, Manoela Marques Ortega
Summary: The study reviewed the relationship between SNVs within miRNA sequences or their target genes and epilepsy susceptibility. It found that SNVs rs2910164 and rs57095329 may modify the expression level of miR-146a and the risk for epilepsy, while other SNVs could interfere in inflammatory pathway genes. The main limitation of the studies is the small sample size.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Public, Environmental & Occupational Health
Matheus Negri Boschiero, Camila Vantini Capasso Palamim, Manoela Marques Ortega, Renan Marrichi Mauch, Fernando Augusto Lima Marson
Summary: This article provides an overview of the first year of the COVID-19 pandemic in Brazil from a social and political perspective and discusses the key factors contributing to the country's failed management of the disease, resulting in over 11 million cases and 270,000 deaths. The impacts of COVID-19 on different regions, indigenous populations, healthcare workers, and internal social disparities are addressed, along with the significant role of political instability and anti-scientific actions in exacerbating the situation.
ANNALS OF GLOBAL HEALTH
(2021)
Review
Dermatology
Hoda Keshmiri Neghab, Mohammad Hasan Soheilifar, Michael Grusch, Manoela Marques Ortega, Gholamreza Esmaeeli Djavid, Ali Akbar Saboury, Bahram Goliaei
Summary: This paper summarizes the current optogenetic tools stimulated by different light sources and outlines the various biomedical applications of optogenetics, not only for neuronal circuits but also for various kinds of cells and tissues. The potential of optogenetics for treating neurological disorders, cardiac arrhythmia, visual impairment, hearing loss, and urinary bladder diseases is highlighted, as well as the clarification of mechanisms underlying cancer progression and stem cell differentiation. Optogenetics shows promise in treating a broad spectrum of disorders and is expected to benefit more patients in the future.
LASERS IN SURGERY AND MEDICINE
(2022)
Review
Clinical Neurology
Gabriel Alves Bonafe, Matheus Negri Boschiero, Andre Rodrigues Sodre, Jussara Vaz Ziegler, Thalita Rocha, Manoela Marques Ortega
Summary: Many plant-derived compounds have potential antitumor effects on glioblastoma (GBM) cell lines by enhancing apoptosis-related pathways and cell cycle impairment. Caffeine, dipotassium glycyrrhizinate (DPG), curcumin, and euphol have shown promising results in inhibiting GBM cell growth. They exert their effects through modulation of microRNAs (miRs) and various signaling pathways.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Renata Parissi Buainain, Carlos Tadeu Parisi Oliveira, Fernando Augusto Lima Marson, Manoela Marques Ortega
Summary: This study aimed to investigate the epidemiological aspects of individuals with epilepsy in a region of Southeast Brazil. The results showed a lower prevalence rate of epilepsy compared to other regions and a higher proportion of structural epilepsy type.
FRONTIERS IN NEUROLOGY
(2022)
Review
Public, Environmental & Occupational Health
Paulo Queiroz Luciano, Renan Binatti, Andre Rodrigues Sodre, Sergio Roberto Zajac, Fernando Augusto Lima Marson, Manoela Marques Ortega
Summary: This article reports rare cases of unusual thrombosis and thrombocytopenia after administration of the ChAdOx1 nCoV-19 vaccine. It includes a description of a case of VITT in a 66-year-old woman who received the vaccine. The study emphasizes the importance of understanding the immunohypersensitivity mechanisms associated with vaccine reactions in order to reduce their occurrences and increase confidence in vaccine administration.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Genetics & Heredity
Matheus Negri Boschiero, Camila Vantini Capasso Palamim, Manoela Marques Ortega, Fernando Augusto Lima Marson
Summary: The study aimed to compare the COVID-19 death rate among hospitalized patients with Down syndrome in Brazil and tease apart the unique effects of COVID-19 and Down syndrome through comparing disease characteristics.
Article
Oncology
Gabriel Alves Bonafe, Jessica Silva dos Santos, Anna Maria Alves de Piloto Fernandes, Jussara Vaz Ziegler, Fernando Augusto Lima Marson, Thalita Rocha, Patricia de Oliveira Carvalho, Manoela Marques Ortega
Summary: Dipotassium glycyrrhizinate (DPG) suppresses the nuclear factor kappa B (NF-kappa B) pathway in glioblastoma (GBM) cells by upregulating miR-4443 and miR-3620, leading to inhibition of cell growth and stem cell subpopulation formation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Camila dos Santos Leite, Gabriel Alves Bonafe, Oscar Cesar Pires, Tanila Wood dos Santos, Geovanna Pacciulli Pereira, Jose Aires Pereira, Thalita Rocha, Carlos Augusto Real Martinez, Manoela Marques Ortega, Marcelo Lima Ribeiro
Summary: The study aimed to evaluate the anti-inflammatory effect of topical Dipotassium Glycyrrhizinate (DPG) on wound healing. Results showed that DPG treatment reduced inflammatory exudate, eliminated active hyperemia, increased granulation tissue, promoted tissue reepithelialization, and enhanced total collagen. In addition, DPG treatment decreased the expression of pro-inflammatory cytokines while increasing the expression of anti-inflammatory cytokine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jessica Silva dos Santos, Amanda Janaina Suzan, Gabriel Alves Bonafe, Anna Maria Alves de Piloto Fernandes, Giovanna Barbarini Longato, Marcia Aparecida Antonio, Patricia de Oliveira Carvalho, Manoela Marques Ortega
Summary: Enzymatic hydrolysis of Sophora japonica extract using hesperidinase and galactosidase resulted in a kaempferol-enriched extract with enhanced anti-cancer activity. Both extracts, KPF-BBR and KPF-ABR, showed significant inhibition of cell viability and induction of apoptosis in human high-degree gliomas. They also demonstrated inhibitory effects on cell migration and proliferation, with KPF-ABR being the most effective as an antitumor candidate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Gabriel Alves Bonafe, Jessica Silva dos Santos, Jussara Vaz Ziegler, Fernando Augusto Lima Marson, Thalita Rocha, Manoela Marques Ortega
Summary: The study found that dipotassium glycyrrhizinate (DPG) can significantly decrease the viability of melanoma cells, induce apoptosis, and inhibit their proliferation and migration. Additionally, DPG can degrade melanospheres and inhibit the formation of cancer stem-like cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Pathology
Matheus Negri Boschiero, Jose Roberto Lutti Filho, Manoela Marques Ortega, Fernando Augusto Lima Marson
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Camila dos Santos Leite, Gabriel Alves Bonafe, Juliana Carvalho Santos, Carlos Augusto Real Martinez, Manoela Marques Ortega, Marcelo Lima Ribeiro
Summary: Intestinal diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancer (CRC), pose a significant health burden globally. Licorice, a traditional Chinese medicine, exhibits anti-inflammatory and antioxidant properties that may have therapeutic potential for intestinal disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Nathalia M. S. Sansone, Matheus N. Boschiero, Manoela M. Ortega, Isadora A. Ribeiro, Andressa O. Peixoto, Roberto T. Mendes, Fernando A. L. Marson
Summary: During the COVID-19 pandemic, Brazilian Indigenous peoples faced an increased risk of death, with factors such as male gender, older age (>= 60 y.o.), and need for ventilatory support being associated with an enhanced risk. The study also found that older age (>= 43 y.o.), loss of smell, and fever were factors that could help differentiate SARS caused by COVID-19 or other etiologic agents.
LANCET REGIONAL HEALTH-AMERICAS
(2022)
Review
Otorhinolaryngology
Juliana Carron, Caroline Torricelli, Janet K. Silva, Gabriela S. R. Queiroz, Manoela M. Ortega, Carmen S. P. Lima, Gustavo J. Lourenco
Summary: Head and neck squamous cell carcinoma (HN SCC) is the eighth most common cancer worldwide. In addition to tobacco and alcohol consumption, genetic and epigenetic alterations play a critical role in the occurrence and progression of HNSCC. microRNAs (miRNAs) are small noncoding RNAs that regulate various cellular processes and have the potential to serve as diagnostic markers and therapeutic targets for HNSCC.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)